[Hub]/) : Traits : Trunk predicted mass :

chr22:41,232,594-43,226,599

Best TWAS P=3.54e-10 · Best GWAS P=1.48e-15 conditioned to 2.15e-09

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex WBP2NL 0.28 0.25 enet 16 0.35 1.3e-43 5.2 5.2 1.9e-07 -0.35 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous CYP2D6 0.26 0.10 enet 34 0.20 1.2e-16 -3.5 -6.0 2.3e-09 0.45 1.00 0.00 FALSE
3 GTEx Breast Mammary Tissue POLR3H 0.15 0.02 enet 15 0.03 9.0e-03 5.1 5.3 1.1e-07 -0.22 0.18 0.10 FALSE
4 GTEx Breast Mammary Tissue (Male) CYP2D6 0.34 -0.01 lasso 6 0.00 3.2e-01 5.1 -5.4 6.4e-08 0.36 0.11 0.10 FALSE
5 GTEx Breast Mammary Tissue (Female) POLR3H 0.09 -0.01 lasso 6 -0.01 6.4e-01 -5.1 5.7 1.2e-08 -0.46 0.04 0.06 FALSE
6 GTEx Breast Mammary Tissue (Female) DESI1 0.14 0.07 lasso 4 0.11 4.2e-04 -5.1 5.5 3.5e-08 -0.45 0.08 0.12 FALSE
7 GTEx Colon Sigmoid DESI1 0.21 0.08 enet 6 0.11 1.2e-04 -5.1 5.3 1.0e-07 -0.47 0.40 0.05 FALSE
8 GTEx Lung RP5-821D11.7 0.08 0.02 enet 21 0.04 6.6e-04 4.3 6.3 3.5e-10 -0.40 0.53 0.04 TRUE
9 GTEx Muscle Skeletal POLR3H 0.17 0.12 lasso 3 0.11 8.0e-11 5.2 5.2 1.6e-07 -0.18 1.00 0.00 FALSE
10 GTEx Nerve Tibial CYP2D6 0.32 0.21 lasso 6 0.24 2.8e-17 4.8 -5.2 2.2e-07 0.39 1.00 0.00 FALSE
11 GTEx Nerve Tibial NAGA 0.12 0.09 lasso 6 0.08 1.8e-06 5.0 5.2 2.2e-07 -0.29 0.99 0.00 FALSE
12 GTEx Spleen CCDC134 0.23 0.00 enet 14 0.09 2.7e-03 -5.1 5.7 1.1e-08 -0.40 0.07 0.07 FALSE
13 GTEx Testis SREBF2 0.25 0.03 lasso 12 0.04 4.6e-03 4.7 5.6 2.7e-08 -0.41 0.62 0.04 FALSE
14 ROSMAP Brain Pre-frontal Cortex NAGA 0.08 0.10 lasso 4 0.09 7.3e-12 5.3 5.2 2.2e-07 -0.30 1.00 0.00 FALSE
15 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma WBP2NL 0.06 0.04 blup 140 0.03 9.6e-05 -5.1 6.1 1.0e-09 -0.53 0.58 0.24 FALSE
16 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma WBP2NL 0.10 0.04 blup 140 0.05 1.8e-06 -3.8 5.8 8.7e-09 -0.40 0.98 0.00 FALSE
17 The Cancer Genome Atlas Brain Lower Grade Glioma FAM109B 0.04 0.03 lasso 3 0.03 8.7e-05 5.2 5.1 3.0e-07 -0.29 0.00 0.97 FALSE
18 The Cancer Genome Atlas Pancreatic Adenocarcinoma CSDC2 0.25 0.01 enet 11 0.06 2.3e-03 -3.4 -5.8 5.4e-09 0.21 0.00 0.00 FALSE
19 The Cancer Genome Atlas Prostate Adenocarcinoma WBP2NL 0.04 0.03 lasso 8 0.03 5.6e-04 5.3 5.5 4.4e-08 -0.34 0.56 0.03 FALSE