TWAS
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Forced vital capacity (FVC)
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chr17:970,413-2,420,934
Best TWAS P=8.28e-08 · Best GWAS P=5.64e-07 conditioned to 0.78
1M
1.2M
1.4M
1.6M
1.8M
2M
2.2M
2.4M
0
1
2
3
4
5
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Cells Transformed fibroblasts
SERPINF1
0.20
0.11
lasso
3
0.16
5.6e-12
5
-5.4
8.3e-08
-0.91
0.00
1.00
TRUE
2
GTEx
Brain Cortex
SMYD4
0.34
0.17
lasso
4
0.23
5.3e-07
4
-5.1
2.7e-07
-0.80
0.03
0.66
FALSE
1
GTEx
Adipose Subcutaneous
SERPINF1
0.19
0.05
lasso
6
0.02
6.3e-03
5
-5.1
3.1e-07
-0.96
0.00
0.96
FALSE