TWAS hub - AGRP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0566	0.0309	0.00230	-0.001	0.01	0.016	NA	0.000	0.430	0.02500	5.3e-03	NA	0.35000
2	TCGA	Ovarian Serous Cystadenocarcinoma	0.1120	0.0550	0.00091	0.014	0.05	0.067	NA	0.056	0.034	0.00027	2.5e-05	NA	0.00012
3	TCGA	Stomach Adenocarcinoma	0.0440	0.0270	0.00560	0.020	0.03	0.020	NA	0.009	0.012	0.00300	1.3e-02	NA	0.06600

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Hair/balding pattern: Pattern 4	11.5	27.8	36.9	-4.4	-5.2	-6.1
Standing height	8.0	78.9	93.9	-7.7	-9.7	-9.1
Hypothyroidism (self reported)	7.5	17.1	36.6	2.7	2.8	6.0
Comparative height size at age 10	7.2	39.4	55.7	-4.7	-6.4	-7.5
Hypothyroidism/myxoedema (self-reported)	6.1	11.9	22.8	2.6	2.5	4.8
Trunk fat-free mass	5.7	33.0	56.0	-5.4	-7.5	-3.8
Trunk predicted mass	5.7	32.6	54.8	-5.3	-7.4	-3.8
Height	5.6	108.5	132.2	-8.8	-11.5	-10.8
Current tobacco smoking	5.3	8.7	12.1	-1.6	-3.5	-3.4
Qualifications: CSEs or equivalent	5.1	6.7	11.2	2.1	2.2	3.3
Medication: Omeprazole	5.1	6.0	6.7	-2.5	-2.6	-2.3
Medication: Levothyroxine sodium	4.9	8.4	15.0	2.1	2.4	3.9
Smoking status: Current	4.8	7.5	10.4	-1.4	-3.2	-3.2
Alcohol intake versus 10 years previously	4.7	7.0	9.6	-2.1	-3.1	-2.6
Waist Hip Ratio (WHR)	4.5	20.2	36.6	-3.4	-3.6	-6.0
Arm fat-free mass (right)	4.3	22.2	39.7	-4.3	-6.3	-2.9
Chronic bronchitis/emphysema (mother)	4.2	4.9	6.5	2.5	2.4	1.6
Arm predicted mass (right)	4.2	21.3	38.9	-4.1	-6.2	-2.8
Whole body fat-free mass	4.1	23.4	41.9	-4.5	-6.5	-2.8
Arm fat-free mass (left)	4.1	20.9	36.0	-4.0	-6.0	-3.3
Medication: Omeprazole (e.g. Zanprol)	4.1	5.0	5.6	-2.4	-2.1	-2.2
Arm predicted mass (left)	4.1	20.9	36.1	-4.0	-6.0	-3.3
Chronotype (morning person)	4.0	9.1	12.7	-2.8	-3.6	-2.6
Serious illness, injury or assault to yourself	4.0	4.9	6.4	-1.9	-2.2	-2.5
Basal metabolic rate	4.0	22.2	38.7	-4.4	-6.2	-3.0
Breastfed as a baby	3.9	4.9	7.3	1.5	2.7	2.2
Family relationship satisfaction	3.9	4.8	9.8	-1.1	-1.9	-3.1
Lung FEV1/FVC ratio	3.7	18.8	26.7	4.9	2.3	5.2
Whole body water mass	3.7	21.2	38.2	-4.2	-6.2	-2.7
Forced vital capacity (FVC)	3.4	13.3	17.3	-4.2	-4.0	-2.5
Blood Red Count	3.2	31.3	63.7	4.0	3.8	8.0
Osteoporosis (self-reported)	3.1	3.8	7.8	-2.8	-1.3	-1.4
Ovarian Cancer	3.0	4.0	5.1	-2.3	-1.5	-2.1
Ever highly irritable/argumentative for 2 days	2.9	3.5	5.8	-1.4	-1.7	-2.4
Alzheimer’s Disease (in father)	2.8	3.1	6.9	1.4	0.6	2.6
Forced vital capacity (FVC), Best measure	2.8	10.4	14.8	-3.7	-3.9	-1.6
Mineral and other dietary supplements	2.8	3.7	9.5	0.9	3.1	0.9
Medication: Ibuprofen	2.7	3.3	5.3	1.9	2.3	0.9
Smoking status: Previous	2.7	4.0	5.5	2.0	1.6	2.3
Tinnitus: Yes, now most or all of the time	2.7	3.2	3.5	1.9	1.8	1.7
Weight	2.6	13.0	20.9	-3.3	-4.6	-2.7
HDL Cholesterol	2.5	4.2	11.2	3.4	1.0	0.7
