Best TWAS P=2.8e-09 · Best GWAS P=6.36e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FAM175A | 0.06 | 0.06 | enet | 7 | 0.06 | 8.9e-08 | 5.0 | -5.1 | 2.6e-07 | 0.77 | 0.21 | 0.79 | FALSE |
| 2 | GTEx | Skin Sun Exposed Lower leg | MRPS18C | 0.14 | 0.12 | enet | 14 | 0.08 | 2.6e-07 | -5.3 | -5.4 | 7.1e-08 | 0.78 | 0.13 | 0.87 | FALSE |
| 3 | GTEx | Testis | HELQ | 0.15 | 0.10 | enet | 12 | 0.08 | 2.3e-04 | -5.0 | -5.5 | 4.8e-08 | 0.81 | 0.09 | 0.90 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | MRPS18C | 0.04 | 0.05 | lasso | 6 | 0.03 | 2.7e-05 | -5.8 | -5.7 | 1.4e-08 | 0.99 | 0.01 | 0.99 | FALSE |
| 5 | YFS | Blood | AGPAT9 | 0.12 | 0.14 | enet | 34 | 0.17 | 1.9e-53 | -4.4 | 5.4 | 7.2e-08 | -0.79 | 0.92 | 0.08 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HELQ | 0.01 | 0.02 | lasso | 2 | 0.02 | 4.6e-05 | -5.7 | -5.9 | 2.8e-09 | 0.98 | 0.01 | 0.98 | TRUE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FAM175A | 0.02 | 0.03 | lasso | 3 | 0.03 | 3.6e-04 | -5.3 | 5.8 | 6.0e-09 | -0.93 | 0.01 | 0.93 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HELQ | 0.05 | 0.04 | enet | 5 | 0.04 | 1.7e-05 | -5.5 | -5.7 | 9.5e-09 | 0.87 | 0.02 | 0.98 | FALSE |