Best TWAS P=4.44e-09 · Best GWAS P=2.59e-16 conditioned to 2.04e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | DCLRE1B | 0.19 | 0.02 | lasso | 5 | 0.03 | 9.1e-03 | 5.7 | -5.7 | 1.3e-08 | -0.56 | 0.16 | 0.63 | FALSE |
| 2 | GTEx | Testis | RSBN1 | 0.09 | 0.09 | enet | 6 | 0.09 | 8.9e-05 | 5.8 | -5.6 | 2.0e-08 | -0.48 | 0.52 | 0.06 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PTPN22 | 0.02 | 0.01 | blup | 67 | 0.01 | 9.6e-03 | 5.4 | 5.5 | 4.9e-08 | 0.71 | 0.11 | 0.37 | FALSE |
| 4 | The Cancer Genome Atlas | Glioblastoma Multiforme | DCLRE1B | 0.20 | -0.01 | blup | 39 | 0.04 | 3.0e-02 | 5.1 | -5.2 | 2.3e-07 | -0.57 | 0.01 | 0.28 | FALSE |
| 5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | BCL2L15 | 0.09 | 0.00 | blup | 42 | 0.04 | 1.1e-02 | 4.7 | 5.9 | 4.4e-09 | 0.53 | 0.02 | 0.05 | TRUE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | DCLRE1B | 0.06 | 0.04 | enet | 11 | 0.04 | 4.3e-05 | 5.4 | -5.8 | 6.9e-09 | -0.64 | 0.02 | 0.96 | FALSE |