Best TWAS P=6.8e-10 · Best GWAS P=1.15e-10 conditioned to 0.000221
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Lung | NFATC3 | 0.04 | 0.01 | lasso | 4 | 0.01 | 4.1e-02 | 5.8 | -6.0 | 1.7e-09 | -0.32 | 0.09 | 0.73 | FALSE |
| 2 | GTEx | Thyroid | PLA2G15 | 0.06 | 0.04 | enet | 5 | 0.04 | 5.7e-04 | 6.2 | 6.2 | 6.8e-10 | 0.38 | 0.04 | 0.95 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KCTD19 | 0.02 | 0.02 | blup | 29 | 0.03 | 3.5e-06 | -4.4 | -5.2 | 1.9e-07 | -0.03 | 0.01 | 0.86 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | NFATC3 | 0.22 | 0.05 | lasso | 3 | 0.06 | 3.6e-04 | 3.4 | -5.5 | 2.9e-08 | -0.35 | 0.01 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NFATC3 | 0.11 | 0.04 | enet | 4 | 0.04 | 2.8e-05 | 6.1 | -6.1 | 1.2e-09 | -0.36 | 0.00 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NFATC3 | 0.23 | 0.05 | lasso | 2 | 0.06 | 8.5e-08 | 6.1 | -5.5 | 2.9e-08 | -0.31 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | AGRP | 0.11 | 0.01 | enet | 6 | 0.07 | 2.5e-05 | 4.9 | -6.0 | 1.9e-09 | -0.12 | 0.00 | 0.36 | TRUE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NFATC3 | 0.26 | 0.09 | enet | 4 | 0.13 | 9.8e-06 | 6.1 | -5.1 | 3.1e-07 | -0.29 | 0.01 | 0.96 | FALSE |
| 9 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | NFATC3 | 0.46 | 0.16 | lasso | 4 | 0.20 | 1.7e-07 | -3.5 | -5.3 | 8.6e-08 | -0.33 | 0.02 | 0.98 | FALSE |