Best TWAS P=2.67e-10 · Best GWAS P=1.08e-10 conditioned to 0.346
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cortex | RP11-152H18.3 | 0.41 | 0.04 | enet | 25 | 0.11 | 7.6e-04 | 3.4 | -5.6 | 1.8e-08 | 0.03 | 0.09 | 0.26 | TRUE |
| 2 | GTEx | Prostate | SBF2 | 0.21 | 0.05 | lasso | 7 | 0.03 | 6.7e-02 | 6.0 | 6.3 | 2.7e-10 | -0.86 | 0.04 | 0.76 | TRUE |
| 3 | GTEx | Testis | SBF2 | 0.10 | 0.01 | lasso | 5 | 0.02 | 5.0e-02 | 5.7 | -6.0 | 1.4e-09 | 0.82 | 0.05 | 0.87 | FALSE |
| 4 | NTR | Blood | ADM | 0.04 | 0.04 | enet | 13 | 0.04 | 1.6e-13 | 6.0 | -6.3 | 3.2e-10 | 0.88 | 0.03 | 0.97 | FALSE |
| 5 | NTR | Blood | WEE1 | 0.02 | 0.00 | bslmm | 367 | 0.00 | 1.0e-02 | 0.7 | -5.4 | 6.6e-08 | 0.33 | 0.10 | 0.18 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | SBF2-AS1 | 0.03 | 0.00 | bslmm | 362 | 0.01 | 4.4e-03 | -1.7 | 6.0 | 1.6e-09 | -0.59 | 0.04 | 0.61 | FALSE |
| 7 | YFS | Blood | ADM | 0.08 | 0.11 | enet | 25 | 0.12 | 9.4e-36 | 6.2 | -6.3 | 3.2e-10 | 0.85 | 0.02 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF143 | 0.02 | 0.02 | lasso | 2 | 0.02 | 4.5e-03 | 5.2 | -5.4 | 7.7e-08 | 0.07 | 0.01 | 0.89 | TRUE |