Hub : Genes

C16orf3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1920	0.0420	6.5e-10	0.099	0.085	0.101	0.094	0.091	4.8e-12	1.6e-10	2.7e-12	1.7e-11	3.7e-11
2	TCGA	Breast Invasive Carcinoma	0.0213	0.0112	2.8e-03	0.016	0.009	0.011	NA	0.013	2.8e-04	5.5e-03	1.9e-03	NA	6.8e-04
3	TCGA	Brain Lower Grade Glioma	0.0535	0.0294	1.5e-03	0.010	0.022	0.005	NA	0.012	2.1e-02	1.2e-03	7.6e-02	NA	1.5e-02
4	TCGA	Liver Hepatocellular Carcinoma	0.2620	0.0720	5.6e-10	0.269	0.223	0.244	NA	0.154	4.9e-13	8.1e-11	8.5e-12	NA	1.0e-07
5	TCGA	Prostate Adenocarcinoma	0.0312	0.0189	9.1e-03	0.018	0.016	0.021	NA	0.019	4.5e-03	7.4e-03	2.5e-03	NA	3.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.2	1.8	5.3	-2.3	0.3	-0.3	0.6	-1.8
Bipolar Disorder or Schizophrenia	0.9	2.2	7.2	-1.5	0.5	0.2	1.2	-2.7
Depressed Affect (Nagel 2018)	0.4	0.8	1.4	-1.1	-0.2	0.2	-1.2	1.0
Depression (Nagel 2018)	0.1	0.1	0.3	0.2	0.3	0.4	-0.4	0.5
Intelligence (Savage-Jansen 2018)	2.3	6.9	13.5	-1.2	2.2	2.4	-3.0	3.7
Neuroticism (Nagel 2018)	0.4	0.8	2.3	1.5	-1.3	-0.1	0.4	-0.0
Schizophrenia (2018)	0.5	1.1	3.9	-0.1	0.4	0.5	1.0	-2.0
Schizophrenia vs Biploar Disorder	0.6	0.8	2.0	1.1	-0.2	-0.7	0.3	-1.4
Worry (Nagel 2018)	1.5	3.1	5.7	2.4	-1.7	-0.2	2.4	-1.1
Alzheimer’s Disease (in mother)	1.7	2.0	4.2	-1.5	1.8	2.0	-0.4	0.3
Alzheimer’s Disease (in father)	1.9	2.0	4.7	-0.4	1.8	2.2	-1.3	0.6
Alzheimer’s Disease (including proxy)	2.6	3.8	9.1	-1.4	2.5	3.0	-1.0	0.9
Crohns Disease (2017)	0.8	1.8	4.9	-0.8	0.8	0.9	-2.2	1.4
Irritable Bowel Disease (IBD)	0.4	0.9	2.1	-0.9	0.8	0.4	-1.4	0.9
Ulcerative Colitis (UC)	0.0	0.0	0.2	-0.4	0.2	-0.1	-0.0	0.1
Major Depression (MDD)	7.4	8.9	11.2	2.6	-2.6	-3.1	3.3	-3.2
Reaction Time	0.1	0.2	0.6	-0.4	0.0	0.8	-0.6	0.3
Verbal and Numeric Reasoning (VNR)	1.1	2.6	6.6	0.2	1.0	1.3	-1.9	2.6
Breast Cancer	0.9	2.1	8.9	0.2	1.0	3.0	-0.5	0.3
Ovarian Cancer	2.6	3.4	6.6	-1.5	2.6	2.3	-1.7	0.4
Prostate Cancer	1.5	2.1	8.6	1.1	-0.2	-0.5	0.6	-2.9
Age at First Birth	2.0	2.9	6.1	1.7	-2.5	-2.0	0.2	1.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.2	1.6	5.0	2.2	-1.1	-1.0	0.5	-0.7
Coronary Artery Disease (CAD)	1.6	2.0	3.3	-1.2	1.8	1.8	-1.1	0.8
Crohns Disease (2012)	1.5	2.5	4.3	-1.8	0.7	1.3	-1.7	2.1
Mean Putamen Volume	0.7	0.8	2.4	1.6	-1.1	-0.3	0.4	0.3
Fasting Glucose	0.6	0.7	2.5	-0.1	-0.7	-1.6	-0.7	-0.2
HbA1C	1.5	1.7	3.5	-1.9	1.8	1.1	-0.4	0.5
HDL Cholesterol	0.4	0.6	1.5	0.9	0.5	1.2	-0.2	0.8
LDL Cholesterol	1.7	2.7	9.3	-0.5	-0.6	-1.6	0.9	-3.0
Lupus	0.5	0.8	3.2	0.4	-0.2	-0.2	0.8	-1.8
Neuroticism (2016)	0.7	1.0	2.5	0.4	-1.6	-0.7	1.2	0.4
Primary Biliary Cirrhosis	0.2	0.2	0.8	-0.5	0.9	0.4	-0.1	0.2
Rheumatoid Arthritis	0.8	1.1	3.2	-0.9	-0.0	-1.8	0.1	-1.2
Schizophrenia (2014)	0.9	2.0	5.2	-1.9	1.0	-0.2	0.3	-2.3
Triglycerides	0.5	0.8	2.2	-1.5	0.7	-0.9	-0.7	-0.5
Type 2 Diabetes (T2D) (2012)	1.7	2.0	6.1	-2.5	1.6	0.2	-0.9	0.7
