TWAS hub - DOK7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1320	0.0500	8.5e-04	0.014	0.036	0.048	0.044	0.033	6.2e-03	3.0e-05	1.4e-06	3.6e-06	6.8e-05
2	METSIM	Adipose	0.0478	0.0192	1.9e-03	0.025	0.019	0.016	0.019	0.013	9.2e-05	6.7e-04	1.7e-03	7.0e-04	3.8e-03
3	ROSMAP	Brain Pre-frontal Cortex	0.1023	0.0320	8.2e-05	0.098	0.025	0.067	0.079	0.093	1.6e-12	3.3e-04	4.9e-09	2.5e-10	6.2e-12
4	TCGA	Breast Invasive Carcinoma	0.0238	0.0125	5.5e-03	0.018	0.009	0.015	NA	0.017	1.1e-04	3.9e-03	3.9e-04	NA	1.5e-04
5	TCGA	Lung Adenocarcinoma	0.0543	0.0265	3.1e-03	0.034	0.013	0.023	NA	0.027	7.2e-05	1.1e-02	9.2e-04	NA	3.5e-04
6	TCGA	Prostate Adenocarcinoma	0.3471	0.0565	0.0e+00	0.267	0.249	0.275	NA	0.258	6.2e-28	6.8e-26	7.7e-29	NA	7.3e-27
7	TCGA	Thyroid Carcinoma	0.2220	0.0610	3.4e-09	0.103	0.082	0.138	NA	0.143	3.0e-10	2.3e-08	2.2e-13	NA	9.2e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Number of full brothers	4.2	5.3	8.0	0.4	-1.1	2.7	2.6	2.8	2.7	2.5
Asthma	3.8	7.4	13.5	-1.7	0.1	-3.0	-2.9	-2.8	-3.7	-3.2
Asthma (self-reported)	3.8	7.5	13.9	-1.6	0.2	-3.0	-2.9	-2.8	-3.7	-3.3
Ulcerative Colitis (UC)	3.5	6.6	20.0	-1.1	-0.1	2.4	2.5	2.4	2.7	4.5
Hearing difficulty/problems: Yes	3.4	5.2	8.4	-0.7	-2.9	-2.6	-2.7	-2.8	-2.0	-1.0
Emphysema/chronic bronchitis	3.4	3.9	6.1	-2.2	0.3	-1.8	-1.8	-2.0	-2.3	-2.5
Ever taken oral contraceptive pill	3.3	3.7	7.3	-1.7	-0.4	-2.0	-1.9	-1.8	-2.2	-2.7
Wheeze or whistling in the chest in last year	3.0	5.4	10.9	-2.5	0.9	-2.4	-2.3	-2.3	-3.3	-1.8
Frequency of depressed mood in last 2 weeks	2.9	4.0	6.1	-1.5	0.3	-2.2	-2.3	-2.2	-2.5	-2.2
Forced expiratory volume in 1-second (FEV1)	2.9	9.9	29.7	-0.2	1.5	-2.9	-2.8	-2.9	-3.6	-5.5
High cholesterol (Self-reported)	2.9	5.1	15.8	0.7	-1.6	2.1	1.9	1.7	2.4	4.0
Ever used hormone-replacement therapy (HRT)	2.7	3.4	5.7	1.9	1.3	2.4	2.3	2.1	1.5	0.5
Medication: Seretide 50 evohaler	2.7	3.1	8.4	-0.5	-0.6	-1.6	-1.7	-1.7	-2.1	-2.9
Lung cancer (father)	2.6	3.0	5.4	0.7	1.6	2.1	2.2	2.3	1.7	0.0
Wears glasses or contact lenses	2.6	3.0	7.5	2.7	0.7	1.9	1.8	1.5	1.7	0.8
Irritable Bowel Disease (IBD)	2.5	5.9	20.6	-1.1	-0.7	2.0	2.1	2.2	2.4	4.5
Had other major operations	2.5	3.1	4.3	2.0	1.6	1.9	1.8	2.1	1.8	0.7
Peak expiratory flow (PEF)	2.5	5.7	14.8	-0.4	2.2	-2.0	-2.0	-2.2	-2.7	-3.8
Handedness (chirality/laterality): Left-handed	2.5	3.0	5.2	0.9	-0.4	1.9	1.9	1.9	2.3	2.0
Breast Cancer	2.4	5.9	8.6	-2.2	1.4	-2.9	-2.7	-2.8	-2.8	-1.6
Systolic blood pressure, automated reading	2.4	6.8	20.8	0.7	-0.5	2.4	2.4	2.5	3.0	4.6
Forced vital capacity (FVC)	2.4	9.2	34.3	0.3	2.4	-2.3	-2.1	-2.2	-3.0	-5.9
Ulcerative Colitis	2.3	3.4	12.5	0.0	1.3	1.6	1.6	1.6	1.3	3.5
Hypothyroidism/myxoedema (self-reported)	2.2	4.4	6.6	1.1	0.3	2.6	2.5	2.5	2.2	2.3
Alzheimer’s Disease (including proxy)	2.1	3.0	4.2	-0.1	-2.0	-2.0	-1.8	-1.8	-2.1	-1.5
Hypothyroidism (self reported)	2.1	4.9	7.5	1.4	-0.0	2.6	2.5	2.5	2.3	2.7
Respiratory disease	2.1	4.7	9.5	-1.5	0.7	-2.0	-2.0	-1.9	-3.0	-3.1
Crohns Disease (2012)	2.0	3.1	12.2	0.0	-2.1	2.3	0.0	0.0	0.0	3.5
Cardiovascular Disease	2.0	6.7	16.7	2.0	-2.3	2.2	2.0	2.0	2.7	4.1
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	4.7	2.2	-0.2	1.6	1.5	1.7	1.7	1.7
Medication: Co-codamol	2.0	2.4	5.6	2.4	-1.0	1.1	1.1	1.2	1.9	1.6
