[Hub]/) : Traits : Trunk fat-free mass :

chr19:6,419,098-9,273,800

Best TWAS P=1.65e-18 · Best GWAS P=7.15e-16 conditioned to 2.11e-17

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous MARCH2 0.30 0.30 lasso 6 0.31 5.9e-26 6.1 6.2 5.4e-10 0.01 0.00 1.00 FALSE
2 GTEx Adipose Visceral Omentum MARCH2 0.27 0.17 lasso 4 0.15 4.0e-08 5.9 6.0 1.7e-09 0.00 0.01 0.99 FALSE
3 GTEx Adrenal Gland MARCH2 0.29 0.14 lasso 4 0.22 1.5e-08 5.8 5.6 2.6e-08 0.01 0.01 0.99 FALSE
4 GTEx Artery Aorta MARCH2 0.52 0.46 lasso 5 0.50 2.0e-31 6.1 6.1 1.4e-09 0.00 0.00 1.00 FALSE
5 GTEx Artery Coronary MARCH2 0.22 0.12 lasso 5 0.16 5.4e-06 5.8 5.9 3.6e-09 0.00 0.01 0.98 FALSE
6 GTEx Artery Tibial MARCH2 0.36 0.37 lasso 5 0.44 5.0e-37 5.2 6.0 2.6e-09 0.00 0.01 0.99 FALSE
7 GTEx Brain Caudate basal ganglia MARCH2 0.43 0.13 enet 33 0.21 1.2e-06 6.1 5.7 1.4e-08 -0.02 0.01 0.98 FALSE
8 GTEx Brain Cerebellum MARCH2 0.35 0.22 lasso 5 0.19 2.9e-06 6.1 6.2 6.9e-10 0.01 0.00 0.99 FALSE
9 GTEx Brain Frontal Cortex BA9 MARCH2 0.48 0.13 lasso 10 0.14 1.2e-04 6.1 6.0 1.5e-09 -0.01 0.01 0.97 FALSE
10 GTEx Brain Nucleus accumbens basal ganglia MARCH2 0.30 0.21 lasso 5 0.28 3.9e-08 5.8 6.1 1.1e-09 0.01 0.01 0.99 FALSE
11 GTEx Brain Putamen basal ganglia MARCH2 0.52 0.25 lasso 10 0.37 9.0e-10 6.1 5.7 1.0e-08 -0.01 0.01 0.99 FALSE
12 GTEx Breast Mammary Tissue MARCH2 0.24 0.13 lasso 7 0.11 4.6e-06 6.1 6.2 6.6e-10 -0.01 0.00 1.00 FALSE
13 GTEx Breast Mammary Tissue (Female) MARCH2 0.26 0.14 lasso 6 0.11 3.3e-04 6.1 6.0 1.9e-09 -0.01 0.01 0.98 FALSE
14 GTEx Cells Transformed fibroblasts MARCH2 0.35 0.27 enet 14 0.35 2.6e-27 6.1 6.0 2.2e-09 -0.01 0.00 1.00 FALSE
15 GTEx Colon Sigmoid MARCH2 0.33 0.14 lasso 7 0.25 2.4e-09 5.2 5.8 7.9e-09 -0.01 0.01 0.99 FALSE
16 GTEx Esophagus Gastroesophageal Junction MARCH2 0.40 0.24 enet 52 0.25 1.2e-09 6.1 6.3 3.2e-10 0.05 0.00 1.00 FALSE
17 GTEx Esophagus Mucosa MARCH2 0.42 0.35 enet 14 0.36 3.1e-25 5.9 5.7 9.5e-09 0.00 0.01 0.99 FALSE
18 GTEx Esophagus Muscularis MARCH2 0.34 0.30 enet 22 0.32 6.9e-20 6.1 6.4 1.4e-10 0.00 0.00 1.00 FALSE
19 GTEx Esophagus Muscularis ZNF414 0.18 0.09 lasso 3 0.07 3.2e-05 -5.7 -5.8 6.2e-09 -0.06 0.05 0.94 FALSE
20 GTEx Heart Atrial Appendage MARCH2 0.26 0.18 enet 36 0.21 1.2e-09 5.9 5.7 1.6e-08 0.01 0.00 1.00 FALSE
