[Hub]/) : Traits : Trunk fat-free mass : ← →

chr19:6,419,098-9,273,800

Best TWAS P=1.65e-18 · Best GWAS P=7.15e-16 conditioned to 2.11e-17

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYO1F	0.05	0.01	blup	42	0.03	2.2e-04	-5.2	-8.8	1.7e-18	-0.02	0.01	0.75	TRUE
23	GTEx	Lung	EVI5L	0.17	0.10	lasso	7	0.12	7.9e-10	5.5	6.3	2.2e-10	0.02	0.02	0.98	TRUE
38	ROSMAP	Brain Pre-frontal Cortex	INSR	0.15	0.09	bslmm	487	0.08	6.2e-11	-7.4	6.2	6.6e-10	0.01	0.09	0.91	TRUE
29	GTEx	Skin Not Sun Exposed Suprapubic	MARCH2	0.42	0.33	enet	27	0.35	5.6e-20	5.9	6.8	9.4e-12	-0.01	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PRAM1	0.03	0.01	blup	44	0.01	7.3e-02	5.8	-6.6	5.0e-11	-0.01	0.01	0.80	FALSE
59	The Cancer Genome Atlas	Stomach Adenocarcinoma	PRAM1	0.05	0.02	blup	44	0.01	3.4e-02	-5.6	-6.5	8.0e-11	-0.05	0.02	0.40	FALSE
18	GTEx	Esophagus Muscularis	MARCH2	0.34	0.30	enet	22	0.32	6.9e-20	6.1	6.4	1.4e-10	0.00	0.00	1.00	FALSE
21	GTEx	Heart Left Ventricle	MARCH2	0.36	0.26	enet	21	0.28	3.3e-15	5.9	6.4	2.1e-10	-0.02	0.00	1.00	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	MARCH2	0.40	0.24	enet	52	0.25	1.2e-09	6.1	6.3	3.2e-10	0.05	0.00	1.00	FALSE
31	GTEx	Stomach	MARCH2	0.33	0.05	enet	27	0.11	6.9e-06	5.2	6.3	3.2e-10	0.05	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	MARCH2	0.30	0.30	lasso	6	0.31	5.9e-26	6.1	6.2	5.4e-10	0.01	0.00	1.00	FALSE
41	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MARCH2	0.08	0.06	lasso	5	0.06	5.5e-04	6.1	6.2	5.9e-10	0.01	0.00	0.98	FALSE
12	GTEx	Breast Mammary Tissue	MARCH2	0.24	0.13	lasso	7	0.11	4.6e-06	6.1	6.2	6.6e-10	-0.01	0.00	1.00	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	MARCH2	0.12	0.15	lasso	4	0.15	6.9e-16	6.1	6.2	6.7e-10	0.01	0.00	1.00	FALSE
8	GTEx	Brain Cerebellum	MARCH2	0.35	0.22	lasso	5	0.19	2.9e-06	6.1	6.2	6.9e-10	0.01	0.00	0.99	FALSE
58	The Cancer Genome Atlas	Stomach Adenocarcinoma	MARCH2	0.09	0.10	blup	42	0.10	6.1e-08	6.1	6.2	6.9e-10	0.00	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	MARCH2	0.06	0.06	lasso	3	0.06	7.5e-12	6.1	6.2	7.0e-10	-0.01	0.00	1.00	FALSE
22	GTEx	Lung	MARCH2	0.36	0.25	lasso	8	0.29	2.8e-22	6.1	6.1	9.6e-10	-0.01	0.00	1.00	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	MARCH2	0.30	0.21	lasso	5	0.28	3.9e-08	5.8	6.1	1.1e-09	0.01	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	MARCH2	0.10	0.10	enet	9	0.12	1.9e-13	5.8	6.1	1.3e-09	0.00	0.01	0.99	FALSE
4	GTEx	Artery Aorta	MARCH2	0.52	0.46	lasso	5	0.50	2.0e-31	6.1	6.1	1.4e-09	0.00	0.00	1.00	FALSE
30	GTEx	Skin Sun Exposed Lower leg	MARCH2	0.33	0.33	lasso	6	0.34	4.1e-29	6.1	6.0	1.4e-09	0.00	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MARCH2	0.08	0.10	enet	5	0.10	2.6e-11	6.1	6.1	1.4e-09	0.00	0.00	1.00	FALSE
9	GTEx	Brain Frontal Cortex BA9	MARCH2	0.48	0.13	lasso	10	0.14	1.2e-04	6.1	6.0	1.5e-09	-0.01	0.01	0.97	FALSE
2	GTEx	Adipose Visceral Omentum	MARCH2	0.27	0.17	lasso	4	0.15	4.0e-08	5.9	6.0	1.7e-09	0.00	0.01	0.99	FALSE
34	NTR	Blood	MARCH2	0.05	0.06	lasso	4	0.06	1.0e-18	5.8	6.0	1.8e-09	0.01	0.01	0.99	FALSE
13	GTEx	Breast Mammary Tissue (Female)	MARCH2	0.26	0.14	lasso	6	0.11	3.3e-04	6.1	6.0	1.9e-09	-0.01	0.01	0.98	FALSE
14	GTEx	Cells Transformed fibroblasts	MARCH2	0.35	0.27	enet	14	0.35	2.6e-27	6.1	6.0	2.2e-09	-0.01	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MARCH2	0.07	0.07	blup	42	0.08	1.4e-07	5.8	6.0	2.3e-09	0.00	0.02	0.98	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF414	0.04	0.01	blup	39	0.02	1.9e-03	-5.8	-6.0	2.3e-09	-0.04	0.03	0.91	FALSE
