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chr16:88,858,246-90,172,696

Best TWAS P=1.01e-17 · Best GWAS P=2.04e-14 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C16orf3	0.19	0.10	enet	17	0.10	2.7e-12	7.648	7.1	1.0e-12	0.86	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	DBNDD1	0.25	0.02	lasso	7	0.03	2.6e-03	7.648	6.9	5.8e-12	0.92	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	DEF8	0.11	0.02	enet	16	0.06	1.3e-05	5.344	5.6	2.4e-08	0.29	0.31	0.07	FALSE
4	GTEx	Adipose Visceral Omentum	AC092143.1	0.19	0.02	lasso	4	0.02	2.2e-02	-3.583	-5.3	1.5e-07	-0.17	0.11	0.05	TRUE
5	GTEx	Adrenal Gland	DBNDD1	0.45	0.24	lasso	9	0.28	1.2e-10	7.648	6.8	1.1e-11	0.89	0.00	1.00	FALSE
6	GTEx	Artery Aorta	CDK10	0.33	0.07	enet	27	0.18	2.7e-10	4.177	-5.8	6.6e-09	-0.19	0.99	0.00	FALSE
7	GTEx	Artery Aorta	SPIRE2	0.48	0.23	enet	23	0.26	8.3e-15	-4.018	-6.1	9.1e-10	-0.27	1.00	0.00	FALSE
8	GTEx	Artery Coronary	DBNDD1	0.28	0.19	lasso	2	0.13	3.2e-05	7.648	7.8	5.8e-15	1.00	0.00	1.00	FALSE
9	GTEx	Artery Tibial	DBNDD1	0.31	0.20	enet	20	0.27	2.0e-21	7.648	8.6	1.0e-17	0.86	0.00	1.00	TRUE
10	GTEx	Brain Cerebellar Hemisphere	GAS8	0.66	0.33	enet	59	0.36	3.7e-10	7.648	5.7	1.6e-08	0.74	0.00	1.00	FALSE
11	GTEx	Brain Cerebellar Hemisphere	URAHP	0.66	0.28	enet	53	0.46	1.7e-13	7.648	5.2	2.4e-07	0.75	0.00	1.00	FALSE
12	GTEx	Brain Cerebellum	GAS8	0.60	0.41	lasso	10	0.37	8.0e-12	7.648	7.4	1.0e-13	0.99	0.00	1.00	FALSE
13	GTEx	Brain Cerebellum	URAHP	0.60	0.38	lasso	9	0.33	1.7e-10	7.648	7.2	8.3e-13	0.97	0.00	1.00	FALSE
14	GTEx	Brain Cortex	GAS8	0.28	0.16	lasso	6	0.14	1.3e-04	7.648	7.3	2.4e-13	0.93	0.00	0.99	TRUE
15	GTEx	Brain Cortex	URAHP	0.34	0.19	enet	15	0.17	2.4e-05	7.648	6.8	1.4e-11	0.85	0.00	1.00	FALSE
16	GTEx	Brain Hypothalamus	SPG7	0.43	0.06	enet	28	0.24	1.9e-06	1.040	-5.4	6.8e-08	-0.42	0.02	0.71	FALSE
17	GTEx	Breast Mammary Tissue	SPIRE2	0.21	0.04	lasso	5	0.05	1.0e-03	-4.018	-5.7	1.1e-08	-0.28	0.05	0.67	FALSE
18	GTEx	Breast Mammary Tissue (Male)	SNORD68	0.12	0.00	enet	28	0.03	8.2e-02	6.495	7.0	3.8e-12	0.57	0.02	0.62	FALSE
19	GTEx	Breast Mammary Tissue (Male)	SPIRE2	0.27	-0.01	enet	29	0.04	3.4e-02	5.344	-7.7	1.2e-14	-0.41	0.04	0.28	FALSE
20	GTEx	Cells Transformed fibroblasts	DBNDD1	0.32	0.20	enet	36	0.20	1.2e-14	7.648	8.1	6.0e-16	0.91	0.00	1.00	FALSE
21	GTEx	Colon Sigmoid	DBNDD1	0.42	0.13	lasso	5	0.18	7.6e-07	7.648	7.8	6.4e-15	0.91	0.00	1.00	FALSE
22	GTEx	Colon Sigmoid	CDK10	0.37	0.12	lasso	8	0.22	2.2e-08	4.309	-5.3	1.1e-07	-0.15	0.60	0.02	TRUE
23	GTEx	Colon Transverse	DBNDD1	0.62	0.40	enet	40	0.44	1.2e-22	7.648	7.8	7.8e-15	0.91	0.00	1.00	FALSE
24	GTEx	Esophagus Muscularis	DBNDD1	0.32	0.13	enet	23	0.14	1.2e-08	7.648	7.8	4.3e-15	0.82	0.00	1.00	FALSE
25	GTEx	Esophagus Muscularis	SPIRE2	0.46	0.26	enet	21	0.35	3.7e-22	-4.018	-6.2	5.4e-10	-0.30	1.00	0.00	FALSE
26	GTEx	Heart Atrial Appendage	DBNDD1	0.52	0.29	enet	27	0.27	9.8e-13	7.648	8.4	3.5e-17	0.89	0.00	1.00	FALSE
27	GTEx	Heart Left Ventricle	DBNDD1	0.24	0.18	lasso	4	0.20	7.6e-11	7.648	8.2	3.4e-16	0.96	0.00	1.00	FALSE
28	GTEx	Lung	DBNDD1	0.24	0.14	lasso	6	0.16	1.7e-12	7.648	7.5	5.6e-14	0.92	0.00	1.00	FALSE
29	GTEx	Nerve Tibial	DBNDD1	0.25	0.15	lasso	4	0.11	3.3e-08	7.648	7.7	9.9e-15	0.99	0.00	1.00	FALSE