Average weekly spirits intake	2.5	3.0	3.3	-1.8	-1.8	-1.6
Happiness	2.5	3.0	8.4	-0.3	-0.8	-2.9
Body Mass Index (BMI) (2010)	2.4	3.3	4.7	1.8	1.4	2.2
Waist circumference	2.4	8.9	11.2	-2.5	-3.4	-3.0
Sitting height	2.3	16.2	19.8	-4.4	-4.5	-3.0
Nervous feelings	2.3	4.3	6.7	0.9	2.6	2.3
Eye problems/disorders: Cataract	2.3	2.6	3.2	1.6	1.8	1.5
Prostate Cancer	2.2	3.2	6.5	-2.5	-0.8	-1.6
Leg predicted mass (left)	2.2	11.5	21.4	-3.3	-4.6	-1.4
Medication: Paracetamol	2.2	3.6	8.5	-1.2	-0.9	-2.9
Gout (self-reported)	2.2	3.0	3.5	1.6	1.7	1.9
Friendships satisfaction	2.2	2.7	6.6	1.2	0.0	-2.6
Fractured/broken bones in last 5 years	2.2	2.8	3.2	-1.8	-1.8	-1.5
Leg fat-free mass (left)	2.1	11.1	20.8	-3.2	-4.6	-1.4
Alcohol usually taken with meals	2.1	3.4	5.2	1.3	1.8	2.3
Falls in the last year	2.1	2.8	3.9	-2.0	-1.3	-1.6
Impedance of leg (right)	2.0	9.9	24.7	-1.9	-1.2	-5.0
Suffer from ‘nerves’	2.0	3.1	5.4	0.7	1.8	2.3
Risk taking	2.0	2.9	4.0	-1.0	-2.0	-1.9
Myopia	2.0	2.9	5.0	1.2	1.5	2.2
Bipolar Disorder (2018)	1.9	3.0	5.7	0.0	1.8	2.4
Bipolar Disorder or Schizophrenia	1.9	4.7	9.7	0.0	2.1	3.1
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	2.5	1.1	1.6	1.6
Comparative body size at age 10	1.9	5.4	11.6	0.5	-3.4	-2.0
Leg fat-free mass (right)	1.9	10.2	20.9	-2.9	-4.6	-1.1
Leg predicted mass (right)	1.9	10.1	20.5	-2.9	-4.5	-1.2
High blood pressure (mother)	1.8	2.5	4.4	0.6	2.1	1.7
Impedance of leg (left)	1.8	9.0	23.6	-1.3	-1.3	-4.9
Medication: Seretide 50 evohaler	1.8	2.0	4.7	-1.0	-0.5	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	6.0	-1.5	-2.4	-1.8
Average weekly champagne plus white wine intake	1.8	2.5	4.4	2.1	1.7	0.5
Number of operations (self-reported)	1.8	2.7	2.7	1.6	1.7	1.6
Pack years of smoking	1.8	2.6	4.8	-1.5	-1.0	-2.2
Hearing difficulty/problems: Yes	1.7	2.7	5.5	1.0	2.3	1.2
Pack years adult smoking proportion	1.7	2.6	4.8	-1.4	-0.9	-2.2
Trunk fat mass	1.7	7.2	9.1	-2.3	-3.0	-2.7
Heel T-Score	1.6	12.4	26.7	5.2	2.6	2.0
Forced expiratory volume in 1-second (FEV1)	1.6	5.5	9.2	-2.7	-3.0	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	4.8	2.2	0.9	0.4
Fasting Glucose	1.5	1.8	2.8	-1.7	-0.9	-1.3
Frequency of depressed mood in last 2 weeks	1.5	2.1	3.3	1.8	1.6	0.7
Relative age voice broke	1.5	2.3	4.4	2.1	1.0	1.2
Diabetes (self-reported)	1.5	2.3	4.8	-2.2	-0.9	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.5	2.0	4.4	1.2	2.1	0.1
Pulse wave Arterial Stiffness index	1.5	1.7	1.9	-1.3	-1.4	-1.3
Exposure to tobacco smoke outside home	1.5	2.0	2.6	-1.6	-1.2	-1.3
Emphysema/chronic bronchitis	1.5	1.7	2.6	-1.6	-0.8	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	3.3	-1.2	-0.7	-1.8
Supplements: Fish oil (including cod liver oil)	1.5	1.9	4.7	-0.9	-2.2	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	8.3	-2.3	-2.9	0.0
