Best TWAS P=8.49e-08 · Best GWAS P=3.63e-08 conditioned to 0.00595
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NOP58 | 0.05 | 0.02 | blup | 365 | 0.03 | 3.2e-04 | -3.8 | -5.4 | 8.5e-08 | -0.63 | 0.24 | 0.42 | TRUE |
| 2 | GTEx | Artery Aorta | RP11-686O6.2 | 0.14 | 0.09 | enet | 10 | 0.07 | 1.7e-04 | -4.7 | -5.2 | 1.7e-07 | -0.35 | 0.26 | 0.66 | FALSE |
| 3 | GTEx | Artery Tibial | RP11-686O6.2 | 0.14 | 0.08 | lasso | 8 | 0.11 | 8.5e-09 | -4.6 | -5.1 | 3.0e-07 | -0.37 | 0.38 | 0.60 | FALSE |
| 4 | GTEx | Lung | RP11-686O6.2 | 0.19 | 0.14 | lasso | 7 | 0.13 | 6.4e-10 | -4.7 | -5.1 | 2.8e-07 | -0.34 | 0.21 | 0.78 | FALSE |
| 5 | GTEx | Nerve Tibial | RP11-686O6.2 | 0.07 | 0.05 | enet | 8 | 0.05 | 1.9e-04 | -4.7 | -5.2 | 2.0e-07 | -0.42 | 0.16 | 0.80 | FALSE |
| 6 | GTEx | Pancreas | ICA1L | 0.17 | 0.07 | lasso | 8 | 0.10 | 4.9e-05 | -4.2 | 5.3 | 1.3e-07 | 0.38 | 0.09 | 0.44 | FALSE |