[Hub]/) : Traits : Trunk fat-free mass :

chr10:101,548,177-103,428,898

Best TWAS P=1.07e-32 · Best GWAS P=2.22e-30 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex SEC31B 0.13 0.21 lasso 3 0.20 4.1e-24 -5.5 5.5 3.4e-08 0.05 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous SEC31B 0.32 0.39 lasso 5 0.38 5.1e-33 -5.5 5.5 4.7e-08 0.05 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous RP11-179B2.2 0.15 0.08 lasso 6 0.08 3.2e-07 9.3 10.1 4.9e-24 0.90 0.02 0.98 FALSE
4 GTEx Adipose Visceral Omentum SEC31B 0.18 0.28 lasso 10 0.27 1.5e-14 -5.0 5.5 5.0e-08 0.07 1.00 0.00 FALSE
5 GTEx Adipose Visceral Omentum RP11-179B2.2 0.13 0.02 lasso 3 0.03 6.5e-03 11.4 11.0 4.6e-28 0.99 0.01 0.99 FALSE
6 GTEx Artery Aorta RP11-179B2.2 0.16 0.11 lasso 2 0.09 7.6e-06 11.4 11.3 1.9e-29 0.98 0.00 1.00 FALSE
7 GTEx Artery Tibial SEC31B 0.25 0.32 lasso 6 0.33 1.3e-26 -5.0 5.2 1.7e-07 0.07 1.00 0.00 FALSE
8 GTEx Artery Tibial RP11-179B2.2 0.11 0.09 lasso 4 0.08 8.8e-07 11.4 11.3 1.6e-29 0.96 0.00 1.00 FALSE
9 GTEx Brain Cerebellum RP11-179B2.2 0.37 0.21 lasso 4 0.20 1.4e-06 11.5 11.9 1.1e-32 0.96 0.00 0.99 TRUE
10 GTEx Brain Cortex SEC31B 0.18 0.09 lasso 7 0.07 7.1e-03 -5.0 5.2 1.5e-07 0.07 0.40 0.03 FALSE
11 GTEx Brain Frontal Cortex BA9 RP11-179B2.2 0.22 0.15 lasso 2 0.11 7.2e-04 11.5 10.8 3.3e-27 0.98 0.01 0.97 FALSE
12 GTEx Breast Mammary Tissue SEC31B 0.17 0.26 lasso 5 0.25 2.9e-13 -5.5 5.3 8.7e-08 0.05 1.00 0.00 FALSE
13 GTEx Breast Mammary Tissue RP11-179B2.2 0.11 0.09 lasso 2 0.07 1.8e-04 11.4 10.7 8.4e-27 0.96 0.01 0.98 FALSE
14 GTEx Breast Mammary Tissue (Male) SEC31B 0.13 0.08 lasso 4 0.10 3.0e-03 -5.5 5.5 4.4e-08 0.05 0.27 0.04 FALSE
15 GTEx Breast Mammary Tissue (Male) RP11-179B2.2 0.16 -0.01 enet 4 -0.01 7.1e-01 -10.8 11.0 2.2e-28 0.77 0.03 0.49 FALSE
16 GTEx Breast Mammary Tissue (Female) RP11-179B2.2 0.19 0.00 lasso 3 -0.01 5.1e-01 9.3 6.9 5.3e-12 0.65 0.03 0.42 FALSE
17 GTEx Cells EBV-transformed lymphocytes SEC31B 0.23 0.11 enet 13 0.12 9.2e-05 -5.5 5.1 2.9e-07 0.07 0.75 0.01 FALSE
18 GTEx Cells Transformed fibroblasts SEC31B 0.14 0.19 enet 17 0.22 1.6e-16 -5.5 5.3 1.2e-07 0.06 1.00 0.00 FALSE
19 GTEx Colon Transverse SEC31B 0.28 0.12 lasso 3 0.09 3.3e-05 -5.5 5.7 1.1e-08 0.07 0.98 0.00 FALSE
