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chr10:103,527,782-105,647,095

Best TWAS P=1.08e-17 · Best GWAS P=2.07e-15 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ACTR1A	0.03	0.01	blup	347	0.01	5.6e-02	4.83	7.2	5.2e-13	0.70	0.06	0.66	FALSE
2	GTEx	Adipose Subcutaneous	WBP1L	0.05	0.00	enet	8	0.00	5.3e-01	-5.86	5.8	7.7e-09	0.43	0.11	0.14	FALSE
3	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	4.25	7.3	2.7e-13	0.80	0.03	0.91	TRUE
4	GTEx	Adrenal Gland	TMEM180	0.19	0.15	enet	12	0.09	3.5e-04	-5.41	-7.3	2.6e-13	-0.53	0.28	0.60	FALSE
5	GTEx	Artery Aorta	NT5C2	0.08	0.02	lasso	7	0.01	1.2e-01	-4.22	-6.2	6.2e-10	-0.43	0.07	0.80	FALSE
6	GTEx	Artery Coronary	TMEM180	0.14	0.05	enet	13	0.04	2.4e-02	-5.34	-5.8	7.0e-09	-0.40	0.21	0.22	FALSE
7	GTEx	Artery Coronary	CYP17A1-AS1	0.20	-0.01	enet	21	0.04	2.3e-02	-0.12	5.2	2.3e-07	0.36	0.06	0.15	FALSE
8	GTEx	Artery Tibial	NT5C2	0.06	0.04	lasso	9	0.02	1.5e-02	6.97	-7.3	2.3e-13	-0.74	0.08	0.79	FALSE
9	GTEx	Artery Tibial	CYP17A1-AS1	0.08	0.08	lasso	8	0.06	2.8e-05	6.97	7.0	2.4e-12	0.75	0.34	0.61	FALSE
10	GTEx	Brain Cerebellar Hemisphere	TMEM180	0.23	0.23	lasso	10	0.10	1.3e-03	-5.43	-5.5	3.7e-08	-0.35	0.62	0.20	FALSE
11	GTEx	Brain Cerebellar Hemisphere	ARL3	0.15	0.02	enet	18	0.11	1.1e-03	-6.67	6.0	1.7e-09	0.53	0.09	0.28	FALSE
12	GTEx	Brain Cerebellum	TMEM180	0.25	0.29	enet	11	0.26	3.5e-08	-5.48	-6.0	2.7e-09	-0.38	0.78	0.20	FALSE
13	GTEx	Brain Cerebellum	ARL3	0.20	0.09	enet	32	0.07	3.7e-03	6.45	6.5	8.0e-11	0.66	0.07	0.83	FALSE
14	GTEx	Brain Cerebellum	TRIM8	0.34	-0.01	enet	25	0.07	4.7e-03	-0.78	-5.8	8.7e-09	-0.46	0.08	0.30	TRUE
15	GTEx	Brain Cortex	CYP17A1-AS1	0.15	0.13	lasso	7	0.14	1.3e-04	6.45	8.0	1.5e-15	0.83	0.07	0.78	FALSE
16	GTEx	Brain Hypothalamus	TMEM180	0.21	0.20	lasso	5	0.12	8.5e-04	-5.62	-5.6	2.1e-08	-0.33	0.28	0.09	FALSE
17	GTEx	Brain Hypothalamus	CYP17A1-AS1	0.34	0.10	lasso	10	0.05	2.6e-02	7.94	8.3	8.8e-17	0.93	0.03	0.83	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	CYP17A1-AS1	0.39	0.22	lasso	3	0.19	8.2e-06	6.39	6.2	4.3e-10	0.80	0.08	0.68	FALSE
19	GTEx	Breast Mammary Tissue	TMEM180	0.17	0.16	enet	9	0.17	3.6e-09	-5.62	-5.7	1.0e-08	-0.33	1.00	0.00	FALSE
20	GTEx	Breast Mammary Tissue	CYP17A1-AS1	0.10	-0.01	enet	28	0.00	2.4e-01	7.91	7.2	4.4e-13	0.75	0.05	0.72	FALSE
21	GTEx	Breast Mammary Tissue (Male)	CYP17A1-AS1	0.06	0.00	lasso	3	0.01	2.1e-01	-6.79	7.5	5.6e-14	0.73	0.03	0.17	TRUE
22	GTEx	Breast Mammary Tissue (Female)	TMEM180	0.18	0.06	lasso	4	0.07	4.5e-03	-5.88	-6.7	1.6e-11	-0.42	0.19	0.40	FALSE
23	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	4.86	7.1	1.1e-12	0.54	0.06	0.21	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	ACTR1A	0.22	0.18	lasso	3	0.19	8.0e-07	-6.20	7.3	3.2e-13	0.70	0.29	0.50	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	RP11-18I14.11	0.17	0.08	lasso	8	0.09	8.7e-04	-7.25	7.5	4.2e-14	0.57	0.14	0.40	FALSE
