[Hub]/) : Traits : Had menopause :

chr2:26,592,429-28,607,344

Best TWAS P=1.98e-11 · Best GWAS P=1.89e-11 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex GTF3C2 0.06 0.09 lasso 8 0.08 7.2e-10 5.6 -5.4 6.0e-08 -0.90 0.11 0.89 FALSE
2 CommonMind Brain Pre-frontal Cortex IFT172 0.06 0.09 enet 16 0.09 3.9e-11 6.5 6.1 1.0e-09 0.94 0.03 0.97 FALSE
3 CommonMind Brain Pre-frontal Cortex PPM1G 0.03 0.01 bslmm 305 0.00 8.7e-02 6.5 6.2 4.1e-10 0.88 0.04 0.94 FALSE
4 GTEx Adipose Subcutaneous NRBP1 0.07 0.04 lasso 5 0.05 6.9e-05 6.5 -5.8 6.7e-09 -0.85 0.04 0.95 FALSE
5 GTEx Adipose Subcutaneous PPM1G 0.04 0.05 lasso 2 0.04 4.9e-04 6.5 -6.4 1.2e-10 -0.95 0.04 0.93 FALSE
6 GTEx Adipose Subcutaneous AC074117.10 0.06 0.04 lasso 5 0.02 4.8e-03 5.8 -5.9 4.0e-09 -0.90 0.05 0.92 FALSE
7 GTEx Adipose Visceral Omentum NRBP1 0.05 0.05 lasso 4 0.04 2.5e-03 6.5 -6.5 6.0e-11 -0.96 0.04 0.88 FALSE
8 GTEx Adipose Visceral Omentum PPM1G 0.06 0.01 lasso 5 0.01 1.1e-01 6.5 -6.4 1.3e-10 -0.95 0.04 0.73 FALSE
9 GTEx Adipose Visceral Omentum KRTCAP3 0.10 0.07 lasso 4 0.06 5.2e-04 5.6 5.7 1.1e-08 0.91 0.05 0.94 FALSE
10 GTEx Adipose Visceral Omentum AC074117.10 0.14 0.09 lasso 3 0.08 5.0e-05 5.7 -5.9 4.3e-09 -0.93 0.05 0.95 FALSE
11 GTEx Adrenal Gland KRTCAP3 0.11 0.16 lasso 4 0.15 4.9e-06 6.5 6.7 3.0e-11 0.98 0.04 0.96 FALSE
12 GTEx Artery Aorta NRBP1 0.06 0.07 enet 8 0.06 2.6e-04 5.5 -5.6 1.8e-08 -0.84 0.07 0.87 FALSE
13 GTEx Artery Aorta AC074117.10 0.06 0.04 lasso 3 0.03 6.8e-03 5.7 -5.7 1.3e-08 -0.92 0.04 0.85 FALSE
14 GTEx Artery Coronary NRBP1 0.09 0.01 enet 14 0.03 4.4e-02 3.9 -5.4 7.1e-08 -0.65 0.10 0.58 FALSE
15 GTEx Artery Tibial NRBP1 0.07 0.03 lasso 11 0.05 1.3e-04 6.5 -5.2 1.6e-07 -0.81 0.08 0.89 FALSE
16 GTEx Artery Tibial SNX17 0.11 0.07 enet 31 0.04 3.3e-04 6.5 -5.8 7.4e-09 -0.80 0.04 0.96 FALSE
17 GTEx Artery Tibial PPM1G 0.06 0.02 lasso 4 0.03 2.3e-03 5.7 -5.5 2.8e-08 -0.92 0.05 0.85 FALSE
18 GTEx Artery Tibial AC074117.10 0.13 0.14 lasso 5 0.13 1.1e-10 5.7 -5.9 3.6e-09 -0.93 0.08 0.92 FALSE
19 GTEx Brain Cerebellum AC074117.10 0.13 0.08 enet 6 0.07 4.4e-03 6.2 6.3 2.1e-10 0.95 0.04 0.75 FALSE
20 GTEx Brain Cortex KRTCAP3 0.19 0.10 lasso 2 0.12 3.7e-04 6.4 6.0 2.2e-09 0.88 0.04 0.88 FALSE
21 GTEx Cells EBV-transformed lymphocytes NRBP1 0.11 0.13 enet 13 0.15 1.2e-05 6.5 -6.5 1.1e-10 -0.95 0.04 0.93 FALSE
