[Hub]/) : Traits : Forced vital capacity (FVC) :

chr2:177,559,549-179,672,547

Best TWAS P=4.88e-12 · Best GWAS P=1.23e-10 conditioned to 0.146

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TTC30A 0.12 0.09 lasso 8 0.09 5.4e-11 -6.4 -6.1 9.4e-10 0.98 0.01 0.99 FALSE
2 GTEx Adrenal Gland AC073834.3 0.12 0.10 lasso 2 0.07 1.5e-03 -6.4 -6.6 4.5e-11 0.99 0.03 0.85 FALSE
3 GTEx Artery Aorta AC073834.3 0.11 0.10 enet 11 0.12 3.7e-07 -5.7 -6.1 9.9e-10 0.93 0.06 0.94 FALSE
4 GTEx Brain Cerebellum TTC30A 0.13 0.13 lasso 2 0.14 5.8e-05 -5.4 -5.8 5.6e-09 0.87 0.07 0.80 FALSE
5 GTEx Brain Nucleus accumbens basal ganglia AC073834.3 0.16 0.01 enet 33 0.05 2.1e-02 -6.0 -6.6 4.0e-11 0.70 0.11 0.75 FALSE
6 GTEx Breast Mammary Tissue AC073834.3 0.13 0.12 lasso 4 0.08 4.9e-05 -5.8 -6.3 2.8e-10 0.82 0.11 0.88 FALSE
7 GTEx Breast Mammary Tissue (Male) AC073834.3 0.22 0.13 enet 18 0.07 8.7e-03 -5.4 -6.6 4.0e-11 0.83 0.08 0.74 FALSE
8 GTEx Breast Mammary Tissue (Female) AC073834.3 0.04 -0.01 lasso 4 -0.01 6.0e-01 -5.7 -5.8 9.0e-09 0.85 0.04 0.13 FALSE
9 GTEx Cells Transformed fibroblasts AC073834.3 0.13 0.16 lasso 2 0.16 6.7e-12 -6.4 -6.7 2.2e-11 0.99 0.01 0.99 FALSE
10 GTEx Esophagus Gastroesophageal Junction AC073834.3 0.10 0.09 lasso 3 0.06 3.7e-03 -6.4 -6.7 2.7e-11 0.97 0.03 0.92 FALSE
11 GTEx Esophagus Mucosa AC073834.3 0.06 0.07 lasso 3 0.06 8.3e-05 -6.4 -6.6 5.1e-11 0.99 0.02 0.97 FALSE
12 GTEx Esophagus Muscularis AGPS 0.06 0.03 lasso 3 0.02 2.7e-02 -5.6 -6.2 6.6e-10 0.95 0.04 0.92 FALSE
13 GTEx Esophagus Muscularis AC073834.3 0.06 0.02 lasso 3 0.01 5.6e-02 -5.4 -5.9 4.4e-09 0.88 0.05 0.76 FALSE
14 GTEx Nerve Tibial AGPS 0.16 0.04 enet 11 0.06 3.8e-05 -4.6 -5.6 1.8e-08 0.64 0.24 0.71 FALSE
15 GTEx Nerve Tibial AC073834.3 0.09 0.05 lasso 2 0.03 2.1e-03 -6.4 -6.3 2.1e-10 1.00 0.01 0.98 FALSE
16 GTEx Pituitary AC073834.3 0.18 0.18 lasso 7 0.12 7.2e-04 -6.1 -6.6 5.2e-11 0.79 0.08 0.76 FALSE
17 GTEx Skin Sun Exposed Lower leg AC073834.3 0.07 0.07 lasso 3 0.06 9.5e-06 -6.4 -6.5 5.8e-11 1.00 0.01 0.99 FALSE
18 GTEx Spleen AC073834.3 0.17 0.08 enet 22 0.08 3.6e-03 -5.9 -6.9 4.9e-12 0.81 0.06 0.79 TRUE
19 GTEx Testis AC073834.3 0.24 0.23 lasso 7 0.26 4.8e-12 -6.4 -6.5 1.0e-10 0.97 0.01 0.99 FALSE
20 GTEx Thyroid AC073834.3 0.12 0.09 enet 9 0.09 1.4e-07 -6.2 -6.1 1.2e-09 0.96 0.02 0.98 FALSE
21 ROSMAP Brain Pre-frontal Cortex PDE11A 0.05 0.04 blup 622 0.04 1.9e-06 -4.9 -5.4 8.2e-08 0.68 0.55 0.40 FALSE
22 YFS Blood AGPS 0.02 0.01 bslmm 504 0.01 6.5e-05 -6.1 5.6 1.8e-08 -0.70 0.08 0.82 FALSE
23 The Cancer Genome Atlas Brain Lower Grade Glioma PDE11A 0.07 0.02 blup 282 0.04 8.7e-06 -6.0 -5.8 6.3e-09 0.70 0.19 0.76 FALSE
24 The Cancer Genome Atlas Brain Lower Grade Glioma TTC30A 0.05 0.03 enet 23 0.04 4.1e-05 -6.4 -5.4 5.5e-08 0.67 0.01 0.98 FALSE