Had menopause	2.0	2.5	4.3	2.1	-0.5	1.7	1.7	1.6	1.5	1.7
Rheumatoid Arthritis	1.9	2.7	3.2	1.5	-1.8	1.8	1.6	1.8	1.6	1.3
Hearing difficulty/problems with background noise	1.9	3.0	6.3	0.0	-0.2	-2.0	-1.8	-2.0	-1.9	-2.5
Alcohol intake frequency.	1.9	4.5	7.4	-0.2	-2.0	-2.2	-2.5	-2.7	-2.7	-1.5
Had major operations	1.9	2.2	4.5	0.9	0.0	1.4	1.5	1.6	1.9	2.1
Ever had prostate specific antigen (PSA) test	1.9	2.2	5.7	2.4	-1.6	1.1	1.1	1.1	1.6	0.9
Illnesses of siblings	1.8	2.6	12.5	0.8	3.5	1.1	1.3	1.1	0.6	0.4
Illnesses of father: High blood pressure	1.8	2.3	4.3	1.5	0.2	1.5	1.4	1.4	1.7	2.1
Supplements: Calcium	1.8	2.0	3.5	0.8	0.0	1.9	1.9	1.7	1.7	0.8
Alcohol drinker status: Previous	1.8	2.0	3.5	0.9	-0.6	-1.4	-1.5	-1.7	-1.9	-1.5
Depression (Nagel 2018)	1.7	2.5	3.9	-1.2	-1.2	-1.7	-1.8	-1.5	-2.0	-1.7
Ever had hysterectomy (womb removed)	1.7	1.9	3.8	0.8	-1.0	1.5	1.4	1.3	1.4	2.0
Supplements: Glucosamine	1.7	2.2	4.1	0.3	0.3	-1.8	-1.7	-1.7	-1.4	-2.0
Past tobacco smoking	1.7	3.2	7.0	-2.7	0.6	-1.7	-1.7	-1.9	-2.2	-0.7
Alcohol intake versus 10 years previously	1.7	2.6	4.3	-0.8	-2.1	-1.7	-1.9	-1.8	-1.3	-1.4
Mouth/teeth dental problems: Loose teeth	1.7	2.0	4.4	0.7	-1.3	1.4	1.3	1.4	2.1	1.3
Heart disease (mother)	1.7	2.1	2.9	-0.9	-0.9	-1.6	-1.6	-1.7	-1.4	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	11.0	-3.3	0.7	-1.3	-1.2	-1.1	-1.9	-2.5
Loneliness, isolation	1.7	2.3	3.5	-0.9	-1.3	-1.8	-1.8	-1.5	-1.9	-1.3
Number of self-reported non-cancer illnesses	1.7	2.9	5.1	1.0	0.4	2.3	2.0	1.9	1.6	2.0
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	3.4	-0.1	1.8	1.6	1.7	1.6	1.7	0.9
Alzheimer’s Disease (in father)	1.6	1.8	5.2	-0.9	-2.3	-1.2	-1.2	-1.3	-1.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.1	16.9	1.1	1.9	-1.8	-1.7	-1.8	-2.2	-4.1
Forced vital capacity (FVC), Best measure	1.6	5.9	22.1	1.5	2.8	-1.5	-1.3	-1.3	-1.9	-4.7
Cholesterol lowering medication	1.6	2.3	7.0	-0.2	-0.2	1.6	1.5	1.4	1.5	2.6
Systolic Blood Pressure	1.5	7.4	28.2	0.9	-0.7	2.3	2.2	2.2	2.8	5.3
Angina	1.5	2.0	4.4	-1.1	0.5	1.6	1.6	1.4	1.0	2.1
Pack years adult smoking proportion	1.5	2.4	4.0	0.8	-0.6	2.0	1.9	2.0	1.3	1.6
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	7.0	-2.7	0.9	-1.1	-1.0	-1.0	-1.1	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.4	-2.1	-0.7	-1.6	-1.5	-1.3	-1.9	-1.1
Medication: Ramipril	1.5	2.0	5.0	1.0	-2.1	0.7	0.8	0.8	1.3	2.2
Angina (self-reported)	1.5	2.0	5.7	-1.2	0.2	1.4	1.4	1.2	1.0	2.4
Smoking status: Previous	1.5	2.2	4.2	2.1	-0.6	1.4	1.5	1.6	1.7	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	7.8	1.5	-0.5	-1.8	-1.7	-1.6	-1.7	-2.8
Mean Putamen Volume	1.4	1.6	2.6	1.5	-0.2	1.4	1.5	1.6	1.5	0.3
Severe depression (siblings)	1.4	1.6	2.8	-0.2	-0.7	1.3	1.3	1.5	1.5	1.7
Townsend deprivation index at recruitment	1.4	1.9	3.5	0.8	0.6	1.9	1.8	1.9	1.5	0.2
High blood pressure	1.4	3.8	8.4	0.6	-1.3	2.0	2.0	1.9	2.2	2.9
Prospective memory result	1.4	1.7	2.8	1.7	-0.8	1.6	1.5	1.4	1.5	-0.2
Glaucoma (self-reported)	1.4	1.7	3.0	1.2	-0.1	1.7	1.6	1.6	1.4	0.4
Medication: Omeprazole	1.4	1.6	4.0	-0.7	0.5	-1.2	-1.2	-1.3	-1.5	-2.0
Vascular/heart problems diagnosed by doctor	1.4	3.8	10.5	-0.7	1.4	-1.8	-1.8	-1.7	-2.0	-3.2
Basal cell carcinoma (self-reported)	1.4	1.7	3.6	0.7	-1.0	1.4	1.4	1.2	1.3	1.9