Birth weight	1.4	3.0	6.1	-0.6	-1.6	-2.5
Whole body fat mass	1.4	5.8	7.8	-2.1	-2.8	-2.2
Leg fat mass (right)	1.4	5.6	8.5	-2.1	-2.9	-2.0
Leg pain on walking	1.4	1.8	4.7	0.3	-0.7	-2.2
Stomach or abdominal pain in last month	1.3	1.7	3.5	0.9	1.9	0.9
Supplements: Glucosamine	1.3	1.7	3.4	-1.0	-1.8	-0.9
Financial difficulties in last 2 years	1.3	1.7	2.9	-0.0	-1.5	-1.7
Hair/balding pattern: Pattern 3	1.3	1.9	2.8	1.2	1.7	1.3
Qualifications: A levels/AS levels or equivalent	1.3	2.8	4.0	-2.0	-1.6	-1.3
Birth weight of first child	1.3	2.4	3.0	1.7	1.7	1.2
Illnesses of father: Heart disease	1.3	1.8	2.6	-1.4	-1.6	-0.9
Average weekly red wine intake	1.3	2.0	3.1	-0.4	-1.6	-1.8
Illnesses of father: High blood pressure	1.3	1.7	2.7	0.4	1.5	1.6
Alcohol drinker status: Previous	1.3	1.4	3.6	0.8	1.9	-0.1
Leg fat mass (left)	1.3	5.0	8.6	-1.8	-2.9	-1.8
Heart attack	1.2	1.6	2.5	1.4	1.6	0.3
Time employed in main current job	1.2	1.4	3.9	-0.2	0.6	2.0
Glaucoma (self-reported)	1.2	1.4	2.2	-1.5	-1.4	-0.4
Medication: Amlodipine	1.2	1.6	3.3	-0.6	1.1	1.8
Neck or shoulder pain in last month	1.2	1.7	3.6	1.9	1.0	0.7
Qualifications: nursing, teaching	1.2	1.9	3.6	1.5	0.3	1.9
Schizophrenia (2018)	1.1	2.3	4.8	0.0	1.5	2.2
Reaction Time	1.1	2.0	2.1	-1.5	-1.4	-1.4
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.8	0.0	1.0	1.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.7	0.2	0.4	1.9
Peak expiratory flow (PEF)	1.1	2.6	3.1	-1.5	-1.6	1.8
Breast cancer (self-reported)	1.1	1.3	2.3	0.5	1.5	1.1
Financial situation satisfaction	1.1	1.4	4.2	0.2	-0.1	-2.0
Medication: Paracetamol	1.1	1.7	3.6	-0.8	-0.9	-1.9
Medication: Lisinopril	1.1	1.4	2.5	-0.1	-1.3	-1.6
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.1	1.4	1.4	0.2
Lupus	1.0	1.5	2.6	1.6	1.4	-0.0
Maternal smoking around birth	1.0	1.5	2.0	-1.0	-1.4	-1.2
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.1	0.7	-1.2	-1.4
Qualifications: College or University degree	1.0	3.2	5.4	-0.8	-1.9	-2.3
Medication for pain relief, constipation, heartburn	1.0	1.7	3.9	-0.0	-1.1	2.0
Diabetes diagnosed by doctor	1.0	1.7	3.7	-1.9	-0.5	-1.0
Depression (Nagel 2018)	0.9	1.3	2.8	1.7	1.1	-0.3
Mean Putamen Volume	0.9	1.0	2.2	0.0	1.5	0.9
Supplements: Zinc	0.9	1.0	1.4	1.2	0.8	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.7	2.4	0.6	-0.2
Number of incorrect matches in round	0.9	1.5	4.3	-0.5	-0.0	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.4	0.8	-0.6	-1.5
Impedance of whole body	0.9	4.7	13.3	-0.6	0.6	-3.6
Coronary Artery Disease (CAD)	0.8	0.9	2.8	0.0	0.0	-1.7
Hip circumference	0.8	3.5	6.1	-2.0	-2.5	-0.7
Health satisfaction	0.8	1.0	1.9	-0.9	0.6	-1.4
Guilty feelings	0.8	1.1	1.9	-0.4	-1.4	-1.1
Diabetes (mother)	0.7	0.8	1.3	-1.1	-0.4	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.0	1.1	1.4	0.1