Ulcerative Colitis	0.2	0.3	0.9	-1.0	-0.1	-0.2	-0.3	0.6
Blood Eosinophil Count	0.1	0.4	0.6	-0.8	0.7	0.4	-0.8	0.4
Blood Platelet Count	0.1	1.5	3.3	-0.7	-1.2	-0.5	-1.3	1.8
Blood Red Count	0.2	1.6	3.9	1.0	0.1	1.3	2.0	-1.1
Blood White Count	0.4	3.0	7.3	-1.6	2.2	2.7	-0.4	0.3
Heel T-Score	0.7	5.6	11.6	-2.7	-2.7	-3.4	1.4	0.3
BMI	0.7	4.3	11.0	0.1	-0.6	-3.3	0.3	-3.2
Height	2.3	44.2	161.3	-12.7	2.1	-0.1	-4.5	6.0
Waist Hip Ratio (WHR)	0.4	1.7	2.9	-1.5	1.7	1.6	-0.9	-0.2
Systolic Blood Pressure	0.3	1.4	4.2	2.0	-0.6	0.8	-0.2	1.3
Smoking Status	1.7	4.1	13.0	-3.6	2.0	1.2	-1.5	-0.3
Allergy or Eczema	0.2	0.6	1.0	-1.0	1.0	0.2	-0.8	-0.2
Cardiovascular Disease	0.3	1.0	4.0	2.0	-0.4	-0.3	0.8	0.1
Hypothyroidism (self reported)	0.6	1.5	4.2	-2.0	1.2	0.8	-1.0	-0.3
Respiratory disease	2.7	5.9	18.3	-4.3	1.3	0.8	-2.5	1.7
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.5	-0.8	-0.9	-1.2	0.5	-0.8
Lung FEV1/FVC ratio	0.6	2.9	9.7	-1.3	3.1	0.5	-1.6	0.4
Lung FVC	0.1	0.7	2.0	-1.4	-0.2	0.4	1.0	0.4
Neuroticism	0.7	1.6	5.3	2.3	-1.3	0.0	0.8	-0.6
Chronotype (morning person)	0.3	0.6	1.3	0.5	-0.2	1.1	-0.4	1.1
Hair Pigment	317.2	9044.3	37636.0	194.0	-70.5	-18.7	46.7	-9.2
Tanning	363.8	4441.6	15625.0	-125.0	60.4	28.6	-44.6	11.3
Hand grip strength (left)	0.9	2.4	6.3	-2.0	-1.3	-0.2	-0.1	2.5
Number of treatments/medications taken	0.2	0.4	1.5	1.2	-0.3	-0.4	0.3	-0.3
Average weekly spirits intake	0.7	0.9	2.8	1.7	-1.0	-0.4	0.2	0.6
Sensitivity / hurt feelings	0.7	1.2	1.6	1.2	-1.2	-0.3	1.2	-1.3
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	-0.6	0.3	-0.5	-0.2	0.0
Hearing difficulty/problems: Yes	2.6	4.0	6.8	-2.5	2.1	0.6	-2.6	1.4
Relative age of first facial hair	5.9	12.2	50.7	7.1	-2.8	0.3	1.5	-0.1
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	5.5	0.4	-0.8	-0.0	1.9	-2.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.8	0.4	0.9	0.3	-0.4	-0.0
Ever had hysterectomy (womb removed)	0.9	1.0	2.8	-0.3	-1.0	0.2	1.0	-1.7
Systolic blood pressure, automated reading	0.3	0.7	2.8	1.7	-0.9	0.4	0.2	0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	-0.8	0.3	0.2	0.2	-0.3
Angina	1.4	1.8	4.4	1.9	-0.4	-0.3	1.0	-2.1
Medication for hormone replacement therapy	0.4	0.4	0.9	-0.0	-0.8	-1.0	-0.3	0.7
Vitamin and mineral supplements	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.1	0.3
Supplements: Zinc	1.1	1.2	1.4	-1.1	1.2	1.2	-1.1	1.1
Medication: Co-codamol	1.5	1.8	4.6	-1.3	1.0	0.3	-1.3	2.2
Medication: Metformin	1.0	1.4	2.3	0.6	-1.5	-1.5	1.3	-0.3
Diabetes (father)	1.0	1.3	2.7	-0.2	-1.6	-0.6	1.4	-1.2
Diabetes (mother)	0.4	0.5	2.0	-1.4	0.3	-0.2	-0.7	-0.2
Severe depression (siblings)	0.4	0.5	1.7	-1.3	-0.3	-0.2	0.6	-0.5
Pack years adult smoking proportion	0.5	0.8	1.9	-1.4	-0.3	-1.2	0.2	-0.9
Impedance of leg (right)	0.6	2.8	8.6	-2.9	-0.1	1.4	0.1	1.9
Leg fat-free mass (left)	0.9	4.8	13.3	-3.6	0.4	-2.5	-2.0	0.2
