Best TWAS P=3.46e-10 · Best GWAS P=4.2e-13 conditioned to 0.0122
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ATG7 | 0.07 | 0.07 | lasso | 3 | 0.07 | 3.3e-09 | -5.5 | 5.2 | 1.6e-07 | -0.56 | 0.99 | 0.01 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | VGLL4 | 0.04 | 0.02 | blup | 511 | 0.02 | 7.8e-04 | -4.8 | -6.1 | 8.8e-10 | 0.67 | 0.28 | 0.55 | FALSE |
| 3 | GTEx | Muscle Skeletal | ATG7 | 0.06 | 0.02 | lasso | 4 | 0.03 | 8.6e-04 | -5.2 | 5.6 | 2.5e-08 | -0.57 | 0.57 | 0.14 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | ATG7 | 0.10 | 0.06 | enet | 12 | 0.04 | 2.1e-03 | -6.5 | -5.5 | 3.2e-08 | 0.75 | 0.04 | 0.91 | FALSE |
| 5 | GTEx | Testis | VGLL4 | 0.18 | -0.01 | lasso | 3 | -0.01 | 6.9e-01 | -5.5 | -5.2 | 1.7e-07 | 0.45 | 0.05 | 0.22 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | VGLL4 | 0.05 | 0.03 | blup | 422 | 0.04 | 3.7e-06 | -5.6 | -6.3 | 3.5e-10 | 0.76 | 0.08 | 0.92 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ATG7 | 0.09 | 0.00 | blup | 136 | 0.02 | 7.4e-06 | -3.5 | -5.5 | 3.8e-08 | 0.58 | 0.16 | 0.83 | TRUE |