[Hub]/) : Traits : Age when periods started (menarche) : ← →

chr16:28,825,605-31,026,427

Best TWAS P=5.08e-12 · Best GWAS P=2.76e-09 conditioned to 0.168

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	RP11-231C14.4	0.06	0.07	enet	5	0.07	4.7e-06	5.94	-6.0	1.8e-09	-0.93	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	INO80E	0.10	0.16	enet	19	0.15	4.5e-12	-5.28	6.0	2.1e-09	0.79	0.28	0.72	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-231C14.4	0.07	0.01	enet	18	0.03	1.2e-02	5.94	-6.0	2.3e-09	-0.77	0.02	0.91	FALSE
4	GTEx	Adipose Visceral Omentum	INO80E	0.14	0.14	enet	17	0.19	3.7e-10	-5.28	5.4	6.1e-08	0.75	0.26	0.74	FALSE
5	GTEx	Adipose Visceral Omentum	SEZ6L2	0.05	0.01	enet	10	0.01	9.4e-02	5.53	-5.3	1.3e-07	-0.96	0.02	0.87	FALSE
6	GTEx	Adipose Visceral Omentum	AC009133.12	0.05	0.01	lasso	2	0.00	2.3e-01	-5.24	-5.6	2.4e-08	-0.79	0.06	0.34	FALSE
7	GTEx	Adrenal Gland	INO80E	0.35	0.00	lasso	4	0.05	5.4e-03	5.17	6.4	1.4e-10	0.50	0.05	0.47	FALSE
8	GTEx	Artery Aorta	CDIPT	0.09	0.04	lasso	3	0.02	3.6e-02	-4.21	-5.2	2.6e-07	-0.39	0.06	0.28	FALSE
9	GTEx	Artery Aorta	TBX6	0.14	0.02	lasso	7	0.03	1.2e-02	-3.43	-5.3	1.1e-07	-0.62	0.14	0.67	FALSE
10	GTEx	Artery Aorta	INO80E	0.12	0.17	enet	11	0.17	1.9e-09	5.17	5.4	5.3e-08	0.77	0.24	0.76	FALSE
11	GTEx	Artery Aorta	SLX1A-SULT1A3	0.07	0.00	enet	17	0.00	2.6e-01	-4.05	-5.3	1.3e-07	-0.76	0.06	0.54	FALSE
12	GTEx	Artery Coronary	TBX6	0.22	0.00	enet	17	0.02	6.7e-02	5.94	-5.8	8.2e-09	-0.78	0.04	0.60	FALSE
13	GTEx	Artery Tibial	RP11-231C14.4	0.04	0.04	enet	4	0.02	9.2e-03	5.58	-5.7	1.2e-08	-0.99	0.02	0.91	FALSE
14	GTEx	Artery Tibial	INO80E	0.23	0.15	enet	21	0.19	6.7e-15	-5.23	6.7	2.7e-11	0.82	0.12	0.88	FALSE
15	GTEx	Artery Tibial	CTD-2574D22.4	0.05	0.02	enet	9	0.03	1.2e-03	4.77	5.1	3.1e-07	0.83	0.02	0.95	FALSE
16	GTEx	Brain Cerebellum	INO80E	0.23	0.10	enet	8	0.14	5.7e-05	5.17	6.6	5.2e-11	0.65	0.18	0.70	FALSE
17	GTEx	Breast Mammary Tissue	MVP	0.18	0.08	enet	13	0.06	6.0e-04	-3.64	-5.2	1.7e-07	-0.48	0.24	0.18	FALSE
18	GTEx	Breast Mammary Tissue	INO80E	0.17	0.12	enet	14	0.13	2.3e-07	5.17	6.3	2.4e-10	0.83	0.20	0.80	FALSE
19	GTEx	Breast Mammary Tissue (Male)	TBX6	0.12	0.01	enet	21	0.00	3.2e-01	3.44	-5.3	1.4e-07	-0.55	0.04	0.25	FALSE
20	GTEx	Breast Mammary Tissue (Female)	INO80E	0.20	0.13	lasso	7	0.06	7.3e-03	5.17	5.3	9.1e-08	0.63	0.09	0.32	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	MAPK3	0.23	0.12	enet	8	0.08	1.5e-03	5.90	6.0	1.6e-09	0.94	0.01	0.99	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	TBX6	0.19	0.17	lasso	4	0.17	4.1e-06	4.95	-5.5	3.9e-08	-0.89	0.04	0.94	FALSE
23	GTEx	Cells Transformed fibroblasts	MVP	0.11	0.09	enet	5	0.09	2.5e-07	-3.49	5.7	1.4e-08	0.36	0.71	0.22	FALSE
24	GTEx	Cells Transformed fibroblasts	MAPK3	0.12	0.05	lasso	10	0.04	3.7e-04	5.93	6.1	1.1e-09	0.94	0.02	0.98	FALSE
