Hub : Genes

CYCSP10

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.319 0.105 0.0051 -0.010 NA 0.005 NA -0.008 0.89 NA 0.22 NA 0.63
2 GTEx Cells EBV-transformed lymphocytes 0.186 0.082 0.0097 0.009 NA -0.009 NA -0.007 0.16 NA 0.83 NA 0.66

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.1 0.2 0.4 0.3
Bipolar Disorder or Schizophrenia 0.2 0.4 0.8 0.2 0.9
Depressed Affect (Nagel 2018) 1.1 2.3 4.5 2.1 -0.3
Depression (Nagel 2018) 0.1 0.2 0.4 0.1 -0.6
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.3 0.5 0.1
Neuroticism (Nagel 2018) 0.7 1.7 3.4 1.8 0.3
Schizophrenia (2018) 0.2 0.4 0.8 -0.1 0.9
Schizophrenia vs Biploar Disorder 0.7 1.0 1.7 -1.3 0.5
Worry (Nagel 2018) 0.4 0.8 0.9 1.0 0.8
Alzheimer’s Disease (in mother) 0.6 0.7 0.8 -0.7 0.9
Alzheimer’s Disease (in father) 0.1 0.1 0.2 0.4 -0.0
Alzheimer’s Disease (including proxy) 0.4 0.5 0.8 0.4 0.9
Crohns Disease (2017) 0.0 0.1 0.1 0.0 0.3
Irritable Bowel Disease (IBD) 2.0 4.8 5.6 -2.4 2.0
Ulcerative Colitis (UC) 5.2 9.7 10.5 -3.2 3.0
Major Depression (MDD) 1.0 1.2 2.2 -1.5 -0.3
Reaction Time 0.1 0.2 0.3 0.5 0.5
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.1 -0.5 1.0
Breast Cancer 0.4 0.9 1.5 -0.6 -1.2
Ovarian Cancer 0.6 0.8 0.8 -0.9 0.9
Prostate Cancer 0.6 0.8 1.6 0.1 1.3
Age at First Birth 0.1 0.2 0.3 -0.5 -0.2
Bipolar Disorder (2011) 2.4 2.3 2.8 -1.3 1.7
Body Mass Index (BMI) (2010) 0.3 0.4 0.4 0.7 0.5
Coronary Artery Disease (CAD) 0.1 0.1 0.2 0.1 0.5
Crohns Disease (2012) 0.3 0.5 0.9 -0.4 1.0
Mean Putamen Volume 0.4 0.4 0.6 0.5 -0.8
Fasting Glucose 0.0 0.0 0.1 0.0 0.3
HbA1C 0.2 0.2 0.3 0.2 -0.5
HDL Cholesterol 0.1 0.2 0.3 -0.1 0.6
LDL Cholesterol 1.0 1.5 2.6 1.6 0.6
Lupus 1.1 1.7 2.9 -1.7 -0.8
Neuroticism (2016) 1.7 2.4 4.7 2.2 0.4
Primary Biliary Cirrhosis 0.1 0.2 0.3 -0.6 -0.3
Rheumatoid Arthritis 0.5 0.7 1.3 0.4 -1.1
Schizophrenia (2014) 1.2 2.7 5.3 -0.4 2.3
Triglycerides 0.2 0.3 0.5 -0.7 -0.4
Type 2 Diabetes (T2D) (2012) 1.2 1.4 2.1 0.8 1.5
Ulcerative Colitis 7.4 10.7 12.3 -3.0 3.5
Blood Eosinophil Count 0.5 3.8 4.0 -2.0 1.9
Blood Platelet Count 0.0 0.0 0.0 -0.2 -0.2
Blood Red Count 0.0 0.4 0.5 0.6 -0.7
Blood White Count 0.1 0.8 1.5 0.0 -1.2
Heel T-Score 0.6 4.6 6.8 1.5 2.6
BMI 1.9 11.2 17.9 2.1 -4.2
Height 0.8 16.3 31.7 0.9 -5.6
Waist Hip Ratio (WHR) 0.3 1.2 1.3 -1.0 1.1
Systolic Blood Pressure 0.0 0.2 0.5 -0.7 -0.1
Smoking Status 1.6 3.9 7.7 0.2 -2.8
Allergy or Eczema 0.1 0.4 0.6 -0.4 0.8
Cardiovascular Disease 0.5 1.6 2.9 -0.5 -1.7
Hypothyroidism (self reported) 1.3 2.9 3.8 -1.9 1.4
Respiratory disease 0.2 0.5 0.6 -0.8 -0.6
Type 2 Diabetes (T2D) (2018) 1.1 2.1 4.3 0.0 -2.1
Lung FEV1/FVC ratio 1.1 5.5 9.3 -1.3 3.0
Lung FVC 0.0 0.2 0.4 0.6 -0.1
Neuroticism 0.9 2.1 3.3 1.8 0.9
Chronotype (morning person) 0.3 0.6 1.2 -0.0 -1.1
Hair Pigment 0.2 4.5 8.6 0.5 -2.9
Tanning 0.1 1.3 2.3 0.6 -1.5
Hand grip strength (left) 0.3 0.7 0.7 0.9 -0.8
Number of treatments/medications taken 1.2 2.1 3.9 0.6 -2.0