30	GTEx	Nerve Tibial	DEF8	0.08	0.05	enet	6	0.05	3.2e-04	-3.312	7.0	1.8e-12	0.35	0.10	0.69	FALSE
31	GTEx	Pancreas	DBNDD1	0.26	0.16	enet	15	0.18	5.6e-08	7.648	7.8	6.7e-15	0.85	0.00	1.00	TRUE
32	GTEx	Skin Not Sun Exposed Suprapubic	DBNDD1	0.40	0.19	lasso	5	0.19	8.2e-11	7.648	8.1	6.6e-16	0.96	0.00	1.00	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	GAS8	0.24	0.00	enet	23	0.08	2.6e-05	-1.816	5.4	6.3e-08	0.46	0.14	0.24	FALSE
34	GTEx	Skin Sun Exposed Lower leg	DBNDD1	0.27	0.05	enet	32	0.14	6.9e-12	7.648	7.1	9.5e-13	0.58	0.00	1.00	FALSE
35	GTEx	Skin Sun Exposed Lower leg	SPATA33	0.10	0.01	enet	25	0.05	6.3e-05	0.836	-5.2	1.7e-07	-0.64	0.02	0.96	TRUE
36	GTEx	Small Intestine Terminal Ileum	AC092143.1	0.25	0.02	lasso	18	0.02	9.8e-02	-3.987	-5.7	1.4e-08	-0.23	0.08	0.12	FALSE
37	GTEx	Stomach	DBNDD1	0.16	0.07	lasso	2	0.11	4.2e-06	7.648	7.9	4.0e-15	0.84	0.00	1.00	FALSE
38	GTEx	Stomach	GAS8	0.16	-0.01	enet	26	0.06	7.0e-04	3.625	5.8	7.4e-09	0.46	0.03	0.48	FALSE
39	GTEx	Stomach	CDK10	0.35	0.12	enet	12	0.22	6.4e-11	4.177	-5.2	1.6e-07	-0.22	0.90	0.00	FALSE
40	GTEx	Thyroid	DBNDD1	0.26	0.21	lasso	4	0.20	1.2e-15	7.648	7.6	2.4e-14	0.98	0.00	1.00	FALSE
41	GTEx	Whole Blood	MC1R	0.08	0.00	enet	18	0.00	5.5e-01	3.858	-7.3	3.0e-13	-0.32	0.05	0.07	TRUE
42	METSIM	Adipose	DBNDD1	0.27	0.04	bslmm	271	0.08	2.3e-12	7.648	6.9	4.4e-12	0.69	0.00	1.00	FALSE
43	METSIM	Adipose	RP11-368I7.4	0.04	0.03	enet	12	0.02	2.2e-04	4.309	6.5	8.6e-11	0.19	0.66	0.02	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	DPEP1	0.05	0.01	enet	7	0.02	5.2e-05	7.012	6.5	7.2e-11	0.64	0.00	0.99	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	FANCA	0.09	0.01	blup	78	0.05	7.8e-11	2.630	-5.5	3.2e-08	-0.40	0.95	0.02	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DPEP1	0.06	0.00	enet	5	0.02	2.5e-03	-4.129	6.5	6.1e-11	0.49	0.01	0.48	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C16orf55	0.07	0.05	enet	3	0.04	8.2e-06	6.495	-6.8	7.8e-12	-0.81	0.01	0.99	TRUE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FANCA	0.15	0.16	enet	13	0.16	4.2e-18	-3.656	-5.7	1.0e-08	-0.35	1.00	0.00	FALSE
49	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SPIRE2	0.19	0.07	enet	11	0.15	1.0e-08	-3.248	-6.7	2.0e-11	-0.52	0.15	0.74	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	CDK10	0.15	0.03	blup	42	0.08	3.7e-09	2.398	-5.4	7.2e-08	-0.28	0.49	0.08	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	DBNDD1	0.06	0.02	blup	66	0.04	4.1e-05	2.658	5.5	3.8e-08	0.49	0.03	0.05	FALSE
52	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MC1R	0.18	-0.01	blup	50	0.04	9.9e-03	-3.310	-6.0	2.4e-09	-0.16	0.01	0.05	TRUE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	DBNDD1	0.25	0.00	blup	65	0.06	1.1e-06	0.047	6.3	2.2e-10	0.58	0.01	0.03	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	DPEP1	0.08	0.03	enet	3	0.04	3.2e-05	7.012	7.5	5.9e-14	0.84	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	FANCA	0.08	0.03	blup	76	0.02	2.1e-03	6.495	-6.3	3.8e-10	-0.50	0.00	0.92	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	DBNDD1	0.17	0.00	blup	66	0.04	6.6e-05	3.441	5.7	1.6e-08	0.63	0.04	0.10	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	SPIRE2	0.12	0.06	enet	10	0.08	8.5e-08	-3.445	-6.3	3.7e-10	-0.46	0.60	0.23	FALSE