Best TWAS P=2.37e-15 · Best GWAS P=3.38e-12 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DTX2P1-UPK3BP1-PMS2P11 | 0.18 | 0.09 | enet | 21 | 0.12 | 6.1e-15 | 6.2 | 7.9 | 2.4e-15 | 0.82 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | RP11-467H10.2 | 0.12 | 0.00 | lasso | 6 | 0.01 | 2.1e-02 | 2.8 | 5.9 | 3.9e-09 | 0.05 | 0.13 | 0.10 | TRUE |
| 3 | GTEx | Adipose Visceral Omentum | TMEM60 | 0.20 | 0.13 | lasso | 8 | 0.11 | 2.3e-06 | -5.1 | -5.2 | 1.9e-07 | -0.01 | 0.88 | 0.11 | FALSE |
| 4 | GTEx | Artery Aorta | GSAP | 0.19 | 0.07 | lasso | 2 | 0.04 | 2.8e-03 | 6.2 | -6.5 | 8.8e-11 | -0.03 | 0.10 | 0.65 | TRUE |
| 5 | GTEx | Brain Cerebellum | GSAP | 0.38 | 0.30 | lasso | 4 | 0.31 | 6.4e-10 | 6.2 | -6.5 | 9.1e-11 | -0.01 | 0.12 | 0.87 | FALSE |
| 6 | GTEx | Brain Frontal Cortex BA9 | GSAP | 0.38 | 0.22 | lasso | 6 | 0.21 | 3.0e-06 | 6.3 | -7.2 | 5.4e-13 | -0.13 | 0.07 | 0.62 | FALSE |
| 7 | GTEx | Brain Putamen basal ganglia | GSAP | 0.48 | 0.20 | lasso | 12 | 0.15 | 2.2e-04 | 6.2 | -5.6 | 1.8e-08 | -0.11 | 0.08 | 0.54 | TRUE |
| 8 | GTEx | Heart Left Ventricle | GSAP | 0.21 | 0.02 | lasso | 5 | 0.03 | 9.3e-03 | 4.3 | -5.7 | 1.1e-08 | -0.01 | 0.10 | 0.23 | TRUE |
| 9 | GTEx | Muscle Skeletal | GSAP | 0.20 | 0.12 | lasso | 2 | 0.12 | 1.8e-11 | 6.3 | -6.3 | 2.1e-10 | -0.04 | 0.08 | 0.92 | TRUE |
| 10 | GTEx | Ovary | TMEM60 | 0.23 | 0.19 | enet | 7 | 0.13 | 5.2e-04 | -5.0 | -5.2 | 2.4e-07 | 0.01 | 0.18 | 0.12 | TRUE |
| 11 | GTEx | Skin Sun Exposed Lower leg | DTX2P1 | 0.16 | 0.03 | enet | 22 | 0.05 | 4.8e-05 | 7.0 | 5.5 | 3.9e-08 | 0.70 | 0.00 | 0.99 | FALSE |
| 12 | GTEx | Thyroid | GSAP | 0.19 | 0.08 | lasso | 3 | 0.07 | 3.3e-06 | 6.2 | -6.3 | 2.4e-10 | -0.02 | 0.10 | 0.89 | FALSE |
| 13 | GTEx | Thyroid | AC007000.12 | 0.13 | 0.08 | enet | 24 | 0.07 | 2.6e-06 | -4.7 | -6.1 | 1.2e-09 | -0.18 | 0.66 | 0.02 | TRUE |
| 14 | GTEx | Whole Blood | TMEM60 | 0.05 | 0.04 | enet | 7 | 0.03 | 5.4e-04 | -4.8 | -5.1 | 3.1e-07 | -0.02 | 0.85 | 0.13 | TRUE |
| 15 | METSIM | Adipose | TMEM60 | 0.10 | 0.07 | enet | 9 | 0.08 | 2.1e-12 | 4.9 | -5.2 | 2.7e-07 | -0.02 | 0.74 | 0.26 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | GSAP | 0.36 | 0.27 | lasso | 7 | 0.28 | 1.5e-35 | 6.3 | -6.3 | 2.6e-10 | -0.02 | 0.08 | 0.92 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | RSBN1L | 0.09 | 0.07 | enet | 42 | 0.08 | 9.9e-11 | -4.1 | -5.4 | 5.6e-08 | -0.03 | 0.95 | 0.05 | TRUE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMEM60 | 0.02 | 0.02 | lasso | 1 | 0.02 | 2.3e-05 | 5.4 | -5.3 | 8.7e-08 | 0.00 | 0.00 | 1.00 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PION | 0.08 | 0.05 | lasso | 3 | 0.05 | 8.5e-07 | 6.2 | -6.0 | 1.7e-09 | -0.06 | 0.00 | 1.00 | TRUE |
| 20 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TMEM60 | 0.02 | 0.03 | blup | 29 | 0.02 | 6.8e-03 | 5.4 | -5.2 | 2.0e-07 | -0.01 | 0.00 | 0.91 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PION | 0.13 | 0.07 | enet | 9 | 0.08 | 3.4e-09 | 6.2 | -5.8 | 5.9e-09 | -0.03 | 0.00 | 1.00 | FALSE |