TWAS hub - CLK3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1140	0.0510	0.00018	0.068	NA	0.060	NA	0.059	0.00013	NA	0.00031	NA	0.00036
2	GTEx	Artery Tibial	0.0634	0.0325	0.00360	0.021	NA	0.016	NA	0.016	0.00840	NA	0.01800	NA	0.01800

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hand grip strength (left)	7.5	19.7	22.3	4.7	4.1
Sitting height	6.6	46.5	52.0	6.4	7.2
Forced vital capacity (FVC)	6.2	23.8	37.4	3.2	6.1
Forced expiratory volume in 1-second (FEV1)	5.6	18.8	29.6	2.8	5.4
Chronic bronchitis/emphysema (father)	4.7	5.5	8.9	1.5	3.0
Forced vital capacity (FVC), Best measure	4.5	16.5	26.0	2.6	5.1
Ever used hormone-replacement therapy (HRT)	4.4	5.6	6.2	-2.2	-2.5
Ever unenthusiastic/disinterested for a whole week	4.3	5.2	6.0	2.4	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	4.2	13.5	21.0	2.4	4.6
Had menopause	3.9	4.8	5.2	-2.1	-2.3
Age when periods started (menarche)	3.8	9.0	16.0	1.4	4.0
Leg pain on walking	3.8	4.8	6.6	2.6	1.7
Illnesses of father: None of the above (group 1)	3.7	4.6	6.0	-1.8	-2.4
Type 2 Diabetes (T2D) (2012)	3.5	4.0	5.0	1.8	2.2
Hand grip strength (right)	3.5	9.6	11.0	3.3	2.9
Hearing aid user	3.5	4.0	5.9	1.4	2.4
Fasting Glucose	3.4	4.1	4.6	-1.9	-2.1
Frequency of depressed mood in last 2 weeks	3.3	4.6	6.0	1.8	2.5
Serious illness, injury or assault of a close relative in last 2 years	3.3	3.8	6.2	-1.1	-2.5
Arm fat-free mass (right)	3.3	17.2	20.9	4.6	3.7
Frequency of unenthusiasm / disinterest in last 2 weeks	3.0	4.0	4.8	1.8	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.5	4.0	1.7	2.0
Miserableness	3.0	5.2	7.8	1.6	2.8
Multivitamins +/- minerals	2.9	3.7	4.0	1.9	2.0
Health satisfaction	2.8	3.6	5.7	2.4	1.3
Medication: Gliclazide	2.8	3.2	5.7	2.4	0.8
Trunk fat-free mass	2.7	15.7	16.5	4.1	3.9
Trunk predicted mass	2.7	15.3	16.1	4.0	3.8
Arm predicted mass (right)	2.7	13.6	17.1	4.1	3.2
Pulse rate, automated reading	2.7	8.7	12.2	3.5	2.3
Loneliness, isolation	2.7	3.7	5.7	2.4	1.3
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	3.8	2.0	1.4
Diastolic blood pressure, automated reading	2.7	8.2	13.2	3.6	1.8
Hearing difficulty/problems: Yes	2.6	3.9	6.6	1.1	2.6
Illnesses of mother	2.6	3.2	3.7	1.9	1.7
Medication: Paracetamol	2.6	4.3	6.4	1.5	2.5
Medication: Paracetamol	2.6	4.0	5.0	1.8	2.2
Arm fat-free mass (left)	2.6	13.1	15.8	4.0	3.2
Whole body water mass	2.5	14.4	16.4	4.1	3.5
Commuting to job workplace: Car/motor vehicle	2.4	2.7	3.7	1.9	1.3
Whole body fat-free mass	2.4	13.7	15.8	4.0	3.4
Alzheimer’s Disease (in father)	2.3	2.5	3.7	1.1	1.9
Relative age voice broke	2.3	3.5	4.9	-2.2	-1.5
Mouth/teeth dental problems: Mouth ulcers	2.3	3.7	4.8	-1.6	-2.2
Basal metabolic rate	2.3	13.0	15.9	4.0	3.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	7.0	1.5	2.6
Commuting to job workplace: Cycle	2.2	2.6	5.0	-2.2	-0.6
Arm predicted mass (left)	2.2	11.3	13.6	3.7	3.0
Crohns Disease (2012)	2.1	3.4	5.1	1.3	2.3
