[Hub]/) : Traits : Trunk fat-free mass :

chr1:37,628,741-40,737,589

Best TWAS P=4.18e-11 · Best GWAS P=1.01e-11 conditioned to 0.000836

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous SF3A3 0.17 0.12 lasso 4 0.11 2.6e-09 5.16 5.2 2.0e-07 -0.07 0.05 0.95 FALSE
2 GTEx Adipose Visceral Omentum FHL3 0.10 0.02 enet 9 0.00 1.9e-01 5.44 5.7 1.1e-08 -0.07 0.05 0.82 FALSE
3 GTEx Adipose Visceral Omentum SF3A3 0.20 0.18 lasso 2 0.18 1.5e-09 5.56 5.4 6.5e-08 -0.07 0.03 0.97 FALSE
4 GTEx Adrenal Gland PABPC4 0.20 0.09 lasso 8 0.06 3.0e-03 4.70 -5.8 5.6e-09 -0.77 0.05 0.80 FALSE
5 GTEx Adrenal Gland FHL3 0.24 0.15 enet 17 0.34 7.4e-13 5.16 6.6 4.2e-11 -0.02 0.01 0.99 TRUE
6 GTEx Artery Aorta FHL3 0.35 0.22 lasso 4 0.27 3.9e-15 5.16 6.0 2.3e-09 -0.05 0.01 0.99 FALSE
7 GTEx Artery Aorta SF3A3 0.12 0.19 lasso 2 0.18 6.6e-10 5.16 5.2 1.9e-07 -0.08 0.06 0.94 FALSE
8 GTEx Artery Aorta INPP5B 0.21 0.13 lasso 3 0.21 5.5e-12 -3.90 5.3 1.1e-07 -0.03 0.11 0.88 FALSE
9 GTEx Artery Coronary FHL3 0.31 0.22 lasso 5 0.18 1.3e-06 5.16 5.3 1.4e-07 -0.07 0.04 0.94 FALSE
10 GTEx Artery Coronary INPP5B 0.27 0.28 enet 5 0.18 1.4e-06 4.97 5.3 1.4e-07 -0.07 0.05 0.95 FALSE
11 GTEx Artery Coronary RP11-109P14.10 0.26 0.10 enet 10 0.00 3.7e-01 5.16 5.6 2.3e-08 -0.07 0.02 0.96 FALSE
12 GTEx Artery Tibial FHL3 0.13 0.11 lasso 2 0.13 1.1e-10 5.56 5.8 5.2e-09 -0.06 0.02 0.98 FALSE
13 GTEx Artery Tibial SF3A3 0.16 0.11 enet 8 0.12 1.2e-09 5.16 5.3 8.9e-08 -0.06 0.04 0.96 FALSE
14 GTEx Artery Tibial UTP11L 0.09 0.14 lasso 3 0.12 1.1e-09 5.56 5.8 8.0e-09 -0.06 0.02 0.98 FALSE
15 GTEx Breast Mammary Tissue SF3A3 0.14 0.18 lasso 2 0.16 8.5e-09 5.16 5.3 1.2e-07 -0.08 0.06 0.94 FALSE
16 GTEx Breast Mammary Tissue (Female) PABPC4 0.10 0.00 enet 9 0.01 1.5e-01 6.22 -6.1 1.2e-09 -0.83 0.03 0.47 FALSE
17 GTEx Breast Mammary Tissue (Female) SF3A3 0.08 0.16 lasso 1 0.10 6.2e-04 5.16 5.2 2.4e-07 -0.08 0.04 0.70 FALSE
18 GTEx Cells EBV-transformed lymphocytes SF3A3 0.23 0.11 enet 18 0.09 5.8e-04 5.56 5.8 7.9e-09 -0.05 0.02 0.93 FALSE