26	GTEx	Cells Transformed fibroblasts	TMEM180	0.05	0.04	lasso	2	0.01	3.3e-02	-7.41	7.4	1.2e-13	0.56	0.15	0.55	TRUE
27	GTEx	Colon Sigmoid	TMEM180	0.32	0.41	lasso	3	0.38	1.5e-14	-5.48	-5.6	2.8e-08	-0.34	1.00	0.00	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	TMEM180	0.22	0.23	enet	11	0.27	3.0e-10	-5.62	-5.4	5.8e-08	-0.41	0.89	0.09	FALSE
29	GTEx	Esophagus Mucosa	SUFU	0.08	0.02	enet	18	0.01	4.2e-02	-2.92	-6.3	3.8e-10	-0.63	0.45	0.40	FALSE
30	GTEx	Esophagus Muscularis	SUFU	0.07	0.04	enet	18	0.03	5.2e-03	-5.62	-7.8	4.5e-15	-0.56	0.29	0.50	FALSE
31	GTEx	Esophagus Muscularis	TMEM180	0.23	0.22	enet	19	0.19	1.6e-11	-5.62	-5.4	5.8e-08	-0.33	1.00	0.00	FALSE
32	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	-3.00	-6.7	2.7e-11	-0.39	0.05	0.38	FALSE
33	GTEx	Liver	TMEM180	0.28	0.17	enet	36	0.17	1.7e-05	-7.25	-8.6	1.1e-17	-0.62	0.23	0.71	TRUE
34	GTEx	Lung	CYP17A1-AS1	0.06	0.08	lasso	3	0.06	1.6e-05	6.39	6.9	4.5e-12	0.88	0.04	0.95	FALSE
35	GTEx	Muscle Skeletal	WBP1L	0.04	0.00	enet	26	0.02	1.8e-03	4.66	5.2	2.2e-07	0.36	0.09	0.17	FALSE
36	GTEx	Nerve Tibial	CYP17A1-AS1	0.14	0.08	lasso	6	0.06	7.2e-05	6.38	6.5	9.1e-11	0.81	0.44	0.32	FALSE
37	GTEx	Pituitary	NT5C2	0.19	-0.01	lasso	10	0.01	1.8e-01	-5.88	-6.6	5.0e-11	-0.29	0.07	0.07	TRUE
38	GTEx	Skin Sun Exposed Lower leg	SUFU	0.06	0.05	enet	12	0.06	8.4e-06	-7.25	7.3	2.1e-13	0.55	0.31	0.68	FALSE
39	GTEx	Skin Sun Exposed Lower leg	ACTR1A	0.08	0.06	enet	10	0.07	2.7e-06	-7.42	6.1	1.0e-09	0.52	0.25	0.73	TRUE
40	GTEx	Testis	TMEM180	0.19	0.05	enet	24	0.12	7.9e-06	-5.41	-5.3	9.5e-08	-0.43	0.46	0.48	FALSE
41	GTEx	Uterus	TMEM180	0.22	0.00	enet	23	0.00	2.6e-01	-5.34	-6.0	1.8e-09	-0.51	0.05	0.28	FALSE
42	NTR	Blood	ACTR1A	0.03	0.03	enet	19	0.03	1.4e-09	-5.62	7.5	6.0e-14	0.54	0.96	0.04	FALSE
43	NTR	Blood	TRIM8	0.02	0.01	enet	11	0.01	2.1e-03	-5.62	6.2	7.5e-10	0.58	0.42	0.47	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	CYP17A1-AS1	0.15	0.18	lasso	6	0.19	1.3e-23	6.45	6.7	1.9e-11	0.80	1.00	0.00	FALSE
45	YFS	Blood	ARL3	0.39	0.14	enet	30	0.20	7.0e-63	2.40	5.8	8.1e-09	0.56	1.00	0.00	FALSE
46	YFS	Blood	TRIM8	0.04	0.04	lasso	6	0.05	1.2e-15	-5.93	6.5	7.5e-11	0.51	1.00	0.00	FALSE
47	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	6.13	-6.5	9.1e-11	-0.62	0.20	0.79	FALSE
48	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C10orf32	0.06	0.06	blup	54	0.08	1.2e-07	3.73	-5.6	1.9e-08	-0.58	0.35	0.65	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	AS3MT	0.05	0.05	enet	10	0.05	4.7e-11	6.13	-5.7	1.2e-08	-0.59	0.93	0.07	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf26	0.03	0.02	enet	5	0.02	1.6e-04	-6.68	-6.5	7.5e-11	-0.58	0.85	0.08	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	SFXN2	0.12	0.09	lasso	4	0.10	4.4e-19	5.37	-5.4	7.1e-08	-0.52	1.00	0.00	TRUE
