[Hub]/) : Traits : Forced vital capacity (FVC) : ← →

chr2:218,300,530-220,374,137

Best TWAS P=1.38e-14 · Best GWAS P=7e-10 conditioned to 1.18e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
70	METSIM	Adipose	CXCR2	0.04	0.00	blup	436	0.02	1.1e-03	-5.6	7.7	1.4e-14	0.08	0.08	0.73	TRUE
6	GTEx	Adipose Visceral Omentum	PNKD	0.11	0.00	enet	31	0.00	2.3e-01	-4.7	7.6	3.0e-14	-0.22	0.05	0.65	TRUE
73	ROSMAP	Brain Pre-frontal Cortex	RP11-378A13.1	0.44	0.64	bslmm	431	0.64	1.1e-107	-5.9	6.6	4.4e-11	-0.03	0.02	0.98	FALSE
10	GTEx	Artery Aorta	TMBIM1	0.17	0.20	enet	29	0.19	1.2e-10	-5.7	6.4	1.3e-10	0.01	0.05	0.95	FALSE
63	GTEx	Testis	RP11-378A13.1	0.37	0.18	enet	22	0.22	2.7e-10	-5.7	6.3	2.1e-10	0.03	0.06	0.94	FALSE
46	GTEx	Muscle Skeletal	RP11-378A13.1	0.19	0.27	enet	23	0.31	1.7e-30	-5.9	6.3	3.7e-10	0.03	0.03	0.97	FALSE
43	GTEx	Lung	RP11-378A13.1	0.27	0.30	enet	19	0.37	2.3e-29	-5.7	6.2	4.4e-10	0.00	0.04	0.96	FALSE
69	METSIM	Adipose	AAMP	0.03	0.00	bslmm	433	0.01	7.1e-03	-5.5	6.2	6.2e-10	0.01	0.10	0.72	FALSE
50	GTEx	Pancreas	RP11-378A13.1	0.29	0.14	enet	24	0.16	4.4e-07	-6.0	6.2	6.9e-10	0.01	0.04	0.96	FALSE
29	GTEx	Cells EBV-transformed lymphocytes	RP11-378A13.1	0.18	0.14	lasso	6	0.13	4.6e-05	-5.9	6.2	7.4e-10	0.00	0.07	0.84	FALSE
32	GTEx	Colon Sigmoid	RP11-378A13.1	0.31	0.33	enet	23	0.34	6.0e-13	-5.9	6.1	1.0e-09	0.02	0.03	0.97	FALSE
25	GTEx	Breast Mammary Tissue	RP11-378A13.1	0.27	0.26	enet	20	0.30	1.3e-15	-5.9	6.1	1.1e-09	0.03	0.05	0.95	FALSE
7	GTEx	Adipose Visceral Omentum	TMBIM1	0.17	0.03	enet	31	0.03	1.1e-02	-5.9	6.1	1.3e-09	0.05	0.06	0.89	FALSE
39	GTEx	Heart Left Ventricle	TMBIM1	0.12	0.08	enet	11	0.07	1.4e-04	-5.6	6.1	1.3e-09	0.04	0.05	0.95	FALSE
26	GTEx	Breast Mammary Tissue (Female)	ARPC2	0.12	-0.01	lasso	5	-0.01	7.1e-01	-5.5	6.0	1.5e-09	0.02	0.06	0.35	FALSE
2	GTEx	Adipose Subcutaneous	PNKD	0.12	0.08	lasso	3	0.07	4.2e-06	-5.9	6.0	1.6e-09	0.04	0.06	0.94	FALSE
38	GTEx	Heart Atrial Appendage	RP11-378A13.1	0.26	0.17	enet	13	0.22	2.0e-10	-6.0	6.0	1.6e-09	0.03	0.04	0.96	FALSE
14	GTEx	Artery Tibial	TMBIM1	0.18	0.14	enet	30	0.13	3.2e-10	-5.7	6.0	1.8e-09	0.03	0.07	0.93	FALSE
5	GTEx	Adipose Subcutaneous	RP11-378A13.1	0.25	0.34	lasso	9	0.37	2.4e-31	-5.7	6.0	2.0e-09	0.03	0.06	0.94	FALSE
47	GTEx	Nerve Tibial	ARPC2	0.29	0.30	enet	27	0.26	1.1e-18	-5.4	6.0	2.0e-09	-0.01	0.25	0.75	FALSE