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	1.9	-1.0	0.3	-1.4
Loud music exposure frequency	0.7	0.8	1.4	-1.0	-1.2	0.1
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.8	0.5	0.9	1.3
Overall health rating	0.7	1.4	2.9	-1.7	-0.2	-1.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.5	1.2	0.1	1.2
Medication: Atorvastatin	0.7	0.9	1.5	-1.2	-0.9	-0.6
Commuting to job workplace: Cycle	0.7	0.8	2.0	1.4	-0.6	0.0
Heart disease (siblings)	0.7	0.8	1.4	-1.2	-0.9	-0.4
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.7	-1.3	-1.0	-0.8
Diabetes (father)	0.6	0.7	0.8	0.8	0.9	0.8
Hair/balding pattern: Pattern 2	0.6	0.8	1.8	-0.7	-1.3	0.4
Impedance of arm (right)	0.6	2.7	5.3	0.4	1.6	-2.3
Tense / ‘highly strung’	0.6	1.0	1.4	1.2	1.2	0.2
Blood clot in the leg (DVT)	0.6	0.8	1.3	0.7	1.1	0.7
Age at first live birth	0.6	1.1	2.5	0.6	0.7	1.6
Knee pain experienced in last month	0.6	1.0	2.7	0.2	-1.6	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.0	0.2	-0.4	-1.4
Arm fat mass (left)	0.6	2.3	4.0	-1.4	-2.0	-1.0
Medication: Bendroflumethiazide	0.6	0.8	2.1	0.2	-0.6	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.0	0.6	1.0	0.9
Worry (Nagel 2018)	0.5	1.0	1.8	0.4	1.3	1.1
Breast Cancer	0.5	1.3	2.6	-0.5	-1.0	-1.6
Schizophrenia (2014)	0.5	1.2	2.4	0.0	1.1	1.6
Smoking Status	0.5	1.2	3.1	0.0	-1.7	-0.8
Medication for hormone replacement therapy	0.5	0.5	1.4	1.2	0.4	-0.1
Severe depression (siblings)	0.5	0.5	1.0	1.0	0.6	-0.4
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.9	0.7	1.4	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.3	1.8	0.4	0.1
Mouth/teeth dental problems	0.5	0.7	1.5	0.6	0.6	1.2
Pain all over the body in last month	0.5	0.6	1.2	-0.5	-1.1	-0.5
Father’s age at death	0.5	0.7	2.1	0.1	-0.1	1.4
Medication: Cholesterol lowering	0.5	0.7	2.0	0.0	0.4	1.4
Lung cancer (father)	0.5	0.6	1.5	0.6	1.2	0.3
Impedance of arm (left)	0.5	2.1	3.3	0.2	1.8	-1.7
Arm fat mass (right)	0.5	2.0	3.5	-1.2	-1.9	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.8	0.8	0.6	0.9
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	-0.8	-0.6	-1.0
Had major operations	0.5	0.5	1.1	-1.0	-0.7	-0.2
Illnesses of siblings: Diabetes	0.5	0.6	1.4	0.2	1.2	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.4	0.3	-0.5	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	0.9	1.0	0.9	0.9
Irritability	0.5	0.8	1.1	1.1	0.5	1.0
Unable to work because of sickness or disability	0.5	0.7	1.5	-0.6	-1.2	-0.4
Pain experienced in last month	0.5	0.9	1.9	-1.4	-0.0	0.9
Rheumatoid Arthritis	0.4	0.5	1.0	0.0	1.0	0.7
Blood Eosinophil Count	0.4	3.2	9.2	0.3	0.4	-3.0
Lung FVC	0.4	2.3	6.2	-2.5	-0.7	0.5
Sensitivity / hurt feelings	0.4	0.7	1.3	-0.6	-1.1	-0.7
Medication: Co-codamol	0.4	0.5	0.9	0.6	0.9	0.4
