[Hub]/) : Traits : Had menopause : →

chr2:26,592,429-28,607,344

Best TWAS P=1.98e-11 · Best GWAS P=1.89e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GTF3C2	0.06	0.09	lasso	8	0.08	7.2e-10	5.6	-5.4	6.0e-08	-0.90	0.11	0.89	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IFT172	0.06	0.09	enet	16	0.09	3.9e-11	6.5	6.1	1.0e-09	0.94	0.03	0.97	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PPM1G	0.03	0.01	bslmm	305	0.00	8.7e-02	6.5	6.2	4.1e-10	0.88	0.04	0.94	FALSE
4	GTEx	Adipose Subcutaneous	NRBP1	0.07	0.04	lasso	5	0.05	6.9e-05	6.5	-5.8	6.7e-09	-0.85	0.04	0.95	FALSE
5	GTEx	Adipose Subcutaneous	PPM1G	0.04	0.05	lasso	2	0.04	4.9e-04	6.5	-6.4	1.2e-10	-0.95	0.04	0.93	FALSE
6	GTEx	Adipose Subcutaneous	AC074117.10	0.06	0.04	lasso	5	0.02	4.8e-03	5.8	-5.9	4.0e-09	-0.90	0.05	0.92	FALSE
7	GTEx	Adipose Visceral Omentum	NRBP1	0.05	0.05	lasso	4	0.04	2.5e-03	6.5	-6.5	6.0e-11	-0.96	0.04	0.88	FALSE
8	GTEx	Adipose Visceral Omentum	PPM1G	0.06	0.01	lasso	5	0.01	1.1e-01	6.5	-6.4	1.3e-10	-0.95	0.04	0.73	FALSE
9	GTEx	Adipose Visceral Omentum	KRTCAP3	0.10	0.07	lasso	4	0.06	5.2e-04	5.6	5.7	1.1e-08	0.91	0.05	0.94	FALSE
10	GTEx	Adipose Visceral Omentum	AC074117.10	0.14	0.09	lasso	3	0.08	5.0e-05	5.7	-5.9	4.3e-09	-0.93	0.05	0.95	FALSE
11	GTEx	Adrenal Gland	KRTCAP3	0.11	0.16	lasso	4	0.15	4.9e-06	6.5	6.7	3.0e-11	0.98	0.04	0.96	FALSE
12	GTEx	Artery Aorta	NRBP1	0.06	0.07	enet	8	0.06	2.6e-04	5.5	-5.6	1.8e-08	-0.84	0.07	0.87	FALSE
13	GTEx	Artery Aorta	AC074117.10	0.06	0.04	lasso	3	0.03	6.8e-03	5.7	-5.7	1.3e-08	-0.92	0.04	0.85	FALSE
14	GTEx	Artery Coronary	NRBP1	0.09	0.01	enet	14	0.03	4.4e-02	3.9	-5.4	7.1e-08	-0.65	0.10	0.58	FALSE
15	GTEx	Artery Tibial	NRBP1	0.07	0.03	lasso	11	0.05	1.3e-04	6.5	-5.2	1.6e-07	-0.81	0.08	0.89	FALSE
16	GTEx	Artery Tibial	SNX17	0.11	0.07	enet	31	0.04	3.3e-04	6.5	-5.8	7.4e-09	-0.80	0.04	0.96	FALSE
17	GTEx	Artery Tibial	PPM1G	0.06	0.02	lasso	4	0.03	2.3e-03	5.7	-5.5	2.8e-08	-0.92	0.05	0.85	FALSE
18	GTEx	Artery Tibial	AC074117.10	0.13	0.14	lasso	5	0.13	1.1e-10	5.7	-5.9	3.6e-09	-0.93	0.08	0.92	FALSE
19	GTEx	Brain Cerebellum	AC074117.10	0.13	0.08	enet	6	0.07	4.4e-03	6.2	6.3	2.1e-10	0.95	0.04	0.75	FALSE
20	GTEx	Brain Cortex	KRTCAP3	0.19	0.10	lasso	2	0.12	3.7e-04	6.4	6.0	2.2e-09	0.88	0.04	0.88	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	NRBP1	0.11	0.13	enet	13	0.15	1.2e-05	6.5	-6.5	1.1e-10	-0.95	0.04	0.93	FALSE
