TWAS hub - CDC42

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0666	0.0227	0.0011	0.025	0.026	0.024	0.033	0.040	0.00031	0.00023	0.00035	3.3e-05	5.7e-06
2	TCGA	Lung Squamous Cell Carcinoma	0.0694	0.0326	0.0013	0.007	0.003	0.014	NA	0.001	0.04500	0.14000	0.00950	NA	2.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Sitting height	9.9	70.6	118.8	10.9	4.7
Forced expiratory volume in 1-second (FEV1), predicted	8.7	18.0	18.1	4.3	4.2
Intelligence (Savage-Jansen 2018)	7.8	24.1	36.1	3.5	6.0
Medication: Omeprazole (e.g. Zanprol)	7.3	8.9	11.7	-3.4	-2.5
Fluid intelligence score	6.6	13.6	20.5	2.6	4.5
Commuting to job workplace: Walk	6.6	7.1	9.4	3.1	2.2
Qualifications: O levels/GCSEs or equivalent	6.2	9.9	14.3	2.4	3.8
Qualifications: A levels/AS levels or equivalent	5.4	11.9	13.8	3.2	3.7
Standing height	5.3	52.8	85.7	9.3	4.5
Eye problems/disorders: Diabetes related eye disease	5.1	5.6	5.7	2.4	2.4
Height	4.6	89.4	148.8	12.2	5.5
Reaction Time	4.5	8.7	11.6	3.4	2.4
Verbal and Numeric Reasoning (VNR)	4.5	10.7	16.2	2.3	4.0
Taking other prescription medications	4.5	6.9	12.2	-3.5	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	4.5	14.5	14.9	3.9	3.8
Forced expiratory volume in 1-second (FEV1)	4.4	14.9	15.7	3.8	4.0
Trunk fat-free mass	4.1	23.4	30.6	5.5	4.0
Trunk predicted mass	4.1	23.6	31.2	5.6	4.0
Whole body water mass	4.0	22.7	27.6	5.2	4.2
Ever used hormone-replacement therapy (HRT)	3.9	4.9	7.1	-1.7	-2.7
Forced vital capacity (FVC)	3.9	15.0	18.7	4.3	3.4
Back pain experienced in last month	3.9	5.7	7.8	-2.8	-1.9
Leg fat-free mass (left)	3.8	20.3	22.2	4.7	4.3
Leg predicted mass (left)	3.8	20.2	22.0	4.7	4.3
Number of full sisters	3.8	4.6	6.5	-2.6	-1.6
Whole body fat-free mass	3.8	21.9	26.7	5.2	4.1
Medication: Omeprazole	3.7	4.4	5.8	-2.4	-1.8
Forced vital capacity (FVC), Best measure	3.6	13.3	15.5	3.9	3.3
Handedness (chirality/laterality): Left-handed	3.6	4.3	5.5	1.8	2.3
Basal metabolic rate	3.6	19.8	23.2	4.8	4.0
Leg fat-free mass (right)	3.5	18.5	20.9	4.6	4.0
Leg predicted mass (right)	3.5	18.9	21.4	4.6	4.0
Arm predicted mass (left)	3.5	17.6	20.9	4.6	3.8
Pain all over the body in last month	3.4	3.7	4.9	2.2	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.4	4.1	8.2	-2.9	0.1
Commuting to job workplace: Car/motor vehicle	3.4	3.9	5.6	-2.4	-1.5
Arm fat-free mass (right)	3.3	17.0	20.8	4.6	3.6
Arm predicted mass (right)	3.3	16.8	21.1	4.6	3.5
Number of full brothers	3.2	4.0	4.5	-1.9	-2.1
Qualifications: College or University degree	3.2	10.1	12.2	3.5	2.8
Heel T-Score	3.1	24.7	43.7	6.6	2.4
HbA1C	3.0	3.4	3.5	-1.9	-1.8
Number of live births	2.9	4.1	4.3	-2.1	-2.0
Mean Putamen Volume	2.8	3.2	4.9	2.2	1.2
Qualifications: None of the above	2.8	6.0	9.7	-1.5	-3.1
Hair/balding pattern: Pattern 3	2.8	4.2	8.2	-2.9	-0.4
Arm fat-free mass (left)	2.8	14.1	16.0	4.0	3.5
Ever had prostate specific antigen (PSA) test	2.7	3.2	4.9	-1.2	-2.2
Noisy workplace	2.6	3.2	4.8	-1.3	-2.2
Birth weight	2.6	5.6	7.6	2.8	1.9