Trunk fat percentage	0.4	1.7	2.8	-1.1	-1.1	-1.7
Hand grip strength (right)	0.4	1.0	1.7	-1.0	-1.3	0.4
Average weekly fortified wine intake	0.4	0.4	0.6	-0.6	-0.7	-0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.5	0.6	0.7	-0.6
Medication: Atenolol	0.4	0.5	0.9	-1.0	-0.8	-0.1
Past tobacco smoking	0.4	0.8	1.8	-1.3	-0.1	-0.8
Allergy	0.4	0.9	1.5	-0.3	-1.2	-1.0
Number of live births	0.4	0.5	1.5	1.2	0.2	0.2
Pulse rate	0.4	0.7	1.2	-0.8	-0.4	-1.1
Mouth/teeth dental problems: Dentures	0.4	0.7	1.4	-1.2	0.3	-0.9
Asthma	0.4	0.9	1.3	1.1	1.0	0.6
Depression (self-reported)	0.4	0.5	0.8	-0.8	-0.9	-0.1
Illnesses of mother	0.4	0.5	1.0	-0.1	-1.0	-0.6
Leg fat percentage (right)	0.4	1.4	1.9	-1.0	-1.2	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	-0.7	0.0	-1.0
Number of children fathered	0.4	0.5	0.8	-0.9	-0.4	0.7
Eye problems/disorders: None of the above	0.4	0.5	1.3	-0.2	-0.4	-1.1
Medication: Allopurinol	0.4	0.5	0.9	0.6	0.6	0.9
Mean time to correctly identify matches	0.4	0.7	1.1	-0.8	-0.7	-1.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	0.4	0.6	1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	0.4	0.7	-1.0
Medication: Gliclazide	0.4	0.4	0.7	-0.7	-0.3	0.8
Illnesses of father: None of the above (group 1)	0.4	0.4	0.9	0.7	0.9	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.2	-0.3	0.3	1.5
Commuting to job workplace: Public transport	0.4	0.5	0.5	0.7	0.7	-0.7
Medication: Blood pressure	0.4	0.7	1.4	0.8	1.2	-0.0
Alcohol drinker status: Never	0.4	0.5	1.2	-1.1	-0.4	0.4
Ever smoked	0.4	0.7	1.7	1.3	-0.1	0.5
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.9	0.4	1.0	0.4
Ever depressed for a whole week	0.4	0.4	1.2	-0.3	-0.2	-1.1
Supplements: Calcium	0.4	0.5	0.7	-0.6	0.9	0.6
Crohns Disease (2017)	0.3	0.7	1.2	-1.1	-0.7	-0.6
Crohns Disease (2012)	0.3	0.5	1.6	0.0	-1.3	0.1
HbA1C	0.3	0.3	0.7	-0.2	-0.8	0.5
Blood White Count	0.3	2.3	5.3	0.2	1.2	-2.3
BMI	0.3	1.9	4.9	0.8	-0.4	2.2
Number of treatments/medications taken	0.3	0.5	1.0	1.0	0.7	-0.4
Ever had hysterectomy (womb removed)	0.3	0.4	0.5	-0.3	-0.7	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	0.6	0.8	0.2
Hearing difficulty/problems with background noise	0.3	0.5	1.2	-0.3	1.1	0.4
Qualifications: None of the above	0.3	0.5	0.8	-0.9	-0.5	-0.8
Medication: Lansoprazole	0.3	0.3	0.6	0.8	0.2	-0.5
Headache pain in last month	0.3	0.5	0.8	0.8	0.9	-0.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.7	0.9	0.5	-0.6
Body fat percentage	0.3	1.1	1.8	-0.7	-1.0	-1.4
Wheeze or whistling in the chest in last year	0.3	0.6	1.5	-0.4	0.0	-1.2
Pulse wave peak to peak time	0.3	0.4	0.6	0.8	0.7	0.4
Shortness of breath walking on level ground	0.3	0.3	0.5	-0.6	0.3	-0.7
Medication: Blood pressure	0.3	0.6	1.7	-1.3	-0.2	-0.1
Migraine (self-reported)	0.3	0.4	0.9	0.9	0.1	0.6
