Best TWAS P=2.5e-14 · Best GWAS P=6.19e-14 conditioned to 0.222
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | HTR1D | 0.11 | 0.07 | enet | 21 | 0.09 | 1.1e-10 | -5.7 | 6.5 | 7.5e-11 | -0.78 | 0.44 | 0.56 | FALSE |
2 | GTEx | Adipose Visceral Omentum | LUZP1 | 0.15 | 0.08 | lasso | 7 | 0.09 | 1.8e-05 | 4.0 | 5.2 | 2.4e-07 | -0.53 | 0.20 | 0.32 | FALSE |
3 | GTEx | Artery Tibial | LUZP1 | 0.25 | 0.02 | enet | 51 | 0.11 | 3.4e-09 | -6.7 | 5.2 | 2.2e-07 | -0.45 | 0.16 | 0.76 | FALSE |
4 | GTEx | Brain Cortex | LUZP1 | 0.23 | 0.14 | lasso | 5 | 0.10 | 7.8e-04 | -7.4 | 7.4 | 1.4e-13 | -1.00 | 0.02 | 0.81 | FALSE |
5 | GTEx | Brain Frontal Cortex BA9 | RP1-184J9.2 | 0.38 | 0.00 | lasso | 11 | 0.00 | 4.3e-01 | -7.0 | 6.1 | 1.0e-09 | -0.54 | 0.05 | 0.17 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | LUZP1 | 0.09 | 0.09 | lasso | 4 | 0.08 | 2.8e-06 | -7.4 | 7.4 | 1.2e-13 | -1.00 | 0.01 | 0.99 | FALSE |
7 | GTEx | Esophagus Muscularis | RP1-184J9.2 | 0.07 | 0.08 | enet | 6 | 0.05 | 6.1e-04 | -5.6 | 5.5 | 3.2e-08 | -0.72 | 0.36 | 0.50 | FALSE |
8 | GTEx | Muscle Skeletal | LUZP1 | 0.07 | 0.08 | enet | 14 | 0.08 | 3.5e-08 | 4.0 | 5.9 | 3.3e-09 | -0.62 | 0.07 | 0.93 | FALSE |
9 | GTEx | Pancreas | LINC00339 | 0.33 | 0.18 | enet | 12 | 0.18 | 3.5e-08 | 4.3 | -5.4 | 6.7e-08 | -0.01 | 0.02 | 0.98 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | KDM1A | 0.09 | 0.01 | lasso | 5 | 0.01 | 1.1e-01 | -6.9 | -5.5 | 4.1e-08 | 0.39 | 0.11 | 0.40 | FALSE |
11 | GTEx | Testis | LUZP1 | 0.17 | 0.09 | lasso | 4 | 0.08 | 2.6e-04 | -7.0 | -7.0 | 2.4e-12 | 0.55 | 0.10 | 0.66 | FALSE |
12 | GTEx | Whole Blood | HP1BP3 | 0.04 | 0.04 | lasso | 4 | 0.02 | 6.3e-03 | -5.1 | -5.2 | 2.2e-07 | 0.03 | 0.69 | 0.09 | TRUE |
13 | METSIM | Adipose | LUZP1 | 0.07 | 0.00 | enet | 30 | 0.01 | 1.1e-02 | 4.0 | 5.7 | 1.2e-08 | -0.36 | 0.12 | 0.49 | TRUE |
14 | ROSMAP | Brain Pre-frontal Cortex | CDC42 | 0.07 | 0.02 | lasso | 6 | 0.04 | 5.7e-06 | 3.0 | 5.5 | 3.2e-08 | 0.01 | 0.10 | 0.89 | TRUE |
15 | ROSMAP | Brain Pre-frontal Cortex | HTR1D | 0.10 | 0.10 | lasso | 4 | 0.12 | 1.3e-14 | -5.7 | 5.3 | 1.4e-07 | -0.67 | 0.88 | 0.12 | FALSE |
16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | WNT4 | 0.03 | 0.01 | blup | 72 | 0.02 | 3.8e-05 | 3.5 | 5.3 | 1.2e-07 | -0.04 | 0.25 | 0.50 | TRUE |
17 | The Cancer Genome Atlas | Colon Adenocarcinoma | HTR1D | 0.10 | 0.07 | enet | 7 | 0.08 | 3.8e-05 | -6.8 | 7.3 | 2.8e-13 | -0.94 | 0.02 | 0.98 | FALSE |
18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HTR1D | 0.24 | 0.12 | lasso | 4 | 0.12 | 1.2e-05 | -7.0 | 7.6 | 2.5e-14 | -0.76 | 0.04 | 0.94 | TRUE |
19 | The Cancer Genome Atlas | Rectum Adenocarcinoma | HTR1D | 0.19 | 0.12 | enet | 11 | 0.13 | 7.3e-04 | -7.5 | 7.0 | 2.4e-12 | -0.94 | 0.01 | 0.91 | FALSE |