20 GTEx Esophagus Gastroesophageal Junction SEC31B 0.15 0.21 lasso 4 0.20 8.0e-08 -5.5 5.5 4.4e-08 0.05 0.96 0.00 FALSE
21 GTEx Esophagus Mucosa SEC31B 0.14 0.18 lasso 4 0.17 2.0e-11 -5.5 5.5 4.4e-08 0.05 1.00 0.00 FALSE
22 GTEx Esophagus Mucosa HIF1AN 0.14 0.08 lasso 7 0.09 2.2e-06 -5.7 5.5 4.6e-08 0.09 0.98 0.00 FALSE
23 GTEx Esophagus Muscularis SEC31B 0.18 0.19 lasso 4 0.20 4.5e-12 -5.5 5.5 5.1e-08 0.05 1.00 0.00 FALSE
24 GTEx Esophagus Muscularis RP11-179B2.2 0.15 0.16 lasso 3 0.16 8.1e-10 11.2 11.2 3.5e-29 0.98 0.01 0.99 FALSE
25 GTEx Heart Atrial Appendage MRPL43 0.16 0.07 lasso 4 0.09 5.8e-05 -4.6 -5.5 3.7e-08 -0.62 0.39 0.14 FALSE
26 GTEx Heart Left Ventricle RP11-179B2.2 0.15 0.18 enet 2 0.14 4.8e-08 11.5 11.5 2.3e-30 1.00 0.00 1.00 FALSE
27 GTEx Lung SEC31B 0.19 0.21 enet 18 0.20 2.0e-15 -5.0 5.2 1.9e-07 0.07 1.00 0.00 FALSE
28 GTEx Lung RP11-179B2.2 0.18 0.12 lasso 3 0.12 1.7e-09 11.5 10.9 7.3e-28 0.99 0.00 1.00 FALSE
29 GTEx Muscle Skeletal HIF1AN 0.05 0.06 lasso 1 0.05 1.6e-05 -5.5 -5.5 3.4e-08 -0.06 0.94 0.00 FALSE
30 GTEx Nerve Tibial SEC31B 0.42 0.42 lasso 9 0.43 1.4e-32 -5.5 5.4 6.6e-08 0.06 1.00 0.00 FALSE
31 GTEx Nerve Tibial RP11-179B2.2 0.15 0.08 lasso 2 0.12 6.4e-09 11.2 9.0 2.1e-19 0.88 0.01 0.99 FALSE
32 GTEx Pancreas SEC31B 0.24 0.19 lasso 5 0.17 9.9e-08 -5.5 5.3 1.0e-07 0.06 0.97 0.00 FALSE
33 GTEx Prostate SEC31B 0.18 0.14 lasso 2 0.12 6.7e-04 -5.4 5.5 5.1e-08 0.05 0.38 0.05 FALSE
34 GTEx Skin Not Sun Exposed Suprapubic SEC31B 0.15 0.16 lasso 4 0.15 8.3e-09 -5.5 5.5 4.4e-08 0.05 0.99 0.00 FALSE
35 GTEx Skin Not Sun Exposed Suprapubic HIF1AN 0.13 0.03 lasso 5 0.02 3.4e-02 -5.6 6.0 2.1e-09 0.04 0.26 0.03 TRUE
36 GTEx Skin Not Sun Exposed Suprapubic RP11-179B2.2 0.27 0.15 enet 36 0.15 2.0e-08 11.5 9.7 4.0e-22 0.75 0.00 1.00 FALSE
37 GTEx Skin Sun Exposed Lower leg SEC31B 0.20 0.34 lasso 4 0.34 8.3e-29 -5.5 5.4 6.7e-08 0.06 1.00 0.00 FALSE
38 GTEx Skin Sun Exposed Lower leg HIF1AN 0.07 0.05 lasso 8 0.03 2.2e-03 -5.7 5.6 2.5e-08 0.06 0.93 0.00 FALSE
39 GTEx Skin Sun Exposed Lower leg RP11-179B2.2 0.12 0.09 lasso 2 0.08 1.7e-07 9.2 8.8 1.1e-18 0.86 0.06 0.94 FALSE