Trunk fat percentage	2.1	8.6	25.6	-5.1	2.1	-2.7	-1.6	-1.8
Hand grip strength (right)	0.5	1.5	4.1	-1.5	-0.8	-0.3	0.2	2.0
Townsend deprivation index at recruitment	0.6	0.9	2.1	0.2	1.3	-0.6	-0.4	-1.5
Current tobacco smoking	1.3	2.1	6.7	-2.6	0.7	-0.4	-1.3	1.1
Average weekly fortified wine intake	2.2	2.6	6.6	2.6	-1.3	1.6	0.8	1.1
Maternal smoking around birth	1.0	1.5	4.1	-2.0	1.4	-0.3	-1.0	-0.6
Fed-up feelings	0.1	0.2	0.3	-0.3	0.6	-0.1	-0.4	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	-0.9	0.6	-0.4	0.0	-0.4
Relative age voice broke	1.5	2.3	11.2	3.3	-0.1	0.4	0.1	-0.1
Taking other prescription medications	0.2	0.3	0.8	-0.5	0.5	-0.5	-0.2	-0.9
Age when periods started (menarche)	0.3	0.7	1.8	0.8	-1.0	-0.2	1.3	-0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.6	-0.0	0.5	-0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	3.1	-1.3	-1.7	-1.7	1.4	-1.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.3	-0.1	-0.6	-1.1	0.8	-0.8
Qualifications: CSEs or equivalent	0.6	0.8	2.0	-0.7	0.9	-0.4	-1.4	0.7
Serious illness, injury or assault to yourself	0.6	0.7	1.1	1.0	-1.0	0.9	0.9	0.1
High blood pressure	0.9	2.5	9.4	3.1	-1.0	-0.6	1.2	-0.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.4	-1.2	1.1	0.1	-0.9	0.4
Multivitamins +/- minerals	1.2	1.5	2.9	-1.7	1.3	0.7	-1.3	0.8
Stomach or abdominal pain in last month	1.7	2.2	7.4	-1.1	0.4	-1.2	0.9	-2.7
Supplements: Glucosamine	0.2	0.3	0.8	0.8	-0.2	-0.9	0.1	0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	-0.2	-0.0	0.3	1.0	-1.2
Medication: Atenolol	1.0	1.3	4.5	2.1	-0.2	0.8	0.8	-0.7
Medication: Levothyroxine sodium	0.4	0.7	1.9	-1.4	0.7	0.4	-0.9	0.5
Sitting height	0.9	6.1	23.4	-4.8	-0.0	-0.6	-1.5	2.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.5	0.1	0.2	-0.5	0.3
High blood pressure (mother)	1.6	2.2	4.3	1.4	-1.9	-1.1	2.1	-0.1
Body mass index (BMI)	0.6	2.5	6.4	-0.7	0.6	-2.5	-0.6	-2.2
Impedance of leg (left)	0.7	3.2	8.1	-2.9	0.1	1.9	0.5	1.9
Leg predicted mass (left)	0.9	4.7	13.3	-3.6	0.5	-2.4	-2.0	0.3
Trunk fat mass	2.1	9.0	29.6	-5.4	1.8	-2.7	-1.9	-1.1
Waist circumference	1.4	5.3	13.9	-3.7	1.4	-2.1	-2.1	-1.1
Number of incorrect matches in round	1.2	2.1	4.0	-1.7	1.4	1.0	-2.0	0.7
Past tobacco smoking	2.3	4.2	6.1	2.5	-2.5	-2.4	1.7	-0.2
Alcohol usually taken with meals	0.5	0.9	1.3	1.2	-0.9	-0.2	1.0	-1.0
Nervous feelings	0.8	1.5	2.6	1.4	-1.3	-0.0	1.6	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.5	1.5	0.3	-0.6	0.8	-1.6
Hearing difficulty/problems with background noise	2.3	3.8	5.6	-2.1	2.4	2.0	-2.0	0.8
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	1.0	0.9	0.7	-0.2	-0.1
Had menopause	2.0	2.5	8.6	1.7	0.8	2.9	-0.4	0.3
Had other major operations	2.5	3.0	6.2	-0.9	-1.8	-2.5	1.4	-1.8