18	GTEx	Brain Cerebellum	RP11-378A13.1	0.46	0.52	enet	15	0.46	2.5e-15	-6.0	6.0	2.1e-09	0.02	0.03	0.97	FALSE
51	GTEx	Pituitary	TMBIM1	0.20	0.16	enet	13	0.02	8.4e-02	-5.9	6.0	2.3e-09	0.03	0.05	0.88	FALSE
52	GTEx	Pituitary	RP11-378A13.1	0.64	0.52	enet	19	0.52	2.7e-15	-6.0	6.0	2.6e-09	0.03	0.04	0.96	FALSE
66	GTEx	Vagina	RP11-378A13.1	0.22	0.07	enet	11	0.03	7.1e-02	-5.9	6.0	2.6e-09	0.04	0.05	0.69	FALSE
24	GTEx	Brain Putamen basal ganglia	RP11-378A13.1	0.35	0.28	enet	18	0.29	1.2e-07	-5.9	5.9	2.9e-09	0.05	0.04	0.96	FALSE
4	GTEx	Adipose Subcutaneous	ARPC2	0.16	0.16	enet	12	0.17	4.4e-14	-5.4	5.9	3.0e-09	0.01	0.16	0.84	FALSE
78	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMBIM1	0.02	0.01	blup	49	0.02	2.6e-03	-5.6	5.9	3.4e-09	0.04	0.03	0.92	FALSE
9	GTEx	Adrenal Gland	RP11-378A13.1	0.25	0.22	enet	17	0.30	3.2e-11	-5.7	5.9	3.5e-09	0.03	0.05	0.95	FALSE
33	GTEx	Colon Transverse	RP11-378A13.1	0.35	0.31	lasso	6	0.43	4.6e-22	-5.7	5.9	3.7e-09	0.03	0.06	0.94	FALSE
35	GTEx	Esophagus Mucosa	RP11-378A13.1	0.28	0.32	enet	27	0.39	1.3e-27	-5.9	5.9	3.7e-09	0.01	0.03	0.97	FALSE
20	GTEx	Brain Frontal Cortex BA9	RP11-378A13.1	0.38	0.54	enet	24	0.49	7.2e-15	-5.9	5.9	3.8e-09	0.03	0.03	0.97	FALSE
8	GTEx	Adipose Visceral Omentum	RP11-378A13.1	0.30	0.28	enet	30	0.32	2.9e-17	-6.0	5.9	3.9e-09	0.03	0.03	0.97	FALSE
19	GTEx	Brain Cortex	RP11-378A13.1	0.61	0.56	enet	23	0.61	6.7e-21	-5.9	5.9	4.0e-09	0.03	0.03	0.97	FALSE
11	GTEx	Artery Aorta	RP11-378A13.1	0.28	0.28	enet	20	0.31	2.2e-17	-6.0	5.9	4.1e-09	0.03	0.03	0.97	FALSE
1	GTEx	Adipose Subcutaneous	BCS1L	0.06	0.01	enet	9	0.04	2.3e-04	-3.2	5.9	4.3e-09	0.06	0.07	0.23	FALSE
75	YFS	Blood	GPBAR1	0.04	0.06	lasso	10	0.06	2.3e-18	-5.9	-5.9	4.4e-09	-0.02	0.03	0.97	FALSE
13	GTEx	Artery Coronary	RP11-378A13.1	0.34	0.36	lasso	8	0.38	1.2e-13	-5.7	5.9	4.6e-09	0.04	0.06	0.94	FALSE
15	GTEx	Artery Tibial	RP11-378A13.1	0.20	0.17	enet	13	0.24	7.6e-19	-4.7	5.8	4.9e-09	0.03	0.08	0.92	FALSE
23	GTEx	Brain Nucleus accumbens basal ganglia	RP11-378A13.1	0.47	0.51	lasso	5	0.48	1.5e-14	-5.9	-5.8	5.1e-09	-0.02	0.03	0.97	FALSE
30	GTEx	Cells Transformed fibroblasts	TMBIM1	0.15	0.25	lasso	3	0.27	2.2e-20	-5.7	5.8	5.4e-09	0.06	0.10	0.90	FALSE
72	NTR	Blood	ARPC2	0.02	0.01	blup	462	0.01	4.8e-05	-4.8	5.8	5.4e-09	0.14	0.08	0.92	FALSE