40 GTEx Spleen SEC31B 0.21 0.12 lasso 3 0.05 2.3e-02 -5.5 5.6 2.0e-08 0.05 0.28 0.09 FALSE
41 GTEx Testis SEC31B 0.11 0.11 lasso 5 0.08 2.5e-04 -5.5 5.5 3.2e-08 0.05 0.84 0.01 FALSE
42 GTEx Testis HIF1AN 0.12 0.08 lasso 3 0.06 1.6e-03 -5.8 5.8 8.9e-09 0.08 0.33 0.04 FALSE
43 GTEx Thyroid SEC31B 0.28 0.32 lasso 5 0.31 4.9e-24 -5.5 5.3 1.3e-07 0.03 1.00 0.00 FALSE
44 GTEx Thyroid RP11-179B2.2 0.18 0.12 lasso 7 0.11 8.3e-09 9.3 10.0 9.9e-24 0.91 0.05 0.95 FALSE
45 GTEx Uterus SEC31B 0.40 0.14 lasso 18 0.05 3.1e-02 -5.6 5.5 3.6e-08 0.02 0.36 0.04 FALSE
46 GTEx Whole Blood HIF1AN 0.15 0.12 enet 7 0.12 8.7e-11 -5.7 5.6 1.7e-08 0.06 1.00 0.00 FALSE
47 METSIM Adipose MRPL43 0.05 0.04 bslmm 422 0.04 1.9e-06 -5.0 7.7 1.1e-14 0.46 0.90 0.07 FALSE
48 METSIM Adipose SEC31B 0.15 0.27 enet 29 0.28 1.0e-41 -5.4 5.1 3.0e-07 0.05 1.00 0.00 FALSE
49 NTR Blood HIF1AN 0.02 0.03 lasso 2 0.02 1.4e-07 -5.5 5.6 2.3e-08 0.05 1.00 0.00 FALSE
50 NTR Blood SEC31B 0.03 0.03 lasso 4 0.03 1.1e-10 -5.5 5.5 4.9e-08 0.06 1.00 0.00 FALSE
51 ROSMAP Brain Pre-frontal Cortex MRPL43 0.10 0.08 bslmm 411 0.09 1.2e-11 -5.0 -6.5 8.6e-11 -0.56 1.00 0.00 FALSE
52 YFS Blood HIF1AN 0.06 0.06 lasso 30 0.07 2.5e-22 -5.0 5.2 1.7e-07 0.07 1.00 0.00 FALSE
53 The Cancer Genome Atlas Breast Invasive Carcinoma MRPL43 0.02 0.02 enet 4 0.03 1.5e-06 -5.0 -5.2 1.6e-07 -0.51 0.98 0.00 FALSE
54 The Cancer Genome Atlas Breast Invasive Carcinoma SEC31B 0.09 0.13 blup 51 0.15 7.1e-29 -5.5 5.3 1.0e-07 0.05 0.04 0.96 FALSE
55 The Cancer Genome Atlas Colon Adenocarcinoma HIF1AN 0.07 0.03 blup 40 0.05 4.9e-04 -5.5 5.7 1.1e-08 0.05 0.03 0.84 FALSE
56 The Cancer Genome Atlas Colon Adenocarcinoma MRPL43 0.07 0.02 blup 52 0.00 1.7e-01 10.8 -10.1 3.9e-24 -0.80 0.01 0.82 FALSE
57 The Cancer Genome Atlas Colon Adenocarcinoma SEC31B 0.06 0.07 blup 51 0.08 2.9e-05 -5.0 5.5 4.0e-08 0.06 0.04 0.95 FALSE
58 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MRPL43 0.03 0.02 blup 52 0.03 3.0e-04 -4.6 -7.2 7.5e-13 -0.68 0.10 0.50 FALSE
59 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SEC31B 0.05 0.05 blup 51 0.05 1.3e-06 -5.5 5.5 4.7e-08 0.05 0.03 0.97 FALSE
60 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SEC31B 0.05 0.05 blup 51 0.05 8.9e-07 -5.5 5.5 3.8e-08 0.06 0.03 0.97 FALSE