Leg fat-free mass (left)	2.1	10.9	13.8	3.7	2.8
Pulse rate	2.1	3.6	5.1	2.3	1.4
Eye problems/disorders: None of the above	2.1	2.4	3.8	-1.0	-2.0
Knee pain experienced in last month	2.1	3.2	3.8	1.6	1.9
Fed-up feelings	2.0	3.7	4.2	2.1	1.8
Leg predicted mass (left)	2.0	10.6	13.4	3.7	2.8
Impedance of arm (left)	2.0	9.3	10.2	-3.2	-2.9
Mood swings	2.0	3.5	3.6	1.9	1.9
Guilty feelings	2.0	3.1	4.6	1.3	2.1
Ulcerative Colitis	1.9	2.8	4.2	2.1	1.1
Pain all over the body in last month	1.9	2.0	2.7	-1.1	-1.6
Standing height	1.9	18.4	20.8	4.0	4.6
Loud music exposure frequency	1.9	2.1	3.2	1.0	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	3.0	-1.2	-1.7
Irritable Bowel Disease (IBD)	1.8	4.2	5.4	1.7	2.3
Rheumatoid Arthritis	1.8	2.5	3.0	1.7	1.4
Ever had hysterectomy (womb removed)	1.8	2.0	3.1	0.9	1.8
Weight	1.8	9.0	12.9	3.6	2.3
Impedance of arm (right)	1.8	8.4	10.4	-3.2	-2.5
Number of full sisters	1.8	2.2	3.3	1.0	1.8
Overall health rating	1.8	3.9	4.0	2.0	1.9
Ever taken oral contraceptive pill	1.8	2.0	3.1	0.9	1.8
Bipolar Disorder (2018)	1.7	2.7	3.4	1.8	1.4
Bipolar Disorder (2011)	1.7	1.7	2.7	1.6	0.9
Lung FVC	1.7	8.8	16.3	1.2	4.0
Leg fat-free mass (right)	1.7	9.2	12.0	3.5	2.5
Leg predicted mass (right)	1.7	9.2	12.1	3.5	2.5
Medication: Blood pressure	1.7	3.2	4.4	-1.5	-2.1
Depressed Affect (Nagel 2018)	1.6	3.3	3.6	1.9	1.7
Schizophrenia (2018)	1.6	3.4	4.9	-2.2	-1.4
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	2.5	1.6	1.3
Medication: Ibuprofen	1.6	1.9	1.9	1.4	1.4
Family relationship satisfaction	1.6	1.9	3.6	1.9	0.4
Crohns Disease (2017)	1.5	3.4	5.5	1.1	2.3
Major Depression (MDD)	1.5	1.8	1.9	1.3	1.4
Blood Eosinophil Count	1.5	11.6	16.6	-4.1	-2.6
Heel T-Score	1.5	11.7	12.6	-3.5	-3.3
Height	1.5	29.6	32.0	5.7	5.2
Medication: Simvastatin	1.5	2.2	3.1	1.8	-1.1
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	3.5	1.9	1.2
Pulse wave Arterial Stiffness index	1.5	1.7	1.7	1.3	1.3
Pulse wave peak to peak time	1.5	1.7	1.9	-1.4	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	2.0	1.3	1.4
Depression (Nagel 2018)	1.4	2.1	2.1	1.4	1.4
Ulcerative Colitis (UC)	1.4	2.6	2.9	1.7	1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	4.4	-1.5	-2.1
Medication for cholesterol	1.4	2.2	2.4	1.4	1.5
Mother’s age at death	1.4	1.7	2.9	-1.7	-0.7
Exposure to tobacco smoke outside home	1.3	1.7	3.3	1.8	0.4
Medication: Atorvastatin	1.3	1.6	1.7	-1.3	-1.2
Alcohol drinker status: Never	1.3	1.5	2.3	-0.8	-1.5
Age started oral contraceptive pill	1.3	1.7	1.8	-1.3	-1.2
Unable to work because of sickness or disability	1.3	1.7	2.7	0.9	1.6
HbA1C	1.2	1.4	2.7	-0.3	-1.6
Neuroticism score	1.2	2.6	3.9	1.1	2.0
Hip circumference	1.2	5.0	8.7	2.9	1.2
Lung cancer (father)	1.2	1.4	2.6	-0.4	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	2.1	1.4	1.3
Chronic bronchitis/emphysema (mother)	1.2	1.4	1.9	-1.4	-0.9
Heart disease (mother)	1.2	1.4	2.2	1.5	0.8
Leg fat mass (right)	1.2	4.5	7.6	2.8	1.2