Forced vital capacity (FVC)	1.0	3.8	10.4	-2.8	-0.8	-0.3	-0.1	3.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.9	-2.2	-0.8	-1.6	0.4	-0.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.1	-0.1	0.5	0.4	0.6	-1.0
Qualifications: None of the above	0.8	1.8	7.1	0.8	0.1	0.1	1.1	-2.7
Financial difficulties in last 2 years	0.4	0.5	1.6	1.3	0.2	-0.3	0.5	-0.8
Mouth/teeth dental problems	0.4	0.5	2.0	0.6	0.1	0.5	-0.1	1.4
Heart attack	0.1	0.2	0.6	-0.3	-0.4	-0.8	-0.2	-0.3
Allergy	0.6	1.3	5.5	2.4	-0.3	0.7	0.4	0.4
Pain all over the body in last month	1.3	1.4	4.0	-0.1	-0.6	-1.4	0.7	-2.0
Diabetes (self-reported)	0.4	0.6	2.2	-0.1	-0.7	-1.5	0.2	-0.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.2	-0.9	1.1	-0.4	-0.7	-0.7
Medication: Ramipril	0.0	0.0	0.1	0.1	0.1	-0.2	-0.1	-0.2
Medication: Simvastatin	0.5	0.8	1.8	0.5	1.4	0.2	0.7	-1.1
Fluid intelligence score	1.0	2.1	4.8	-0.3	1.2	0.8	-1.9	2.2
Illnesses of siblings	0.5	0.7	1.3	-1.1	-0.1	-0.3	-0.9	1.1
Neuroticism score	0.4	0.8	1.4	1.2	-1.0	-0.7	0.8	-0.6
Weight	1.3	6.3	19.7	-4.4	1.0	-2.5	-2.1	-0.0
Impedance of arm (right)	1.2	5.4	18.2	-4.3	2.0	1.0	-1.6	1.0
Arm fat percentage (right)	1.3	5.2	8.9	-3.0	1.4	-2.9	-1.3	-2.2
Trunk fat-free mass	0.8	4.6	12.4	-3.5	0.0	-0.9	-2.3	2.1
Hip circumference	1.4	5.9	18.7	-4.3	0.9	-2.3	-2.1	0.2
Time employed in main current job	0.6	0.7	2.6	-0.4	-1.6	-0.8	0.5	0.0
Alcohol intake versus 10 years previously	0.8	1.3	3.4	0.5	-1.2	-1.8	0.4	-1.0
Father’s age at death	0.4	0.5	1.3	0.1	0.4	0.3	1.1	-1.0
Worrier / anxious feelings	1.3	2.5	5.0	1.1	-2.1	-0.8	2.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.5	-1.6	0.1	-0.1	0.2	-0.9
Falls in the last year	0.2	0.3	1.0	0.0	-0.0	-0.7	0.4	-1.0
Hair/balding pattern: Pattern 3	1.3	2.0	3.7	1.1	-1.9	-1.9	1.1	0.4
Number of live births	5.8	8.2	13.1	-3.3	3.2	3.6	-2.2	1.3
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	8.2	-2.7	0.1	-0.2	-0.5	2.9
Pulse rate	0.3	0.5	1.7	-0.7	-0.2	-1.3	0.2	-0.6
Happiness	0.3	0.3	0.7	-0.9	-0.5	-0.1	0.7	-0.2
Noisy workplace	0.7	0.9	1.9	1.3	-0.4	1.4	0.6	-0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.0	-0.0	-1.7	-1.3	0.5	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	-0.7	0.1	0.4	-0.2	0.5
Mouth/teeth dental problems: Dentures	2.8	4.7	9.2	2.4	-1.6	-1.5	2.1	-3.0
Asthma	1.5	2.9	12.9	-3.6	0.2	-0.4	-0.9	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.6	-1.6	-0.5	-1.0	-1.2	1.0
Medication: Cholesterol lowering	1.7	2.7	3.7	1.9	-1.0	-1.5	1.9	-1.8
Depression (self-reported)	1.8	2.1	4.0	-2.0	1.5	0.9	-1.8	0.7
Medication: Lansoprazole	4.1	4.6	6.5	1.6	-1.7	-2.5	2.3	-2.6
Prospective memory result	0.2	0.3	1.0	-0.1	0.1	0.0	-1.0	0.6
Lung cancer (father)	1.6	1.9	3.8	-1.9	1.5	0.3	-1.4	1.1
Illnesses of mother	0.1	0.1	0.3	0.3	-0.2	0.2	0.3	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	9.0	-1.9	0.2	-0.1	-1.1	3.0
Pulse wave Arterial Stiffness index	0.5	0.6	1.5	-0.1	0.1	1.2	-0.3	1.1
Impedance of arm (left)	0.9	4.2	14.5	-3.8	1.9	0.9	-1.3	0.8