22 GTEx Cells Transformed fibroblasts NRBP1 0.09 0.08 lasso 3 0.08 7.8e-07 5.7 -6.2 7.9e-10 -0.92 0.04 0.96 FALSE
23 GTEx Cells Transformed fibroblasts PPM1G 0.06 0.00 lasso 4 0.01 3.2e-02 6.3 -6.2 5.7e-10 -0.82 0.05 0.82 FALSE
24 GTEx Cells Transformed fibroblasts IFT172 0.04 0.04 lasso 2 0.02 8.1e-03 6.7 6.7 2.0e-11 1.00 0.03 0.90 TRUE
25 GTEx Cells Transformed fibroblasts AC074117.10 0.21 0.19 enet 23 0.18 1.6e-13 5.8 -5.7 1.6e-08 -0.85 0.60 0.40 FALSE
26 GTEx Colon Sigmoid AC074117.10 0.13 0.18 lasso 3 0.14 1.1e-05 5.7 -5.8 6.3e-09 -0.93 0.05 0.95 FALSE
27 GTEx Colon Transverse NRBP1 0.08 0.03 enet 14 0.00 2.0e-01 5.5 -6.0 1.8e-09 -0.87 0.05 0.73 FALSE
28 GTEx Colon Transverse AC074117.10 0.13 0.13 enet 16 0.14 2.3e-07 5.6 -5.6 2.3e-08 -0.90 0.05 0.95 FALSE
29 GTEx Esophagus Gastroesophageal Junction NRBP1 0.11 0.01 enet 23 0.02 7.7e-02 4.5 -5.5 3.1e-08 -0.64 0.08 0.50 FALSE
30 GTEx Esophagus Gastroesophageal Junction AC074117.10 0.12 0.13 enet 9 0.09 4.9e-04 6.5 -6.3 2.8e-10 -0.87 0.04 0.93 FALSE
31 GTEx Esophagus Mucosa NRBP1 0.13 0.06 enet 13 0.06 4.1e-05 5.8 -5.9 3.1e-09 -0.88 0.11 0.88 FALSE
32 GTEx Esophagus Mucosa AC074117.10 0.12 0.14 lasso 8 0.14 2.1e-09 5.8 -6.3 3.2e-10 -0.90 0.04 0.96 FALSE
33 GTEx Esophagus Muscularis NRBP1 0.07 0.04 lasso 6 0.04 1.3e-03 5.8 -5.2 1.9e-07 -0.82 0.06 0.88 FALSE
34 GTEx Esophagus Muscularis PPM1G 0.06 0.10 lasso 2 0.07 3.7e-05 6.5 -6.3 2.4e-10 -0.96 0.04 0.95 FALSE
35 GTEx Esophagus Muscularis AC074117.10 0.17 0.14 enet 5 0.09 6.6e-06 5.8 -5.7 1.1e-08 -0.89 0.11 0.89 FALSE
36 GTEx Lung NRBP1 0.05 0.05 enet 9 0.05 1.7e-04 5.7 -6.2 4.3e-10 -0.93 0.05 0.94 FALSE
37 GTEx Lung AC074117.10 0.07 0.06 lasso 6 0.05 6.6e-05 5.7 -5.9 2.8e-09 -0.92 0.05 0.94 FALSE
38 GTEx Muscle Skeletal SNX17 0.18 0.24 lasso 6 0.26 6.2e-26 6.4 -6.4 1.4e-10 -0.94 0.04 0.96 FALSE
39 GTEx Muscle Skeletal KRTCAP3 0.08 0.06 lasso 4 0.04 3.1e-05 6.5 6.5 7.2e-11 0.96 0.04 0.96 FALSE
40 GTEx Nerve Tibial NRBP1 0.06 0.00 enet 9 0.02 2.0e-02 5.8 -5.7 1.1e-08 -0.83 0.05 0.93 FALSE
41 GTEx Nerve Tibial PPM1G 0.09 0.06 lasso 4 0.05 1.2e-04 5.5 -5.4 6.5e-08 -0.81 0.07 0.90 FALSE
42 GTEx Nerve Tibial AC074117.10 0.04 0.05 lasso 2 0.04 7.7e-04 6.4 -6.0 1.5e-09 -0.91 0.08 0.76 FALSE
43 GTEx Ovary AC074117.10 0.16 0.04 enet 9 0.05 2.0e-02 6.5 -5.6 2.0e-08 -0.92 0.04 0.79 FALSE