25	GTEx	Cells Transformed fibroblasts	PPP4C	0.04	0.06	lasso	1	0.05	8.0e-05	-5.23	5.2	1.7e-07	0.82	0.18	0.73	FALSE
26	GTEx	Cells Transformed fibroblasts	TMEM219	0.10	0.05	enet	28	0.06	1.6e-05	-5.23	5.3	1.2e-07	0.78	0.12	0.88	FALSE
27	GTEx	Cells Transformed fibroblasts	INO80E	0.04	0.03	enet	5	0.06	5.5e-05	-5.28	6.4	1.9e-10	0.73	0.18	0.69	FALSE
28	GTEx	Cells Transformed fibroblasts	SEZ6L2	0.11	0.08	lasso	2	0.07	2.9e-06	-5.46	-5.5	5.2e-08	-0.35	0.10	0.87	FALSE
29	GTEx	Colon Transverse	RP11-231C14.4	0.07	0.04	enet	8	0.06	8.0e-04	-5.25	-5.4	6.7e-08	-0.77	0.08	0.70	FALSE
30	GTEx	Colon Transverse	INO80E	0.14	0.17	enet	16	0.19	3.3e-09	5.17	5.5	5.1e-08	0.77	0.33	0.67	FALSE
31	GTEx	Colon Transverse	RP11-347C12.1	0.15	0.06	enet	11	0.11	9.4e-06	3.51	-5.3	1.1e-07	-0.61	0.21	0.51	FALSE
32	GTEx	Esophagus Mucosa	RP11-231C14.4	0.07	0.00	enet	11	0.00	4.9e-01	-5.28	-6.9	6.1e-12	-0.84	0.02	0.79	FALSE
33	GTEx	Esophagus Mucosa	INO80E	0.12	0.16	enet	14	0.20	4.6e-13	5.17	5.6	1.7e-08	0.80	0.28	0.72	FALSE
34	GTEx	Esophagus Muscularis	INO80E	0.10	0.11	enet	20	0.07	4.6e-05	-5.27	5.7	1.5e-08	0.81	0.18	0.82	FALSE
35	GTEx	Esophagus Muscularis	RP11-347C12.1	0.07	0.05	lasso	4	0.07	2.8e-05	3.51	-5.4	5.2e-08	-0.82	0.02	0.97	FALSE
36	GTEx	Heart Atrial Appendage	INO80E	0.14	0.17	lasso	3	0.19	5.7e-09	-5.28	5.5	3.5e-08	0.80	0.24	0.76	FALSE
37	GTEx	Heart Atrial Appendage	RP11-347C12.1	0.07	0.04	lasso	3	0.02	3.1e-02	5.01	-5.2	2.7e-07	-0.75	0.06	0.53	FALSE
38	GTEx	Heart Left Ventricle	TBX6	0.16	0.14	enet	10	0.12	7.8e-07	4.68	-5.4	5.6e-08	-0.74	0.16	0.82	FALSE
39	GTEx	Heart Left Ventricle	INO80E	0.06	0.07	lasso	7	0.08	6.1e-05	-5.25	5.5	2.8e-08	0.89	0.05	0.92	FALSE
40	GTEx	Lung	INO80E	0.18	0.17	lasso	8	0.19	1.0e-14	5.17	5.7	1.2e-08	0.81	0.30	0.70	FALSE
41	GTEx	Lung	RP11-347C12.2	0.04	0.03	enet	11	0.04	8.8e-04	4.70	-5.6	1.8e-08	-0.79	0.07	0.84	FALSE
42	GTEx	Muscle Skeletal	RP11-347C12.1	0.04	0.02	enet	7	0.04	1.8e-04	3.51	-5.2	1.8e-07	-0.71	0.09	0.86	FALSE
43	GTEx	Muscle Skeletal	AC009133.12	0.04	0.00	lasso	4	0.00	5.3e-01	-5.49	-6.1	1.1e-09	-0.45	0.02	0.36	FALSE
44	GTEx	Nerve Tibial	INO80E	0.26	0.34	enet	30	0.38	3.5e-28	-5.25	6.3	3.4e-10	0.80	0.24	0.76	FALSE
45	GTEx	Nerve Tibial	SEZ6L2	0.07	0.02	enet	12	0.04	3.9e-04	-5.46	-5.8	5.8e-09	-0.40	0.16	0.50	FALSE
46	GTEx	Ovary	YPEL3	0.33	0.10	enet	27	0.14	3.5e-04	-3.43	-6.0	2.7e-09	-0.47	0.11	0.13	FALSE
47	GTEx	Pituitary	INO80E	0.27	0.29	lasso	8	0.27	1.9e-07	-5.24	5.7	1.2e-08	0.82	0.22	0.76	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	CORO1A	0.06	0.02	lasso	4	0.00	2.0e-01	5.56	5.5	3.1e-08	0.80	0.04	0.81	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	RP11-231C14.4	0.07	0.01	enet	11	0.03	1.1e-02	-0.79	-5.5	3.3e-08	-0.67	0.02	0.83	FALSE