Allergy	1.3	3.1	4.2	1.4	-0.5	2.0	1.9	2.0	1.9	1.9
Breastfed as a baby	1.3	1.6	2.5	0.9	-1.6	1.2	1.2	1.0	1.5	1.3
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.2	-0.1	0.6	-1.7	-1.7	-1.8	-1.5	-1.8
Guilty feelings	1.3	1.9	3.8	-0.8	0.1	-1.6	-1.6	-1.4	-1.4	-1.9
Lung FVC	1.2	5.9	18.7	3.3	1.8	-1.4	-1.3	-1.5	-1.6	-4.3
Happiness	1.2	1.5	3.1	-0.8	-0.4	-1.3	-1.3	-1.4	-1.8	-1.2
High blood pressure (siblings)	1.2	1.8	6.8	-0.6	-2.6	-1.3	-1.5	-1.3	-0.2	-0.0
Hearing aid user	1.2	1.3	2.2	-0.6	-0.6	-1.5	-1.5	-1.3	-1.1	-1.2
Body Mass Index (BMI) (2010)	1.1	1.6	5.1	0.0	-0.9	-1.0	-1.0	-1.0	-1.4	-2.3
HDL Cholesterol	1.1	1.9	3.2	0.5	0.8	1.7	1.7	1.8	1.7	0.1
Waist Hip Ratio (WHR)	1.1	4.8	7.1	-0.7	-1.6	2.5	2.4	2.3	2.7	2.6
Medication: Simvastatin	1.1	1.6	3.3	1.6	-1.1	1.1	1.0	1.0	1.0	1.8
Time employed in main current job	1.1	1.3	3.5	-1.2	1.9	-0.5	-0.4	-0.2	-0.8	-1.7
Headache pain in last month	1.1	1.9	4.5	-0.7	0.7	-1.0	-1.1	-1.2	-2.1	-2.1
Gout (self-reported)	1.1	1.5	5.9	-1.1	-1.2	0.2	0.2	0.1	1.3	2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	2.4	0.5	-1.4	-1.5	-1.5	-1.4	-1.2	-0.4
Family relationship satisfaction	1.1	1.3	3.2	-1.0	-1.8	-1.1	-1.0	-1.1	-0.8	0.9
Hypertension (Self-reported)	1.1	3.0	7.1	1.0	-1.4	1.7	1.6	1.6	1.8	2.7
Osteoarthritis (self-reported)	1.1	1.4	2.1	0.5	1.3	1.5	1.4	1.2	1.3	0.6
Eye problems/disorders: Glaucoma	1.1	1.3	2.4	0.8	1.0	1.5	1.6	1.5	0.8	0.0
Pack years of smoking	1.1	1.6	2.7	0.9	-0.8	1.6	1.5	1.6	1.0	1.3
Serious illness, injury or assault to yourself	1.0	1.2	3.0	1.3	-0.5	0.8	0.7	0.8	1.2	1.7
Multivitamins +/- minerals	1.0	1.2	1.9	1.0	1.0	1.0	1.0	1.2	1.4	1.0
Leg predicted mass (left)	1.0	5.1	21.6	-1.7	0.7	-1.3	-1.3	-1.2	-2.4	-4.7
Fluid intelligence score	1.0	2.1	8.3	-2.3	2.9	-0.3	-0.0	-0.1	-0.9	0.2
Depression (self-reported)	1.0	1.2	1.7	-0.7	0.3	-1.2	-1.3	-1.3	-1.3	-1.2
Medication: Lansoprazole	1.0	1.1	6.9	-0.1	2.6	0.1	0.2	0.1	-0.5	-0.7
Loud music exposure frequency	1.0	1.1	4.3	-0.5	2.1	0.5	0.4	0.2	0.0	-1.7
Pulse wave peak to peak time	1.0	1.2	2.4	-0.3	1.5	-1.1	-1.0	-1.2	-1.3	-0.8
Qualifications: College or University degree	1.0	3.0	5.7	-0.5	0.4	-2.4	-2.3	-2.4	-1.6	-1.2
Migraine (self-reported)	1.0	1.3	2.2	0.9	0.1	-1.2	-1.2	-1.2	-1.5	-1.2
Leg fat-free mass (right)	1.0	5.3	20.8	-2.0	0.9	-1.4	-1.3	-1.2	-2.6	-4.6
Illnesses of father: None of the above (group 1)	1.0	1.2	3.3	0.2	1.8	1.2	1.4	1.1	0.4	0.0
Leg predicted mass (right)	1.0	5.3	21.0	-1.9	0.8	-1.4	-1.3	-1.2	-2.6	-4.6
Commuting to job workplace: Public transport	1.0	1.2	2.1	-1.4	-0.3	-1.4	-1.4	-1.2	-0.8	-0.4
Verbal and Numeric Reasoning (VNR)	0.9	2.2	6.0	-2.4	1.1	-1.3	-1.1	-1.2	-1.6	-1.0
Coronary Artery Disease (CAD)	0.9	1.0	4.5	0.0	-2.1	-0.1	0.0	0.1	0.7	1.5
Leg fat-free mass (left)	0.9	4.7	20.3	-1.7	0.6	-1.2	-1.1	-1.1	-2.3	-4.5
Age when periods started (menarche)	0.9	2.1	9.1	0.8	0.9	0.9	0.9	0.8	1.4	3.0
High blood pressure (mother)	0.9	1.3	6.7	1.3	-2.6	-0.1	-0.1	-0.2	0.7	0.6
Hair/balding pattern: Pattern 2	0.9	1.2	2.6	-1.6	-0.0	-1.2	-1.2	-1.1	-1.1	-0.5
Trunk fat-free mass	0.9	4.9	21.4	-1.1	2.0	-1.1	-1.0	-1.0	-2.2	-4.6
Qualifications: A levels/AS levels or equivalent	0.9	2.1	3.3	-0.6	1.4	-1.8	-1.7	-1.8	-1.4	-1.1
Illnesses of mother	0.9	1.1	2.1	-0.8	1.4	-0.9	-1.0	-0.9	-1.4	-0.8