Comparative height size at age 10	1.2	6.6	6.9	2.5	2.6
Commuting to job workplace: Walk	1.2	1.3	1.4	-1.2	-1.1
Ever smoked	1.2	2.0	2.8	-1.7	-1.1
Ever depressed for a whole week	1.2	1.5	2.9	1.7	0.4
Type 2 Diabetes (T2D) (2018)	1.1	2.1	3.1	1.8	-1.0
Qualifications: CSEs or equivalent	1.1	1.5	2.9	0.2	-1.7
Diabetes (self-reported)	1.1	1.7	3.1	1.8	-0.5
Falls in the last year	1.1	1.5	2.1	1.0	1.4
Happiness	1.1	1.4	2.7	1.6	0.3
Noisy workplace	1.1	1.4	2.0	0.9	1.4
Tense / ‘highly strung’	1.1	1.8	2.9	0.9	1.7
Hair/balding pattern: Pattern 4	1.1	2.6	3.9	1.2	2.0
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	1.8	-1.3	0.9
Mouth/teeth dental problems: Loose teeth	1.1	1.3	1.7	0.9	1.3
Medication for pain relief, constipation, heartburn	1.1	2.0	3.3	-0.8	-1.8
Mean time to correctly identify matches	1.1	2.2	4.0	-2.0	-0.5
Had major operations	1.1	1.3	1.3	1.2	1.1
Smoking status: Previous	1.1	1.7	3.1	-1.8	-0.5
Wears glasses or contact lenses	1.1	1.3	1.4	1.2	1.1
High cholesterol (Self-reported)	1.1	1.9	3.8	0.1	-1.9
Fractured/broken bones in last 5 years	1.1	1.4	2.0	-1.4	-0.9
Prostate Cancer	1.0	1.4	2.2	0.7	1.5
Past tobacco smoking	1.0	1.8	3.2	1.8	0.7
Medication: Ramipril	1.0	1.3	2.6	-0.1	-1.6
Gout (self-reported)	1.0	1.4	2.8	0.2	1.7
Medication: Amlodipine	1.0	1.4	2.4	-0.6	-1.5
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.0	0.7	1.4
Diabetes diagnosed by doctor	1.0	1.7	2.1	1.5	-1.1
Eye problems/disorders: Cataract	1.0	1.2	2.0	0.6	1.4
Commuting to job workplace: Public transport	1.0	1.2	2.3	-0.3	-1.5
Ever had prostate specific antigen (PSA) test	1.0	1.1	1.6	-0.8	-1.3
Cholesterol lowering medication	1.0	1.5	2.9	0.1	-1.7
Supplements: Calcium	1.0	1.1	1.8	-0.6	-1.4
Alcohol drinker status: Previous	1.0	1.1	2.2	1.5	0.0
Impedance of whole body	1.0	5.0	6.3	-2.5	-1.9
Blood Platelet Count	0.9	10.6	12.0	3.0	3.5
Supplements: Zinc	0.9	1.0	1.9	-0.1	-1.4
Illnesses of siblings	0.9	1.3	2.1	0.7	1.5
Hair/balding pattern: Pattern 3	0.9	1.3	1.8	1.3	0.9
Ever highly irritable/argumentative for 2 days	0.9	1.0	1.9	1.4	0.4
Headache pain in last month	0.9	1.6	1.6	1.3	1.2
Medication: Ventolin 100micrograms inhaler	0.9	1.1	1.5	0.9	1.2
Suffer from ‘nerves’	0.9	1.4	1.8	-1.3	-1.0
Illnesses of father: Heart disease	0.9	1.2	1.3	1.1	1.1
Eye problems/disorders: Glaucoma	0.9	1.0	2.0	0.0	1.4
Pain experienced in last month	0.9	1.5	2.4	-0.7	-1.6
Blood Red Count	0.8	7.5	15.0	-0.1	-3.9
Medication: Metformin	0.8	1.2	1.6	1.3	-0.9
Depression (self-reported)	0.8	0.9	1.6	1.3	0.5
Medication: Omeprazole	0.8	1.0	1.6	-0.7	-1.2
Alcohol intake frequency.	0.8	1.7	3.5	-0.2	-1.9
Financial situation satisfaction	0.8	0.9	1.4	1.2	0.7
Leg fat mass (left)	0.8	3.2	5.8	2.4	0.8
Tanning	0.7	8.2	9.3	3.1	2.6
Hair/balding pattern: Pattern 2	0.7	0.9	1.4	-0.6	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	2.4	-0.8	-1.6
Number of full brothers	0.7	0.9	1.6	0.5	1.3
Long-standing illness, disability or infirmity	0.7	1.1	1.4	0.9	1.2