19 GTEx Cells Transformed fibroblasts FHL3 0.24 0.17 lasso 4 0.15 1.4e-11 5.56 5.6 2.2e-08 -0.06 0.02 0.98 FALSE
20 GTEx Esophagus Gastroesophageal Junction SF3A3 0.23 0.11 lasso 6 0.08 7.7e-04 5.56 5.4 6.8e-08 -0.08 0.04 0.94 FALSE
21 GTEx Esophagus Mucosa FHL3 0.14 0.14 lasso 5 0.12 3.4e-08 5.56 5.7 1.4e-08 -0.07 0.03 0.97 FALSE
22 GTEx Esophagus Mucosa SF3A3 0.08 0.06 lasso 4 0.05 1.5e-04 5.56 5.5 4.0e-08 -0.07 0.04 0.96 FALSE
23 GTEx Esophagus Mucosa BMP8A 0.08 0.02 lasso 2 0.01 1.4e-01 -2.48 5.3 1.4e-07 0.69 0.08 0.86 FALSE
24 GTEx Esophagus Mucosa PPIEL 0.11 0.02 lasso 3 0.02 9.4e-03 5.72 5.4 5.5e-08 0.76 0.13 0.58 FALSE
25 GTEx Esophagus Muscularis SF3A3 0.14 0.03 enet 13 0.06 2.9e-04 5.56 5.4 7.0e-08 -0.10 0.03 0.93 FALSE
26 GTEx Esophagus Muscularis RP11-109P14.10 0.17 0.11 lasso 6 0.13 3.6e-08 -4.27 5.2 1.8e-07 -0.03 0.23 0.76 FALSE
27 GTEx Heart Atrial Appendage SF3A3 0.15 0.12 lasso 4 0.08 1.4e-04 5.16 5.3 1.1e-07 -0.07 0.05 0.89 FALSE
28 GTEx Lung FHL3 0.14 0.07 enet 24 0.13 6.0e-10 5.09 5.3 1.1e-07 -0.01 0.02 0.98 FALSE
29 GTEx Lung SF3A3 0.21 0.20 lasso 2 0.21 1.1e-15 5.56 5.4 6.4e-08 -0.07 0.03 0.97 FALSE
30 GTEx Nerve Tibial FHL3 0.20 0.12 lasso 7 0.14 1.9e-10 4.97 5.5 3.1e-08 -0.05 0.02 0.98 FALSE
31 GTEx Nerve Tibial SF3A3 0.35 0.36 lasso 4 0.35 7.6e-26 5.16 5.2 1.9e-07 -0.07 0.12 0.87 FALSE
32 GTEx Nerve Tibial RP11-69E11.8 0.05 0.00 lasso 3 0.01 6.9e-02 4.70 -5.1 2.9e-07 -0.75 0.03 0.86 FALSE
33 GTEx Ovary RP11-69E11.4 0.25 0.05 enet 11 0.03 6.7e-02 4.60 5.6 2.7e-08 0.68 0.05 0.43 FALSE
34 GTEx Pancreas FHL3 0.17 0.05 lasso 3 0.10 6.6e-05 -5.91 6.1 1.3e-09 0.00 0.00 1.00 FALSE
35 GTEx Skin Not Sun Exposed Suprapubic FHL3 0.11 0.11 lasso 4 0.07 1.0e-04 5.40 5.4 5.6e-08 -0.05 0.02 0.97 FALSE
36 GTEx Skin Not Sun Exposed Suprapubic SF3A3 0.24 0.14 lasso 4 0.15 1.1e-08 5.16 5.3 1.4e-07 -0.07 0.06 0.94 FALSE
37 GTEx Skin Sun Exposed Lower leg RP11-69E11.4 0.13 0.12 lasso 6 0.15 1.3e-12 5.90 5.7 1.4e-08 0.72 0.42 0.58 FALSE
38 GTEx Skin Sun Exposed Lower leg FHL3 0.15 0.09 lasso 5 0.10 1.2e-08 -5.91 5.7 1.3e-08 -0.01 0.00 1.00 FALSE