Average weekly spirits intake 0.0 0.1 0.1 -0.3 -0.2
Sensitivity / hurt feelings 0.2 0.4 0.6 -0.5 0.8
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 -0.0 0.4
Hearing difficulty/problems: Yes 0.6 1.0 1.9 -0.0 -1.4
Relative age of first facial hair 0.5 1.1 2.0 -1.4 -0.4
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 0.7 0.8 -0.8
Ever used hormone-replacement therapy (HRT) 1.0 1.2 2.5 1.6 -0.0
Ever had hysterectomy (womb removed) 0.5 0.6 0.7 0.7 -0.8
Systolic blood pressure, automated reading 0.0 0.1 0.3 0.5 -0.1
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.7 0.1 -1.3
Angina 2.3 3.0 5.9 -0.0 -2.4
Medication for hormone replacement therapy 1.8 2.0 3.6 1.9 0.6
Vitamin and mineral supplements 0.5 0.7 1.4 0.2 -1.2
Supplements: Zinc 1.4 1.6 3.1 1.8 0.2
Medication: Co-codamol 3.2 3.8 7.1 0.7 -2.7
Medication: Metformin 1.1 1.5 3.1 0.0 -1.8
Diabetes (father) 0.6 0.7 1.4 0.3 1.2
Diabetes (mother) 0.2 0.3 0.5 -0.3 -0.7
Severe depression (siblings) 0.4 0.4 0.7 0.9 -0.3
Pack years adult smoking proportion 0.5 0.8 1.4 -1.2 -0.4
Impedance of leg (right) 2.0 9.5 14.5 -2.1 3.8
Leg fat-free mass (left) 4.0 21.4 29.5 3.6 -5.4
Trunk fat percentage 1.8 7.4 8.7 2.4 -3.0
Hand grip strength (right) 0.3 0.8 1.4 0.6 -1.2
Townsend deprivation index at recruitment 0.1 0.1 0.2 -0.5 0.1
Current tobacco smoking 0.2 0.4 0.7 -0.3 -0.8
Average weekly fortified wine intake 0.3 0.4 0.6 -0.3 0.8
Maternal smoking around birth 0.0 0.0 0.0 0.2 0.2
Fed-up feelings 0.2 0.3 0.4 0.6 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.2 -0.7 -1.1
Relative age voice broke 0.9 1.4 2.6 -1.6 -0.5
Taking other prescription medications 0.9 1.3 1.8 0.9 -1.3
Age when periods started (menarche) 0.3 0.6 1.1 -0.4 1.0
Bilateral oophorectomy (both ovaries removed) 1.6 1.8 3.7 0.2 -1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.1 -0.3 -0.3
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.1 -0.3 -1.0
Qualifications: CSEs or equivalent 0.1 0.2 0.3 0.3 0.5
Serious illness, injury or assault to yourself 3.4 4.2 4.2 2.0 -2.0
High blood pressure 0.7 1.8 1.9 -1.4 -1.3
Hayfever, allergic rhinitis or eczema 0.9 2.0 3.3 -1.8 0.9
Multivitamins +/- minerals 0.1 0.1 0.1 -0.3 0.2
Stomach or abdominal pain in last month 0.3 0.3 0.3 -0.6 -0.6
Supplements: Glucosamine 0.6 0.8 1.5 -0.4 1.2
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.1 -0.0 -0.2
Medication: Atenolol 1.7 2.2 4.4 -2.1 0.0
Medication: Levothyroxine sodium 0.0 0.1 0.1 -0.3 0.2
Sitting height 1.2 8.8 14.4 1.8 -3.8
Chronic bronchitis/emphysema (father) 0.0 0.1 0.1 -0.1 -0.3
High blood pressure (mother) 0.2 0.3 0.4 0.7 -0.3
Body mass index (BMI) 2.8 11.7 13.8 3.1 -3.7
Impedance of leg (left) 1.7 8.3 13.2 -1.8 3.6
Leg predicted mass (left) 3.9 20.9 29.1 3.6 -5.4
Trunk fat mass 3.0 13.1 16.3 3.1 -4.0
Waist circumference 2.7 9.8 13.1 2.6 -3.6
Number of incorrect matches in round 1.4 2.3 3.9 2.0 0.9
