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chr19:17,473,015-19,478,051

Best TWAS P=5.39e-18 · Best GWAS P=3.93e-19 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KIAA1683	0.09	0.06	enet	14	0.10	6.6e-12	-3.460	5.9	4.0e-09	0.13	0.87	0.13	FALSE
2	GTEx	Adipose Subcutaneous	AC005253.4	0.11	0.06	enet	23	0.04	1.6e-04	0.039	5.2	2.2e-07	0.22	0.28	0.26	FALSE
3	GTEx	Colon Transverse	SSBP4	0.18	0.01	enet	21	0.00	3.6e-01	5.744	-5.1	2.9e-07	-0.25	0.05	0.34	FALSE
4	GTEx	Colon Transverse	KIAA1683	0.15	0.02	lasso	3	0.02	3.3e-02	-3.729	6.2	4.2e-10	0.15	0.32	0.18	FALSE
5	GTEx	Nerve Tibial	KIAA1683	0.25	0.22	lasso	9	0.28	5.2e-20	7.585	5.8	7.0e-09	0.08	0.99	0.01	FALSE
6	GTEx	Pancreas	AC007192.6	0.19	0.00	enet	28	0.01	1.3e-01	8.795	-5.7	1.4e-08	-0.29	0.03	0.64	FALSE
7	GTEx	Testis	PDE4C	0.39	0.44	lasso	2	0.43	5.8e-21	-5.643	-5.6	1.7e-08	-0.39	1.00	0.00	FALSE
8	GTEx	Testis	AC068499.10	0.38	0.41	lasso	3	0.40	6.8e-19	-5.643	-5.8	8.3e-09	-0.41	1.00	0.00	FALSE
9	GTEx	Thyroid	KIAA1683	0.11	0.07	enet	14	0.12	2.1e-09	5.064	7.4	1.1e-13	0.23	0.30	0.69	FALSE
10	GTEx	Vagina	LRRC25	0.63	0.02	enet	2	0.04	5.3e-02	7.585	-7.6	3.3e-14	-0.20	0.04	0.15	FALSE
11	METSIM	Adipose	IL12RB1	0.05	0.05	lasso	3	0.04	2.8e-07	5.332	-5.2	2.4e-07	-0.41	0.92	0.08	FALSE
12	NTR	Blood	IFI30	0.03	0.02	lasso	6	0.02	8.8e-08	8.250	6.7	2.7e-11	0.31	0.14	0.86	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	PDE4C	0.18	0.12	enet	17	0.19	3.3e-24	-2.911	-5.8	4.9e-09	-0.22	0.80	0.20	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	JUND	0.17	0.17	lasso	5	0.20	2.7e-25	7.585	6.5	7.9e-11	0.13	1.00	0.00	TRUE
15	ROSMAP	Brain Pre-frontal Cortex	KLHL26	0.22	0.13	bslmm	382	0.18	2.6e-22	-4.623	5.5	5.0e-08	0.01	1.00	0.00	FALSE
16	YFS	Blood	IFI30	0.08	0.04	bslmm	405	0.08	1.1e-23	-1.093	5.4	6.8e-08	0.12	0.91	0.09	FALSE
17	YFS	Blood	KIAA1683	0.51	0.40	enet	65	0.46	9.9e-171	7.570	5.5	3.7e-08	0.05	1.00	0.00	FALSE
18	YFS	Blood	MAST3	0.06	0.04	lasso	5	0.04	4.2e-12	8.795	-8.4	6.3e-17	-0.56	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IL12RB1	0.07	0.02	lasso	3	0.01	6.4e-02	5.332	-5.5	4.0e-08	-0.43	0.14	0.08	FALSE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	IL12RB1	0.11	0.03	blup	58	0.03	7.3e-03	5.036	-5.3	1.3e-07	-0.49	0.18	0.14	FALSE
21	The Cancer Genome Atlas	Glioblastoma Multiforme	JUND	0.17	0.00	blup	57	0.03	5.4e-02	7.585	7.6	3.3e-14	0.25	0.01	0.59	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IL12RB1	0.05	0.03	enet	11	0.05	2.3e-06	-2.269	-5.2	1.9e-07	-0.44	0.50	0.39	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	JUND	0.05	0.04	lasso	1	0.04	4.3e-05	7.585	7.6	3.3e-14	0.20	0.13	0.21	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAST3	0.04	0.02	blup	65	0.01	7.3e-02	8.795	-6.9	4.6e-12	-0.53	0.01	0.53	FALSE
25	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	JUND	0.11	0.03	blup	58	0.04	1.4e-03	-3.751	7.2	6.9e-13	0.22	0.04	0.08	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	JUND	0.04	0.03	lasso	2	0.02	7.9e-04	7.585	7.5	6.7e-14	0.19	0.17	0.14	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAST3	0.02	0.02	lasso	3	0.01	1.5e-02	8.591	-8.6	5.4e-18	-0.95	0.01	0.93	TRUE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IL12RB1	0.07	0.04	blup	58	0.06	4.9e-07	5.036	-6.3	3.8e-10	-0.57	0.87	0.10	FALSE
29	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KIAA1683	0.09	0.05	lasso	4	0.06	1.3e-07	7.585	5.4	6.5e-08	0.05	0.83	0.09	FALSE
30	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CRTC1	0.33	0.08	lasso	5	0.12	3.6e-05	-4.623	-5.8	8.8e-09	0.04	0.04	0.52	TRUE
31	The Cancer Genome Atlas	Testicular Germ Cell Tumors	IL12RB1	0.10	0.01	enet	10	0.06	2.6e-03	1.845	-7.1	1.7e-12	-0.62	0.01	0.61	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	IL12RB1	0.08	0.04	lasso	3	0.05	8.9e-06	4.318	-5.8	8.2e-09	-0.46	0.36	0.42	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	MAST3	0.04	0.02	lasso	2	0.00	3.4e-01	8.591	-8.6	9.4e-18	-0.95	0.02	0.85	FALSE