Arm fat mass (right)	1.1	4.4	9.1	-3.0	1.0	-2.8	-1.3	-1.6
Trunk predicted mass	0.8	4.5	12.0	-3.5	0.0	-0.7	-2.3	2.2
Standing height	2.3	22.9	77.6	-8.8	1.1	0.2	-3.6	4.8
Length of working week for main job	0.9	1.0	2.8	0.8	-0.7	-1.7	0.9	-0.8
Exposure to tobacco smoke at home	0.3	0.3	0.7	-0.9	-0.4	-0.3	-0.0	-0.8
Breastfed as a baby	0.8	1.0	2.0	1.0	-0.1	-1.4	0.5	-1.4
Tense / ‘highly strung’	0.4	0.6	1.7	0.8	-0.6	-0.2	1.3	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	4.8	-2.2	1.9	1.0	-1.1	-0.9
Hair/balding pattern: Pattern 4	2.2	5.2	21.2	4.6	-1.5	0.1	1.6	-0.3
Birth weight of first child	1.1	2.0	5.1	-2.3	1.3	1.0	-1.1	1.0
Peak expiratory flow (PEF)	0.7	1.7	5.4	-1.5	-0.4	-0.5	-0.3	2.3
Pulse wave reflection index	1.3	1.6	5.0	1.1	-0.2	2.2	-0.1	1.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	-0.1	0.6	0.7	-1.0	0.3
Loud music exposure frequency	2.3	2.5	3.4	-1.6	1.5	1.4	-1.8	1.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.2	-1.1	0.1	-0.2	-0.9	1.5
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	6.7	-1.8	0.6	0.7	-1.7	2.6
Blood clot in the leg (DVT)	0.8	1.0	3.8	-0.7	0.2	-0.8	0.5	-2.0
Medication: Paracetamol	0.1	0.1	0.4	-0.2	0.2	0.7	-0.5	0.1
Headache pain in last month	0.2	0.3	0.5	-0.4	0.2	0.7	-0.7	-0.3
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	4.5	-2.0	1.3	1.7	-2.1	1.6
Glaucoma (self-reported)	1.0	1.2	1.9	-1.4	1.1	0.3	-1.1	1.2
Gout (self-reported)	0.5	0.7	1.1	-1.0	-0.7	-1.0	-0.2	1.0
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	6.1	-2.5	1.1	0.7	-1.2	0.4
Medication: Amlodipine	0.4	0.6	1.1	1.1	0.5	1.1	0.1	0.6
Medication: Ventolin 100micrograms inhaler	1.3	1.6	4.3	-2.1	1.0	0.1	-1.5	0.7
Birth weight	3.7	7.9	14.9	-2.3	3.9	2.6	-3.2	1.6
Chronic bronchitis/emphysema (mother)	2.4	2.8	10.8	-3.3	0.0	-0.9	-1.3	0.8
High blood pressure (siblings)	0.7	1.1	2.4	1.6	-0.3	0.3	1.4	-0.9
Forced vital capacity (FVC), Best measure	1.0	3.8	10.2	-2.8	-0.3	-0.1	-0.9	3.2
Body fat percentage	1.5	5.9	15.8	-4.0	1.5	-2.6	-1.2	-1.9
Leg fat percentage (right)	0.7	2.4	4.9	-2.2	0.3	-2.0	-0.3	-1.8
Arm fat-free mass (right)	0.5	2.3	6.3	-2.5	-0.3	-1.6	-1.3	1.0
Exposure to tobacco smoke outside home	0.7	0.9	3.2	-1.8	1.0	-0.4	-0.5	-0.3
Comparative body size at age 10	1.3	3.6	8.7	2.3	3.0	1.3	-1.5	-0.5
Number of full brothers	0.9	1.2	3.6	-1.9	-0.8	-1.2	0.4	0.1
Worry too long after embarrassment	4.8	8.1	26.4	5.1	-2.4	-1.6	1.7	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.3	-0.9	0.7	-0.2	-0.1	-1.5
Wheeze or whistling in the chest in last year	0.7	1.3	5.4	-2.3	0.7	0.5	-0.4	0.3
Number of children fathered	3.1	3.5	6.7	-2.6	0.6	1.6	-1.6	2.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	0.2	-0.3	0.4	0.2	0.4
Age at first live birth	1.6	2.8	5.6	2.2	-2.4	-0.6	1.8	0.0
Pulse wave peak to peak time	0.5	0.5	1.8	-0.6	-0.1	-1.3	0.0	-0.7