Past tobacco smoking 0.4 0.7 1.5 0.1 1.2
Alcohol usually taken with meals 0.4 0.7 1.2 1.1 -0.4
Nervous feelings 0.3 0.5 0.8 0.9 -0.4
Frequency of tenseness / restlessness in last 2 weeks 2.4 3.7 6.8 2.6 -0.7
Hearing difficulty/problems with background noise 0.6 1.0 1.5 -0.7 1.2
Hair/balding pattern: Pattern 2 0.3 0.4 0.6 -0.8 0.4
Had menopause 0.2 0.2 0.4 0.6 0.2
Had other major operations 0.6 0.8 1.4 -0.4 1.2
Forced vital capacity (FVC) 0.1 0.5 1.0 -0.0 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.1 0.2 0.3 0.4
Ever unenthusiastic/disinterested for a whole week 0.0 0.0 0.0 -0.1 -0.0
Qualifications: None of the above 1.1 2.3 4.5 2.1 -0.1
Financial difficulties in last 2 years 0.8 1.1 2.0 0.3 1.4
Mouth/teeth dental problems 0.9 1.3 1.9 -0.8 1.4
Heart attack 1.3 1.7 2.2 1.1 -1.5
Allergy 0.5 1.2 2.4 1.6 -0.1
Pain all over the body in last month 0.9 1.0 1.1 0.9 -1.1
Diabetes (self-reported) 0.3 0.4 0.9 0.1 -0.9
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 2.2 -0.8 1.5
Medication: Ramipril 0.5 0.6 1.1 0.2 -1.1
Medication: Simvastatin 0.2 0.4 0.6 0.4 -0.7
Fluid intelligence score 0.1 0.2 0.4 0.6 0.0
Illnesses of siblings 3.5 4.9 7.6 -1.5 2.8
Neuroticism score 0.8 1.7 2.1 1.5 1.1
Weight 4.3 21.0 27.9 3.8 -5.3
Impedance of arm (right) 1.9 8.6 9.4 -2.8 3.1
Arm fat percentage (right) 1.4 5.7 5.7 2.4 -2.4
Trunk fat-free mass 2.9 16.7 22.0 3.4 -4.7
Hip circumference 4.1 17.7 23.4 3.5 -4.8
Time employed in main current job 1.9 2.2 4.3 0.4 2.1
Alcohol intake versus 10 years previously 2.5 3.8 5.9 1.3 -2.4
Father’s age at death 0.8 1.0 1.6 1.3 -0.6
Worrier / anxious feelings 0.2 0.4 0.7 0.8 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 1.4 1.0 -1.2
Falls in the last year 0.2 0.2 0.4 -0.0 0.7
Hair/balding pattern: Pattern 3 0.1 0.2 0.4 0.6 0.1
Number of live births 0.7 1.0 1.4 -0.8 1.2
Forced expiratory volume in 1-second (FEV1) 0.0 0.0 0.1 -0.3 0.0
Pulse rate 0.1 0.2 0.4 -0.1 0.6
Happiness 0.2 0.3 0.4 -0.3 0.6
Noisy workplace 1.1 1.4 2.7 -1.6 0.3
Qualifications: A levels/AS levels or equivalent 0.9 2.0 3.7 -0.5 1.9
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.5 0.5 -0.7
Mouth/teeth dental problems: Dentures 0.3 0.4 0.7 0.4 -0.9
Asthma 0.2 0.4 0.4 -0.6 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.3 0.6 0.1
Medication: Cholesterol lowering 0.1 0.2 0.4 -0.2 -0.7
Depression (self-reported) 0.3 0.4 0.7 -0.8 0.2
Medication: Lansoprazole 0.3 0.4 0.7 -0.8 -0.1
Prospective memory result 0.9 1.2 2.2 -1.5 0.3
Lung cancer (father) 0.2 0.3 0.4 -0.6 0.4
Illnesses of mother 0.2 0.2 0.4 -0.2 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.0 0.0 -0.2 0.0
Pulse wave Arterial Stiffness index 1.1 1.3 2.6 0.3 1.6
Impedance of arm (left) 1.7 8.0 8.0 -2.8 2.8
Arm fat mass (right) 2.6 10.7 13.3 2.8 -3.6
Trunk predicted mass 2.7 15.7 20.7 3.3 -4.6
Standing height 1.0 10.1 17.1 1.8 -4.1
Length of working week for main job 0.3 0.4 0.6 0.4 -0.7