22	GTEx	Cells Transformed fibroblasts	NRBP1	0.09	0.08	lasso	3	0.08	7.8e-07	5.7	-6.2	7.9e-10	-0.92	0.04	0.96	FALSE
23	GTEx	Cells Transformed fibroblasts	PPM1G	0.06	0.00	lasso	4	0.01	3.2e-02	6.3	-6.2	5.7e-10	-0.82	0.05	0.82	FALSE
24	GTEx	Cells Transformed fibroblasts	IFT172	0.04	0.04	lasso	2	0.02	8.1e-03	6.7	6.7	2.0e-11	1.00	0.03	0.90	TRUE
25	GTEx	Cells Transformed fibroblasts	AC074117.10	0.21	0.19	enet	23	0.18	1.6e-13	5.8	-5.7	1.6e-08	-0.85	0.60	0.40	FALSE
26	GTEx	Colon Sigmoid	AC074117.10	0.13	0.18	lasso	3	0.14	1.1e-05	5.7	-5.8	6.3e-09	-0.93	0.05	0.95	FALSE
27	GTEx	Colon Transverse	NRBP1	0.08	0.03	enet	14	0.00	2.0e-01	5.5	-6.0	1.8e-09	-0.87	0.05	0.73	FALSE
28	GTEx	Colon Transverse	AC074117.10	0.13	0.13	enet	16	0.14	2.3e-07	5.6	-5.6	2.3e-08	-0.90	0.05	0.95	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	NRBP1	0.11	0.01	enet	23	0.02	7.7e-02	4.5	-5.5	3.1e-08	-0.64	0.08	0.50	FALSE
30	GTEx	Esophagus Gastroesophageal Junction	AC074117.10	0.12	0.13	enet	9	0.09	4.9e-04	6.5	-6.3	2.8e-10	-0.87	0.04	0.93	FALSE
31	GTEx	Esophagus Mucosa	NRBP1	0.13	0.06	enet	13	0.06	4.1e-05	5.8	-5.9	3.1e-09	-0.88	0.11	0.88	FALSE
32	GTEx	Esophagus Mucosa	AC074117.10	0.12	0.14	lasso	8	0.14	2.1e-09	5.8	-6.3	3.2e-10	-0.90	0.04	0.96	FALSE
33	GTEx	Esophagus Muscularis	NRBP1	0.07	0.04	lasso	6	0.04	1.3e-03	5.8	-5.2	1.9e-07	-0.82	0.06	0.88	FALSE
34	GTEx	Esophagus Muscularis	PPM1G	0.06	0.10	lasso	2	0.07	3.7e-05	6.5	-6.3	2.4e-10	-0.96	0.04	0.95	FALSE
35	GTEx	Esophagus Muscularis	AC074117.10	0.17	0.14	enet	5	0.09	6.6e-06	5.8	-5.7	1.1e-08	-0.89	0.11	0.89	FALSE
36	GTEx	Lung	NRBP1	0.05	0.05	enet	9	0.05	1.7e-04	5.7	-6.2	4.3e-10	-0.93	0.05	0.94	FALSE
37	GTEx	Lung	AC074117.10	0.07	0.06	lasso	6	0.05	6.6e-05	5.7	-5.9	2.8e-09	-0.92	0.05	0.94	FALSE
38	GTEx	Muscle Skeletal	SNX17	0.18	0.24	lasso	6	0.26	6.2e-26	6.4	-6.4	1.4e-10	-0.94	0.04	0.96	FALSE
39	GTEx	Muscle Skeletal	KRTCAP3	0.08	0.06	lasso	4	0.04	3.1e-05	6.5	6.5	7.2e-11	0.96	0.04	0.96	FALSE
40	GTEx	Nerve Tibial	NRBP1	0.06	0.00	enet	9	0.02	2.0e-02	5.8	-5.7	1.1e-08	-0.83	0.05	0.93	FALSE
41	GTEx	Nerve Tibial	PPM1G	0.09	0.06	lasso	4	0.05	1.2e-04	5.5	-5.4	6.5e-08	-0.81	0.07	0.90	FALSE
42	GTEx	Nerve Tibial	AC074117.10	0.04	0.05	lasso	2	0.04	7.7e-04	6.4	-6.0	1.5e-09	-0.91	0.08	0.76	FALSE
43	GTEx	Ovary	AC074117.10	0.16	0.04	enet	9	0.05	2.0e-02	6.5	-5.6	2.0e-08	-0.92	0.04	0.79	FALSE
