Hub : Genes

PCDHB3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2560	0.0470	0.0e+00	0.192	0.178	0.195	0.207	0.190	7.5e-23	3.4e-21	3.4e-23	1e-24	1.4e-22
2	GTEx	Artery Aorta	0.0950	0.0420	8.5e-03	0.006	NA	0.015	NA	0.013	1.5e-01	NA	4.7e-02	NA	6.1e-02
3	GTEx	Artery Coronary	0.2390	0.1040	9.7e-03	0.096	NA	0.041	NA	0.046	4.1e-04	NA	1.6e-02	NA	1.2e-02
4	GTEx	Artery Tibial	0.0884	0.0401	9.2e-03	0.022	NA	0.012	NA	0.022	6.8e-03	NA	3.7e-02	NA	7.4e-03
5	GTEx	Breast Mammary Tissue	0.1190	0.0510	1.3e-03	0.003	NA	0.045	NA	0.008	2.3e-01	NA	2.4e-03	NA	1.2e-01
6	GTEx	Breast Mammary Tissue (Male)	0.1357	0.0693	2.0e-02	-0.011	NA	-0.013	NA	-0.013	6.8e-01	NA	9.0e-01	NA	9.6e-01
7	GTEx	Testis	0.3910	0.0900	1.4e-06	0.235	NA	0.165	NA	0.195	8.8e-11	NA	8.8e-08	NA	4.6e-09
8	GTEx	Thyroid	0.0950	0.0400	5.4e-03	-0.002	NA	0.018	NA	0.000	5.7e-01	NA	1.4e-02	NA	3.1e-01
9	TCGA	Esophageal Carcinoma	0.1470	0.0690	4.7e-03	0.051	0.022	-0.009	NA	0.006	1.0e-02	6.6e-02	8.1e-01	NA	2.0e-01
10	TCGA	Prostate Adenocarcinoma	0.0295	0.0175	8.6e-03	-0.002	0.010	0.003	NA	0.010	5.3e-01	2.9e-02	1.4e-01	NA	2.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.7	1.1	3.7	-0.6	0.4	-0.4	-0.5	1.9	1.6	0.3	0.7	-0.5	-1.8
Bipolar Disorder or Schizophrenia	1.5	3.6	16.6	-2.3	-1.3	-1.7	-1.9	1.3	-0.4	1.7	0.8	-0.6	-4.1
Depressed Affect (Nagel 2018)	1.9	4.0	7.5	2.5	2.4	2.7	2.2	-0.7	0.1	-2.1	0.6	1.7	2.7
Depression (Nagel 2018)	1.3	2.0	7.2	1.4	1.3	1.4	0.8	-0.4	0.0	-1.0	1.2	2.0	2.7
Intelligence (Savage-Jansen 2018)	1.2	3.6	8.6	2.0	2.6	1.6	2.0	-0.4	2.0	-1.6	1.7	0.7	2.9
Neuroticism (Nagel 2018)	0.5	1.2	2.4	1.6	0.3	1.2	0.8	-1.2	-0.5	-1.6	-0.7	0.8	1.4
Schizophrenia (2018)	1.9	3.9	14.6	-2.5	-1.9	-1.8	-2.1	0.5	-1.8	1.9	0.5	-0.4	-3.8
Schizophrenia vs Biploar Disorder	0.9	1.2	5.9	0.4	-0.2	-0.8	-1.1	-1.9	-2.4	0.1	0.4	0.2	-0.7
Worry (Nagel 2018)	0.3	0.5	1.2	0.8	0.0	1.1	0.9	-0.6	-0.4	-1.1	-0.8	0.5	-0.2
Alzheimer’s Disease (in mother)	0.4	0.5	2.2	-0.3	-1.0	0.2	0.0	0.5	0.3	0.1	-0.7	-1.5	-0.8
Alzheimer’s Disease (in father)	0.9	1.0	2.5	1.4	1.2	1.2	1.6	-0.7	-0.1	-1.2	-0.6	-0.3	-0.7
Alzheimer’s Disease (including proxy)	0.6	0.9	3.8	0.1	-0.5	0.7	0.8	0.3	-0.1	-0.3	-1.1	-1.4	-1.9
Crohns Disease (2017)	0.8	1.8	7.0	1.6	-0.1	0.1	-0.2	-2.6	-1.9	-1.1	0.8	0.2	1.8
Irritable Bowel Disease (IBD)	1.0	2.3	9.1	1.6	-0.5	0.5	0.1	-2.6	-3.0	-1.3	0.3	0.3	1.4
Ulcerative Colitis (UC)	0.6	1.2	5.6	1.1	-0.2	0.8	0.5	-1.6	-2.4	-1.1	-0.2	-0.1	0.3
