Best TWAS P=4.88e-12 · Best GWAS P=1.23e-10 conditioned to 0.146
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TTC30A | 0.12 | 0.09 | lasso | 8 | 0.09 | 5.4e-11 | -6.4 | -6.1 | 9.4e-10 | 0.98 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adrenal Gland | AC073834.3 | 0.12 | 0.10 | lasso | 2 | 0.07 | 1.5e-03 | -6.4 | -6.6 | 4.5e-11 | 0.99 | 0.03 | 0.85 | FALSE |
| 3 | GTEx | Artery Aorta | AC073834.3 | 0.11 | 0.10 | enet | 11 | 0.12 | 3.7e-07 | -5.7 | -6.1 | 9.9e-10 | 0.93 | 0.06 | 0.94 | FALSE |
| 4 | GTEx | Brain Cerebellum | TTC30A | 0.13 | 0.13 | lasso | 2 | 0.14 | 5.8e-05 | -5.4 | -5.8 | 5.6e-09 | 0.87 | 0.07 | 0.80 | FALSE |
| 5 | GTEx | Brain Nucleus accumbens basal ganglia | AC073834.3 | 0.16 | 0.01 | enet | 33 | 0.05 | 2.1e-02 | -6.0 | -6.6 | 4.0e-11 | 0.70 | 0.11 | 0.75 | FALSE |
| 6 | GTEx | Breast Mammary Tissue | AC073834.3 | 0.13 | 0.12 | lasso | 4 | 0.08 | 4.9e-05 | -5.8 | -6.3 | 2.8e-10 | 0.82 | 0.11 | 0.88 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Male) | AC073834.3 | 0.22 | 0.13 | enet | 18 | 0.07 | 8.7e-03 | -5.4 | -6.6 | 4.0e-11 | 0.83 | 0.08 | 0.74 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Female) | AC073834.3 | 0.04 | -0.01 | lasso | 4 | -0.01 | 6.0e-01 | -5.7 | -5.8 | 9.0e-09 | 0.85 | 0.04 | 0.13 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | AC073834.3 | 0.13 | 0.16 | lasso | 2 | 0.16 | 6.7e-12 | -6.4 | -6.7 | 2.2e-11 | 0.99 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Esophagus Gastroesophageal Junction | AC073834.3 | 0.10 | 0.09 | lasso | 3 | 0.06 | 3.7e-03 | -6.4 | -6.7 | 2.7e-11 | 0.97 | 0.03 | 0.92 | FALSE |
| 11 | GTEx | Esophagus Mucosa | AC073834.3 | 0.06 | 0.07 | lasso | 3 | 0.06 | 8.3e-05 | -6.4 | -6.6 | 5.1e-11 | 0.99 | 0.02 | 0.97 | FALSE |
| 12 | GTEx | Esophagus Muscularis | AGPS | 0.06 | 0.03 | lasso | 3 | 0.02 | 2.7e-02 | -5.6 | -6.2 | 6.6e-10 | 0.95 | 0.04 | 0.92 | FALSE |
| 13 | GTEx | Esophagus Muscularis | AC073834.3 | 0.06 | 0.02 | lasso | 3 | 0.01 | 5.6e-02 | -5.4 | -5.9 | 4.4e-09 | 0.88 | 0.05 | 0.76 | FALSE |
| 14 | GTEx | Nerve Tibial | AGPS | 0.16 | 0.04 | enet | 11 | 0.06 | 3.8e-05 | -4.6 | -5.6 | 1.8e-08 | 0.64 | 0.24 | 0.71 | FALSE |
| 15 | GTEx | Nerve Tibial | AC073834.3 | 0.09 | 0.05 | lasso | 2 | 0.03 | 2.1e-03 | -6.4 | -6.3 | 2.1e-10 | 1.00 | 0.01 | 0.98 | FALSE |
| 16 | GTEx | Pituitary | AC073834.3 | 0.18 | 0.18 | lasso | 7 | 0.12 | 7.2e-04 | -6.1 | -6.6 | 5.2e-11 | 0.79 | 0.08 | 0.76 | FALSE |
| 17 | GTEx | Skin Sun Exposed Lower leg | AC073834.3 | 0.07 | 0.07 | lasso | 3 | 0.06 | 9.5e-06 | -6.4 | -6.5 | 5.8e-11 | 1.00 | 0.01 | 0.99 | FALSE |
| 18 | GTEx | Spleen | AC073834.3 | 0.17 | 0.08 | enet | 22 | 0.08 | 3.6e-03 | -5.9 | -6.9 | 4.9e-12 | 0.81 | 0.06 | 0.79 | TRUE |
| 19 | GTEx | Testis | AC073834.3 | 0.24 | 0.23 | lasso | 7 | 0.26 | 4.8e-12 | -6.4 | -6.5 | 1.0e-10 | 0.97 | 0.01 | 0.99 | FALSE |
| 20 | GTEx | Thyroid | AC073834.3 | 0.12 | 0.09 | enet | 9 | 0.09 | 1.4e-07 | -6.2 | -6.1 | 1.2e-09 | 0.96 | 0.02 | 0.98 | FALSE |
| 21 | ROSMAP | Brain Pre-frontal Cortex | PDE11A | 0.05 | 0.04 | blup | 622 | 0.04 | 1.9e-06 | -4.9 | -5.4 | 8.2e-08 | 0.68 | 0.55 | 0.40 | FALSE |
| 22 | YFS | Blood | AGPS | 0.02 | 0.01 | bslmm | 504 | 0.01 | 6.5e-05 | -6.1 | 5.6 | 1.8e-08 | -0.70 | 0.08 | 0.82 | FALSE |
| 23 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PDE11A | 0.07 | 0.02 | blup | 282 | 0.04 | 8.7e-06 | -6.0 | -5.8 | 6.3e-09 | 0.70 | 0.19 | 0.76 | FALSE |
| 24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TTC30A | 0.05 | 0.03 | enet | 23 | 0.04 | 4.1e-05 | -6.4 | -5.4 | 5.5e-08 | 0.67 | 0.01 | 0.98 | FALSE |