Best TWAS P=3.54e-10 · Best GWAS P=1.48e-15 conditioned to 2.15e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | WBP2NL | 0.28 | 0.25 | enet | 16 | 0.35 | 1.3e-43 | 5.2 | 5.2 | 1.9e-07 | -0.35 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | CYP2D6 | 0.26 | 0.10 | enet | 34 | 0.20 | 1.2e-16 | -3.5 | -6.0 | 2.3e-09 | 0.45 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | POLR3H | 0.15 | 0.02 | enet | 15 | 0.03 | 9.0e-03 | 5.1 | 5.3 | 1.1e-07 | -0.22 | 0.18 | 0.10 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | CYP2D6 | 0.34 | -0.01 | lasso | 6 | 0.00 | 3.2e-01 | 5.1 | -5.4 | 6.4e-08 | 0.36 | 0.11 | 0.10 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | POLR3H | 0.09 | -0.01 | lasso | 6 | -0.01 | 6.4e-01 | -5.1 | 5.7 | 1.2e-08 | -0.46 | 0.04 | 0.06 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | DESI1 | 0.14 | 0.07 | lasso | 4 | 0.11 | 4.2e-04 | -5.1 | 5.5 | 3.5e-08 | -0.45 | 0.08 | 0.12 | FALSE |
| 7 | GTEx | Colon Sigmoid | DESI1 | 0.21 | 0.08 | enet | 6 | 0.11 | 1.2e-04 | -5.1 | 5.3 | 1.0e-07 | -0.47 | 0.40 | 0.05 | FALSE |
| 8 | GTEx | Lung | RP5-821D11.7 | 0.08 | 0.02 | enet | 21 | 0.04 | 6.6e-04 | 4.3 | 6.3 | 3.5e-10 | -0.40 | 0.53 | 0.04 | TRUE |
| 9 | GTEx | Muscle Skeletal | POLR3H | 0.17 | 0.12 | lasso | 3 | 0.11 | 8.0e-11 | 5.2 | 5.2 | 1.6e-07 | -0.18 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Nerve Tibial | CYP2D6 | 0.32 | 0.21 | lasso | 6 | 0.24 | 2.8e-17 | 4.8 | -5.2 | 2.2e-07 | 0.39 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Nerve Tibial | NAGA | 0.12 | 0.09 | lasso | 6 | 0.08 | 1.8e-06 | 5.0 | 5.2 | 2.2e-07 | -0.29 | 0.99 | 0.00 | FALSE |
| 12 | GTEx | Spleen | CCDC134 | 0.23 | 0.00 | enet | 14 | 0.09 | 2.7e-03 | -5.1 | 5.7 | 1.1e-08 | -0.40 | 0.07 | 0.07 | FALSE |
| 13 | GTEx | Testis | SREBF2 | 0.25 | 0.03 | lasso | 12 | 0.04 | 4.6e-03 | 4.7 | 5.6 | 2.7e-08 | -0.41 | 0.62 | 0.04 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | NAGA | 0.08 | 0.10 | lasso | 4 | 0.09 | 7.3e-12 | 5.3 | 5.2 | 2.2e-07 | -0.30 | 1.00 | 0.00 | FALSE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | WBP2NL | 0.06 | 0.04 | blup | 140 | 0.03 | 9.6e-05 | -5.1 | 6.1 | 1.0e-09 | -0.53 | 0.58 | 0.24 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | WBP2NL | 0.10 | 0.04 | blup | 140 | 0.05 | 1.8e-06 | -3.8 | 5.8 | 8.7e-09 | -0.40 | 0.98 | 0.00 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FAM109B | 0.04 | 0.03 | lasso | 3 | 0.03 | 8.7e-05 | 5.2 | 5.1 | 3.0e-07 | -0.29 | 0.00 | 0.97 | FALSE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CSDC2 | 0.25 | 0.01 | enet | 11 | 0.06 | 2.3e-03 | -3.4 | -5.8 | 5.4e-09 | 0.21 | 0.00 | 0.00 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | WBP2NL | 0.04 | 0.03 | lasso | 8 | 0.03 | 5.6e-04 | 5.3 | 5.5 | 4.4e-08 | -0.34 | 0.56 | 0.03 | FALSE |