44	GTEx	Prostate	AC074117.10	0.14	0.01	lasso	5	0.02	8.8e-02	5.8	-5.8	5.9e-09	-0.88	0.06	0.63	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	NRBP1	0.19	0.15	lasso	7	0.16	6.0e-09	5.7	-6.0	2.8e-09	-0.92	0.05	0.95	FALSE
46	GTEx	Skin Sun Exposed Lower leg	NRBP1	0.10	0.08	lasso	6	0.08	3.6e-07	6.5	-6.1	1.0e-09	-0.93	0.04	0.96	FALSE
47	GTEx	Skin Sun Exposed Lower leg	SLC4A1AP	0.04	0.01	lasso	3	0.02	1.7e-02	6.5	6.3	2.5e-10	0.92	0.04	0.83	FALSE
48	GTEx	Testis	NRBP1	0.16	0.09	lasso	3	0.06	1.8e-03	5.8	-5.6	2.7e-08	-0.88	0.05	0.92	FALSE
49	GTEx	Testis	AC074117.10	0.14	0.08	lasso	6	0.12	4.5e-06	6.5	-5.8	5.0e-09	-0.90	0.05	0.95	FALSE
50	GTEx	Testis	RP11-195B17.1	0.13	0.00	lasso	4	0.02	4.5e-02	5.7	-5.3	1.4e-07	-0.81	0.04	0.24	FALSE
51	GTEx	Thyroid	CAD	0.07	0.01	enet	15	0.02	6.1e-03	6.4	-5.8	5.8e-09	-0.85	0.04	0.94	FALSE
52	GTEx	Thyroid	NRBP1	0.08	0.07	enet	29	0.04	3.7e-04	6.4	-5.2	1.8e-07	-0.77	0.04	0.95	FALSE
53	GTEx	Thyroid	PPM1G	0.06	0.06	lasso	3	0.06	2.2e-05	6.5	-6.6	5.1e-11	-0.96	0.04	0.96	FALSE
54	GTEx	Thyroid	AC074117.10	0.17	0.14	lasso	4	0.15	2.7e-11	6.5	-5.9	3.2e-09	-0.94	0.06	0.94	FALSE
55	GTEx	Thyroid	AC109828.1	0.12	0.02	enet	24	0.04	4.3e-04	6.4	-5.4	6.6e-08	-0.75	0.04	0.93	FALSE
56	GTEx	Vagina	AC074117.10	0.14	0.04	enet	13	0.06	1.4e-02	6.4	-6.2	7.7e-10	-0.90	0.04	0.75	FALSE
57	GTEx	Whole Blood	KRTCAP3	0.12	0.05	enet	10	0.05	9.9e-06	6.5	6.0	1.5e-09	0.95	0.03	0.97	FALSE
58	METSIM	Adipose	KRTCAP3	0.05	0.01	blup	288	0.03	1.6e-05	6.5	5.7	1.2e-08	0.86	0.04	0.96	FALSE
59	METSIM	Adipose	NRBP1	0.06	0.09	lasso	3	0.08	1.6e-12	5.8	-5.7	9.6e-09	-0.87	0.05	0.95	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	SNX17	0.27	0.35	lasso	10	0.34	7.9e-46	6.5	6.5	8.8e-11	0.93	0.04	0.96	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	IFT172	0.07	0.02	blup	287	0.03	5.8e-05	5.7	5.3	9.4e-08	0.83	0.04	0.95	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	KRTCAP3	0.06	0.05	blup	279	0.05	3.1e-07	6.5	6.0	1.8e-09	0.88	0.04	0.96	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	ZNF513	0.04	0.05	blup	280	0.05	1.3e-06	6.5	-6.2	4.1e-10	-0.91	0.04	0.96	FALSE
64	YFS	Blood	KRTCAP3	0.12	0.18	bslmm	286	0.18	1.0e-55	6.3	6.6	4.5e-11	0.94	0.04	0.96	FALSE
65	YFS	Blood	NRBP1	0.01	0.01	lasso	6	0.01	9.1e-06	6.5	-5.4	8.0e-08	-0.88	0.04	0.96	FALSE