Worry too long after embarrassment	2.6	4.3	8.2	-2.9	-0.7
Respiratory disease	2.4	5.4	6.5	-2.5	-2.1
Weight	2.4	11.7	12.0	3.4	3.5
Lung cancer (father)	2.4	2.8	2.9	1.7	1.6
Basal cell carcinoma (self-reported)	2.4	2.9	3.5	1.5	1.9
Lupus	2.3	3.4	5.8	-1.0	2.4
Lung FEV1/FVC ratio	2.3	11.8	20.8	1.7	4.6
Bipolar Disorder or Schizophrenia	2.2	5.4	5.9	-2.2	-2.4
Prospective memory result	2.2	2.7	3.2	-1.5	-1.8
Breastfed as a baby	2.2	2.7	3.0	1.5	1.7
Medication: Co-codamol	2.1	2.4	3.7	-1.9	-1.1
Serious illness, injury or assault to yourself	2.0	2.4	2.7	-1.4	-1.7
Birth weight of first child	2.0	3.6	7.2	2.7	-0.1
Had menopause	1.9	2.4	3.9	-0.9	-2.0
Mouth/teeth dental problems: Loose teeth	1.9	2.2	4.4	-0.0	-2.1
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	3.6	-1.0	-1.9
Mood swings	1.9	3.4	4.0	-1.7	-2.0
Diabetes (self-reported)	1.8	2.8	4.1	1.2	2.0
Mean time to correctly identify matches	1.8	3.5	5.8	2.4	1.1
Commuting to job workplace: Public transport	1.7	2.0	2.4	1.5	1.3
Pulse wave peak to peak time	1.6	1.9	2.1	1.5	1.3
Emphysema/chronic bronchitis	1.6	1.8	2.7	-1.6	-0.9
Comparative height size at age 10	1.6	8.6	17.0	4.1	0.4
Knee pain experienced in last month	1.6	2.5	5.0	-2.2	-0.1
Ever smoked	1.6	2.8	5.5	0.4	2.3
Myopia	1.6	2.3	3.9	0.8	2.0
Number of treatments/medications taken	1.5	2.6	4.4	-2.1	-0.9
Diabetes (father)	1.5	1.9	2.3	1.5	-1.2
Multivitamins +/- minerals	1.5	1.9	2.9	-1.7	-0.9
Medication: Lansoprazole	1.5	1.8	3.4	-1.9	-0.3
Ever highly irritable/argumentative for 2 days	1.5	1.8	2.9	-0.8	-1.7
Wheeze or whistling in the chest in last year	1.5	2.7	2.9	-1.6	-1.7
Medication for pain relief, constipation, heartburn	1.5	2.6	4.9	2.2	0.6
Ever had bowel cancer screening	1.5	1.8	3.3	0.5	1.8
Schizophrenia vs Biploar Disorder	1.4	1.8	2.3	-1.1	-1.5
Major Depression (MDD)	1.4	1.7	2.2	-1.5	-1.1
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	3.2	1.8	-0.7
Hair/balding pattern: Pattern 4	1.4	3.3	5.1	2.2	1.3
Peak expiratory flow (PEF)	1.4	3.2	3.7	1.9	1.7
Blood clot in the leg (DVT)	1.4	1.8	2.2	1.5	1.1
Guilty feelings	1.4	2.2	4.0	-2.0	-0.5
Medication: Lisinopril	1.4	1.8	2.2	1.5	1.2
Depression (self-reported)	1.3	1.6	3.1	-1.8	0.1
Exposure to tobacco smoke at home	1.3	1.5	3.0	-1.7	0.1
Headache pain in last month	1.3	2.3	4.6	-0.0	-2.1
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.9	1.7	0.6
Wears glasses or contact lenses	1.3	1.5	2.7	-1.6	-0.4
Pack years of smoking	1.3	1.9	3.1	1.8	-0.9
Crohns Disease (2017)	1.2	2.6	2.6	-1.6	-1.6
HDL Cholesterol	1.2	2.0	4.0	2.0	-0.3
Medication for hormone replacement therapy	1.2	1.3	2.4	0.5	-1.6
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.8	1.7	0.3
Medication: Allopurinol	1.2	1.6	1.7	-1.2	-1.3
Family relationship satisfaction	1.2	1.5	2.6	0.7	1.6
Diabetes diagnosed by doctor	1.2	2.0	2.0	1.4	1.4
Osteoporosis (self-reported)	1.2	1.4	2.7	-1.6	-0.4
Bipolar Disorder (2018)	1.1	1.8	3.6	-1.9	0.0
Breast Cancer	1.1	2.5	5.0	2.2	0.3
