Best TWAS P=4.68e-22 · Best GWAS P=4.87e-22 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | KIAA1683 | 0.09 | 0.06 | enet | 14 | 0.10 | 6.6e-12 | -4.55 | 7.3 | 2.0e-13 | 0.78 | 0.03 | 0.97 | FALSE |
2 | GTEx | Adipose Subcutaneous | KIAA1683 | 0.14 | 0.09 | enet | 6 | 0.16 | 2.5e-13 | -2.76 | 6.5 | 9.1e-11 | 0.80 | 0.01 | 0.99 | FALSE |
3 | GTEx | Adipose Subcutaneous | AC005253.4 | 0.11 | 0.06 | enet | 23 | 0.04 | 1.6e-04 | 0.17 | 5.9 | 4.4e-09 | 0.38 | 0.18 | 0.54 | FALSE |
4 | GTEx | Artery Tibial | KIAA1683 | 0.16 | 0.08 | enet | 11 | 0.15 | 8.2e-12 | -2.76 | 5.3 | 1.4e-07 | 0.60 | 0.49 | 0.51 | FALSE |
5 | GTEx | Colon Transverse | SSBP4 | 0.18 | 0.01 | enet | 21 | 0.00 | 3.6e-01 | 6.05 | -6.3 | 3.9e-10 | -0.38 | 0.06 | 0.23 | TRUE |
6 | GTEx | Colon Transverse | KIAA1683 | 0.15 | 0.02 | lasso | 3 | 0.02 | 3.3e-02 | -4.65 | 7.9 | 3.0e-15 | 0.88 | 0.00 | 0.98 | FALSE |
7 | GTEx | Esophagus Muscularis | KIAA1683 | 0.10 | 0.04 | lasso | 3 | 0.06 | 1.1e-04 | -2.76 | 6.4 | 2.0e-10 | 0.80 | 0.01 | 0.99 | FALSE |
8 | GTEx | Muscle Skeletal | PDE4C | 0.11 | 0.05 | lasso | 6 | 0.06 | 7.7e-07 | -3.21 | -5.2 | 2.4e-07 | -0.54 | 0.97 | 0.02 | FALSE |
9 | GTEx | Nerve Tibial | KIAA1683 | 0.25 | 0.22 | lasso | 9 | 0.28 | 5.2e-20 | 9.65 | 7.6 | 3.3e-14 | 0.87 | 0.00 | 1.00 | FALSE |
10 | GTEx | Pancreas | AC007192.6 | 0.19 | 0.00 | enet | 28 | 0.01 | 1.3e-01 | 9.18 | -6.5 | 6.1e-11 | -0.47 | 0.06 | 0.26 | FALSE |
11 | GTEx | Pituitary | KIAA1683 | 0.43 | 0.25 | lasso | 3 | 0.17 | 3.9e-05 | 6.86 | 6.8 | 7.8e-12 | 0.80 | 0.02 | 0.92 | FALSE |
12 | GTEx | Testis | PDE4C | 0.39 | 0.44 | lasso | 2 | 0.43 | 5.8e-21 | -5.40 | -5.4 | 6.8e-08 | -0.07 | 1.00 | 0.00 | FALSE |
13 | GTEx | Testis | AC068499.10 | 0.38 | 0.41 | lasso | 3 | 0.40 | 6.8e-19 | -5.40 | -5.5 | 3.4e-08 | -0.08 | 1.00 | 0.00 | FALSE |
14 | GTEx | Thyroid | KIAA1683 | 0.11 | 0.07 | enet | 14 | 0.12 | 2.1e-09 | 6.86 | 8.8 | 2.1e-18 | 0.75 | 0.03 | 0.97 | FALSE |
15 | GTEx | Vagina | LRRC25 | 0.63 | 0.02 | enet | 2 | 0.04 | 5.3e-02 | 9.65 | -9.7 | 4.7e-22 | -1.00 | 0.01 | 0.72 | TRUE |
16 | METSIM | Adipose | IL12RB1 | 0.05 | 0.05 | lasso | 3 | 0.04 | 2.8e-07 | 5.70 | -5.4 | 5.1e-08 | -0.29 | 0.98 | 0.02 | FALSE |
17 | NTR | Blood | IFI30 | 0.03 | 0.02 | lasso | 6 | 0.02 | 8.8e-08 | 8.72 | 7.3 | 3.2e-13 | 0.47 | 0.82 | 0.16 | FALSE |