65	GTEx	Thyroid	RP11-378A13.1	0.31	0.34	enet	34	0.38	3.7e-30	-5.9	5.8	5.8e-09	0.04	0.03	0.97	FALSE
61	GTEx	Testis	PNKD	0.20	0.19	lasso	3	0.19	1.2e-08	-5.7	5.8	5.9e-09	0.03	0.08	0.92	FALSE
67	GTEx	Whole Blood	PNKD	0.05	0.04	lasso	3	0.03	4.4e-04	-5.9	5.8	6.1e-09	0.04	0.04	0.95	FALSE
74	YFS	Blood	AAMP	0.02	0.02	lasso	3	0.01	4.1e-05	-5.8	5.8	6.6e-09	0.05	0.08	0.92	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	RP11-378A13.1	0.26	0.25	lasso	8	0.28	5.6e-16	-4.7	5.8	7.2e-09	0.04	0.05	0.95	FALSE
57	GTEx	Skin Sun Exposed Lower leg	RP11-378A13.1	0.29	0.36	enet	28	0.40	9.8e-35	-5.9	5.7	9.5e-09	0.06	0.06	0.94	FALSE
27	GTEx	Breast Mammary Tissue (Female)	RP11-378A13.1	0.30	0.11	lasso	10	0.22	3.0e-07	-5.8	5.7	1.0e-08	0.04	0.07	0.93	FALSE
3	GTEx	Adipose Subcutaneous	TMBIM1	0.12	0.08	lasso	5	0.10	2.9e-08	-5.8	5.7	1.1e-08	0.06	0.08	0.92	FALSE
12	GTEx	Artery Coronary	TMBIM1	0.22	0.08	lasso	1	0.03	3.6e-02	-5.7	5.7	1.1e-08	0.03	0.06	0.66	FALSE
42	GTEx	Lung	ARPC2	0.19	0.10	lasso	7	0.09	1.6e-07	-5.8	5.7	1.1e-08	0.07	0.06	0.94	FALSE
71	METSIM	Adipose	TMBIM1	0.14	0.15	lasso	11	0.14	1.3e-20	-5.8	5.7	1.2e-08	0.05	0.07	0.93	FALSE
31	GTEx	Cells Transformed fibroblasts	RP11-378A13.1	0.29	0.26	enet	24	0.31	2.0e-23	-5.8	5.7	1.4e-08	0.01	0.06	0.94	FALSE
68	GTEx	Whole Blood	RP11-378A13.1	0.11	0.13	enet	18	0.15	1.6e-13	-5.9	5.7	1.4e-08	0.04	0.07	0.93	FALSE
83	The Cancer Genome Atlas	Thyroid Carcinoma	TMBIM1	0.02	0.02	blup	49	0.02	9.3e-03	-5.9	5.7	1.4e-08	0.06	0.02	0.65	FALSE
77	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMBIM1	0.04	0.01	blup	49	0.02	4.8e-05	-6.0	5.7	1.6e-08	-0.01	0.02	0.98	FALSE
28	GTEx	Cells EBV-transformed lymphocytes	TMBIM1	0.35	0.24	lasso	10	0.24	2.3e-08	-5.7	5.6	1.7e-08	0.04	0.08	0.92	FALSE
36	GTEx	Esophagus Muscularis	RP11-378A13.1	0.37	0.42	enet	21	0.41	6.9e-27	-5.9	5.6	1.7e-08	0.03	0.03	0.97	FALSE
45	GTEx	Muscle Skeletal	ARPC2	0.23	0.17	enet	18	0.20	1.9e-19	-5.5	5.6	1.8e-08	0.08	0.22	0.78	FALSE
34	GTEx	Esophagus Gastroesophageal Junction	RP11-378A13.1	0.37	0.37	enet	26	0.33	1.1e-12	-5.9	5.6	1.9e-08	0.04	0.03	0.97	FALSE
53	GTEx	Prostate	RP11-378A13.1	0.29	0.12	enet	14	0.10	2.1e-03	-5.7	5.6	2.5e-08	0.03	0.05	0.84	FALSE
16	GTEx	Brain Caudate basal ganglia	RP11-378A13.1	0.55	0.38	enet	17	0.52	4.0e-17	-5.9	5.5	3.1e-08	0.07	0.05	0.95	FALSE