52	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C10orf32	0.16	0.06	blup	54	0.10	1.3e-05	3.73	-5.5	2.8e-08	-0.55	0.04	0.94	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM180	0.04	0.02	enet	9	0.05	4.2e-04	1.30	5.7	1.3e-08	0.38	0.02	0.82	FALSE
54	The Cancer Genome Atlas	Esophageal Carcinoma	SFXN2	0.26	0.02	blup	48	0.10	4.9e-04	5.37	-6.0	2.5e-09	-0.76	0.01	0.71	FALSE
55	The Cancer Genome Atlas	Glioblastoma Multiforme	AS3MT	0.15	0.05	blup	62	0.10	5.1e-04	3.73	-5.8	5.5e-09	-0.64	0.03	0.72	FALSE
56	The Cancer Genome Atlas	Glioblastoma Multiforme	C10orf32	0.27	0.09	lasso	8	0.17	7.3e-06	4.46	-5.3	1.5e-07	-0.60	0.09	0.69	FALSE
57	The Cancer Genome Atlas	Glioblastoma Multiforme	SFXN2	0.27	0.02	blup	47	0.11	3.1e-04	5.37	-5.2	1.8e-07	-0.70	0.02	0.55	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ACTR1A	0.02	0.02	lasso	5	0.02	4.6e-03	-5.37	5.6	2.7e-08	0.34	0.02	0.80	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AS3MT	0.05	0.05	blup	62	0.06	1.1e-07	7.28	-5.8	6.1e-09	-0.65	0.18	0.82	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM180	0.03	0.03	blup	52	0.04	3.9e-05	-7.39	5.9	3.1e-09	0.43	0.02	0.98	TRUE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AS3MT	0.04	0.05	enet	3	0.04	8.6e-06	6.13	-6.1	8.6e-10	-0.61	0.07	0.91	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	SUFU	0.03	0.03	lasso	1	0.03	2.0e-04	-5.49	-5.5	4.0e-08	-0.33	0.10	0.87	TRUE
63	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SFXN2	0.20	0.08	blup	48	0.13	9.3e-07	5.37	-5.8	7.2e-09	-0.67	0.13	0.82	FALSE
64	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM180	0.08	0.07	blup	52	0.09	1.9e-10	-7.25	6.4	1.7e-10	0.51	0.01	0.99	FALSE
65	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM180	0.05	0.02	blup	52	0.04	1.5e-05	-6.43	5.8	5.0e-09	0.48	0.02	0.94	FALSE
66	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SUFU	0.03	0.02	blup	90	0.02	1.5e-02	-7.41	-7.1	9.8e-13	-0.49	0.02	0.78	FALSE
67	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AS3MT	0.13	0.14	blup	62	0.13	5.6e-06	6.97	-6.5	5.6e-11	-0.71	0.22	0.76	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	AS3MT	0.16	0.21	lasso	9	0.24	2.5e-24	6.13	-5.3	9.0e-08	-0.64	0.96	0.04	FALSE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	C10orf95	0.02	0.03	lasso	2	0.02	4.7e-03	-5.34	-5.4	5.4e-08	-0.33	0.03	0.83	FALSE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM180	0.16	0.27	lasso	4	0.27	4.3e-28	-7.23	-7.2	4.6e-13	-0.54	0.02	0.98	TRUE
71	The Cancer Genome Atlas	Rectum Adenocarcinoma	C10orf32	0.17	0.14	blup	52	0.14	3.2e-04	6.97	-7.1	1.6e-12	-0.71	0.04	0.62	FALSE
72	The Cancer Genome Atlas	Thyroid Carcinoma	AS3MT	0.23	0.18	lasso	3	0.18	1.8e-17	6.13	-5.9	3.3e-09	-0.60	1.00	0.00	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf26	0.06	0.05	lasso	5	0.04	4.1e-05	6.75	-6.2	7.5e-10	-0.75	0.11	0.82	FALSE
74	The Cancer Genome Atlas	Thyroid Carcinoma	CYP17A1	0.04	0.02	lasso	1	0.02	3.9e-03	7.28	-7.3	3.3e-13	-0.66	0.03	0.66	FALSE