6	GTEx	Artery Tibial	MARCH2	0.36	0.37	lasso	5	0.44	5.0e-37	5.2	6.0	2.6e-09	0.00	0.01	0.99	FALSE
32	GTEx	Testis	MARCH2	0.26	0.22	enet	12	0.22	6.8e-10	6.1	5.9	3.0e-09	-0.01	0.00	1.00	FALSE
5	GTEx	Artery Coronary	MARCH2	0.22	0.12	lasso	5	0.16	5.4e-06	5.8	5.9	3.6e-09	0.00	0.01	0.98	FALSE
25	GTEx	Nerve Tibial	MARCH2	0.31	0.32	lasso	5	0.35	1.3e-25	5.8	5.9	3.7e-09	-0.01	0.01	0.99	FALSE
27	GTEx	Pancreas	MARCH2	0.19	0.09	lasso	3	0.08	2.8e-04	5.9	5.9	3.7e-09	-0.01	0.01	0.97	FALSE
26	GTEx	Nerve Tibial	ZNF414	0.18	0.08	lasso	6	0.09	5.3e-07	-5.6	-5.9	4.1e-09	-0.05	0.06	0.94	FALSE
33	GTEx	Vagina	MARCH2	0.60	0.05	enet	24	0.14	4.3e-04	5.8	5.8	4.9e-09	0.08	0.02	0.66	FALSE
19	GTEx	Esophagus Muscularis	ZNF414	0.18	0.09	lasso	3	0.07	3.2e-05	-5.7	-5.8	6.2e-09	-0.06	0.05	0.94	FALSE
24	GTEx	Muscle Skeletal	MARCH2	0.21	0.18	enet	20	0.19	2.7e-18	6.1	5.8	6.3e-09	-0.01	0.00	1.00	FALSE
15	GTEx	Colon Sigmoid	MARCH2	0.33	0.14	lasso	7	0.25	2.4e-09	5.2	5.8	7.9e-09	-0.01	0.01	0.99	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRAM1	0.04	0.03	enet	10	0.04	1.3e-04	6.1	-5.8	8.9e-09	0.00	0.00	0.88	FALSE
17	GTEx	Esophagus Mucosa	MARCH2	0.42	0.35	enet	14	0.36	3.1e-25	5.9	5.7	9.5e-09	0.00	0.01	0.99	FALSE
28	GTEx	Prostate	MARCH2	0.66	0.20	lasso	9	0.19	1.4e-05	5.8	5.7	9.5e-09	-0.01	0.01	0.95	FALSE
11	GTEx	Brain Putamen basal ganglia	MARCH2	0.52	0.25	lasso	10	0.37	9.0e-10	6.1	5.7	1.0e-08	-0.01	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF414	0.06	0.03	blup	40	0.04	4.4e-05	-5.7	-5.7	1.0e-08	-0.05	0.03	0.87	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	PRAM1	0.04	0.00	enet	15	0.01	4.5e-02	4.6	-5.7	1.1e-08	0.01	0.07	0.60	FALSE
45	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ZNF414	0.09	0.14	lasso	4	0.13	9.6e-08	-5.6	-5.7	1.2e-08	-0.05	0.04	0.96	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	MARCH2	0.08	0.06	lasso	3	0.08	1.9e-09	6.1	5.7	1.2e-08	-0.01	0.00	1.00	FALSE
7	GTEx	Brain Caudate basal ganglia	MARCH2	0.43	0.13	enet	33	0.21	1.2e-06	6.1	5.7	1.4e-08	-0.02	0.01	0.98	FALSE
42	The Cancer Genome Atlas	Colon Adenocarcinoma	MARCH2	0.08	0.11	blup	42	0.08	1.4e-05	5.2	5.7	1.4e-08	-0.01	0.02	0.97	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	ZNF414	0.07	0.07	lasso	4	0.06	2.7e-08	-5.7	-5.7	1.5e-08	-0.06	0.06	0.94	FALSE
20	GTEx	Heart Atrial Appendage	MARCH2	0.26	0.18	enet	36	0.21	1.2e-09	5.9	5.7	1.6e-08	0.01	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MARCH2	0.11	0.07	blup	42	0.09	9.8e-06	5.8	5.6	1.8e-08	-0.01	0.01	0.99	FALSE
3	GTEx	Adrenal Gland	MARCH2	0.29	0.14	lasso	4	0.22	1.5e-08	5.8	5.6	2.6e-08	0.01	0.01	0.99	FALSE
35	NTR	Blood	PRAM1	0.04	0.02	bslmm	351	0.02	1.1e-06	5.8	-5.4	7.4e-08	-0.02	0.01	0.99	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	MARCH2	0.19	0.09	blup	42	0.14	9.3e-14	5.8	5.3	9.7e-08	0.02	0.01	0.99	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	PRAM1	0.04	0.00	blup	44	0.02	2.4e-03	3.0	-5.3	1.3e-07	0.00	0.01	0.49	FALSE
57	The Cancer Genome Atlas	Soft Tissue Sarcoma	MARCH2	0.06	0.04	lasso	2	0.03	5.4e-03	4.0	5.3	1.4e-07	0.01	0.01	0.88	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MARCH2	0.10	0.05	enet	10	0.08	4.9e-09	6.1	5.2	1.8e-07	-0.01	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MARCH2	0.12	0.13	lasso	1	0.12	6.5e-06	5.2	5.2	2.1e-07	-0.01	0.02	0.90	FALSE