Best TWAS P=1.72e-09 · Best GWAS P=4.14e-11 conditioned to 0.00457
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ECM2 | 0.11 | 0.10 | lasso | 10 | 0.09 | 1.1e-05 | -4.3 | -5.2 | 1.8e-07 | 0.79 | 0.29 | 0.70 | FALSE |
| 2 | GTEx | Brain Cerebellum | ZNF484 | 0.21 | 0.01 | lasso | 9 | 0.01 | 1.7e-01 | -5.7 | -5.4 | 7.6e-08 | 0.79 | 0.08 | 0.29 | FALSE |
| 3 | GTEx | Esophagus Muscularis | BICD2 | 0.09 | 0.02 | enet | 26 | 0.07 | 5.0e-05 | -4.6 | -5.5 | 3.6e-08 | 0.57 | 0.04 | 0.80 | FALSE |
| 4 | GTEx | Heart Left Ventricle | ECM2 | 0.07 | 0.05 | lasso | 3 | 0.02 | 3.1e-02 | -5.8 | -5.6 | 2.6e-08 | 0.75 | 0.06 | 0.78 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | IPPK | 0.17 | 0.07 | enet | 8 | 0.07 | 2.7e-06 | -6.4 | 6.0 | 2.1e-09 | -0.90 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Testis | NFIL3 | 0.47 | 0.33 | enet | 8 | 0.29 | 3.8e-13 | -5.7 | 5.8 | 9.0e-09 | 0.01 | 0.02 | 0.98 | TRUE |
| 7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | IPPK | 0.06 | 0.03 | blup | 49 | 0.04 | 5.8e-03 | -6.2 | 6.0 | 1.7e-09 | -0.88 | 0.01 | 0.66 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BICD2 | 0.06 | 0.02 | blup | 52 | 0.05 | 2.9e-06 | -5.8 | -5.8 | 8.4e-09 | 0.81 | 0.03 | 0.96 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | ECM2 | 0.10 | 0.04 | lasso | 2 | 0.04 | 4.2e-05 | -6.0 | -6.0 | 2.1e-09 | 0.90 | 0.00 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | IPPK | 0.03 | 0.02 | blup | 51 | 0.01 | 3.2e-02 | -6.1 | 5.8 | 5.7e-09 | -0.87 | 0.03 | 0.65 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | IPPK | 0.03 | 0.04 | blup | 50 | 0.04 | 6.7e-05 | -6.1 | 5.8 | 6.7e-09 | -0.94 | 0.01 | 0.98 | FALSE |