Major Depression (MDD)	2.0	2.5	5.1	2.3	1.6	1.2	0.6	0.5	0.6	-2.3	1.9	2.2	1.0
Reaction Time	0.4	0.8	3.2	-0.5	-0.8	-1.2	-1.3	0.1	0.2	0.2	0.2	1.1	1.8
Verbal and Numeric Reasoning (VNR)	0.4	1.0	5.0	0.7	0.7	0.8	1.1	-1.2	-0.2	-0.4	0.4	-0.3	2.2
Breast Cancer	0.3	0.7	2.2	-0.8	1.0	-0.0	0.3	1.0	1.4	1.5	-0.2	-0.3	0.4
Ovarian Cancer	0.4	0.5	1.7	0.8	0.2	-0.1	-0.0	-1.3	-0.7	-0.4	-0.3	0.3	1.3
Prostate Cancer	0.3	0.5	1.5	0.2	-0.4	-0.7	-0.7	0.1	0.4	-0.7	-1.0	-1.2	0.3
Age at First Birth	2.3	3.3	10.0	2.5	3.2	1.9	1.8	0.2	1.2	-2.4	0.6	-1.1	-1.4
Bipolar Disorder (2011)	1.3	1.3	3.4	-1.9	-1.2	-1.6	-1.6	0.9	0.9	1.2	0.4	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	0.7	-0.4	-0.9	-0.1	-0.3	-0.4	-0.3	0.1	-0.1	-0.5	-0.3
Coronary Artery Disease (CAD)	0.5	0.7	2.0	-1.1	-1.4	-1.0	-0.7	-0.1	-0.5	1.1	0.1	0.6	-0.0
Crohns Disease (2012)	1.0	1.6	4.2	1.5	0.7	0.8	0.5	-1.9	-2.0	-1.7	0.8	0.5	0.8
Mean Putamen Volume	0.4	0.5	1.5	-0.2	-0.4	-1.2	-1.2	-0.4	0.6	0.1	0.7	-0.7	0.0
Fasting Glucose	0.9	1.1	3.8	0.0	-0.8	-0.9	-0.9	-1.5	-1.4	-0.1	-2.0	0.6	-0.7
HbA1C	0.9	1.0	2.9	-1.3	-1.7	-0.6	-0.5	-0.1	-0.5	1.1	-1.2	-1.2	-0.7
HDL Cholesterol	0.5	0.9	1.8	-1.3	-0.6	0.4	1.0	1.3	1.0	1.3	-0.3	-1.0	-0.1
LDL Cholesterol	0.9	1.5	3.8	-1.4	-1.9	-1.6	-1.7	-0.2	-1.1	1.0	-0.0	-0.4	-1.0
Lupus	0.6	1.0	2.9	0.9	1.6	1.1	0.9	0.9	1.7	-0.7	-0.0	0.2	0.5
Neuroticism (2016)	0.6	0.9	4.4	0.7	-0.3	-0.4	-0.7	-0.6	-0.5	-1.1	-0.2	1.3	2.1
Primary Biliary Cirrhosis	1.1	1.5	6.0	0.9	0.3	0.2	0.2	-1.9	-1.6	-0.4	-0.3	2.5	1.2
Rheumatoid Arthritis	0.5	0.7	2.4	-0.3	0.8	-1.5	-1.1	0.1	1.6	0.3	-0.4	-0.4	0.3
Schizophrenia (2014)	0.7	1.7	6.5	-1.4	-0.8	-1.3	-1.3	0.1	-1.5	1.2	-0.4	0.4	-2.5
Triglycerides	0.3	0.5	2.0	-0.9	-0.4	-0.6	-1.1	0.4	-0.6	-0.0	1.4	0.6	0.0
Type 2 Diabetes (T2D) (2012)	2.5	2.9	6.0	2.0	1.6	2.3	2.5	-1.5	-0.9	-1.5	0.9	1.9	1.5
Ulcerative Colitis	0.5	0.7	4.6	0.2	-0.7	-0.2	-0.6	-0.8	-2.1	-0.2	0.3	0.4	0.3
Blood Eosinophil Count	0.2	1.4	4.8	-1.6	-1.5	-1.2	-2.2	0.8	0.6	1.3	-0.0	-0.3	0.2
Blood Platelet Count	0.3	3.0	12.2	-1.5	-0.5	-0.9	-0.7	3.5	2.5	1.4	1.4	-1.9	-0.2
Blood Red Count	0.1	1.2	3.0	-0.8	-1.4	-0.3	-0.8	1.7	0.5	0.0	1.7	-1.5	-0.9
Blood White Count	1.9	13.8	36.6	-6.0	-5.5	-3.4	-4.6	2.0	-0.8	5.5	1.2	-0.5	-1.5
Heel T-Score	0.4	3.0	6.6	2.0	1.5	2.6	2.3	-1.6	-1.1	-1.8	-1.4	0.7	-1.4
BMI	0.5	3.2	9.2	-0.9	-2.5	-1.5	-2.4	-1.0	-1.7	1.2	0.7	1.2	3.0