Pack years adult smoking proportion	1.1	1.7	3.1	1.8	-0.5
Fed-up feelings	1.1	2.1	3.3	-1.8	-0.9
Mouth/teeth dental problems: Dentures	1.1	1.9	2.0	-1.4	-1.3
Gout (self-reported)	1.1	1.5	1.6	-1.2	-1.3
High blood pressure (siblings)	1.1	1.6	3.0	0.5	1.7
Overall health rating	1.1	2.4	4.7	-2.2	0.2
Hearing aid user	1.1	1.3	2.4	-1.6	-0.3
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.4	-0.6	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	2.2	1.5	0.8
Age at First Birth	1.0	1.4	2.2	0.8	1.5
Lung FVC	1.0	5.3	9.8	0.9	3.1
Hearing difficulty/problems: Yes	1.0	1.5	1.5	-1.2	-1.2
Supplements: Zinc	1.0	1.1	1.2	-1.0	-1.1
Trunk fat mass	1.0	4.4	6.6	1.5	2.6
Medication: Ramipril	1.0	1.3	2.6	-0.3	-1.6
Arm fat mass (right)	1.0	4.0	7.6	0.7	2.7
Fractured/broken bones in last 5 years	1.0	1.2	2.4	-1.6	0.3
Body Mass Index (BMI) (2010)	0.9	1.2	2.1	-1.4	-0.5
Triglycerides	0.9	1.5	2.1	-1.4	-0.9
Type 2 Diabetes (T2D) (2018)	0.9	1.6	2.2	1.5	1.0
Medication: Atenolol	0.9	1.1	1.7	-0.7	-1.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.2	-1.5	-0.0
Had major operations	0.9	1.0	1.7	1.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	2.5	1.2	1.6
Arm fat mass (left)	0.9	3.9	6.9	0.9	2.6
Alcohol drinker status: Previous	0.9	1.0	1.3	0.8	1.1
Depressed Affect (Nagel 2018)	0.8	1.8	3.4	-1.9	-0.4
Neuroticism (Nagel 2018)	0.8	1.9	3.5	-1.9	-0.5
Alzheimer’s Disease (including proxy)	0.8	1.2	2.2	-1.5	0.5
Neuroticism	0.8	1.9	3.3	-1.8	-0.7
Average weekly spirits intake	0.8	1.0	1.2	-0.9	-1.1
Medication: Metformin	0.8	1.2	1.3	1.0	1.1
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	1.9	0.2	1.4
Supplements: Glucosamine	0.8	1.0	1.9	-0.3	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	3.3	1.8	-0.4
Financial difficulties in last 2 years	0.8	1.0	1.1	-1.1	0.9
Neuroticism score	0.8	1.7	2.8	-1.7	-0.8
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	1.8	-1.2	1.3
Whole body fat mass	0.8	3.4	5.8	1.0	2.4
Average weekly red wine intake	0.8	1.1	1.3	1.0	1.1
Breast cancer (self-reported)	0.8	0.9	1.2	-1.1	-0.8
Osteoarthritis (self-reported)	0.8	1.1	1.7	-0.7	-1.3
Medication: Gliclazide	0.8	0.9	1.2	1.1	0.8
Smoking status: Current	0.8	1.3	2.1	-1.4	-0.8
Ever taken oral contraceptive pill	0.8	0.8	1.6	-0.3	1.3
Mother’s age at death	0.8	1.0	1.2	1.1	0.8
Average weekly beer plus cider intake	0.8	1.1	1.2	-1.0	-1.1
Current tobacco smoking	0.7	1.1	1.3	-1.1	-1.0
Had other major operations	0.7	0.9	1.2	-0.8	-1.1
Illnesses of mother	0.7	0.9	1.8	-1.3	0.0
Medication: Ventolin 100micrograms inhaler	0.7	0.8	1.6	-1.3	0.2
Health satisfaction	0.7	0.9	1.3	-1.1	-0.7
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.6	-1.2	-0.3
Heart disease (siblings)	0.7	0.9	1.5	-0.5	1.2
Worry (Nagel 2018)	0.6	1.2	2.1	-1.5	-0.5
Primary Biliary Cirrhosis	0.6	0.9	1.4	-1.2	-0.5
Schizophrenia (2014)	0.6	1.4	2.8	-1.7	0.0
Diabetes (mother)	0.6	0.7	1.2	1.1	-0.6
Townsend deprivation index at recruitment	0.6	0.8	1.2	-1.1	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.5	1.6	-0.4