Blood clot in the leg (DVT)	0.9	1.2	2.4	-0.5	1.6	1.1	1.2	1.1	1.2	0.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.0	-1.4	-0.1	-1.3	-1.1	-1.2	-1.2	0.6
Supplements: Vitamin C	0.9	1.1	3.5	0.6	1.9	0.9	0.9	1.0	1.0	-0.2
Whole body fat-free mass	0.9	5.1	22.5	-1.4	1.6	-1.2	-1.1	-1.0	-2.3	-4.7
Mineral and other dietary supplements	0.9	1.2	1.9	-0.3	-0.5	1.3	1.3	1.4	1.1	1.3
Whole body water mass	0.9	5.2	22.7	-1.5	1.6	-1.2	-1.1	-1.0	-2.4	-4.8
Ever smoked	0.9	1.5	6.0	2.5	-0.7	0.8	0.9	1.0	1.2	-0.3
Basal metabolic rate	0.9	4.7	19.2	-1.8	1.0	-1.3	-1.2	-1.1	-2.3	-4.4
Number of operations (self-reported)	0.9	1.4	1.7	1.3	0.9	1.3	1.3	1.3	0.9	1.1
Commuting to job workplace: Cycle	0.9	1.1	4.1	0.7	2.0	0.3	0.4	0.4	0.6	-1.5
Arm predicted mass (left)	0.9	4.8	17.9	-1.6	1.1	-1.4	-1.4	-1.3	-2.4	-4.2
Bipolar Disorder or Schizophrenia	0.8	1.9	2.9	0.0	-0.1	-1.7	-1.6	-1.6	-1.6	-1.6
Neuroticism (2016)	0.8	1.2	2.2	0.8	-0.8	-1.1	-0.9	-1.1	-1.1	-1.5
Stomach or abdominal pain in last month	0.8	1.0	6.0	-2.5	-0.4	-0.4	-0.3	0.1	-0.6	-0.2
Sitting height	0.8	5.8	29.4	-0.4	0.7	-1.6	-1.4	-1.3	-2.1	-5.4
Worrier / anxious feelings	0.8	1.4	6.0	1.3	-2.5	-1.0	-0.7	-0.8	-0.2	-0.0
Mouth/teeth dental problems: Dentures	0.8	1.3	2.7	1.4	-1.7	1.0	1.0	1.3	1.0	-0.0
Pulse wave Arterial Stiffness index	0.8	0.9	2.0	0.1	-1.4	1.0	1.0	1.1	1.1	0.3
Trunk predicted mass	0.8	4.6	20.4	-1.1	2.0	-1.0	-0.9	-0.8	-2.0	-4.5
Medication: Ventolin 100micrograms inhaler	0.8	1.1	3.6	-0.6	1.9	-0.2	-0.3	-0.5	-1.0	-1.4
Arm fat-free mass (right)	0.8	4.1	18.6	-1.1	1.5	-0.9	-0.8	-0.8	-2.1	-4.3
Comparative body size at age 10	0.8	2.1	8.6	-0.8	-2.9	0.3	0.2	0.2	1.1	2.0
Arm predicted mass (right)	0.8	4.3	18.1	-1.2	1.6	-1.0	-1.0	-1.0	-2.3	-4.2
Leg pain on walking	0.8	1.0	2.0	0.0	-1.0	-1.1	-0.9	-1.1	-1.4	-1.0
Commuting to job workplace: Walk	0.8	0.9	5.2	2.3	0.5	0.4	0.5	0.5	0.2	-0.3
Average weekly champagne plus white wine intake	0.8	1.1	3.7	1.9	0.3	0.6	0.7	0.6	1.1	1.3
Arm fat-free mass (left)	0.8	4.1	16.6	-1.4	1.2	-1.2	-1.2	-1.1	-2.2	-4.1
Age started oral contraceptive pill	0.8	1.0	3.5	0.5	-0.3	0.7	0.7	0.8	1.3	1.9
Bipolar Disorder (2018)	0.7	1.1	1.9	0.0	0.6	-1.2	-1.2	-1.0	-1.4	-1.2
Depressed Affect (Nagel 2018)	0.7	1.4	5.3	1.7	-2.3	0.5	0.5	0.6	0.7	0.6
Crohns Disease (2017)	0.7	1.6	6.4	-0.3	-1.5	0.6	0.6	0.7	1.0	2.5
Fasting Glucose	0.7	0.8	2.8	-0.4	1.7	0.7	0.9	1.0	0.7	0.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.1	-0.7	0.1	0.7	0.6	0.6	1.3	1.5
Average weekly fortified wine intake	0.7	0.8	2.0	1.4	0.3	0.7	0.7	0.7	1.0	0.9
Number of incorrect matches in round	0.7	1.1	3.2	0.5	-1.8	0.8	0.9	0.7	1.4	0.8
Nervous feelings	0.7	1.3	2.4	-0.7	0.2	-1.2	-1.0	-1.2	-1.6	-1.5
Mouth/teeth dental problems	0.7	1.0	3.6	0.6	1.6	0.4	0.4	0.3	0.4	1.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.1	-0.6	1.5	1.1	1.1	1.1	0.5	0.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.2	-1.8	-0.9	-0.3	-0.3	-0.5	-0.4	-1.2
Medication: Paracetamol	0.7	1.2	2.0	-0.0	0.4	-1.3	-1.3	-1.3	-1.4	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.6	-1.0	0.8	0.1	0.2	0.2	0.6	1.9
Medication: Allopurinol	0.7	1.0	3.8	-0.6	-1.9	-0.5	-0.5	-0.7	0.6	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.5	-1.6	0.2	-0.7	-0.7	-0.7	-0.7	-1.2
Osteoporosis (self-reported)	0.7	0.8	1.7	1.2	-0.7	0.5	0.6	0.5	1.1	1.3
