Best TWAS P=8.27e-17 · Best GWAS P=6.88e-17 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | RP1-125I3.2 | 0.06 | 0.04 | enet | 19 | 0.03 | 3.3e-03 | 5.8 | -6.9 | 4.3e-12 | -0.48 | 0.09 | 0.40 | FALSE |
| 2 | GTEx | Esophagus Mucosa | DHDDS | 0.11 | 0.06 | lasso | 4 | 0.04 | 6.6e-04 | -5.7 | -6.0 | 1.6e-09 | -0.20 | 0.57 | 0.02 | FALSE |
| 3 | GTEx | Esophagus Mucosa | PDIK1L | 0.10 | 0.09 | lasso | 6 | 0.09 | 8.8e-07 | 8.2 | -8.1 | 5.7e-16 | -0.97 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Nerve Tibial | PDIK1L | 0.09 | 0.01 | enet | 10 | 0.03 | 2.2e-03 | 6.0 | -6.2 | 7.5e-10 | -0.74 | 0.21 | 0.72 | FALSE |
| 5 | GTEx | Pancreas | CNKSR1 | 0.20 | 0.03 | enet | 20 | 0.04 | 7.3e-03 | 5.9 | -6.8 | 1.5e-11 | -0.56 | 0.08 | 0.44 | FALSE |
| 6 | GTEx | Pituitary | CNKSR1 | 0.38 | 0.16 | lasso | 7 | 0.15 | 1.4e-04 | 4.9 | -6.2 | 6.8e-10 | -0.71 | 0.07 | 0.79 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | CNKSR1 | 0.15 | 0.10 | lasso | 7 | 0.09 | 1.0e-05 | 4.9 | -6.1 | 1.2e-09 | -0.72 | 0.21 | 0.78 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | PDIK1L | 0.22 | 0.05 | enet | 37 | 0.11 | 8.3e-07 | 8.2 | -6.3 | 2.8e-10 | -0.81 | 0.02 | 0.98 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | CNKSR1 | 0.10 | 0.04 | enet | 21 | 0.04 | 2.2e-04 | 5.0 | -5.4 | 8.1e-08 | -0.49 | 0.23 | 0.52 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | PDIK1L | 0.14 | 0.05 | enet | 23 | 0.12 | 3.1e-10 | 8.2 | -6.3 | 3.4e-10 | -0.77 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Thyroid | DHDDS | 0.14 | 0.08 | enet | 22 | 0.07 | 5.8e-06 | 6.6 | -6.3 | 2.3e-10 | -0.12 | 0.67 | 0.03 | TRUE |
| 12 | GTEx | Thyroid | CNKSR1 | 0.10 | 0.04 | lasso | 7 | 0.03 | 2.1e-03 | 6.5 | -6.9 | 4.7e-12 | -0.71 | 0.10 | 0.88 | FALSE |
| 13 | GTEx | Whole Blood | CEP85 | 0.07 | 0.01 | enet | 17 | 0.02 | 1.3e-02 | -2.2 | -5.2 | 2.5e-07 | -0.29 | 0.16 | 0.43 | FALSE |
| 14 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TRIM63 | 0.03 | 0.02 | blup | 33 | 0.02 | 4.6e-03 | 8.3 | 8.0 | 9.2e-16 | 0.93 | 0.01 | 0.90 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PDIK1L | 0.02 | 0.01 | blup | 37 | 0.02 | 6.1e-05 | 8.3 | -6.5 | 7.2e-11 | -0.88 | 0.02 | 0.94 | FALSE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TRIM63 | 0.15 | 0.16 | lasso | 2 | 0.16 | 2.3e-32 | 8.3 | 8.3 | 8.3e-17 | 1.00 | 0.00 | 1.00 | TRUE |