44 GTEx Prostate AC074117.10 0.14 0.01 lasso 5 0.02 8.8e-02 5.8 -5.8 5.9e-09 -0.88 0.06 0.63 FALSE
45 GTEx Skin Not Sun Exposed Suprapubic NRBP1 0.19 0.15 lasso 7 0.16 6.0e-09 5.7 -6.0 2.8e-09 -0.92 0.05 0.95 FALSE
46 GTEx Skin Sun Exposed Lower leg NRBP1 0.10 0.08 lasso 6 0.08 3.6e-07 6.5 -6.1 1.0e-09 -0.93 0.04 0.96 FALSE
47 GTEx Skin Sun Exposed Lower leg SLC4A1AP 0.04 0.01 lasso 3 0.02 1.7e-02 6.5 6.3 2.5e-10 0.92 0.04 0.83 FALSE
48 GTEx Testis NRBP1 0.16 0.09 lasso 3 0.06 1.8e-03 5.8 -5.6 2.7e-08 -0.88 0.05 0.92 FALSE
49 GTEx Testis AC074117.10 0.14 0.08 lasso 6 0.12 4.5e-06 6.5 -5.8 5.0e-09 -0.90 0.05 0.95 FALSE
50 GTEx Testis RP11-195B17.1 0.13 0.00 lasso 4 0.02 4.5e-02 5.7 -5.3 1.4e-07 -0.81 0.04 0.24 FALSE
51 GTEx Thyroid CAD 0.07 0.01 enet 15 0.02 6.1e-03 6.4 -5.8 5.8e-09 -0.85 0.04 0.94 FALSE
52 GTEx Thyroid NRBP1 0.08 0.07 enet 29 0.04 3.7e-04 6.4 -5.2 1.8e-07 -0.77 0.04 0.95 FALSE
53 GTEx Thyroid PPM1G 0.06 0.06 lasso 3 0.06 2.2e-05 6.5 -6.6 5.1e-11 -0.96 0.04 0.96 FALSE
54 GTEx Thyroid AC074117.10 0.17 0.14 lasso 4 0.15 2.7e-11 6.5 -5.9 3.2e-09 -0.94 0.06 0.94 FALSE
55 GTEx Thyroid AC109828.1 0.12 0.02 enet 24 0.04 4.3e-04 6.4 -5.4 6.6e-08 -0.75 0.04 0.93 FALSE
56 GTEx Vagina AC074117.10 0.14 0.04 enet 13 0.06 1.4e-02 6.4 -6.2 7.7e-10 -0.90 0.04 0.75 FALSE
57 GTEx Whole Blood KRTCAP3 0.12 0.05 enet 10 0.05 9.9e-06 6.5 6.0 1.5e-09 0.95 0.03 0.97 FALSE
58 METSIM Adipose KRTCAP3 0.05 0.01 blup 288 0.03 1.6e-05 6.5 5.7 1.2e-08 0.86 0.04 0.96 FALSE
59 METSIM Adipose NRBP1 0.06 0.09 lasso 3 0.08 1.6e-12 5.8 -5.7 9.6e-09 -0.87 0.05 0.95 FALSE
60 ROSMAP Brain Pre-frontal Cortex SNX17 0.27 0.35 lasso 10 0.34 7.9e-46 6.5 6.5 8.8e-11 0.93 0.04 0.96 FALSE
61 ROSMAP Brain Pre-frontal Cortex IFT172 0.07 0.02 blup 287 0.03 5.8e-05 5.7 5.3 9.4e-08 0.83 0.04 0.95 FALSE
62 ROSMAP Brain Pre-frontal Cortex KRTCAP3 0.06 0.05 blup 279 0.05 3.1e-07 6.5 6.0 1.8e-09 0.88 0.04 0.96 FALSE
63 ROSMAP Brain Pre-frontal Cortex ZNF513 0.04 0.05 blup 280 0.05 1.3e-06 6.5 -6.2 4.1e-10 -0.91 0.04 0.96 FALSE
64 YFS Blood KRTCAP3 0.12 0.18 bslmm 286 0.18 1.0e-55 6.3 6.6 4.5e-11 0.94 0.04 0.96 FALSE
65 YFS Blood NRBP1 0.01 0.01 lasso 6 0.01 9.1e-06 6.5 -5.4 8.0e-08 -0.88 0.04 0.96 FALSE
66 YFS Blood SNX17 0.05 0.03 blup 288 0.04 1.0e-11 5.7 -5.9 4.4e-09 -0.82 0.06 0.94 FALSE