21	GTEx	Brain Hippocampus	RP11-378A13.1	0.43	0.24	lasso	5	0.15	2.4e-04	-5.9	-5.5	3.1e-08	-0.03	0.05	0.88	FALSE
81	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMBIM1	0.10	0.04	blup	49	0.06	3.0e-03	-5.7	5.5	3.1e-08	0.07	0.03	0.78	FALSE
22	GTEx	Brain Hypothalamus	RP11-378A13.1	0.37	0.44	enet	17	0.45	5.6e-12	-6.0	5.5	3.3e-08	0.03	0.04	0.96	FALSE
58	GTEx	Small Intestine Terminal Ileum	RP11-378A13.1	0.39	0.17	enet	15	0.14	4.5e-04	-6.0	5.4	6.1e-08	-0.01	0.06	0.85	FALSE
44	GTEx	Muscle Skeletal	TMBIM1	0.10	0.06	lasso	9	0.06	3.3e-06	-5.7	5.4	6.3e-08	0.07	0.07	0.93	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	PNKD	0.28	0.28	enet	9	0.26	9.7e-15	-4.8	5.4	6.6e-08	0.06	0.24	0.76	FALSE
48	GTEx	Nerve Tibial	RP11-378A13.1	0.33	0.31	enet	35	0.36	1.0e-26	-6.0	5.4	6.9e-08	0.08	0.03	0.97	FALSE
37	GTEx	Heart Atrial Appendage	TMBIM1	0.11	0.09	lasso	2	0.08	1.8e-04	-5.7	5.4	7.2e-08	0.06	0.12	0.86	FALSE
56	GTEx	Skin Sun Exposed Lower leg	PNKD	0.27	0.29	lasso	8	0.34	3.9e-29	-4.7	5.4	7.4e-08	0.05	0.30	0.70	FALSE
62	GTEx	Testis	TMBIM1	0.27	0.13	enet	20	0.15	2.7e-07	-4.8	5.4	7.6e-08	-0.12	0.09	0.91	FALSE
59	GTEx	Spleen	RP11-378A13.1	0.37	0.41	enet	27	0.41	1.2e-11	-5.9	5.4	8.1e-08	0.04	0.07	0.93	FALSE
82	The Cancer Genome Atlas	Soft Tissue Sarcoma	TMBIM1	0.07	0.04	blup	49	0.03	4.8e-03	-4.6	5.3	9.6e-08	0.08	0.04	0.52	FALSE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF142	0.06	0.05	enet	11	0.05	3.1e-06	-3.6	-5.3	1.1e-07	0.00	0.03	0.37	FALSE
17	GTEx	Brain Cerebellar Hemisphere	RP11-378A13.1	0.53	0.57	enet	24	0.60	3.3e-19	-6.0	5.3	1.2e-07	0.04	0.04	0.96	FALSE
41	GTEx	Lung	PNKD	0.13	0.04	enet	10	0.03	3.7e-03	-5.1	5.3	1.3e-07	0.02	0.05	0.94	FALSE
60	GTEx	Stomach	RP11-378A13.1	0.32	0.32	enet	20	0.34	3.4e-17	-5.8	5.3	1.3e-07	0.03	0.06	0.94	FALSE
49	GTEx	Pancreas	PNKD	0.12	0.10	lasso	3	0.08	3.6e-04	-4.7	5.2	1.7e-07	0.02	0.09	0.56	FALSE
40	GTEx	Heart Left Ventricle	RP11-378A13.1	0.21	0.16	enet	27	0.19	1.3e-10	-5.7	5.2	1.8e-07	0.03	0.04	0.96	FALSE
76	YFS	Blood	PNKD	0.08	0.07	lasso	6	0.09	2.9e-27	-5.1	5.2	2.1e-07	0.02	0.68	0.32	FALSE
80	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC11A1	0.03	0.03	blup	51	0.03	1.4e-04	-4.1	-5.2	2.2e-07	-0.05	0.01	0.51	FALSE
64	GTEx	Thyroid	CYP27A1	0.07	0.05	enet	23	0.04	4.8e-04	-4.0	-5.1	2.9e-07	-0.04	0.86	0.02	FALSE