Best TWAS P=9.48e-09 · Best GWAS P=2.76e-07 conditioned to 0.831
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PCDHA2 | 0.04 | 0.03 | blup | 478 | 0.03 | 5.0e-05 | -5.0 | -5.2 | 2.4e-07 | 0.86 | 0.04 | 0.95 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | ZMAT2 | 0.06 | 0.10 | blup | 360 | 0.09 | 1.4e-11 | -5.1 | -5.7 | 9.5e-09 | 0.88 | 0.03 | 0.97 | TRUE |
| 3 | GTEx | Brain Hypothalamus | HARS | 0.14 | -0.01 | enet | 15 | -0.01 | 6.3e-01 | 4.7 | 5.1 | 2.9e-07 | -0.72 | 0.06 | 0.35 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | PCDHB3 | 0.12 | 0.00 | enet | 22 | 0.04 | 2.4e-03 | 1.6 | -5.3 | 1.0e-07 | 0.29 | 0.17 | 0.19 | FALSE |
| 5 | GTEx | Heart Left Ventricle | PCDHB5 | 0.11 | 0.05 | lasso | 3 | 0.06 | 5.3e-04 | 4.4 | 5.6 | 1.8e-08 | -0.72 | 0.11 | 0.58 | FALSE |
| 6 | GTEx | Nerve Tibial | HARS | 0.07 | 0.01 | enet | 16 | 0.04 | 1.1e-03 | -4.8 | 5.3 | 1.5e-07 | -0.85 | 0.05 | 0.92 | FALSE |
| 7 | METSIM | Adipose | DND1 | 0.08 | 0.11 | lasso | 5 | 0.10 | 7.3e-15 | -4.9 | 5.2 | 1.9e-07 | -0.94 | 0.05 | 0.95 | FALSE |
| 8 | YFS | Blood | WDR55 | 0.15 | 0.21 | bslmm | 337 | 0.21 | 8.6e-67 | -5.1 | -5.2 | 2.4e-07 | 1.00 | 0.02 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | NDUFA2 | 0.03 | 0.02 | blup | 42 | 0.04 | 1.1e-03 | 4.6 | 5.2 | 1.8e-07 | -0.94 | 0.02 | 0.72 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZMAT2 | 0.03 | 0.03 | enet | 6 | 0.04 | 1.3e-04 | -5.0 | -5.3 | 1.1e-07 | 0.92 | 0.02 | 0.90 | FALSE |
| 11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | WDR55 | 0.04 | 0.01 | blup | 45 | 0.03 | 3.7e-03 | 4.7 | -5.2 | 2.0e-07 | 0.93 | 0.02 | 0.66 | FALSE |