21 GTEx Heart Left Ventricle MARCH2 0.36 0.26 enet 21 0.28 3.3e-15 5.9 6.4 2.1e-10 -0.02 0.00 1.00 FALSE
22 GTEx Lung MARCH2 0.36 0.25 lasso 8 0.29 2.8e-22 6.1 6.1 9.6e-10 -0.01 0.00 1.00 FALSE
23 GTEx Lung EVI5L 0.17 0.10 lasso 7 0.12 7.9e-10 5.5 6.3 2.2e-10 0.02 0.02 0.98 TRUE
24 GTEx Muscle Skeletal MARCH2 0.21 0.18 enet 20 0.19 2.7e-18 6.1 5.8 6.3e-09 -0.01 0.00 1.00 FALSE
25 GTEx Nerve Tibial MARCH2 0.31 0.32 lasso 5 0.35 1.3e-25 5.8 5.9 3.7e-09 -0.01 0.01 0.99 FALSE
26 GTEx Nerve Tibial ZNF414 0.18 0.08 lasso 6 0.09 5.3e-07 -5.6 -5.9 4.1e-09 -0.05 0.06 0.94 FALSE
27 GTEx Pancreas MARCH2 0.19 0.09 lasso 3 0.08 2.8e-04 5.9 5.9 3.7e-09 -0.01 0.01 0.97 FALSE
28 GTEx Prostate MARCH2 0.66 0.20 lasso 9 0.19 1.4e-05 5.8 5.7 9.5e-09 -0.01 0.01 0.95 FALSE
29 GTEx Skin Not Sun Exposed Suprapubic MARCH2 0.42 0.33 enet 27 0.35 5.6e-20 5.9 6.8 9.4e-12 -0.01 0.00 1.00 FALSE
30 GTEx Skin Sun Exposed Lower leg MARCH2 0.33 0.33 lasso 6 0.34 4.1e-29 6.1 6.0 1.4e-09 0.00 0.00 1.00 FALSE
31 GTEx Stomach MARCH2 0.33 0.05 enet 27 0.11 6.9e-06 5.2 6.3 3.2e-10 0.05 0.01 0.99 FALSE
32 GTEx Testis MARCH2 0.26 0.22 enet 12 0.22 6.8e-10 6.1 5.9 3.0e-09 -0.01 0.00 1.00 FALSE
33 GTEx Vagina MARCH2 0.60 0.05 enet 24 0.14 4.3e-04 5.8 5.8 4.9e-09 0.08 0.02 0.66 FALSE
34 NTR Blood MARCH2 0.05 0.06 lasso 4 0.06 1.0e-18 5.8 6.0 1.8e-09 0.01 0.01 0.99 FALSE
35 NTR Blood PRAM1 0.04 0.02 bslmm 351 0.02 1.1e-06 5.8 -5.4 7.4e-08 -0.02 0.01 0.99 FALSE
36 ROSMAP Brain Pre-frontal Cortex PRAM1 0.04 0.00 enet 15 0.01 4.5e-02 4.6 -5.7 1.1e-08 0.01 0.07 0.60 FALSE
37 ROSMAP Brain Pre-frontal Cortex ZNF414 0.07 0.07 lasso 4 0.06 2.7e-08 -5.7 -5.7 1.5e-08 -0.06 0.06 0.94 FALSE
38 ROSMAP Brain Pre-frontal Cortex INSR 0.15 0.09 bslmm 487 0.08 6.2e-11 -7.4 6.2 6.6e-10 0.01 0.09 0.91 TRUE
39 The Cancer Genome Atlas Bladder Urothelial Carcinoma MARCH2 0.07 0.07 blup 42 0.08 1.4e-07 5.8 6.0 2.3e-09 0.00 0.02 0.98 FALSE
40 The Cancer Genome Atlas Breast Invasive Carcinoma MARCH2 0.06 0.06 lasso 3 0.06 7.5e-12 6.1 6.2 7.0e-10 -0.01 0.00 1.00 FALSE
41 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma MARCH2 0.08 0.06 lasso 5 0.06 5.5e-04 6.1 6.2 5.9e-10 0.01 0.00 0.98 FALSE
42 The Cancer Genome Atlas Colon Adenocarcinoma MARCH2 0.08 0.11 blup 42 0.08 1.4e-05 5.2 5.7 1.4e-08 -0.01 0.02 0.97 FALSE