Chest pain or discomfort	0.3	0.4	1.1	-0.2	1.1	-0.0
Supplements: Vitamin C	0.3	0.4	0.7	0.4	0.4	0.9
Loneliness, isolation	0.3	0.4	1.1	0.1	-1.0	-0.5
Long-standing illness, disability or infirmity	0.3	0.5	1.0	-0.7	0.0	-1.0
Medication for cholesterol	0.3	0.4	1.1	-0.1	-0.3	1.0
Back pain experienced in last month	0.3	0.4	0.7	0.9	0.6	-0.3
Number of self-reported non-cancer illnesses	0.3	0.6	0.9	-0.9	0.8	-0.6
Miserableness	0.3	0.5	1.0	-1.0	-0.7	0.1
Ever taken oral contraceptive pill	0.3	0.3	0.4	0.7	0.3	0.7
Eye problems/disorders: Glaucoma	0.3	0.3	0.9	-1.0	-0.3	0.0
Leg fat percentage (left)	0.3	1.0	1.4	-0.4	-1.2	-1.2
Average weekly beer plus cider intake	0.3	0.4	0.8	0.7	0.1	-0.9
Cholesterol lowering medication	0.3	0.4	1.2	-0.2	0.1	-1.1
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	0.0	0.6	-0.7
Alzheimer’s Disease (in mother)	0.2	0.2	0.3	-0.2	-0.5	-0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	0.3	-0.2	0.8
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	-1.0	-0.6	-0.4
Major Depression (MDD)	0.2	0.2	0.6	0.0	0.0	0.8
LDL Cholesterol	0.2	0.3	0.5	0.6	0.2	0.7
Primary Biliary Cirrhosis	0.2	0.3	0.6	0.0	-0.8	-0.5
Blood Platelet Count	0.2	2.5	6.8	0.9	0.1	-2.6
Hair Pigment	0.2	5.9	14.7	1.5	0.9	3.8
Tanning	0.2	1.9	2.2	1.4	-1.3	-1.5
Hand grip strength (left)	0.2	0.5	1.3	-0.4	-1.1	0.4
Fed-up feelings	0.2	0.4	1.2	-1.1	-0.2	0.3
Multivitamins +/- minerals	0.2	0.3	0.7	0.4	-0.0	0.8
Body mass index (BMI)	0.2	0.7	1.9	0.0	-0.4	1.4
Had other major operations	0.2	0.2	0.5	0.3	0.4	0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	-0.1	0.5	-0.8
Medication: Ramipril	0.2	0.3	0.6	-0.2	0.8	-0.5
Worrier / anxious feelings	0.2	0.4	0.9	-0.9	0.1	-0.5
Prospective memory result	0.2	0.2	0.6	0.8	0.1	-0.3
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.2	0.7	-0.3
Pulse wave reflection index	0.2	0.2	0.5	0.1	-0.7	0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	-0.9	-0.5	0.0
High blood pressure (siblings)	0.2	0.3	0.9	-0.2	1.0	0.3
Worry too long after embarrassment	0.2	0.4	0.9	-0.4	1.0	-0.1
Angina (self-reported)	0.2	0.2	0.4	0.0	0.6	0.6
Pulse rate, automated reading	0.2	0.8	1.4	-1.0	1.2	-0.0
Alcohol intake frequency.	0.2	0.5	0.8	0.6	0.7	0.9
Number of full sisters	0.2	0.3	0.5	0.6	0.7	-0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.1	0.7	0.5
Ever had bowel cancer screening	0.2	0.2	0.5	-0.0	0.4	-0.7
Osteoarthritis (self-reported)	0.2	0.2	0.4	0.5	-0.0	0.6
Medication: Aspirin	0.2	0.2	0.4	-0.5	-0.1	-0.6
Age started oral contraceptive pill	0.2	0.3	0.5	0.5	0.7	0.4
Diastolic blood pressure, automated reading	0.2	0.7	1.2	-1.1	-0.8	0.6
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	0.9	-0.4	0.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.2	-0.5	-0.3	-0.4
