Best TWAS P=1.44e-09 · Best GWAS P=6.25e-10 conditioned to 0.0118
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MGAT3 | 0.08 | 0.04 | lasso | 4 | 0.04 | 4.3e-04 | -5.9 | 5.6 | 1.6e-08 | 0.04 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Artery Aorta | APOBEC3G | 0.40 | 0.40 | lasso | 3 | 0.39 | 6.3e-23 | 5.0 | 5.3 | 9.5e-08 | 0.04 | 0.64 | 0.36 | FALSE |
| 3 | GTEx | Esophagus Muscularis | MGAT3 | 0.09 | 0.02 | enet | 15 | 0.02 | 1.3e-02 | -2.2 | 5.2 | 2.0e-07 | 0.08 | 0.08 | 0.62 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | MGAT3 | 0.14 | 0.14 | lasso | 2 | 0.12 | 3.5e-06 | -6.0 | 6.0 | 2.0e-09 | 0.02 | 0.01 | 0.99 | TRUE |
| 5 | GTEx | Lung | COX5BP7 | 0.13 | 0.12 | lasso | 3 | 0.12 | 1.7e-09 | 4.9 | -5.1 | 2.8e-07 | -0.04 | 0.81 | 0.18 | FALSE |
| 6 | GTEx | Nerve Tibial | SYNGR1 | 0.26 | 0.18 | enet | 27 | 0.21 | 3.6e-15 | -5.0 | -5.8 | 5.2e-09 | -0.04 | 0.06 | 0.94 | FALSE |
| 7 | GTEx | Pituitary | APOBEC3G | 0.34 | 0.04 | enet | 11 | 0.11 | 1.2e-03 | 4.9 | 5.7 | 1.1e-08 | 0.04 | 0.15 | 0.09 | TRUE |
| 8 | GTEx | Skin Sun Exposed Lower leg | MGAT3 | 0.13 | 0.05 | lasso | 3 | 0.02 | 4.7e-03 | -6.0 | 5.9 | 3.5e-09 | 0.01 | 0.01 | 0.98 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | APOBEC3G | 0.10 | 0.09 | lasso | 3 | 0.06 | 7.5e-06 | 5.0 | 5.2 | 1.6e-07 | 0.05 | 0.64 | 0.33 | FALSE |
| 10 | GTEx | Vagina | APOBEC3G | 0.23 | 0.07 | lasso | 5 | 0.06 | 1.8e-02 | 4.9 | 5.4 | 7.4e-08 | 0.05 | 0.11 | 0.07 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TNRC6B | 0.02 | 0.01 | blup | 92 | 0.01 | 2.7e-03 | -4.9 | -5.3 | 1.1e-07 | 0.82 | 0.02 | 0.78 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADSL | 0.04 | 0.03 | enet | 6 | 0.03 | 1.6e-04 | -6.1 | -5.2 | 1.9e-07 | 0.86 | 0.00 | 0.94 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | APOBEC3G | 0.15 | 0.04 | enet | 17 | 0.09 | 9.7e-06 | 4.9 | 5.1 | 3.1e-07 | 0.03 | 0.00 | 0.84 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADSL | 0.03 | 0.00 | blup | 33 | 0.01 | 8.9e-03 | -5.9 | -5.3 | 9.6e-08 | 0.82 | 0.01 | 0.61 | FALSE |
| 15 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ADSL | 0.06 | 0.02 | lasso | 2 | 0.03 | 6.6e-03 | -6.0 | -6.0 | 2.4e-09 | 0.97 | 0.00 | 0.81 | FALSE |
| 16 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ADSL | 0.09 | 0.03 | lasso | 3 | 0.01 | 7.7e-02 | -6.1 | -6.1 | 1.4e-09 | 0.91 | 0.00 | 0.76 | TRUE |