43 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MARCH2 0.10 0.05 enet 10 0.08 4.9e-09 6.1 5.2 1.8e-07 -0.01 0.00 1.00 FALSE
44 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma MARCH2 0.11 0.07 blup 42 0.09 9.8e-06 5.8 5.6 1.8e-08 -0.01 0.01 0.99 FALSE
45 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ZNF414 0.09 0.14 lasso 4 0.13 9.6e-08 -5.6 -5.7 1.2e-08 -0.05 0.04 0.96 FALSE
46 The Cancer Genome Atlas Brain Lower Grade Glioma MARCH2 0.10 0.10 enet 9 0.12 1.9e-13 5.8 6.1 1.3e-09 0.00 0.01 0.99 FALSE
47 The Cancer Genome Atlas Brain Lower Grade Glioma MYO1F 0.05 0.01 blup 42 0.03 2.2e-04 -5.2 -8.8 1.7e-18 -0.02 0.01 0.75 TRUE
48 The Cancer Genome Atlas Brain Lower Grade Glioma ZNF414 0.06 0.03 blup 40 0.04 4.4e-05 -5.7 -5.7 1.0e-08 -0.05 0.03 0.87 FALSE
49 The Cancer Genome Atlas Lung Adenocarcinoma MARCH2 0.08 0.06 lasso 3 0.08 1.9e-09 6.1 5.7 1.2e-08 -0.01 0.00 1.00 FALSE
50 The Cancer Genome Atlas Lung Adenocarcinoma PRAM1 0.04 0.00 blup 44 0.02 2.4e-03 3.0 -5.3 1.3e-07 0.00 0.01 0.49 FALSE
51 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MARCH2 0.08 0.10 enet 5 0.10 2.6e-11 6.1 6.1 1.4e-09 0.00 0.00 1.00 FALSE
52 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PRAM1 0.03 0.01 blup 44 0.01 7.3e-02 5.8 -6.6 5.0e-11 -0.01 0.01 0.80 FALSE
53 The Cancer Genome Atlas Pancreatic Adenocarcinoma MARCH2 0.12 0.13 lasso 1 0.12 6.5e-06 5.2 5.2 2.1e-07 -0.01 0.02 0.90 FALSE
54 The Cancer Genome Atlas Prostate Adenocarcinoma MARCH2 0.12 0.15 lasso 4 0.15 6.9e-16 6.1 6.2 6.7e-10 0.01 0.00 1.00 FALSE
55 The Cancer Genome Atlas Prostate Adenocarcinoma PRAM1 0.04 0.03 enet 10 0.04 1.3e-04 6.1 -5.8 8.9e-09 0.00 0.00 0.88 FALSE
56 The Cancer Genome Atlas Prostate Adenocarcinoma ZNF414 0.04 0.01 blup 39 0.02 1.9e-03 -5.8 -6.0 2.3e-09 -0.04 0.03 0.91 FALSE
57 The Cancer Genome Atlas Soft Tissue Sarcoma MARCH2 0.06 0.04 lasso 2 0.03 5.4e-03 4.0 5.3 1.4e-07 0.01 0.01 0.88 FALSE
58 The Cancer Genome Atlas Stomach Adenocarcinoma MARCH2 0.09 0.10 blup 42 0.10 6.1e-08 6.1 6.2 6.9e-10 0.00 0.00 1.00 FALSE
59 The Cancer Genome Atlas Stomach Adenocarcinoma PRAM1 0.05 0.02 blup 44 0.01 3.4e-02 -5.6 -6.5 8.0e-11 -0.05 0.02 0.40 FALSE
60 The Cancer Genome Atlas Thyroid Carcinoma MARCH2 0.19 0.09 blup 42 0.14 9.3e-14 5.8 5.3 9.7e-08 0.02 0.01 0.99 FALSE