Exposure to tobacco smoke at home 0.2 0.2 0.4 -0.6 0.3
Breastfed as a baby 0.4 0.5 0.6 -0.7 0.7
Tense / ‘highly strung’ 0.9 1.4 1.5 1.2 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.1 0.1 -0.1 0.3
Hair/balding pattern: Pattern 4 0.1 0.3 0.5 0.3 -0.7
Birth weight of first child 0.0 0.0 0.0 0.0 0.2
Peak expiratory flow (PEF) 0.1 0.2 0.3 -0.0 0.6
Pulse wave reflection index 0.7 0.8 1.7 0.0 1.3
Ever highly irritable/argumentative for 2 days 1.1 1.4 2.6 1.6 0.4
Loud music exposure frequency 0.6 0.7 1.1 -0.5 1.1
Qualifications: O levels/GCSEs or equivalent 1.6 2.5 4.9 -2.2 0.0
Mouth/teeth dental problems: Bleeding gums 1.8 2.4 2.7 1.6 -1.4
Blood clot in the leg (DVT) 0.2 0.3 0.4 0.5 -0.6
Medication: Paracetamol 0.1 0.2 0.3 -0.5 0.1
Headache pain in last month 1.2 2.1 3.4 0.9 -1.8
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.0 0.2 1.0
Glaucoma (self-reported) 0.3 0.3 0.4 -0.6 0.6
Gout (self-reported) 0.3 0.4 0.7 -0.8 -0.2
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.5 -0.6 0.7
Medication: Amlodipine 0.0 0.0 0.1 -0.2 -0.1
Medication: Ventolin 100micrograms inhaler 0.3 0.3 0.3 0.6 -0.6
Birth weight 1.4 3.0 6.1 -0.2 -2.5
Chronic bronchitis/emphysema (mother) 0.9 1.0 2.0 1.4 0.0
High blood pressure (siblings) 1.8 2.6 2.9 1.7 -1.5
Forced vital capacity (FVC), Best measure 0.2 0.6 1.2 -0.1 -1.1
Body fat percentage 1.7 6.9 7.0 2.6 -2.7
Leg fat percentage (right) 1.4 5.1 6.9 2.6 -1.8
Arm fat-free mass (right) 3.9 20.1 25.2 3.9 -5.0
Exposure to tobacco smoke outside home 2.2 2.9 5.6 -2.4 -0.4
Comparative body size at age 10 0.2 0.5 0.7 -0.8 -0.6
Number of full brothers 1.2 1.5 1.6 1.2 -1.2
Worry too long after embarrassment 2.9 4.9 6.5 1.8 2.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.3 0.6 0.2
Wheeze or whistling in the chest in last year 0.4 0.7 1.3 0.4 -1.1
Number of children fathered 0.0 0.0 0.1 -0.3 -0.0
Reason for reducing amount of alcohol drunk: Health precaution 2.2 2.5 3.5 -1.9 1.2
Age at first live birth 1.1 2.0 3.3 -0.9 1.8
Pulse wave peak to peak time 1.1 1.3 2.6 -0.3 -1.6
Health satisfaction 0.2 0.3 0.6 -0.1 -0.8
Shortness of breath walking on level ground 0.1 0.1 0.3 -0.5 -0.1
Qualifications: College or University degree 2.2 7.0 7.5 -2.7 2.5
Eye problems/disorders: None of the above 1.0 1.1 2.1 -0.3 1.5
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.1 -0.2 0.4
Emphysema/chronic bronchitis 1.6 1.8 3.0 1.7 -0.8
Medication for pain relief, constipation, heartburn 0.9 1.5 2.3 -0.8 1.5
Neck or shoulder pain in last month 1.0 1.4 2.5 0.5 -1.6
Medication: Blood pressure 0.1 0.3 0.4 0.4 -0.6
Angina (self-reported) 2.2 2.9 5.9 -0.1 -2.4
Migraine (self-reported) 1.7 2.2 2.9 1.2 -1.7
Medication: Ibuprofen 0.1 0.1 0.1 0.2 -0.3
Medication: Allopurinol 0.3 0.4 0.6 -0.5 -0.8
Medication: Omeprazole 0.4 0.5 0.7 -0.5 -0.8
Medication: Seretide 50 evohaler 0.2 0.2 0.3 -0.2 0.6
Mean time to correctly identify matches 0.1 0.1 0.2 0.1 0.5