Number of self-reported non-cancer illnesses	0.7	1.2	1.6	-0.9	-1.3
Number of operations (self-reported)	0.7	1.0	2.0	0.3	1.4
Myopia	0.7	1.0	1.5	1.2	0.6
Reaction Time	0.6	1.1	2.3	-1.5	-0.1
Age at First Birth	0.6	0.8	1.5	-1.2	-0.3
Mean Putamen Volume	0.6	0.6	1.3	-1.1	0.1
Number of treatments/medications taken	0.6	1.1	1.3	1.0	1.2
Medication for hormone replacement therapy	0.6	0.7	0.8	-0.9	0.8
Diabetes (father)	0.6	0.7	1.1	0.5	-1.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	-0.5	1.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.0	0.7	1.0
Medication: Atenolol	0.6	0.8	1.4	1.2	-0.4
Waist circumference	0.6	2.4	4.6	2.1	0.4
Time employed in main current job	0.6	0.7	1.2	-0.4	-1.1
Shortness of breath walking on level ground	0.6	0.7	0.8	-0.7	-0.9
Age at last live birth	0.6	0.9	1.6	0.3	1.3
Hypertension (Self-reported)	0.6	1.6	2.6	-0.7	-1.6
Risk taking	0.6	0.8	1.1	0.7	1.0
Ovarian Cancer	0.5	0.7	0.9	-0.9	-0.7
Smoking Status	0.5	1.3	2.1	-1.5	-0.7
Allergy or Eczema	0.5	1.3	1.9	-1.4	-0.9
Cardiovascular Disease	0.5	1.8	3.0	0.8	-1.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.7	0.9	-0.6
High blood pressure	0.5	1.4	2.6	-0.5	-1.6
Trunk fat mass	0.5	2.1	3.7	1.9	0.7
Qualifications: None of the above	0.5	1.1	1.3	-1.0	-1.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.1	-1.0	-0.6
Father’s age at death	0.5	0.6	1.3	0.1	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	0.8	0.7	0.9
Medication: Lansoprazole	0.5	0.6	0.8	-0.6	-0.9
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	0.8	-0.9	0.7
High blood pressure (siblings)	0.5	0.7	0.8	-0.8	-0.9
Angina (self-reported)	0.5	0.7	0.9	-1.0	-0.6
Medication: Allopurinol	0.5	0.7	1.2	-0.3	1.1
Medication: Seretide 50 evohaler	0.5	0.5	0.9	0.4	0.9
Whole body fat mass	0.5	2.1	4.0	2.0	0.5
Supplements: Vitamin C	0.5	0.6	1.0	-0.5	-1.0
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.5	0.6	1.6
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	0.3	1.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.0	-1.0	0.1
Coronary Artery Disease (CAD)	0.4	0.5	1.0	0.1	1.0
HDL Cholesterol	0.4	0.7	0.7	0.8	0.8
LDL Cholesterol	0.4	0.6	0.9	0.6	1.0
Lupus	0.4	0.6	1.0	-0.4	-1.0
Neuroticism (2016)	0.4	0.6	0.6	0.8	0.8
Vitamin and mineral supplements	0.4	0.5	0.8	-0.9	-0.5
Average weekly fortified wine intake	0.4	0.4	0.6	0.7	0.5
Maternal smoking around birth	0.4	0.6	1.2	0.2	1.1
Body mass index (BMI)	0.4	1.8	3.5	1.9	0.2
Alcohol usually taken with meals	0.4	0.7	0.8	-0.7	-0.9
Nervous feelings	0.4	0.8	1.6	-0.1	1.3
Hearing difficulty/problems with background noise	0.4	0.7	1.4	-0.0	1.2
Fluid intelligence score	0.4	0.9	1.4	-0.6	-1.2
Arm fat mass (right)	0.4	1.7	3.2	1.8	0.3
Glaucoma (self-reported)	0.4	0.5	0.9	-0.3	1.0
Leg fat percentage (right)	0.4	1.5	2.8	1.7	0.4
Mineral and other dietary supplements	0.4	0.6	0.7	0.8	0.7
Breast cancer (self-reported)	0.4	0.4	0.7	-0.8	-0.4