66	YFS	Blood	SNX17	0.05	0.03	blup	288	0.04	1.0e-11	5.7	-5.9	4.4e-09	-0.82	0.06	0.94	FALSE
67	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NRBP1	0.05	0.06	lasso	2	0.05	6.0e-05	6.5	-6.5	9.5e-11	-0.93	0.02	0.98	FALSE
68	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PPM1G	0.03	0.02	blup	31	0.02	8.8e-03	6.2	-6.4	1.6e-10	-0.93	0.02	0.72	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	KRTCAP3	0.01	0.00	blup	27	0.00	8.7e-02	6.4	6.5	6.2e-11	0.94	0.02	0.70	FALSE
70	The Cancer Genome Atlas	Breast Invasive Carcinoma	NRBP1	0.03	0.03	blup	29	0.03	1.2e-06	6.4	-6.3	2.3e-10	-0.93	0.02	0.98	FALSE
71	The Cancer Genome Atlas	Colon Adenocarcinoma	NRBP1	0.03	0.04	lasso	1	0.03	5.2e-03	6.5	-6.5	6.4e-11	-0.96	0.02	0.67	FALSE
72	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBP1	0.15	0.10	lasso	2	0.10	5.8e-04	5.8	-5.8	8.1e-09	-0.86	0.01	0.45	FALSE
73	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IFT172	0.02	0.01	blup	43	0.02	2.7e-03	6.4	-6.7	2.8e-11	-0.96	0.02	0.80	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KRTCAP3	0.02	0.01	blup	28	0.01	2.9e-02	6.3	6.4	2.0e-10	0.94	0.02	0.78	FALSE
75	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NRBP1	0.06	0.07	lasso	2	0.07	1.1e-08	6.5	-6.5	8.4e-11	-0.94	0.02	0.98	FALSE
76	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX17	0.02	0.01	blup	26	0.01	2.1e-02	6.5	6.5	1.1e-10	0.93	0.01	0.92	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	KRTCAP3	0.04	0.01	lasso	2	0.02	6.5e-03	6.3	5.3	1.2e-07	0.74	0.01	0.49	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPM1G	0.03	0.03	blup	32	0.02	9.3e-04	6.5	-6.6	4.1e-11	-0.94	0.02	0.94	FALSE
79	The Cancer Genome Atlas	Lung Adenocarcinoma	NRBP1	0.03	0.05	blup	30	0.05	3.7e-06	6.5	-6.5	6.6e-11	-0.95	0.02	0.98	FALSE
80	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IFT172	0.02	0.01	blup	44	0.01	1.4e-02	6.4	-6.7	2.6e-11	-0.93	0.02	0.68	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBP1	0.03	0.03	blup	30	0.03	2.2e-04	6.4	-6.4	1.7e-10	-0.94	0.02	0.97	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPM1G	0.03	0.02	blup	32	0.02	2.4e-03	5.7	-6.2	7.6e-10	-0.94	0.03	0.84	FALSE
83	The Cancer Genome Atlas	Thyroid Carcinoma	KRTCAP3	0.04	0.04	lasso	1	0.03	3.4e-04	6.4	6.5	1.1e-10	0.90	0.02	0.83	FALSE
84	The Cancer Genome Atlas	Thyroid Carcinoma	NRBP1	0.03	0.01	blup	30	0.02	5.3e-03	5.8	-6.2	5.7e-10	-0.93	0.02	0.93	FALSE