Mother’s age at death	0.7	0.9	2.1	1.2	1.4	0.3	0.3	0.5	1.5	-0.5
Medication: Atorvastatin	0.7	0.9	2.7	-1.6	-0.4	0.4	0.3	0.4	0.6	1.6
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.0	-1.4	-0.8	-1.0	-0.9	-0.9	-1.2	0.2
Ovarian Cancer	0.6	0.8	3.5	-0.8	1.9	0.6	0.7	0.4	0.1	-0.9
HbA1C	0.6	0.7	1.3	0.6	-0.9	-1.0	-1.1	-0.8	0.1	0.8
Medication for hormone replacement therapy	0.6	0.7	1.0	0.2	1.0	-0.7	-0.7	-0.9	-1.0	-1.0
Supplements: Zinc	0.6	0.6	2.9	0.7	-1.7	0.4	0.3	0.2	0.7	0.3
Maternal smoking around birth	0.6	0.9	2.7	1.0	-0.7	-0.7	-0.7	-0.7	-0.6	-1.6
Fed-up feelings	0.6	1.2	3.0	1.7	-1.4	-0.5	-0.5	-0.6	-0.7	-1.4
Heart attack	0.6	0.8	1.3	-1.1	-0.8	-0.9	-0.9	-0.9	-1.1	0.1
Pain all over the body in last month	0.6	0.6	1.8	-1.0	1.3	0.7	0.6	0.8	0.3	0.5
Noisy workplace	0.6	0.8	1.6	0.4	-0.1	1.1	1.1	1.2	1.2	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	3.1	-1.0	1.8	0.1	0.1	0.2	-0.3	-0.8
Standing height	0.6	5.9	23.7	-2.0	2.0	-1.5	-1.3	-1.3	-2.1	-4.9
Medication: Amlodipine	0.6	0.8	2.4	-1.3	-0.1	0.7	0.8	0.9	0.2	1.5
Number of full sisters	0.6	0.7	3.3	-1.8	1.2	0.3	0.2	0.3	-0.4	-0.1
Overall health rating	0.6	1.2	2.8	0.4	0.4	1.7	1.5	1.4	0.9	0.7
Age at last live birth	0.6	0.9	1.3	-0.9	0.2	-1.1	-1.1	-1.1	-0.9	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.3	0.5	1.5	-0.2	-0.2	-0.1	-0.4	-1.5
Friendships satisfaction	0.6	0.7	1.7	-0.6	-0.4	-0.8	-0.8	-0.9	-1.3	-0.7
Alzheimer’s Disease (in mother)	0.5	0.6	1.1	0.2	-1.1	-0.9	-0.9	-0.8	-0.8	-0.7
Lupus	0.5	0.8	5.1	0.2	-2.3	0.3	0.3	0.1	0.2	-0.5
Schizophrenia (2014)	0.5	1.0	1.8	0.0	-0.4	-1.3	-1.3	-1.3	-1.1	-0.8
Triglycerides	0.5	0.8	4.2	0.0	-0.9	-0.1	-0.4	-0.3	-0.2	2.1
Allergy or Eczema	0.5	1.3	2.6	-1.1	1.6	-1.1	-1.0	-1.1	-0.9	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.1	-1.0	-0.6	-1.4	-1.3	-1.2	-1.2	-0.2
Qualifications: CSEs or equivalent	0.5	0.7	1.5	-1.2	-0.7	-0.6	-0.6	-0.8	-1.1	-0.4
Medication: Levothyroxine sodium	0.5	0.8	1.2	0.0	1.0	1.1	1.0	1.0	0.6	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.1	-0.8	-1.4	-1.4	-1.4	-1.0	-0.8	-0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	1.1	0.0	-0.7	-0.8	-0.8	-0.8	-0.7
Weight	0.5	2.5	6.9	-1.7	-0.5	-1.3	-1.3	-1.1	-1.7	-2.6
Medication: Cholesterol lowering	0.5	0.8	2.4	0.6	-1.4	-0.4	-0.6	-0.6	-0.2	1.5
Exposure to tobacco smoke at home	0.5	0.5	0.9	0.6	-0.2	0.9	0.8	1.0	0.8	0.6
Tense / ‘highly strung’	0.5	0.9	1.8	-0.1	-0.4	-1.1	-1.0	-0.8	-1.2	-1.3
Birth weight of first child	0.5	0.8	1.6	-1.3	-0.6	-0.8	-0.7	-0.9	-1.2	-0.7
Ever highly irritable/argumentative for 2 days	0.5	0.5	1.9	-0.6	-0.9	0.4	0.5	0.4	0.4	1.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	3.0	-0.6	1.6	-0.1	0.0	-0.0	-0.1	-1.7
Number of children fathered	0.5	0.5	1.4	0.4	1.2	0.7	0.7	0.7	0.7	0.5
Health satisfaction	0.5	0.6	3.4	-0.1	1.9	0.4	0.4	0.3	-0.4	-0.6
Medication: Ibuprofen	0.5	0.6	1.9	-0.3	1.4	0.8	0.9	0.8	0.3	0.3
Mean time to correctly identify matches	0.5	1.0	3.7	1.9	0.5	0.7	0.8	0.7	1.0	-0.2
Illnesses of father: Heart disease	0.5	0.7	1.8	-0.9	-1.3	-0.5	-0.6	-0.4	0.4	1.2
Illnesses of siblings: Diabetes	0.5	0.6	2.0	0.1	-1.4	0.5	0.2	0.1	-0.3	-1.2
Medication for cholesterol	0.5	0.8	1.5	1.2	-1.0	-0.7	-0.8	-0.9	-0.6	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.1	-0.1	-0.5	-1.0	-1.0	-0.9	-0.9	-0.5