Heart disease (mother) 1.9 2.3 3.8 0.9 -1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 5.7 6.8 9.4 -2.0 3.1
Whole body fat mass 2.8 11.8 14.9 3.0 -3.9
Leg fat mass (right) 3.1 12.1 13.8 3.2 -3.7
Arm predicted mass (right) 3.7 18.9 24.7 3.6 -5.0
Pulse rate, automated reading 0.0 0.1 0.1 0.3 -0.2
Alcohol intake frequency. 1.1 2.5 4.6 0.5 -2.2
Comparative height size at age 10 2.4 13.3 20.4 2.5 -4.5
Number of full sisters 0.7 0.8 1.6 -1.3 0.1
Suffer from ‘nerves’ 0.7 1.2 1.4 1.2 -0.9
Overall health rating 1.0 2.2 4.0 2.0 -0.6
Chest pain or discomfort 0.2 0.3 0.6 -0.8 -0.2
Had major operations 1.2 1.4 2.7 0.3 -1.6
Age at last live birth 1.2 1.7 3.3 -0.4 1.8
Family relationship satisfaction 0.2 0.3 0.4 -0.7 0.4
Leg pain on walking 0.2 0.3 0.3 -0.6 -0.5
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.2 4.4 -2.1 -0.1
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.6 0.3 -0.8
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.0 -0.1 0.1
Medication: Aspirin 4.4 5.9 9.3 1.6 -3.0
Supplements: Vitamin C 1.5 1.7 3.0 1.7 -0.7
Knee pain experienced in last month 2.5 3.8 7.2 0.7 -2.7
Hypertension (Self-reported) 0.6 1.7 1.8 -1.4 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 1.5 -0.7 -1.2
Illnesses of father: Heart disease 0.6 0.9 1.8 -1.3 0.1
Illnesses of siblings: Diabetes 0.4 0.5 0.7 -0.6 -0.8
Smoking status: Previous 1.0 1.5 3.0 0.2 -1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.3 1.5 -0.7
Whole body fat-free mass 3.7 21.0 27.7 3.8 -5.3
Leg fat-free mass (right) 4.2 22.5 31.0 3.8 -5.6
Arm fat percentage (left) 1.5 6.0 6.4 2.4 -2.5
Average weekly red wine intake 1.9 2.7 5.4 0.2 -2.3
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.5 -1.6 -0.4
Mood swings 0.4 0.8 1.4 1.2 -0.3
Loneliness, isolation 0.6 0.8 1.3 1.1 0.5
Long-standing illness, disability or infirmity 5.8 8.9 10.2 2.8 -3.2
Ever had bowel cancer screening 0.7 0.8 1.6 1.3 -0.0
Diabetes diagnosed by doctor 1.2 1.9 3.8 0.0 -2.0
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.3 1.1 0.0
Friendships satisfaction 0.7 0.8 1.6 0.1 1.3
Qualifications: nursing, teaching 0.1 0.1 0.2 0.4 0.3
Commuting to job workplace: Walk 2.1 2.3 4.6 -0.1 -2.1
Eye problems/disorders: Cataract 0.5 0.6 1.1 0.2 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 1.1 -1.0 -1.1
Medication for cholesterol 0.6 0.9 1.6 0.5 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.7 -0.8 0.0
Back pain experienced in last month 1.4 2.0 2.7 1.1 -1.6
Mineral and other dietary supplements 0.2 0.3 0.4 -0.4 -0.6
Breast cancer (self-reported) 1.3 1.5 3.0 0.1 1.7
Asthma (self-reported) 0.3 0.6 0.6 -0.8 0.7
Osteoporosis (self-reported) 0.5 0.6 0.6 -0.8 0.8
Osteoarthritis (self-reported) 1.6 2.1 3.3 0.9 -1.8
Medication: Aspirin 3.6 4.7 7.1 1.5 -2.7
Medication: Gliclazide 0.8 0.9 1.0 -1.0 -0.8
Illnesses of father: None of the above (group 1) 0.5 0.6 1.3 1.1 -0.1
Smoking status: Current 0.1 0.2 0.3 -0.3 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.6 -0.4 0.8