Health satisfaction	0.7	0.9	1.8	-0.9	0.3	-1.3	0.6	-1.3
Shortness of breath walking on level ground	0.9	1.1	3.1	-1.8	0.4	-1.1	0.0	-1.0
Qualifications: College or University degree	0.5	1.5	6.4	-0.9	-0.3	-0.3	-0.5	2.5
Eye problems/disorders: None of the above	0.2	0.2	0.6	0.2	-0.8	-0.1	-0.2	0.6
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.1	-1.0	1.2	1.2	-1.5	0.9
Emphysema/chronic bronchitis	1.0	1.1	2.9	-1.4	-0.2	-0.2	0.8	-1.7
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	-0.7	0.2	1.0	0.0	0.5
Neck or shoulder pain in last month	0.8	1.1	3.2	-0.5	0.2	-1.0	1.0	-1.8
Medication: Blood pressure	1.2	2.1	5.2	2.3	-1.1	-1.3	1.4	-0.8
Angina (self-reported)	1.7	2.2	4.6	2.1	-0.5	-0.4	1.2	-2.1
Migraine (self-reported)	0.3	0.4	0.5	-0.7	-0.7	-0.7	0.7	-0.4
Medication: Ibuprofen	0.9	1.1	2.5	-1.6	0.1	-0.0	-1.2	1.3
Medication: Allopurinol	1.9	2.6	5.8	-2.0	0.7	0.1	-1.6	2.4
Medication: Omeprazole	0.8	0.9	3.1	-1.8	0.5	0.6	-0.6	0.6
Medication: Seretide 50 evohaler	2.8	3.2	6.9	-2.6	1.9	1.1	-1.7	1.4
Mean time to correctly identify matches	0.7	1.4	3.3	-1.0	1.0	1.8	-1.2	0.5
Heart disease (mother)	0.2	0.3	1.0	1.0	0.5	-0.0	0.4	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.4	0.1	0.9	-1.0	0.8	-1.2
Whole body fat mass	1.5	6.4	19.0	-4.4	1.2	-2.8	-1.4	-1.3
Leg fat mass (right)	1.0	3.9	8.2	-2.9	0.1	-2.9	-0.7	-1.6
Arm predicted mass (right)	0.4	1.9	5.5	-2.3	-0.4	-1.5	-1.0	0.8
Pulse rate, automated reading	0.1	0.2	1.1	0.1	0.0	-0.2	0.3	-1.0
Alcohol intake frequency.	1.4	3.2	8.7	1.4	-0.8	-1.3	1.7	-2.9
Comparative height size at age 10	1.1	6.0	11.2	-3.4	-2.2	-1.1	-1.2	3.3
Number of full sisters	1.4	1.7	4.6	0.1	-1.0	-2.1	0.9	-1.5
Suffer from ‘nerves’	0.6	0.9	2.9	1.7	-0.7	0.4	0.9	-0.6
Overall health rating	0.6	1.4	4.7	-0.7	0.7	-1.1	0.4	-2.2
Chest pain or discomfort	0.6	0.8	2.3	-0.6	0.0	-0.9	0.8	-1.5
Had major operations	0.5	0.5	1.5	-1.2	-0.7	-0.3	-0.5	0.5
Age at last live birth	0.4	0.5	1.1	0.6	-1.0	-1.0	0.4	0.0
Family relationship satisfaction	0.5	0.7	1.2	-1.1	-0.4	-0.9	-0.0	1.0
Leg pain on walking	1.5	1.9	4.5	-1.6	0.1	-2.1	0.5	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.1	0.2	-1.1	0.5	0.5	0.0
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.0	-1.3	1.4	1.3	-1.1	-0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	-0.4	0.9	1.1	-0.1	0.4
Medication: Aspirin	2.0	2.7	8.8	3.0	-1.0	-1.2	1.0	-1.0
Supplements: Vitamin C	1.2	1.5	3.0	1.3	-1.3	0.4	1.7	-0.9
Knee pain experienced in last month	0.4	0.7	1.7	-1.3	0.9	-0.7	-0.7	-0.0
Hypertension (Self-reported)	0.7	2.0	7.5	2.7	-1.0	-0.8	0.9	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	0.7	0.5	-0.4	-0.0	0.4
Illnesses of father: Heart disease	0.3	0.5	1.2	0.8	0.5	1.1	0.4	-0.3
Illnesses of siblings: Diabetes	1.4	1.8	4.3	1.1	-1.4	-2.1	0.4	-1.1