50	GTEx	Skin Sun Exposed Lower leg	RP11-231C14.4	0.06	0.05	enet	17	0.03	9.6e-04	-5.25	-6.4	2.1e-10	-0.84	0.02	0.97	FALSE
51	GTEx	Skin Sun Exposed Lower leg	INO80E	0.11	0.10	lasso	5	0.10	1.4e-08	-5.28	5.5	3.7e-08	0.76	0.24	0.76	FALSE
52	GTEx	Small Intestine Terminal Ileum	MAPK3	0.17	0.01	lasso	5	0.04	5.4e-02	-5.24	5.8	7.9e-09	0.78	0.04	0.59	FALSE
53	GTEx	Small Intestine Terminal Ileum	INO80E	0.20	0.14	lasso	17	0.08	6.2e-03	-4.04	5.2	2.6e-07	0.83	0.08	0.78	FALSE
54	GTEx	Spleen	INO80E	0.23	0.20	enet	13	0.26	2.6e-07	4.48	5.2	2.3e-07	0.74	0.38	0.55	FALSE
55	GTEx	Stomach	RP11-231C14.4	0.09	0.09	enet	7	0.05	1.5e-03	5.60	-6.1	1.0e-09	-0.96	0.02	0.89	FALSE
56	GTEx	Stomach	INO80E	0.09	0.07	enet	6	0.02	3.4e-02	5.17	5.4	8.0e-08	0.71	0.04	0.86	FALSE
57	GTEx	Testis	INO80E	0.15	0.20	lasso	3	0.19	8.3e-09	-5.23	5.3	9.3e-08	0.82	0.24	0.76	FALSE
58	GTEx	Thyroid	RP11-231C14.4	0.06	0.00	lasso	3	0.02	1.9e-02	5.94	-6.0	1.7e-09	-0.83	0.01	0.82	FALSE
59	GTEx	Thyroid	INO80E	0.15	0.25	lasso	3	0.25	2.0e-19	5.17	5.4	7.1e-08	0.73	0.36	0.64	FALSE
60	NTR	Blood	INO80E	0.01	0.00	bslmm	204	0.00	8.7e-03	2.34	5.4	8.1e-08	0.50	0.10	0.15	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	MAPK3	0.12	0.12	enet	20	0.16	1.8e-20	5.90	5.8	5.3e-09	0.86	0.01	0.99	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	RP11-231C14.4	0.08	0.05	lasso	5	0.04	7.3e-06	5.90	-5.3	1.2e-07	-0.97	0.01	0.99	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	INO80E	0.08	0.13	lasso	2	0.12	1.6e-15	-5.25	5.3	1.4e-07	0.81	0.23	0.77	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	SEZ6L2	0.12	0.08	lasso	3	0.09	4.0e-11	-5.46	5.5	4.9e-08	0.31	0.08	0.92	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	ASPHD1	0.03	0.03	lasso	4	0.02	5.0e-04	5.94	-6.9	5.1e-12	-0.93	0.01	0.98	TRUE
66	ROSMAP	Brain Pre-frontal Cortex	RP11-345J4.8	0.02	0.00	blup	192	0.01	1.9e-02	-4.11	-6.7	2.8e-11	-0.70	0.02	0.35	FALSE
67	YFS	Blood	MAPK3	0.38	0.29	enet	30	0.33	4.7e-113	4.70	5.4	6.1e-08	0.72	0.83	0.16	FALSE
68	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LOC440356	0.03	0.03	blup	33	0.03	1.1e-03	-3.49	5.2	1.6e-07	0.48	0.10	0.32	FALSE
69	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TBX6	0.04	0.03	lasso	3	0.02	1.2e-02	5.56	-5.5	4.7e-08	-0.70	0.00	0.78	FALSE
70	The Cancer Genome Atlas	Breast Invasive Carcinoma	ALDOA	0.02	0.01	enet	9	0.02	9.2e-05	-4.15	-5.4	8.1e-08	-0.84	0.02	0.97	FALSE
71	The Cancer Genome Atlas	Colon Adenocarcinoma	YPEL3	0.08	0.03	lasso	2	0.02	1.7e-02	5.56	-5.5	3.2e-08	-0.70	0.00	0.86	FALSE
72	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MAPK3	0.03	0.01	enet	6	0.02	5.5e-03	4.70	5.3	8.6e-08	0.73	0.00	0.86	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	KCTD13	0.02	0.02	lasso	2	0.02	3.9e-03	5.93	-5.9	2.8e-09	-1.00	0.01	0.88	FALSE