Ulcerative Colitis (UC)	0.1	0.1	0.3	-0.2	-0.5	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.3	-0.1	0.6	0.3
Age at First Birth	0.1	0.1	0.2	-0.1	-0.4	0.5
Neuroticism (2016)	0.1	0.1	0.2	0.0	0.5	-0.1
Systolic Blood Pressure	0.1	0.6	1.4	-0.3	-1.2	0.5
Allergy or Eczema	0.1	0.4	1.1	-0.2	1.0	-0.0
Cardiovascular Disease	0.1	0.4	0.9	-0.5	-1.0	-0.3
Neuroticism	0.1	0.2	0.2	0.5	0.2	0.5
Relative age of first facial hair	0.1	0.3	0.6	0.7	0.5	0.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	-0.5	-0.4	0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	0.1	-0.2	-0.6
Systolic blood pressure, automated reading	0.1	0.2	0.4	-0.2	-0.1	0.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	0.3	0.0	-0.4
Angina	0.1	0.1	0.4	-0.2	0.6	0.2
Vitamin and mineral supplements	0.1	0.1	0.2	-0.4	-0.1	-0.3
Medication: Metformin	0.1	0.1	0.1	-0.2	0.4	0.3
Age when periods started (menarche)	0.1	0.2	0.5	0.7	0.4	0.2
High blood pressure	0.1	0.3	0.4	-0.6	0.6	0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	0.2	0.0	-0.5
Had menopause	0.1	0.2	0.4	-0.2	-0.1	-0.7
Medication: Simvastatin	0.1	0.1	0.2	-0.0	0.2	-0.5
Fluid intelligence score	0.1	0.3	0.8	-0.1	-0.2	-0.9
Illnesses of siblings	0.1	0.2	0.3	0.4	-0.5	0.3
Neuroticism score	0.1	0.1	0.2	-0.0	0.4	0.5
Noisy workplace	0.1	0.1	0.3	0.6	-0.2	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.2	-0.2	-0.5
Length of working week for main job	0.1	0.2	0.2	0.3	-0.4	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.3	-0.1	-0.5
Heart disease (mother)	0.1	0.2	0.3	-0.3	0.2	-0.6
Age at last live birth	0.1	0.1	0.2	0.3	-0.1	0.5
Medication: Aspirin	0.1	0.2	0.3	0.0	0.5	-0.5
Hypertension (Self-reported)	0.1	0.3	0.3	-0.6	0.6	0.6
Mood swings	0.1	0.2	0.6	0.0	0.2	0.8
Asthma (self-reported)	0.1	0.3	0.5	0.7	0.6	0.1
Wears glasses or contact lenses	0.1	0.1	0.3	-0.6	-0.0	0.1
Hearing aid user	0.1	0.1	0.2	0.1	-0.4	-0.1
Mother’s age at death	0.1	0.2	0.4	-0.6	-0.3	-0.2
High cholesterol (Self-reported)	0.1	0.2	0.5	0.4	0.7	0.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.4	0.6	-0.6	0.1
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	-0.1	-0.4	-0.3
Neuroticism (Nagel 2018)	0.0	0.1	0.1	0.1	0.3	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.1	0.1	0.2	-0.3	0.2
Ulcerative Colitis	0.0	0.0	0.1	0.0	0.0	-0.3
Respiratory disease	0.0	0.1	0.2	-0.3	0.4	0.1
Townsend deprivation index at recruitment	0.0	0.0	0.1	-0.3	0.2	0.1
Taking other prescription medications	0.0	0.1	0.1	-0.4	0.0	-0.2
Arm fat percentage (right)	0.0	0.1	0.1	0.3	0.3	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.2	0.2	0.0	-0.4
Number of full brothers	0.0	0.0	0.1	0.1	-0.3	0.2
Arm fat percentage (left)	0.0	0.0	0.1	0.0	0.1	0.3
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.0	-0.3	-0.2

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