Arm fat mass (left)	0.4	1.6	3.2	1.8	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.6	-0.6	-0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.6	-0.8	-0.6
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.5	-1.2	-0.3
Neuroticism (Nagel 2018)	0.3	0.7	1.3	0.3	1.1
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	-0.8	-0.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.4	-0.6	0.6
Breast Cancer	0.3	0.8	1.1	-1.0	-0.7
Systolic Blood Pressure	0.3	1.4	1.7	1.3	-1.0
Systolic blood pressure, automated reading	0.3	0.9	1.7	1.3	-0.1
Angina	0.3	0.4	0.5	-0.7	-0.6
Medication: Co-codamol	0.3	0.4	0.7	0.1	0.8
Current tobacco smoking	0.3	0.4	0.5	0.6	0.7
Medication: Levothyroxine sodium	0.3	0.6	1.0	0.4	1.0
High blood pressure (mother)	0.3	0.4	0.6	-0.7	-0.6
Number of incorrect matches in round	0.3	0.6	1.1	-0.2	-1.0
Financial difficulties in last 2 years	0.3	0.4	0.7	0.8	0.5
Number of live births	0.3	0.5	0.8	0.9	0.4
Medication: Cholesterol lowering	0.3	0.4	0.5	0.7	-0.6
Birth weight of first child	0.3	0.6	1.0	-0.3	1.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.9	0.9	0.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.0	0.2	1.0
Birth weight	0.3	0.7	1.2	0.3	1.1
Medication: Blood pressure	0.3	0.5	1.0	1.0	0.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.6	-0.8	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	-0.8	0.1
Average weekly red wine intake	0.3	0.4	0.6	-0.5	-0.8
Friendships satisfaction	0.3	0.4	0.6	0.8	-0.4
Osteoporosis (self-reported)	0.3	0.3	0.7	-0.8	-0.0
Average weekly champagne plus white wine intake	0.3	0.4	0.5	0.7	0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	0.9	0.1
Worry (Nagel 2018)	0.2	0.4	0.6	-0.4	0.8
Blood White Count	0.2	1.6	2.2	1.5	1.0
Waist Hip Ratio (WHR)	0.2	0.7	1.4	-0.1	-1.2
Neuroticism	0.2	0.5	0.8	0.3	0.9
Chronotype (morning person)	0.2	0.5	0.7	0.6	-0.8
Severe depression (siblings)	0.2	0.3	0.3	0.5	0.6
Townsend deprivation index at recruitment	0.2	0.3	0.5	0.7	-0.3
Taking other prescription medications	0.2	0.4	0.7	0.0	0.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.6	-0.4
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.5	-0.7	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.0	0.8
Had other major operations	0.2	0.3	0.4	0.4	0.6
Mouth/teeth dental problems	0.2	0.4	0.4	0.7	0.6
Heart attack	0.2	0.3	0.4	-0.6	-0.3
Arm fat percentage (right)	0.2	0.7	1.3	0.4	-1.1
Length of working week for main job	0.2	0.2	0.3	0.6	-0.3
Peak expiratory flow (PEF)	0.2	0.5	0.8	-0.5	0.9
Blood clot in the leg (DVT)	0.2	0.3	0.6	0.7	0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.7	-0.9	0.0
Body fat percentage	0.2	0.8	1.3	1.1	-0.5
Age at first live birth	0.2	0.3	0.5	-0.7	0.4
Emphysema/chronic bronchitis	0.2	0.2	0.3	-0.6	0.2
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.6	0.8	0.6
Arm fat percentage (left)	0.2	0.9	1.4	0.6	-1.2
Qualifications: nursing, teaching	0.2	0.3	0.6	0.1	0.8
Asthma (self-reported)	0.2	0.3	0.6	0.8	0.3
Medication: Lisinopril	0.2	0.2	0.4	0.1	-0.6