39 GTEx Spleen RP11-69E11.4 0.25 0.12 lasso 4 0.15 9.3e-05 4.20 5.5 4.9e-08 0.70 0.19 0.59 FALSE
40 GTEx Spleen BMP8A 0.16 0.08 lasso 3 0.05 1.6e-02 5.90 5.2 2.2e-07 0.75 0.07 0.32 FALSE
41 GTEx Thyroid SF3A3 0.13 0.16 lasso 2 0.16 1.7e-12 5.16 5.4 7.0e-08 -0.07 0.03 0.97 FALSE
42 METSIM Adipose FHL3 0.15 0.12 lasso 5 0.14 6.3e-20 -5.91 5.5 3.2e-08 -0.01 0.00 1.00 FALSE
43 METSIM Adipose SF3A3 0.08 0.11 lasso 3 0.11 7.4e-16 5.56 5.6 2.7e-08 -0.07 0.03 0.96 FALSE
44 NTR Blood KIAA0754 0.03 0.00 bslmm 366 0.01 1.6e-03 -0.81 5.7 1.1e-08 0.62 0.08 0.78 FALSE
45 NTR Blood PABPC4 0.01 0.00 blup 383 0.00 2.8e-02 4.70 -6.6 4.4e-11 -0.68 0.05 0.48 TRUE
46 NTR Blood SF3A3 0.10 0.12 lasso 6 0.13 7.2e-39 -5.93 -5.6 2.4e-08 0.01 0.00 1.00 FALSE
47 ROSMAP Brain Pre-frontal Cortex FHL3 0.07 0.06 enet 8 0.06 4.9e-08 4.97 5.3 1.3e-07 -0.08 0.06 0.94 FALSE
48 YFS Blood SF3A3 0.50 0.29 enet 44 0.44 3.2e-162 5.56 5.5 5.1e-08 0.00 0.02 0.98 FALSE
49 The Cancer Genome Atlas Bladder Urothelial Carcinoma FHL3 0.08 0.02 enet 7 0.03 1.1e-03 5.16 5.3 9.1e-08 0.02 0.00 0.95 FALSE
50 The Cancer Genome Atlas Breast Invasive Carcinoma FHL3 0.06 0.01 enet 10 0.01 4.2e-04 -5.91 5.4 6.9e-08 0.00 0.00 0.99 FALSE
51 The Cancer Genome Atlas Colon Adenocarcinoma FHL3 0.10 0.05 lasso 2 0.06 2.9e-04 5.56 6.1 9.5e-10 -0.04 0.00 0.98 FALSE
52 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma BMP8A 0.04 0.03 blup 48 0.04 3.5e-05 4.20 5.5 4.4e-08 0.68 0.02 0.97 FALSE
53 The Cancer Genome Atlas Brain Lower Grade Glioma INPP5B 0.05 0.03 blup 68 0.05 6.7e-06 5.09 5.8 5.1e-09 -0.05 0.03 0.96 FALSE
54 The Cancer Genome Atlas Lung Squamous Cell Carcinoma FHL3 0.08 0.08 lasso 2 0.08 1.4e-09 -5.91 5.8 6.4e-09 0.01 0.00 1.00 FALSE
55 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma FHL3 0.13 0.03 enet 6 0.05 4.9e-04 -5.91 6.4 1.2e-10 -0.07 0.00 0.94 FALSE
56 The Cancer Genome Atlas Stomach Adenocarcinoma FHL3 0.10 0.05 lasso 2 0.03 2.2e-03 -5.91 5.8 9.1e-09 -0.01 0.00 0.96 FALSE
57 The Cancer Genome Atlas Thyroid Carcinoma FHL3 0.12 0.03 enet 8 0.03 6.4e-04 4.97 5.5 2.8e-08 -0.06 0.01 0.99 FALSE