[Hub]/) : Traits : Trunk fat-free mass :

chr1:40,748,755-42,542,658

Best TWAS P=1.23e-44 · Best GWAS P=4.17e-34 conditioned to 0.00924

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta CTPS1 0.10 0.00 enet 8 0.00 4.6e-01 9.195 9.6 8.5e-22 0.75 0.05 0.59 FALSE
2 GTEx Artery Coronary CTPS1 0.25 -0.01 enet 23 0.00 3.0e-01 1.338 5.5 4.7e-08 0.39 0.07 0.13 FALSE
3 GTEx Brain Cerebellum FOXO6 0.35 0.33 enet 21 0.36 1.2e-11 4.154 6.6 3.2e-11 -0.01 0.98 0.01 FALSE
4 GTEx Breast Mammary Tissue (Female) CTPS1 0.12 -0.01 lasso 4 -0.01 7.5e-01 8.586 7.7 9.7e-15 0.61 0.04 0.10 FALSE
5 GTEx Cells EBV-transformed lymphocytes CTPS1 0.26 0.11 lasso 6 0.08 1.6e-03 9.472 9.0 2.3e-19 0.70 0.19 0.35 FALSE
6 GTEx Esophagus Muscularis SCMH1 0.18 0.03 enet 19 0.10 1.1e-06 -1.603 -5.5 3.0e-08 -0.10 0.55 0.04 FALSE
7 GTEx Lung CTPS1 0.06 0.04 lasso 3 0.04 2.4e-04 9.733 10.3 7.1e-25 0.77 0.21 0.63 FALSE
8 GTEx Nerve Tibial SCMH1 0.16 0.03 enet 24 0.07 1.6e-05 11.884 -11.2 3.0e-29 -0.70 0.03 0.96 FALSE
9 GTEx Testis SLFNL1 0.30 0.17 lasso 14 0.28 5.3e-13 11.952 8.8 1.3e-18 0.85 0.01 0.99 FALSE
10 GTEx Testis CTPS1 0.57 0.28 enet 17 0.38 1.0e-17 -3.969 6.7 2.9e-11 0.48 0.97 0.03 FALSE
11 METSIM Adipose CTPS1 0.11 0.09 enet 31 0.09 6.2e-14 -3.969 5.7 1.0e-08 0.28 1.00 0.00 FALSE
12 ROSMAP Brain Pre-frontal Cortex CTPS1 0.04 0.04 enet 7 0.04 9.1e-06 8.557 6.2 6.4e-10 0.59 0.60 0.16 FALSE
13 The Cancer Genome Atlas Breast Invasive Carcinoma SLFNL1 0.03 0.01 enet 6 0.02 5.6e-05 -1.603 6.7 2.1e-11 0.58 0.11 0.73 FALSE
14 The Cancer Genome Atlas Brain Lower Grade Glioma CTPS 0.05 0.04 blup 49 0.03 1.0e-04 -3.969 5.7 1.5e-08 0.33 0.13 0.09 FALSE
15 The Cancer Genome Atlas Brain Lower Grade Glioma SCMH1 0.04 0.01 enet 7 0.02 2.5e-03 -0.038 -8.4 6.3e-17 -0.70 0.01 0.82 FALSE
16 The Cancer Genome Atlas Lung Adenocarcinoma CTPS 0.06 0.00 enet 14 0.02 3.3e-03 -0.938 -5.3 1.4e-07 -0.34 0.03 0.13 FALSE
17 The Cancer Genome Atlas Prostate Adenocarcinoma SCMH1 0.03 0.03 lasso 2 0.02 6.2e-03 12.170 -12.2 4.5e-34 -1.00 0.01 0.96 FALSE
18 The Cancer Genome Atlas Testicular Germ Cell Tumors SCMH1 0.35 0.14 blup 96 0.14 1.5e-05 -5.674 7.0 3.2e-12 0.47 0.18 0.25 FALSE
19 The Cancer Genome Atlas Thyroid Carcinoma SCMH1 0.07 0.08 blup 97 0.07 2.5e-07 11.821 -14.0 1.2e-44 -0.75 0.11 0.89 TRUE