Smoking status: Previous	0.9	1.3	2.1	-1.1	1.3	1.4	-0.6	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	3.0	6.2	19.7	-4.4	0.5	-0.6	-2.3	2.4
Whole body fat-free mass	0.8	4.3	12.4	-3.5	0.2	-1.4	-2.2	1.5
Leg fat-free mass (right)	0.7	3.6	10.1	-3.2	0.4	-2.2	-1.8	0.4
Arm fat percentage (left)	1.2	4.8	7.4	-2.7	1.6	-2.7	-1.2	-2.3
Average weekly red wine intake	0.2	0.2	0.4	0.5	0.4	0.5	0.6	-0.3
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	0.2	-0.9	-0.4	-0.5	0.9
Mood swings	0.7	1.2	5.6	-2.4	0.2	0.3	-0.4	-0.2
Loneliness, isolation	0.3	0.4	1.1	1.0	-0.5	-0.7	0.2	0.4
Long-standing illness, disability or infirmity	1.3	1.9	2.9	0.2	-1.1	-1.7	1.6	-1.7
Ever had bowel cancer screening	0.6	0.7	2.2	0.5	0.5	1.5	-0.2	-0.9
Diabetes diagnosed by doctor	0.4	0.7	2.1	-0.6	-0.9	-1.4	0.4	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	2.9	-1.5	1.7	1.4	-1.7	1.1
Friendships satisfaction	0.4	0.5	1.3	-0.7	-0.6	-1.1	0.6	-0.5
Qualifications: nursing, teaching	0.6	1.0	2.9	-0.7	-1.0	-0.7	0.1	1.7
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.2	0.4	0.3	-0.4	-0.3
Eye problems/disorders: Cataract	0.2	0.3	0.8	-0.4	0.5	0.9	-0.5	-0.0
Mouth/teeth dental problems: Mouth ulcers	1.7	2.6	4.9	-2.2	1.7	1.6	-1.6	0.4
Medication for cholesterol	0.6	0.9	2.9	-1.0	0.4	-0.0	0.8	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	6.7	0.4	-0.0	-1.1	1.0	-2.6
Back pain experienced in last month	0.7	1.0	1.7	-0.4	-1.1	-1.2	1.3	-0.8
Mineral and other dietary supplements	0.9	1.2	2.6	-1.6	0.7	0.4	-1.2	1.0
Breast cancer (self-reported)	0.1	0.1	0.2	-0.2	-0.2	-0.0	-0.3	-0.4
Asthma (self-reported)	1.8	3.6	14.8	-3.9	0.5	-0.1	-1.3	1.2
Osteoporosis (self-reported)	1.6	2.0	4.8	1.8	0.5	-0.0	1.3	-2.2
Osteoarthritis (self-reported)	1.5	1.9	4.6	1.3	-0.5	-1.2	1.3	-2.1
Medication: Aspirin	2.6	3.4	10.7	3.3	-1.1	-1.5	1.2	-1.2
Medication: Gliclazide	0.7	0.8	2.2	0.3	-1.5	-0.9	0.5	-0.6
Illnesses of father: None of the above (group 1)	0.8	1.0	1.7	-1.0	1.2	-0.8	-1.3	-0.6
Smoking status: Current	2.7	4.3	12.0	-3.5	1.3	0.1	-2.0	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.2	-0.5	-1.0	-1.8	0.8	-0.2
Whole body water mass	0.7	4.2	11.9	-3.5	0.2	-1.5	-2.2	1.4
Leg predicted mass (right)	0.7	3.5	9.8	-3.1	0.4	-2.1	-1.7	0.4
Arm fat mass (left)	1.1	4.5	9.3	-3.0	1.1	-2.8	-1.4	-1.5
Number of self-reported non-cancer illnesses	0.9	1.6	4.9	-1.5	0.4	-0.8	0.5	-2.2
Average weekly champagne plus white wine intake	0.5	0.6	1.2	1.1	0.9	0.4	-0.7	0.8
Miserableness	2.1	3.6	11.6	-3.4	1.0	-0.4	-2.0	1.2
Guilty feelings	0.1	0.2	0.5	-0.1	0.3	-0.4	-0.7	-0.3
Wears glasses or contact lenses	1.3	1.5	6.0	2.4	0.3	0.9	0.1	0.7
Ever taken oral contraceptive pill	1.2	1.3	3.6	-1.1	0.4	-0.2	-1.3	1.9
Hearing aid user	0.9	1.0	2.0	1.2	-1.4	0.3	0.6	0.9
Mother’s age at death	1.2	1.6	3.0	1.7	-1.1	0.6	1.7	-0.6
Financial situation satisfaction	2.2	2.8	5.5	-1.5	2.4	2.0	-1.3	0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	0.4	0.5	-0.6	-1.2	0.8