18 | ROSMAP | Brain Pre-frontal Cortex | PDE4C | 0.18 | 0.12 | enet | 17 | 0.19 | 3.3e-24 | -3.42 | -6.4 | 1.4e-10 | -0.57 | 0.99 | 0.01 | FALSE |
19 | ROSMAP | Brain Pre-frontal Cortex | KIAA1683 | 0.23 | 0.14 | bslmm | 409 | 0.24 | 1.4e-30 | -2.76 | 6.9 | 5.9e-12 | 0.84 | 0.00 | 1.00 | FALSE |
20 | ROSMAP | Brain Pre-frontal Cortex | JUND | 0.17 | 0.17 | lasso | 5 | 0.20 | 2.7e-25 | 9.65 | 8.4 | 5.8e-17 | 0.92 | 0.00 | 1.00 | FALSE |
21 | ROSMAP | Brain Pre-frontal Cortex | KLHL26 | 0.22 | 0.13 | bslmm | 382 | 0.18 | 2.6e-22 | -5.09 | 5.9 | 3.9e-09 | 0.05 | 1.00 | 0.00 | TRUE |
22 | YFS | Blood | IFI30 | 0.08 | 0.04 | bslmm | 405 | 0.08 | 1.1e-23 | -1.72 | 6.2 | 6.8e-10 | 0.42 | 1.00 | 0.00 | FALSE |
23 | YFS | Blood | KIAA1683 | 0.51 | 0.40 | enet | 65 | 0.46 | 9.9e-171 | 9.64 | 7.5 | 6.4e-14 | 0.91 | 0.00 | 1.00 | FALSE |
24 | YFS | Blood | MAST3 | 0.06 | 0.04 | lasso | 5 | 0.04 | 4.2e-12 | 9.18 | -8.6 | 5.4e-18 | -0.39 | 0.18 | 0.82 | FALSE |
25 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IL12RB1 | 0.07 | 0.02 | lasso | 3 | 0.01 | 6.4e-02 | 5.70 | -5.8 | 7.7e-09 | -0.32 | 0.13 | 0.16 | FALSE |
26 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | KIAA1683 | 0.05 | 0.04 | enet | 6 | 0.05 | 4.9e-05 | -2.76 | 5.5 | 4.2e-08 | 0.73 | 0.05 | 0.88 | FALSE |
27 | The Cancer Genome Atlas | Colon Adenocarcinoma | IL12RB1 | 0.11 | 0.03 | blup | 58 | 0.03 | 7.3e-03 | 5.05 | -5.1 | 2.7e-07 | -0.19 | 0.19 | 0.10 | FALSE |
28 | The Cancer Genome Atlas | Glioblastoma Multiforme | JUND | 0.17 | 0.00 | blup | 57 | 0.03 | 5.4e-02 | 9.65 | 8.7 | 4.2e-18 | 0.71 | 0.00 | 0.70 | FALSE |
29 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | KIAA1683 | 0.05 | 0.03 | lasso | 4 | 0.04 | 9.1e-06 | -4.55 | 5.6 | 1.8e-08 | 0.68 | 0.16 | 0.84 | FALSE |
30 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IL12RB1 | 0.10 | 0.08 | blup | 58 | 0.09 | 6.9e-10 | 6.05 | -5.3 | 1.2e-07 | -0.30 | 1.00 | 0.00 | FALSE |
31 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | JUND | 0.05 | 0.04 | lasso | 1 | 0.04 | 4.3e-05 | 9.65 | 9.7 | 4.9e-22 | 1.00 | 0.00 | 0.99 | FALSE |
32 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KIAA1683 | 0.09 | 0.07 | lasso | 8 | 0.12 | 2.1e-13 | -2.77 | 6.2 | 6.5e-10 | 0.75 | 0.24 | 0.76 | FALSE |
33 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAST3 | 0.04 | 0.02 | blup | 65 | 0.01 | 7.3e-02 | 9.18 | -6.9 | 5.4e-12 | -0.32 | 0.00 | 0.75 | FALSE |