61 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SEMA4G 0.04 0.01 blup 52 0.02 1.2e-03 9.2 9.3 1.2e-20 0.83 0.01 0.75 FALSE
62 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SEC31B 0.14 0.10 lasso 7 0.10 1.6e-06 -5.6 5.6 2.1e-08 0.05 0.03 0.97 FALSE
63 The Cancer Genome Atlas Brain Lower Grade Glioma NDUFB8 0.02 0.01 blup 38 0.01 1.6e-02 -5.0 -5.7 1.5e-08 -0.06 0.03 0.59 FALSE
64 The Cancer Genome Atlas Brain Lower Grade Glioma SEC31B 0.06 0.06 blup 51 0.06 1.1e-07 -5.4 5.8 7.5e-09 0.05 0.03 0.97 FALSE
65 The Cancer Genome Atlas Brain Lower Grade Glioma SEMA4G 0.03 0.01 blup 52 0.01 4.2e-02 11.2 8.5 2.7e-17 0.83 0.00 0.87 FALSE
66 The Cancer Genome Atlas Liver Hepatocellular Carcinoma MRPL43 0.05 0.05 enet 9 0.05 3.0e-03 -5.0 -5.2 1.7e-07 -0.44 0.12 0.07 FALSE
67 The Cancer Genome Atlas Lung Adenocarcinoma SEC31B 0.06 0.08 enet 10 0.09 4.6e-11 -5.5 5.3 8.9e-08 0.06 0.03 0.97 FALSE
68 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SEC31B 0.11 0.12 enet 15 0.13 1.5e-14 -5.7 5.2 2.0e-07 0.06 0.03 0.97 FALSE
69 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MRPL43 0.06 0.04 blup 51 0.04 7.4e-04 -4.9 -6.0 1.7e-09 -0.52 0.55 0.08 FALSE
70 The Cancer Genome Atlas Pancreatic Adenocarcinoma SEC31B 0.15 0.14 lasso 12 0.15 8.5e-07 -5.4 5.5 3.4e-08 0.06 0.04 0.96 FALSE
71 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma FAM178A 0.14 0.08 lasso 2 0.08 5.9e-04 -9.1 -8.1 6.0e-16 -0.54 0.07 0.14 FALSE
72 The Cancer Genome Atlas Prostate Adenocarcinoma MRPL43 0.13 0.16 lasso 10 0.15 2.4e-15 -5.0 -5.2 1.9e-07 -0.41 1.00 0.00 FALSE
73 The Cancer Genome Atlas Stomach Adenocarcinoma MRPL43 0.10 0.07 blup 51 0.09 3.3e-07 -5.0 -5.2 2.7e-07 -0.42 0.98 0.01 FALSE
74 The Cancer Genome Atlas Stomach Adenocarcinoma SEC31B 0.07 0.09 blup 51 0.09 4.1e-07 -5.1 5.2 2.3e-07 0.07 0.11 0.89 FALSE
75 The Cancer Genome Atlas Testicular Germ Cell Tumors SEC31B 0.24 0.20 blup 51 0.28 1.7e-10 -5.6 5.4 7.5e-08 0.06 0.05 0.95 FALSE
76 The Cancer Genome Atlas Thyroid Carcinoma SEC31B 0.12 0.19 blup 51 0.20 1.1e-18 -5.0 5.4 6.3e-08 0.07 0.31 0.69 FALSE
77 The Cancer Genome Atlas Thyroid Carcinoma SEMA4G 0.07 0.08 blup 52 0.08 5.1e-08 -4.6 7.6 2.9e-14 0.75 0.05 0.94 FALSE