Commuting to job workplace: Public transport	0.9	1.1	2.3	1.1	0.4	0.4	-1.4	1.5
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	-0.2	0.8	0.7	-0.3	0.3
Medication: Blood pressure	0.5	1.0	2.6	1.6	-0.2	0.0	-0.4	1.5
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.4	-0.5	-0.2	0.7	-0.6
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.5	-0.3	-0.2	0.2	-0.4
High cholesterol (Self-reported)	0.2	0.4	1.2	-0.5	0.7	0.2	0.4	-1.1
Medication: Bendroflumethiazide	0.4	0.7	1.2	-0.7	0.0	-0.9	-1.0	1.1
Medication: Paracetamol	0.1	0.2	0.4	0.3	0.1	0.6	0.3	-0.6
Medication: Lisinopril	0.6	0.7	2.9	0.5	-0.4	0.7	-0.2	1.7
Medication: Atorvastatin	1.6	2.0	4.5	0.7	-2.1	-1.9	1.0	-0.3
Illnesses of father: High blood pressure	1.5	1.9	4.1	2.0	-1.3	0.2	1.8	-0.5
Alcohol drinker status: Never	1.4	1.7	3.4	1.8	-0.7	-0.6	1.4	-1.5
Ever smoked	1.5	2.7	4.4	-1.6	2.1	2.1	-1.4	0.6
Basal metabolic rate	0.9	5.2	16.0	-4.0	0.4	-1.9	-2.3	1.1
Leg fat percentage (left)	0.6	2.2	4.5	-2.1	0.4	-1.7	-0.1	-1.8
Arm fat-free mass (left)	0.5	2.6	7.1	-2.7	-0.5	-1.7	-1.4	0.8
Number of operations (self-reported)	0.9	1.4	3.1	-1.8	-1.0	-1.2	0.3	-1.0
Average weekly beer plus cider intake	3.0	4.3	8.2	-1.8	2.2	1.7	-2.9	1.4
Irritability	0.2	0.3	0.6	0.7	-0.8	-0.2	0.8	-0.1
Risk taking	2.2	3.2	4.9	-1.8	2.1	1.3	-2.2	1.3
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.9	1.7	-1.7	0.3	1.4	-0.3
Fractured/broken bones in last 5 years	0.2	0.2	0.5	0.3	-0.4	0.3	0.6	0.7
Age started oral contraceptive pill	3.7	4.7	10.2	3.2	-2.1	-0.9	2.5	-1.2
Diastolic blood pressure, automated reading	0.8	2.4	5.7	-1.2	0.4	0.9	-1.9	2.4
Ever depressed for a whole week	0.1	0.2	0.3	-0.3	0.4	-0.5	-0.2	-0.6
Unable to work because of sickness or disability	0.7	0.9	2.5	0.8	0.6	0.9	0.6	-1.6
Commuting to job workplace: Cycle	1.9	2.3	4.9	1.6	-2.2	-1.5	1.2	0.6
Myopia	3.5	5.0	9.5	-2.1	2.2	3.1	-2.1	1.4
Vascular/heart problems diagnosed by doctor	0.9	2.3	8.2	-2.9	0.9	0.8	-1.1	0.8
Cholesterol lowering medication	0.1	0.2	0.4	0.3	0.6	0.5	0.3	0.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.1	-1.0	0.3	0.3	-0.4	0.5
Pain experienced in last month	0.5	0.8	1.5	1.1	-0.4	1.2	0.1	1.0
Supplements: Calcium	0.8	0.8	2.2	0.7	-0.0	0.5	1.1	-1.5
Basal cell carcinoma (self-reported)	18.4	21.9	71.8	8.5	-4.2	-2.8	3.4	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.8	-0.5	-0.3	-0.9	-0.3	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.9	-0.4	-0.2	-0.7	0.7	-2.0
Heart disease (siblings)	0.3	0.4	0.7	0.7	0.7	0.8	-0.1	0.4
Alcohol drinker status: Previous	1.1	1.2	2.9	-0.2	1.5	1.7	-0.7	-0.8
Pack years of smoking	0.4	0.6	1.1	-0.9	-0.5	-1.0	0.4	-0.9
Impedance of whole body	0.7	3.7	13.5	-3.7	1.2	1.4	-0.5	1.1
Leg fat mass (left)	1.0	3.7	8.5	-2.9	0.2	-2.7	-0.6	-1.5
Arm predicted mass (left)	0.5	2.7	8.4	-2.9	-0.3	-1.4	-1.5	1.0