High blood pressure	0.6	1.5	2.7	1.6	0.6
Waist circumference	0.6	2.1	3.1	1.1	1.8
Past tobacco smoking	0.6	1.0	1.7	0.6	-1.3
Hip circumference	0.6	2.6	4.3	1.0	2.1
Worrier / anxious feelings	0.6	1.1	2.2	-1.5	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.1	-1.1	0.9
Pulse wave Arterial Stiffness index	0.6	0.7	0.8	-0.9	-0.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.6	0.1	1.3
Glaucoma (self-reported)	0.6	0.8	1.2	0.5	1.1
Leg fat percentage (right)	0.6	2.0	3.9	-2.0	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.4	-0.3	1.2
Heart disease (mother)	0.6	0.8	1.4	0.3	-1.2
Supplements: Vitamin C	0.6	0.7	1.2	1.1	-0.4
Loneliness, isolation	0.6	0.8	1.0	-1.0	0.7
Qualifications: nursing, teaching	0.6	0.9	1.3	1.2	0.7
Illnesses of father: High blood pressure	0.6	0.8	1.3	-0.5	1.1
Leg fat percentage (left)	0.6	2.3	4.6	-2.1	0.2
Fasting Glucose	0.5	0.6	1.1	1.1	-0.1
Cardiovascular Disease	0.5	1.5	2.9	1.7	0.4
Qualifications: CSEs or equivalent	0.5	0.7	0.9	-0.9	-0.7
Chronic bronchitis/emphysema (father)	0.5	0.6	1.2	-0.2	-1.1
Impedance of leg (left)	0.5	2.5	4.2	-0.8	-2.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	0.7	-0.9	0.8
Arm fat percentage (right)	0.5	2.1	3.4	-0.9	1.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.1	-1.0	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.4	0.4	1.2
Exposure to tobacco smoke outside home	0.5	0.7	0.9	0.7	0.9
Eye problems/disorders: None of the above	0.5	0.6	0.8	-0.5	-0.9
Angina (self-reported)	0.5	0.7	0.8	-0.9	-0.7
Leg fat mass (right)	0.5	1.9	3.6	0.3	1.9
Medication for cholesterol	0.5	0.8	1.5	0.2	1.2
Mineral and other dietary supplements	0.5	0.7	1.1	0.5	1.0
Medication: Aspirin	0.5	0.6	1.0	0.5	1.0
Number of self-reported non-cancer illnesses	0.5	0.8	1.1	-1.1	-0.7
Average weekly champagne plus white wine intake	0.5	0.7	1.3	0.0	1.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.9	-0.5	-0.9
Alcohol drinker status: Never	0.5	0.5	0.9	0.5	-0.9
Pain experienced in last month	0.5	0.9	1.3	0.7	1.1
Schizophrenia (2018)	0.4	0.9	1.7	-1.3	0.0
Alzheimer’s Disease (in father)	0.4	0.5	0.7	-0.8	0.5
Neuroticism (2016)	0.4	0.6	1.1	-1.1	-0.1
Rheumatoid Arthritis	0.4	0.6	0.8	-0.9	-0.5
Systolic Blood Pressure	0.4	1.8	2.5	1.6	1.1
Hypothyroidism (self reported)	0.4	0.8	1.2	-1.1	0.7
Chronotype (morning person)	0.4	0.9	1.7	0.3	-1.3
Vitamin and mineral supplements	0.4	0.5	0.6	0.8	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.8	-0.5	0.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	0.9	-0.4
Medication: Levothyroxine sodium	0.4	0.7	0.9	-0.7	0.9
Body mass index (BMI)	0.4	1.6	2.5	-0.9	1.6
Number of incorrect matches in round	0.4	0.6	1.0	1.0	0.5
Alcohol usually taken with meals	0.4	0.6	1.1	1.1	-0.2
Nervous feelings	0.4	0.8	1.0	-1.0	-0.8
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	1.0	0.1
Illnesses of siblings	0.4	0.6	0.9	-0.5	-1.0
Father’s age at death	0.4	0.5	0.8	0.5	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.1	-1.0	-0.2