Whole body water mass 3.7 21.0 28.1 3.7 -5.3
Leg predicted mass (right) 4.2 22.2 31.1 3.7 -5.6
Arm fat mass (left) 2.9 12.0 15.6 2.9 -4.0
Number of self-reported non-cancer illnesses 0.5 0.9 1.7 -0.3 -1.3
Average weekly champagne plus white wine intake 0.4 0.5 1.0 -1.0 -0.1
Miserableness 1.8 3.1 3.4 1.8 -1.7
Guilty feelings 0.6 1.0 1.3 0.7 1.2
Wears glasses or contact lenses 0.5 0.6 1.0 -0.4 1.0
Ever taken oral contraceptive pill 0.1 0.1 0.1 -0.1 -0.4
Hearing aid user 0.1 0.1 0.1 -0.3 -0.2
Mother’s age at death 1.2 1.5 2.7 -1.6 0.5
Financial situation satisfaction 0.9 1.2 1.9 -0.6 -1.4
Tinnitus: Yes, now most or all of the time 1.7 2.0 2.7 -1.1 1.6
Commuting to job workplace: Public transport 0.1 0.2 0.3 0.2 0.5
Eye problems/disorders: Glaucoma 0.0 0.0 0.1 0.2 0.1
Medication: Blood pressure 1.3 2.4 3.8 -1.0 -1.9
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.5 -0.6 -1.2
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.3 1.1 -0.1
High cholesterol (Self-reported) 0.3 0.5 0.9 -1.0 0.3
Medication: Bendroflumethiazide 0.1 0.1 0.3 -0.1 0.5
Medication: Paracetamol 0.2 0.3 0.4 -0.6 -0.4
Medication: Lisinopril 0.9 1.1 1.6 -0.8 -1.3
Medication: Atorvastatin 1.2 1.5 2.0 -1.0 1.4
Illnesses of father: High blood pressure 0.6 0.7 1.2 -0.5 -1.1
Alcohol drinker status: Never 1.8 2.1 4.2 0.2 -2.0
Ever smoked 0.4 0.8 1.5 -0.2 -1.2
Basal metabolic rate 3.9 21.8 28.8 3.8 -5.4
Leg fat percentage (left) 1.6 6.0 7.5 2.7 -2.1
Arm fat-free mass (left) 3.8 19.1 26.6 3.4 -5.2
Number of operations (self-reported) 1.5 2.2 3.9 -0.6 -2.0
Average weekly beer plus cider intake 0.4 0.5 0.8 -0.4 0.9
Irritability 1.7 2.9 4.3 2.1 -1.2
Risk taking 0.5 0.7 1.0 0.6 -1.0
Ever had prostate specific antigen (PSA) test 1.1 1.3 2.5 1.6 -0.3
Fractured/broken bones in last 5 years 0.3 0.4 0.8 -0.0 -0.9
Age started oral contraceptive pill 1.7 2.1 3.1 1.1 1.8
Diastolic blood pressure, automated reading 0.1 0.2 0.2 -0.3 -0.5
Ever depressed for a whole week 0.2 0.3 0.6 -0.7 0.2
Unable to work because of sickness or disability 0.7 0.9 1.0 1.0 0.8
Commuting to job workplace: Cycle 0.4 0.5 0.7 0.8 0.7
Myopia 0.2 0.3 0.4 0.6 -0.4
Vascular/heart problems diagnosed by doctor 1.0 2.6 3.9 1.1 2.0
Cholesterol lowering medication 0.2 0.3 0.4 -0.5 0.7
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.2 -0.5 -1.1
Pain experienced in last month 2.1 3.5 6.8 -0.5 2.6
Supplements: Calcium 0.9 1.0 1.8 0.4 1.3
Basal cell carcinoma (self-reported) 0.4 0.5 1.1 0.1 1.0
Heart attack/myocardial infarction (self-reported) 1.5 1.9 2.3 1.2 -1.5
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.2 0.4 -0.5
Heart disease (siblings) 1.6 2.0 2.6 1.2 -1.6
Alcohol drinker status: Previous 0.5 0.5 0.8 -0.9 0.5
Pack years of smoking 0.3 0.4 0.6 -0.8 -0.5
Impedance of whole body 2.0 10.0 12.3 -2.8 3.5
Leg fat mass (left) 3.4 13.5 15.4 3.4 -3.9
Arm predicted mass (left) 4.3 21.9 28.4 3.9 -5.3