Illnesses of father: High blood pressure	0.2	0.2	0.4	0.2	-0.6
Leg fat percentage (left)	0.2	0.9	1.7	1.3	-0.0
Average weekly beer plus cider intake	0.2	0.3	0.3	-0.5	0.6
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	-0.6	-0.2
Body Mass Index (BMI) (2010)	0.1	0.2	0.3	0.5	0.3
Primary Biliary Cirrhosis	0.1	0.2	0.2	0.4	0.4
Schizophrenia (2014)	0.1	0.3	0.5	-0.0	0.7
BMI	0.1	0.8	1.5	1.2	-0.5
Hypothyroidism (self reported)	0.1	0.3	0.6	-0.2	0.7
Hair Pigment	0.1	1.7	2.4	-1.0	1.6
Sensitivity / hurt feelings	0.1	0.2	0.4	-0.7	-0.2
Diabetes (mother)	0.1	0.1	0.2	-0.2	-0.5
Pack years adult smoking proportion	0.1	0.2	0.4	0.6	-0.0
Trunk fat percentage	0.1	0.5	0.8	0.9	-0.4
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.1	0.4
Stomach or abdominal pain in last month	0.1	0.2	0.2	0.4	0.4
Impedance of leg (left)	0.1	0.7	1.0	-1.0	-0.6
Worrier / anxious feelings	0.1	0.1	0.2	-0.3	0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.2	0.4	-0.5
Asthma	0.1	0.2	0.3	0.6	0.1
Exposure to tobacco smoke at home	0.1	0.1	0.1	0.3	0.3
Breastfed as a baby	0.1	0.2	0.3	-0.1	0.5
Comparative body size at age 10	0.1	0.3	0.3	-0.6	-0.5
Worry too long after embarrassment	0.1	0.1	0.2	-0.5	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.5	-0.1
Number of children fathered	0.1	0.2	0.3	-0.1	0.5
Qualifications: College or University degree	0.1	0.2	0.3	-0.5	0.3
Neck or shoulder pain in last month	0.1	0.1	0.2	0.1	0.4
Migraine (self-reported)	0.1	0.1	0.1	0.2	-0.3
Chest pain or discomfort	0.1	0.1	0.1	-0.4	-0.3
Medication: Aspirin	0.1	0.2	0.2	-0.4	-0.5
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.1	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.4	0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.1	0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.3	0.3
Irritability	0.1	0.1	0.2	0.5	-0.0
Heart disease (siblings)	0.1	0.1	0.2	-0.4	-0.3
Pack years of smoking	0.1	0.1	0.2	0.4	-0.2
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.4	-0.2
Triglycerides	0.0	0.0	0.0	-0.2	0.1
Respiratory disease	0.0	0.1	0.2	0.4	0.1
Lung FEV1/FVC ratio	0.0	0.2	0.3	-0.6	-0.2
Average weekly spirits intake	0.0	0.0	0.0	-0.2	0.2
Relative age of first facial hair	0.0	0.0	0.0	-0.1	-0.0
Impedance of leg (right)	0.0	0.2	0.5	-0.7	0.0
Supplements: Glucosamine	0.0	0.0	0.0	-0.2	0.1
Allergy	0.0	0.0	0.0	0.0	0.1
Alcohol intake versus 10 years previously	0.0	0.1	0.1	-0.1	0.3
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	0.2	-0.2
Prospective memory result	0.0	0.1	0.1	0.0	-0.3
Pulse wave reflection index	0.0	0.0	0.0	-0.1	0.2
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	0.1	0.1
Ever had bowel cancer screening	0.0	0.0	0.0	-0.2	-0.2
Back pain experienced in last month	0.0	0.0	0.1	0.3	0.0
Medication: Aspirin	0.0	0.0	0.0	0.0	-0.0
Smoking status: Current	0.0	0.1	0.1	0.4	0.1
Medication: Bendroflumethiazide	0.0	0.0	0.1	-0.0	0.3

Hub : Genes

CLK3

Models

Trait associations