Back pain experienced in last month	0.5	0.7	3.1	-1.8	-0.1	-0.6	-0.6	-0.6	-1.0	-0.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.3	-0.6	-1.1	-0.7	-0.7	-0.6	0.5	0.9
Medication: Paracetamol	0.5	0.8	2.3	0.5	1.5	-0.8	-0.8	-0.8	-0.8	-0.4
Leg fat mass (left)	0.5	1.8	4.0	-2.0	-1.4	-1.1	-1.2	-1.0	-1.3	-1.2
Intelligence (Savage-Jansen 2018)	0.4	1.2	6.0	-2.4	1.4	-0.2	0.0	-0.3	-0.5	0.2
Neuroticism (Nagel 2018)	0.4	0.9	3.3	1.4	-1.8	-0.7	-0.6	-0.5	-0.2	-0.2
Schizophrenia (2018)	0.4	0.9	1.7	0.0	-0.6	-1.2	-1.1	-1.3	-0.9	-1.1
Reaction Time	0.4	0.8	2.0	1.4	0.4	0.9	0.9	0.8	1.1	-0.2
LDL Cholesterol	0.4	0.6	2.3	0.1	-1.3	0.0	-0.1	-0.1	-0.1	1.5
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.1	0.0	-0.6	0.5	0.4	0.5	0.8	1.1
Blood Eosinophil Count	0.4	2.8	6.7	-0.6	1.4	-1.5	-1.4	-1.6	-1.9	-2.6
Height	0.4	7.9	45.4	-1.0	1.8	-1.3	-1.0	-0.8	-1.4	-6.7
Neuroticism	0.4	1.0	3.2	1.8	-1.2	0.6	0.6	0.7	1.0	0.6
Relative age of first facial hair	0.4	0.8	1.7	-0.4	-0.5	-1.0	-0.9	-1.3	-1.2	-0.0
Diabetes (mother)	0.4	0.5	0.7	0.7	-0.4	0.9	0.8	0.5	0.7	-0.7
Impedance of leg (right)	0.4	1.8	8.4	-0.3	-1.0	0.5	0.4	0.4	1.7	2.9
Relative age voice broke	0.4	0.5	1.7	0.8	1.3	0.0	0.1	-0.4	-0.2	1.2
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.1	-0.7	0.8	-1.0	-0.9	-1.0	-0.9	-1.1
Impedance of leg (left)	0.4	1.7	8.8	-1.1	-0.8	0.3	0.2	0.2	1.1	3.0
Financial difficulties in last 2 years	0.4	0.5	1.6	0.9	-1.2	0.0	-0.2	-0.0	0.2	-1.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.4	-0.7	0.2	-0.6	-0.7	-0.7	-1.2	-0.0
Impedance of arm (right)	0.4	1.7	5.2	-1.6	-1.6	0.1	0.2	0.1	1.2	2.3
Falls in the last year	0.4	0.5	2.5	0.1	0.7	0.5	0.4	0.6	-0.2	-1.6
Impedance of arm (left)	0.4	2.0	6.8	-0.8	-1.4	0.9	0.9	0.8	1.6	2.6
Length of working week for main job	0.4	0.4	1.3	0.1	0.4	-0.6	-0.6	-0.5	-0.6	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	3.5	0.3	-0.0	0.1	0.0	-0.2	-0.5	-1.9
Birth weight	0.4	0.8	1.9	-0.6	0.1	-0.9	-0.8	-0.7	-1.0	-1.4
Neck or shoulder pain in last month	0.4	0.5	1.3	0.4	-1.1	0.9	0.8	0.7	-0.1	-0.6
Leg fat mass (right)	0.4	1.4	2.6	-1.6	-1.6	-0.9	-1.0	-0.8	-0.9	-1.2
Suffer from ‘nerves’	0.4	0.6	1.0	0.2	0.1	-1.0	-0.8	-1.0	-1.0	-0.8
Mood swings	0.4	0.7	3.3	1.8	-0.6	0.6	0.6	0.4	0.3	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.3	-0.8	0.9	-0.2	-0.3	-0.3	-0.3	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.5	-1.2	0.4	-0.8	-0.8	-0.8	-0.9	-0.8
Financial situation satisfaction	0.4	0.5	1.4	1.2	0.1	0.7	0.6	0.6	0.8	-0.3
Leg fat percentage (left)	0.4	1.3	4.8	-1.4	-2.2	-0.7	-0.9	-0.7	-0.6	0.4
Unable to work because of sickness or disability	0.4	0.5	1.3	-0.6	0.0	-0.8	-0.8	-0.7	-1.1	-0.6
Pain experienced in last month	0.4	0.7	1.3	0.3	-1.1	-1.1	-1.0	-0.9	-0.5	0.6
Impedance of whole body	0.4	1.8	7.9	-1.0	-1.3	0.4	0.4	0.4	1.4	2.8
Schizophrenia vs Biploar Disorder	0.3	0.4	1.8	0.0	-1.3	0.4	0.5	0.4	0.6	0.5
Worry (Nagel 2018)	0.3	0.6	1.3	1.1	-1.1	-0.7	-0.6	-0.7	-0.6	-0.1
Prostate Cancer	0.3	0.4	1.3	0.1	1.1	-0.4	-0.4	-0.2	-0.1	-1.0
Blood Platelet Count	0.3	3.8	15.8	-1.7	-0.2	-1.5	-1.5	-1.5	-0.8	4.0
Smoking Status	0.3	0.7	1.2	0.8	0.5	0.9	0.9	0.9	1.1	0.0
Chronotype (morning person)	0.3	0.8	1.4	0.3	0.8	-1.2	-1.0	-0.8	-0.8	-1.1
Hand grip strength (left)	0.3	0.7	2.4	-1.6	0.9	-0.5	-0.5	-0.4	-0.7	-0.9