| 17 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TRIM63 | 0.14 | 0.15 | lasso | 1 | 0.14 | 2.2e-07 | 8.2 | 8.2 | 3.5e-16 | 0.98 | 0.01 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Colon Adenocarcinoma | TRIM63 | 0.08 | 0.10 | lasso | 4 | 0.10 | 3.7e-06 | 8.2 | 8.0 | 1.6e-15 | 0.97 | 0.01 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GRRP1 | 0.11 | 0.02 | blup | 52 | 0.03 | 8.8e-05 | -2.8 | 5.7 | 1.2e-08 | 0.50 | 0.02 | 0.28 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PDIK1L | 0.02 | 0.02 | blup | 37 | 0.02 | 2.8e-03 | 8.3 | -8.2 | 2.6e-16 | -0.95 | 0.01 | 0.85 | FALSE |
| 21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC30A2 | 0.03 | 0.02 | lasso | 3 | 0.01 | 1.1e-02 | 5.2 | -6.6 | 3.6e-11 | -0.76 | 0.02 | 0.91 | FALSE |
| 22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TRIM63 | 0.11 | 0.11 | enet | 4 | 0.12 | 9.0e-14 | 8.2 | 7.6 | 3.7e-14 | 0.97 | 0.00 | 1.00 | FALSE |
| 23 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PDIK1L | 0.03 | 0.01 | blup | 37 | 0.02 | 2.6e-03 | 6.8 | -8.1 | 5.6e-16 | -0.86 | 0.01 | 0.58 | FALSE |
| 24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TRIM63 | 0.29 | 0.33 | enet | 20 | 0.33 | 2.5e-38 | 8.2 | 8.3 | 9.9e-17 | 0.95 | 0.00 | 1.00 | FALSE |
| 25 | The Cancer Genome Atlas | Lung Adenocarcinoma | TRIM63 | 0.14 | 0.20 | enet | 7 | 0.21 | 9.4e-24 | 8.1 | 7.8 | 4.5e-15 | 0.97 | 0.01 | 0.99 | FALSE |
| 26 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CNKSR1 | 0.11 | 0.03 | blup | 57 | 0.05 | 3.5e-06 | 6.5 | -5.8 | 8.8e-09 | -0.64 | 0.14 | 0.55 | FALSE |
| 27 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PDIK1L | 0.02 | 0.00 | blup | 37 | 0.02 | 1.2e-03 | 4.2 | -6.9 | 5.6e-12 | -0.90 | 0.02 | 0.74 | FALSE |
| 28 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TRIM63 | 0.16 | 0.11 | lasso | 1 | 0.10 | 2.0e-11 | 8.2 | 8.2 | 1.7e-16 | 0.98 | 0.00 | 1.00 | FALSE |
| 29 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TRIM63 | 0.14 | 0.18 | lasso | 7 | 0.15 | 3.0e-10 | 8.0 | 7.9 | 3.2e-15 | 0.97 | 0.02 | 0.98 | FALSE |
| 30 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RPS6KA1 | 0.11 | 0.05 | lasso | 6 | 0.07 | 8.0e-04 | -4.4 | 5.5 | 5.1e-08 | 0.10 | 0.01 | 0.56 | FALSE |
| 31 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SH3BGRL3 | 0.05 | 0.03 | lasso | 2 | 0.03 | 9.3e-04 | 5.8 | 6.4 | 1.6e-10 | 0.53 | 0.00 | 0.95 | FALSE |
| 32 | The Cancer Genome Atlas | Rectum Adenocarcinoma | TRIM63 | 0.28 | 0.22 | lasso | 3 | 0.20 | 1.7e-05 | 5.2 | 6.5 | 6.0e-11 | 0.74 | 0.02 | 0.88 | FALSE |
| 33 | The Cancer Genome Atlas | Thyroid Carcinoma | TRIM63 | 0.18 | 0.26 | enet | 7 | 0.26 | 3.0e-25 | 8.1 | 8.0 | 1.3e-15 | 0.97 | 0.01 | 0.99 | FALSE |
| 34 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | TRIM63 | 0.19 | 0.07 | blup | 33 | 0.14 | 1.3e-04 | 8.2 | 7.3 | 2.8e-13 | 0.91 | 0.01 | 0.99 | FALSE |