Best TWAS P=2.96e-10 · Best GWAS P=1.16e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | GPRC5B | 0.07 | 0.04 | lasso | 4 | 0.03 | 1.3e-03 | 6.1 | -6.3 | 3.0e-10 | -0.96 | 0.00 | 0.99 | TRUE |
| 2 | GTEx | Breast Mammary Tissue (Male) | AC002550.5 | 0.37 | 0.29 | lasso | 3 | 0.35 | 4.8e-09 | 5.5 | 5.2 | 1.6e-07 | 0.90 | 0.04 | 0.96 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IQCK | 0.03 | 0.03 | blup | 73 | 0.03 | 1.6e-07 | 4.0 | 5.1 | 3.0e-07 | 0.81 | 0.17 | 0.83 | FALSE |
| 4 | The Cancer Genome Atlas | Glioblastoma Multiforme | C16orf88 | 0.34 | 0.07 | lasso | 3 | 0.12 | 1.5e-04 | 4.9 | 5.1 | 3.0e-07 | 0.78 | 0.00 | 0.80 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IQCK | 0.03 | 0.03 | lasso | 3 | 0.02 | 7.2e-04 | 5.5 | 5.6 | 1.7e-08 | 0.94 | 0.00 | 0.99 | FALSE |