34 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | JUND | 0.11 | 0.03 | blup | 58 | 0.04 | 1.4e-03 | -3.73 | 8.3 | 1.3e-16 | 0.57 | 0.03 | 0.43 | TRUE |
35 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | KIAA1683 | 0.13 | 0.02 | blup | 65 | 0.05 | 1.0e-03 | 6.79 | 5.6 | 1.9e-08 | 0.79 | 0.00 | 0.98 | FALSE |
36 | The Cancer Genome Atlas | Brain Lower Grade Glioma | JUND | 0.04 | 0.03 | lasso | 2 | 0.02 | 7.9e-04 | 9.65 | 9.6 | 1.1e-21 | 1.00 | 0.00 | 0.99 | FALSE |
37 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KIAA1683 | 0.16 | 0.11 | lasso | 6 | 0.11 | 2.9e-12 | -2.76 | 5.4 | 6.2e-08 | 0.70 | 0.88 | 0.12 | FALSE |
38 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MAST3 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.5e-02 | 8.97 | -8.9 | 3.6e-19 | -0.23 | 0.02 | 0.88 | TRUE |
39 | The Cancer Genome Atlas | Lung Adenocarcinoma | IL12RB1 | 0.10 | 0.08 | enet | 13 | 0.07 | 3.9e-08 | 6.05 | -5.3 | 1.1e-07 | -0.29 | 1.00 | 0.00 | FALSE |
40 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IL12RB1 | 0.07 | 0.04 | blup | 58 | 0.06 | 4.9e-07 | 5.05 | -6.8 | 1.3e-11 | -0.26 | 0.86 | 0.12 | FALSE |
41 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | KIAA1683 | 0.09 | 0.05 | lasso | 4 | 0.06 | 1.3e-07 | 9.65 | 7.3 | 2.8e-13 | 0.86 | 0.00 | 1.00 | FALSE |
42 | The Cancer Genome Atlas | Soft Tissue Sarcoma | KIAA1683 | 0.07 | 0.00 | blup | 64 | 0.01 | 4.5e-02 | -4.65 | 5.8 | 6.9e-09 | 0.60 | 0.01 | 0.68 | FALSE |
43 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CRTC1 | 0.33 | 0.08 | lasso | 5 | 0.12 | 3.6e-05 | -5.09 | -5.7 | 1.1e-08 | 0.02 | 0.04 | 0.52 | FALSE |
44 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IL12RB1 | 0.10 | 0.01 | enet | 10 | 0.06 | 2.6e-03 | 1.76 | -6.8 | 9.0e-12 | -0.21 | 0.01 | 0.68 | FALSE |
45 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | KIAA1683 | 0.17 | 0.06 | blup | 65 | 0.06 | 3.0e-03 | -4.09 | 5.9 | 3.6e-09 | 0.69 | 0.01 | 0.93 | FALSE |
46 | The Cancer Genome Atlas | Thyroid Carcinoma | IL12RB1 | 0.08 | 0.04 | lasso | 3 | 0.05 | 8.9e-06 | 4.10 | -5.8 | 5.8e-09 | -0.25 | 0.31 | 0.51 | FALSE |
47 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA1683 | 0.15 | 0.09 | lasso | 6 | 0.16 | 5.4e-15 | 6.79 | 6.2 | 6.9e-10 | 0.75 | 0.64 | 0.36 | FALSE |
48 | The Cancer Genome Atlas | Thyroid Carcinoma | MAST3 | 0.04 | 0.02 | lasso | 2 | 0.00 | 3.4e-01 | 8.97 | -8.9 | 6.5e-19 | -0.24 | 0.02 | 0.78 | FALSE |