[Hub]/) : Traits : Trunk fat-free mass :

chr9:97,520,168-100,366,953

Best TWAS P=1.24e-27 · Best GWAS P=7.32e-33 conditioned to 4.18e-09

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex LOC441454 0.05 0.01 lasso 3 0.02 1.5e-03 6.35 7.3 2.2e-13 0.05 0.03 0.66 FALSE
2 GTEx Adipose Subcutaneous HSD17B3 0.21 0.01 enet 31 0.04 1.9e-04 6.63 5.4 7.8e-08 -0.02 0.30 0.25 FALSE
3 GTEx Artery Tibial RP11-435O5.5 0.09 0.04 lasso 2 0.02 7.3e-03 11.20 -10.9 1.2e-27 0.18 0.07 0.74 TRUE
4 GTEx Breast Mammary Tissue CDC14B 0.16 0.02 enet 21 0.02 3.7e-02 9.27 -7.9 2.9e-15 -0.01 0.04 0.92 FALSE
5 GTEx Cells EBV-transformed lymphocytes AAED1 0.17 0.02 lasso 3 0.04 2.4e-02 9.26 8.2 1.9e-16 0.00 0.04 0.62 FALSE
6 GTEx Cells Transformed fibroblasts RP11-435O5.5 0.14 0.04 lasso 4 0.02 7.9e-03 6.24 -6.4 1.4e-10 0.14 0.36 0.02 TRUE
7 GTEx Heart Atrial Appendage RP11-435O5.4 0.18 0.00 lasso 5 0.00 6.2e-01 3.12 -5.9 3.2e-09 0.24 0.07 0.16 TRUE
8 GTEx Liver PTCH1 0.25 0.06 enet 11 0.03 4.9e-02 10.04 6.4 1.5e-10 -0.11 0.16 0.05 FALSE
9 GTEx Nerve Tibial HSD17B3 0.14 0.00 enet 20 0.00 2.4e-01 8.96 6.9 5.4e-12 0.01 0.06 0.56 FALSE
10 GTEx Nerve Tibial ZNF367 0.10 0.05 lasso 3 0.02 7.9e-03 9.54 8.8 1.6e-18 -0.01 0.01 0.98 FALSE
11 GTEx Spleen PTCH1 0.33 0.08 lasso 8 0.18 1.9e-05 0.22 5.3 1.0e-07 0.01 0.18 0.06 TRUE
12 GTEx Testis HABP4 0.19 0.22 lasso 9 0.21 1.1e-09 9.30 9.3 1.2e-20 -0.02 0.04 0.96 FALSE
13 GTEx Thyroid CDC14B 0.15 0.10 lasso 5 0.08 5.3e-07 8.87 -8.9 6.6e-19 -0.03 0.17 0.82 FALSE
14 NTR Blood PTCH1 0.04 0.02 blup 433 0.02 4.1e-08 7.54 6.0 2.2e-09 -0.08 0.98 0.00 TRUE
15 YFS Blood HABP4 0.08 0.09 enet 24 0.11 5.9e-34 9.12 -9.1 6.5e-20 0.03 0.18 0.82 FALSE
16 YFS Blood PTCH1 0.09 0.05 lasso 8 0.05 1.2e-15 7.51 8.3 1.1e-16 -0.10 1.00 0.00 FALSE
17 The Cancer Genome Atlas Breast Invasive Carcinoma CDC14B 0.02 0.01 lasso 1 0.01 3.0e-03 9.44 -9.4 3.6e-21 0.02 0.02 0.73 FALSE
18 The Cancer Genome Atlas Glioblastoma Multiforme CDC14B 0.16 0.17 blup 41 0.19 2.6e-06 9.26 -8.4 3.5e-17 0.02 0.02 0.96 FALSE
19 The Cancer Genome Atlas Glioblastoma Multiforme HABP4 0.08 0.06 blup 44 0.05 1.6e-02 8.76 -9.6 1.2e-21 0.02 0.03 0.52 TRUE
20 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma HABP4 0.02 0.02 blup 44 0.02 7.1e-03 9.26 9.4 3.6e-21 -0.03 0.02 0.76 FALSE
21 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CDC14B 0.03 0.02 blup 42 0.02 2.1e-03 9.26 -9.3 1.0e-20 0.02 0.02 0.79 FALSE
22 The Cancer Genome Atlas Brain Lower Grade Glioma CDC14B 0.05 0.06 lasso 5 0.06 6.5e-07 9.28 -8.7 2.9e-18 0.01 0.03 0.97 FALSE
23 The Cancer Genome Atlas Brain Lower Grade Glioma HABP4 0.05 0.08 lasso 5 0.08 6.9e-09 8.80 -9.0 2.0e-19 0.01 0.05 0.95 FALSE
24 The Cancer Genome Atlas Prostate Adenocarcinoma PTCH1 0.02 0.01 blup 54 0.02 1.1e-03 9.81 -9.8 9.1e-23 0.27 0.04 0.34 FALSE
25 The Cancer Genome Atlas Stomach Adenocarcinoma CDC14B 0.08 0.02 blup 41 0.04 1.0e-03 6.35 -9.5 2.8e-21 0.03 0.02 0.66 FALSE
26 The Cancer Genome Atlas Thyroid Carcinoma CDC14B 0.05 0.07 blup 42 0.08 4.8e-08 9.31 -9.2 5.2e-20 0.03 0.02 0.98 FALSE