Tense / ‘highly strung’	0.4	0.7	1.4	-0.2	-1.2
Number of children fathered	0.4	0.4	0.8	-0.9	-0.2
Age at first live birth	0.4	0.8	1.0	1.0	0.7
Neck or shoulder pain in last month	0.4	0.6	1.2	-0.3	-1.1
Migraine (self-reported)	0.4	0.5	1.0	0.2	-1.0
Medication: Aspirin	0.4	0.5	1.0	0.3	1.0
Arm fat percentage (left)	0.4	1.6	2.7	-0.8	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.6	-0.8	0.5
Eye problems/disorders: Cataract	0.4	0.4	0.6	0.5	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.7	0.5	-0.8
Asthma (self-reported)	0.4	0.9	0.9	-0.9	-0.9
Supplements: Calcium	0.4	0.4	0.8	0.2	-0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	-0.5	0.9
Leg fat mass (left)	0.4	1.7	3.3	0.3	1.8
Depression (Nagel 2018)	0.3	0.5	0.9	-1.0	-0.2
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	-0.8	0.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.0	-1.0	-0.7
Prostate Cancer	0.3	0.5	0.9	0.1	1.0
Bipolar Disorder (2011)	0.3	0.3	0.7	-0.8	0.0
LDL Cholesterol	0.3	0.6	0.9	-0.5	-0.9
BMI	0.3	1.6	2.7	-0.7	1.6
Allergy or Eczema	0.3	0.7	1.1	1.0	0.6
Relative age of first facial hair	0.3	0.7	1.1	1.1	0.5
Impedance of leg (right)	0.3	1.5	2.9	-0.2	-1.7
Trunk fat percentage	0.3	1.3	2.5	0.0	1.6
Relative age voice broke	0.3	0.5	1.1	0.0	1.0
High blood pressure (mother)	0.3	0.5	0.5	0.6	0.7
Heart attack	0.3	0.4	0.5	-0.5	0.7
Alcohol intake versus 10 years previously	0.3	0.5	0.8	-0.9	-0.4
Falls in the last year	0.3	0.4	0.5	-0.7	0.5
Asthma	0.3	0.7	0.9	-0.6	-1.0
Medication: Cholesterol lowering	0.3	0.5	0.9	-0.4	-0.9
Pulse wave reflection index	0.3	0.3	0.5	-0.7	-0.4
Medication: Paracetamol	0.3	0.5	0.7	-0.8	0.7
Medication: Ibuprofen	0.3	0.4	0.8	-0.9	-0.1
Age at last live birth	0.3	0.5	0.7	0.5	-0.8
Hypertension (Self-reported)	0.3	0.8	1.4	1.2	0.4
Friendships satisfaction	0.3	0.3	0.3	0.6	0.6
High cholesterol (Self-reported)	0.3	0.6	0.8	-0.9	-0.7
Irritability	0.3	0.6	1.1	1.0	0.3
Age started oral contraceptive pill	0.3	0.4	0.5	-0.5	-0.7
Commuting to job workplace: Cycle	0.3	0.3	0.3	0.6	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.7	0.9	-0.8	-0.9
Ovarian Cancer	0.2	0.3	0.5	-0.7	-0.2
Crohns Disease (2012)	0.2	0.3	0.6	-0.8	0.0
Tanning	0.2	2.2	4.2	-2.0	-0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	-0.8	-0.1
Angina	0.2	0.2	0.2	-0.5	-0.4
Average weekly fortified wine intake	0.2	0.2	0.4	-0.2	-0.6
Age when periods started (menarche)	0.2	0.4	0.6	0.5	0.7
Hearing difficulty/problems with background noise	0.2	0.3	0.4	0.6	-0.4
Mouth/teeth dental problems	0.2	0.3	0.5	0.2	-0.7
Allergy	0.2	0.4	0.7	-0.3	0.8
Time employed in main current job	0.2	0.2	0.5	-0.0	-0.7
Pulse rate	0.2	0.4	0.7	-0.8	-0.3
Happiness	0.2	0.3	0.4	-0.3	0.6
Impedance of arm (left)	0.2	0.8	0.8	0.9	-0.9
Body fat percentage	0.2	1.0	1.3	-0.7	1.2
Comparative body size at age 10	0.2	0.4	0.5	0.6	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.5	0.7	0.1
Shortness of breath walking on level ground	0.2	0.2	0.2	-0.5	-0.4
