Best TWAS P=8.31e-11 · Best GWAS P=4.46e-11 conditioned to 0.413
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PTPN13 | 0.13 | 0.18 | bslmm | 418 | 0.18 | 6.8e-22 | 5.6 | -5.9 | 4.0e-09 | -0.53 | 0.72 | 0.28 | FALSE |
| 2 | GTEx | Artery Aorta | MAPK10 | 0.15 | 0.17 | enet | 16 | 0.17 | 1.4e-09 | 6.3 | -6.1 | 1.0e-09 | -0.96 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Artery Aorta | RP13-514E23.2 | 0.26 | 0.09 | lasso | 6 | 0.10 | 2.2e-06 | -5.1 | -5.3 | 1.5e-07 | -0.08 | 0.83 | 0.17 | TRUE |
| 4 | GTEx | Artery Tibial | ARHGAP24 | 0.26 | 0.19 | enet | 14 | 0.21 | 2.7e-16 | -5.1 | -5.1 | 3.0e-07 | -0.05 | 0.80 | 0.20 | FALSE |
| 5 | GTEx | Artery Tibial | RP13-514E23.2 | 0.22 | 0.16 | enet | 10 | 0.18 | 1.2e-13 | -5.1 | -5.2 | 1.5e-07 | -0.07 | 0.82 | 0.18 | FALSE |
| 6 | GTEx | Brain Caudate basal ganglia | PTPN13 | 0.26 | 0.16 | enet | 17 | 0.11 | 4.6e-04 | 5.6 | -5.3 | 1.1e-07 | -0.40 | 0.28 | 0.38 | FALSE |
| 7 | GTEx | Colon Sigmoid | MAPK10 | 0.25 | 0.11 | lasso | 8 | 0.07 | 1.6e-03 | 6.3 | -6.5 | 8.3e-11 | -0.89 | 0.02 | 0.96 | TRUE |
| 8 | GTEx | Thyroid | PTPN13 | 0.41 | 0.31 | lasso | 6 | 0.30 | 3.2e-23 | 6.6 | 6.4 | 1.6e-10 | 0.99 | 0.01 | 0.99 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | PTPN13 | 0.09 | 0.03 | blup | 409 | 0.07 | 4.7e-09 | 5.6 | -6.0 | 2.1e-09 | -0.53 | 0.70 | 0.30 | FALSE |