Average weekly spirits intake	0.3	0.3	0.6	-0.8	-0.6	-0.5	-0.5	-0.6	-0.4	-0.4
Medication: Metformin	0.3	0.4	1.0	-0.1	-0.8	0.3	0.3	0.7	0.5	1.0
Trunk fat percentage	0.3	1.4	5.8	-1.7	-2.4	-0.1	-0.2	-0.0	0.1	1.0
Hand grip strength (right)	0.3	0.7	3.3	-1.8	1.0	0.3	0.4	0.4	0.1	-0.6
Medication: Atenolol	0.3	0.4	1.5	1.2	-0.4	0.5	0.4	0.2	-0.2	0.7
Chronic bronchitis/emphysema (father)	0.3	0.3	1.4	1.2	0.4	-0.3	-0.3	-0.3	-0.2	-0.8
Trunk fat mass	0.3	1.1	3.6	-1.9	-1.6	-0.6	-0.6	-0.5	-0.7	-0.7
Qualifications: None of the above	0.3	0.7	0.9	0.8	-0.9	0.9	0.9	0.8	0.7	0.9
Diabetes (self-reported)	0.3	0.4	1.3	-0.1	-0.9	-0.5	-0.6	-0.5	-1.1	-0.3
Arm fat percentage (right)	0.3	1.3	5.0	-1.8	-2.2	-0.4	-0.5	-0.3	-0.1	0.6
Father’s age at death	0.3	0.4	2.5	1.6	0.1	0.2	0.2	-0.1	0.4	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.9	-1.4	0.3	0.2	0.2	0.2	-0.7	-1.0
Pulse rate	0.3	0.5	2.2	-0.1	1.5	0.4	0.5	0.6	0.4	-0.6
Arm fat mass (right)	0.3	1.4	4.1	-2.0	-1.5	-0.8	-0.9	-0.7	-1.0	-0.7
Hair/balding pattern: Pattern 4	0.3	0.6	1.4	0.4	-1.0	0.5	0.5	0.6	0.9	1.2
Body fat percentage	0.3	1.2	5.4	-1.6	-2.3	-0.3	-0.4	-0.2	-0.0	0.8
Leg fat percentage (right)	0.3	1.0	5.0	-0.9	-2.2	-0.5	-0.6	-0.5	-0.0	0.4
Exposure to tobacco smoke outside home	0.3	0.4	2.1	0.2	-1.4	-0.3	-0.4	-0.3	-0.4	-0.7
Eye problems/disorders: None of the above	0.3	0.3	1.2	-0.3	-1.1	0.4	0.5	0.3	0.1	0.7
Whole body fat mass	0.3	1.4	4.4	-2.1	-1.6	-0.7	-0.8	-0.6	-0.9	-0.8
Comparative height size at age 10	0.3	1.7	9.4	-1.1	0.6	-0.4	-0.3	-0.2	-0.9	-3.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.6	-1.0	-1.3	-0.2	-0.3	-0.1	-0.1	0.2
Medication: Aspirin	0.3	0.4	0.8	0.5	-0.1	0.8	0.8	0.9	0.1	0.7
Knee pain experienced in last month	0.3	0.4	1.7	1.3	0.4	0.4	0.4	0.4	0.6	-0.4
Arm fat percentage (left)	0.3	1.0	4.6	-1.4	-2.1	-0.3	-0.4	-0.2	-0.2	0.5
Eye problems/disorders: Cataract	0.3	0.4	0.8	0.9	0.2	-0.6	-0.7	-0.5	-0.2	-0.8
Arm fat mass (left)	0.3	1.2	3.3	-1.8	-1.4	-0.8	-0.8	-0.6	-1.0	-1.0
Miserableness	0.3	0.6	3.0	0.9	-1.7	-0.1	-0.2	-0.3	0.0	0.2
Medication: Blood pressure	0.3	0.6	1.2	0.1	0.0	0.7	0.8	0.8	1.1	1.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	-0.6	0.3	0.8	0.8	0.8	0.3	-0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.0	1.0	0.5	-0.5	-0.4	-0.6	-0.3	-0.6
Medication: Lisinopril	0.3	0.3	0.9	-0.9	-0.3	-0.6	-0.6	-0.4	-0.2	-0.6
Myopia	0.3	0.4	1.1	-1.0	0.6	0.5	0.5	0.4	0.8	0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	-0.4	0.5	-0.5	-0.6	-0.7	-0.7	-0.9
Heart disease (siblings)	0.3	0.4	1.4	0.9	-1.2	-0.1	-0.2	0.1	0.6	0.6
Number of treatments/medications taken	0.2	0.3	1.5	0.1	1.2	-0.0	-0.0	-0.2	-0.7	-0.2
Vitamin and mineral supplements	0.2	0.2	0.4	-0.5	-0.6	-0.4	-0.4	-0.4	-0.6	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	1.0	-1.0	-0.2	-0.2	-0.3	-0.0	-0.4	-0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.3	0.1	0.6	0.6	0.6	-0.1	0.3
Body mass index (BMI)	0.2	0.8	2.0	-1.0	-1.4	-0.7	-0.8	-0.6	-0.9	-0.4
Alcohol usually taken with meals	0.2	0.4	1.2	1.1	1.1	-0.2	-0.2	-0.1	0.3	0.3
Neuroticism score	0.2	0.4	1.4	1.2	-0.7	-0.3	-0.2	-0.2	-0.1	-0.6
Hair/balding pattern: Pattern 3	0.2	0.3	1.3	-0.1	-1.1	-0.5	-0.5	-0.5	-0.6	-0.3
Number of live births	0.2	0.3	0.6	0.4	-0.1	0.7	0.6	0.4	0.8	0.1