Medication: Blood pressure	0.2	0.3	0.6	0.8	0.3
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.5	-0.4
Pulse rate, automated reading	0.2	0.7	1.2	-1.1	-0.3
Alcohol intake frequency.	0.2	0.4	0.7	0.8	0.2
Suffer from ‘nerves’	0.2	0.4	0.7	-0.1	0.8
Leg pain on walking	0.2	0.3	0.5	-0.7	-0.2
Smoking status: Previous	0.2	0.3	0.6	0.0	0.8
Medication: Bendroflumethiazide	0.2	0.4	0.5	0.7	0.5
Medication: Paracetamol	0.2	0.3	0.5	-0.7	0.0
Medication: Atorvastatin	0.2	0.3	0.5	0.3	-0.7
Number of operations (self-reported)	0.2	0.3	0.6	0.0	-0.8
Ever depressed for a whole week	0.2	0.2	0.4	-0.2	0.7
Unable to work because of sickness or disability	0.2	0.3	0.6	-0.8	-0.0
Impedance of whole body	0.2	1.2	2.4	-0.1	-1.6
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.5	0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.5	0.0
Ulcerative Colitis	0.1	0.2	0.4	0.6	0.0
Blood White Count	0.1	0.9	1.4	-1.2	-0.6
Waist Hip Ratio (WHR)	0.1	0.4	0.5	0.7	0.5
Smoking Status	0.1	0.2	0.4	-0.6	-0.4
Hair Pigment	0.1	1.9	3.6	-0.5	1.9
Sensitivity / hurt feelings	0.1	0.3	0.3	-0.5	-0.5
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	-0.6	0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	-0.2	0.2
Hand grip strength (right)	0.1	0.3	0.7	0.8	-0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	0.6	-0.2
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.0	0.5
Medication: Simvastatin	0.1	0.2	0.4	0.0	0.6
Impedance of arm (right)	0.1	0.4	0.7	0.8	-0.4
Loud music exposure frequency	0.1	0.1	0.2	-0.2	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	-0.3	0.3
Illnesses of father: Heart disease	0.1	0.2	0.3	0.5	0.2
Financial situation satisfaction	0.1	0.1	0.2	-0.5	-0.2
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	-0.6	0.1
Medication: Blood pressure	0.1	0.2	0.4	0.4	-0.6
Risk taking	0.1	0.2	0.4	0.0	-0.7
Diastolic blood pressure, automated reading	0.1	0.3	0.5	-0.7	0.2
Cholesterol lowering medication	0.1	0.1	0.2	0.5	0.2
Ulcerative Colitis (UC)	0.0	0.1	0.1	0.1	0.3
Blood Eosinophil Count	0.0	0.3	0.6	-0.8	0.1
Blood Platelet Count	0.0	0.1	0.1	-0.4	0.1
Blood Red Count	0.0	0.5	0.5	0.7	0.7
Hand grip strength (left)	0.0	0.1	0.2	0.4	-0.3
Systolic blood pressure, automated reading	0.0	0.0	0.0	0.1	0.2
Severe depression (siblings)	0.0	0.0	0.0	-0.1	0.1
Maternal smoking around birth	0.0	0.1	0.1	0.2	0.3
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	0.2	0.0
Length of working week for main job	0.0	0.0	0.0	-0.1	0.2
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.0	-0.1	-0.0
Medication: Amlodipine	0.0	0.0	0.0	-0.1	-0.2
Chest pain or discomfort	0.0	0.1	0.1	-0.3	-0.1
Illnesses of siblings: Diabetes	0.0	0.0	0.0	-0.1	0.2
Long-standing illness, disability or infirmity	0.0	0.0	0.0	-0.0	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.0	-0.1	0.2
Illnesses of father: None of the above (group 1)	0.0	0.1	0.1	0.1	0.3
Miserableness	0.0	0.1	0.2	-0.4	0.1

Hub : Genes

CDC42

Models

Trait associations