Best TWAS P=3.36e-08 · Best GWAS P=2.78e-07 conditioned to 0.502
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TRPC4AP | 0.06 | 0.01 | lasso | 6 | 0.01 | 3.8e-02 | -5.1 | -5.5 | 3.4e-08 | 0.87 | 0.02 | 0.89 | TRUE |
| 2 | GTEx | Brain Caudate basal ganglia | MAP1LC3A | 0.12 | 0.04 | enet | 13 | 0.09 | 1.2e-03 | -4.5 | 5.2 | 2.1e-07 | -0.71 | 0.11 | 0.52 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | ITCH | 0.09 | 0.04 | enet | 28 | 0.09 | 2.5e-05 | 3.9 | -5.2 | 2.3e-07 | 0.53 | 0.22 | 0.67 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | RP4-614O4.12 | 0.10 | 0.10 | lasso | 2 | 0.09 | 3.0e-05 | -5.1 | -5.2 | 2.5e-07 | 0.97 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Lung | RP4-614O4.12 | 0.07 | 0.14 | lasso | 1 | 0.13 | 7.1e-10 | -5.1 | -5.1 | 2.8e-07 | 0.99 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | RP4-614O4.12 | 0.10 | 0.13 | lasso | 3 | 0.10 | 5.8e-06 | -5.1 | -5.1 | 2.8e-07 | 0.99 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | RP4-614O4.12 | 0.17 | 0.20 | lasso | 4 | 0.19 | 2.4e-15 | -5.1 | -5.2 | 2.0e-07 | 0.99 | 0.01 | 0.99 | FALSE |