67 The Cancer Genome Atlas Bladder Urothelial Carcinoma NRBP1 0.05 0.06 lasso 2 0.05 6.0e-05 6.5 -6.5 9.5e-11 -0.93 0.02 0.98 FALSE
68 The Cancer Genome Atlas Bladder Urothelial Carcinoma PPM1G 0.03 0.02 blup 31 0.02 8.8e-03 6.2 -6.4 1.6e-10 -0.93 0.02 0.72 FALSE
69 The Cancer Genome Atlas Breast Invasive Carcinoma KRTCAP3 0.01 0.00 blup 27 0.00 8.7e-02 6.4 6.5 6.2e-11 0.94 0.02 0.70 FALSE
70 The Cancer Genome Atlas Breast Invasive Carcinoma NRBP1 0.03 0.03 blup 29 0.03 1.2e-06 6.4 -6.3 2.3e-10 -0.93 0.02 0.98 FALSE
71 The Cancer Genome Atlas Colon Adenocarcinoma NRBP1 0.03 0.04 lasso 1 0.03 5.2e-03 6.5 -6.5 6.4e-11 -0.96 0.02 0.67 FALSE
72 The Cancer Genome Atlas Glioblastoma Multiforme NRBP1 0.15 0.10 lasso 2 0.10 5.8e-04 5.8 -5.8 8.1e-09 -0.86 0.01 0.45 FALSE
73 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IFT172 0.02 0.01 blup 43 0.02 2.7e-03 6.4 -6.7 2.8e-11 -0.96 0.02 0.80 FALSE
74 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma KRTCAP3 0.02 0.01 blup 28 0.01 2.9e-02 6.3 6.4 2.0e-10 0.94 0.02 0.78 FALSE
75 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NRBP1 0.06 0.07 lasso 2 0.07 1.1e-08 6.5 -6.5 8.4e-11 -0.94 0.02 0.98 FALSE
76 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SNX17 0.02 0.01 blup 26 0.01 2.1e-02 6.5 6.5 1.1e-10 0.93 0.01 0.92 FALSE
77 The Cancer Genome Atlas Brain Lower Grade Glioma KRTCAP3 0.04 0.01 lasso 2 0.02 6.5e-03 6.3 5.3 1.2e-07 0.74 0.01 0.49 FALSE
78 The Cancer Genome Atlas Brain Lower Grade Glioma PPM1G 0.03 0.03 blup 32 0.02 9.3e-04 6.5 -6.6 4.1e-11 -0.94 0.02 0.94 FALSE
79 The Cancer Genome Atlas Lung Adenocarcinoma NRBP1 0.03 0.05 blup 30 0.05 3.7e-06 6.5 -6.5 6.6e-11 -0.95 0.02 0.98 FALSE
80 The Cancer Genome Atlas Lung Squamous Cell Carcinoma IFT172 0.02 0.01 blup 44 0.01 1.4e-02 6.4 -6.7 2.6e-11 -0.93 0.02 0.68 FALSE
81 The Cancer Genome Atlas Prostate Adenocarcinoma NRBP1 0.03 0.03 blup 30 0.03 2.2e-04 6.4 -6.4 1.7e-10 -0.94 0.02 0.97 FALSE
82 The Cancer Genome Atlas Prostate Adenocarcinoma PPM1G 0.03 0.02 blup 32 0.02 2.4e-03 5.7 -6.2 7.6e-10 -0.94 0.03 0.84 FALSE
83 The Cancer Genome Atlas Thyroid Carcinoma KRTCAP3 0.04 0.04 lasso 1 0.03 3.4e-04 6.4 6.5 1.1e-10 0.90 0.02 0.83 FALSE
84 The Cancer Genome Atlas Thyroid Carcinoma NRBP1 0.03 0.01 blup 30 0.02 5.3e-03 5.8 -6.2 5.7e-10 -0.93 0.02 0.93 FALSE