Worry too long after embarrassment	0.2	0.3	1.1	1.0	0.2	-0.6	-0.4	-0.5	-0.2	-0.2
Age at first live birth	0.2	0.4	1.2	-0.2	1.1	-0.8	-0.7	-0.6	-0.3	0.0
Shortness of breath walking on level ground	0.2	0.2	0.3	-0.4	-0.6	-0.4	-0.4	-0.5	-0.4	-0.2
Medication: Blood pressure	0.2	0.3	0.9	0.4	-1.0	-0.4	-0.5	-0.5	-0.8	0.1
Pulse rate, automated reading	0.2	0.8	2.9	-1.7	-1.4	0.3	0.4	0.5	0.1	0.1
Chest pain or discomfort	0.2	0.3	1.3	-1.0	0.1	0.2	0.2	0.0	-1.2	-0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	-0.1	-0.4	0.4	0.3	0.4	0.5	0.8
Average weekly red wine intake	0.2	0.2	0.8	0.7	0.6	0.2	0.2	0.3	0.9	-0.0
Long-standing illness, disability or infirmity	0.2	0.3	1.0	1.0	0.6	-0.1	-0.3	-0.4	-0.7	-0.6
Qualifications: nursing, teaching	0.2	0.4	1.6	0.3	1.2	-0.6	-0.6	-0.4	0.0	-0.2
Breast cancer (self-reported)	0.2	0.2	0.8	0.4	-0.9	-0.2	-0.2	0.0	0.5	0.5
Irritability	0.2	0.3	0.7	-0.5	-0.3	0.3	0.3	0.5	0.8	0.8
Risk taking	0.2	0.2	1.4	-1.2	-0.3	0.1	0.2	0.3	0.0	0.0
Fractured/broken bones in last 5 years	0.2	0.2	0.7	-0.8	-0.2	0.1	0.2	0.3	0.4	-0.6
Age at First Birth	0.1	0.2	0.6	0.7	0.4	0.2	0.4	0.2	-0.0	-0.3
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.3	0.1	-0.2	-0.4	-0.5	-0.4	0.2
Blood White Count	0.1	0.6	3.0	-0.4	-0.7	0.0	-0.1	0.3	0.6	1.7
Heel T-Score	0.1	0.5	2.2	0.5	-1.5	-0.1	-0.1	0.4	0.9	-0.2
BMI	0.1	0.7	3.1	-1.8	1.0	-0.4	-0.5	-0.3	-0.7	-0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.6	-0.5	-0.8	0.4	0.3	0.5	0.1	0.7
Lung FEV1/FVC ratio	0.1	0.7	3.5	-0.9	-0.3	-0.2	-0.2	-0.3	0.2	1.9
Hair Pigment	0.1	2.0	3.5	1.2	-1.9	1.1	1.1	1.3	1.4	1.8
Tanning	0.1	1.2	2.3	0.3	0.6	1.2	1.3	1.5	1.2	0.9
Sensitivity / hurt feelings	0.1	0.1	0.3	0.3	-0.3	-0.4	-0.3	-0.4	-0.2	-0.5
Diabetes (father)	0.1	0.2	0.6	-0.3	0.3	0.4	0.3	0.4	0.8	-0.2
Taking other prescription medications	0.1	0.2	0.6	0.8	-0.0	0.2	0.1	-0.0	-0.3	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.7	-0.8	0.3	-0.1	-0.2	-0.1	-0.2	-0.3
Waist circumference	0.1	0.4	1.5	-0.5	-1.2	0.4	0.4	0.5	0.5	0.1
Hip circumference	0.1	0.6	2.2	-0.8	-0.2	-0.5	-0.5	-0.4	-0.8	-1.5
Pulse wave reflection index	0.1	0.1	0.4	-0.2	-0.6	0.0	0.0	0.1	-0.1	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	0.5	0.2	0.5	0.6	0.5	-0.2	0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	1.1	-0.1	-1.0	-0.3	-0.3	-0.3	0.2	0.1
Ever had bowel cancer screening	0.1	0.1	0.6	-0.1	0.3	-0.2	-0.2	0.1	0.3	0.8
Diabetes diagnosed by doctor	0.1	0.1	0.1	-0.3	-0.3	0.3	0.3	0.3	-0.2	0.3
Medication: Aspirin	0.1	0.1	0.3	0.3	-0.4	0.3	0.4	0.5	-0.3	-0.0
Medication: Gliclazide	0.1	0.1	0.4	-0.4	-0.3	0.1	-0.1	0.1	0.3	0.6
Medication: Bendroflumethiazide	0.1	0.2	0.5	-0.7	0.7	-0.0	0.1	0.1	-0.3	0.7
Alcohol drinker status: Never	0.1	0.1	0.3	0.5	0.3	0.2	0.2	0.0	-0.2	0.2
Average weekly beer plus cider intake	0.1	0.2	0.6	0.6	0.0	0.3	0.3	0.2	-0.4	-0.8
Diastolic blood pressure, automated reading	0.1	0.2	1.3	-0.5	-1.1	-0.0	-0.1	0.0	-0.4	-0.2
Ever depressed for a whole week	0.1	0.1	0.7	0.1	0.1	0.1	-0.0	-0.1	-0.2	-0.8
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.2	0.6	0.8	-0.3	0.4	0.5	0.5	0.5	0.2
Current tobacco smoking	0.0	0.0	0.1	-0.2	0.3	-0.1	-0.1	-0.1	0.1	-0.2
Smoking status: Current	0.0	0.1	0.2	0.1	0.4	0.1	0.1	0.1	0.5	-0.0

Hub : Genes

DOK7

Models

Trait associations