Height	0.4	8.1	43.2	2.6	0.9	0.5	1.2	-4.9	-0.3	-1.1	-6.6	-1.2	1.3
Waist Hip Ratio (WHR)	0.8	3.8	11.9	-0.4	-2.1	-0.6	-0.2	-3.4	-3.0	-0.5	-3.5	0.1	-0.9
Systolic Blood Pressure	1.5	7.6	25.6	-3.9	-2.4	-2.1	-2.2	2.7	-0.2	3.1	1.0	-1.5	-5.1
Smoking Status	0.5	1.3	3.5	-0.7	-1.9	-0.4	-0.9	-0.7	-1.1	0.3	-1.0	1.7	1.6
Allergy or Eczema	1.5	4.0	14.4	3.8	3.1	1.8	1.5	-1.9	1.1	-2.4	-0.4	-0.5	0.4
Cardiovascular Disease	0.6	1.8	3.7	-1.8	-1.9	-0.1	-0.5	1.6	-0.3	1.9	1.8	-0.1	-1.3
Hypothyroidism (self reported)	0.7	1.6	5.1	-2.3	-1.8	-1.3	-1.1	0.0	-0.7	1.8	-0.0	1.1	0.1
Respiratory disease	0.6	1.4	6.8	0.2	0.2	0.9	0.1	-1.6	-1.4	0.4	-0.0	1.4	2.6
Type 2 Diabetes (T2D) (2018)	2.3	4.3	9.6	-2.9	-1.8	-3.1	-3.0	1.3	1.8	2.6	0.4	-0.6	-0.3
Lung FEV1/FVC ratio	0.7	3.4	14.7	1.2	-1.4	-0.1	0.5	-3.8	-2.3	-1.3	-2.4	1.5	1.1
Lung FVC	0.7	3.7	13.9	2.1	-0.7	1.3	1.4	-2.2	-1.2	-2.6	-0.4	1.2	3.7
Neuroticism	1.4	3.4	7.6	2.4	0.5	1.6	1.2	-1.8	-0.7	-2.3	-1.3	2.2	2.8
Chronotype (morning person)	1.4	3.2	8.5	1.5	0.7	1.9	2.1	-1.8	-1.8	-2.0	0.7	2.9	1.7
Hair Pigment	0.1	2.7	9.9	-0.5	0.0	-1.4	-1.7	2.0	1.1	-0.0	3.1	-0.9	-2.3
Tanning	0.1	1.7	4.5	1.6	1.8	1.6	2.1	-0.1	0.2	-1.0	-1.0	-1.6	0.3
Hand grip strength (left)	0.1	0.3	1.1	0.3	0.2	0.4	0.5	-0.3	0.4	-0.2	-0.1	-0.7	-1.1
Number of treatments/medications taken	0.9	1.7	5.7	-1.6	0.0	0.3	-0.1	2.4	1.6	1.8	1.6	-0.5	-0.1
Average weekly spirits intake	2.0	2.5	6.9	-1.2	-1.3	-1.5	-1.4	-1.6	-0.2	1.3	-2.6	1.7	1.9
Sensitivity / hurt feelings	0.2	0.3	1.3	0.7	-0.4	0.4	0.2	-0.3	-0.8	-0.3	-1.1	-0.0	0.6
Frequency of depressed mood in last 2 weeks	3.3	4.7	11.5	3.4	2.1	2.9	2.2	-1.3	-0.8	-3.0	0.9	1.4	1.8
Hearing difficulty/problems: Yes	0.9	1.3	4.4	0.9	-0.2	-0.0	0.0	-2.1	-0.7	-0.8	-2.1	0.8	1.4
Relative age of first facial hair	0.2	0.5	2.2	0.7	0.6	0.4	0.5	-1.5	-0.7	-0.4	0.1	-0.9	-0.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.5	-0.1	0.6	0.1	-0.1	-0.1	0.2	0.3	1.6	-0.0	1.3
Ever used hormone-replacement therapy (HRT)	1.7	2.1	6.3	1.5	1.5	2.5	2.3	-0.7	0.5	-1.8	-0.5	0.5	0.9
Ever had hysterectomy (womb removed)	0.4	0.5	2.2	0.5	1.5	0.0	-0.2	0.0	1.1	0.0	0.4	0.5	0.8
Systolic blood pressure, automated reading	0.9	2.5	5.6	-2.4	-2.1	-1.4	-1.6	1.6	-0.2	1.7	-0.1	-1.1	-1.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.1	-0.9	-0.3	-1.5	-1.3	-0.0	1.3	1.0	-0.8	-0.5	0.5
Angina	0.8	1.0	2.3	-1.5	-0.9	-1.1	-1.4	0.4	0.1	1.5	0.5	-1.1	0.4
Medication for hormone replacement therapy	0.5	0.5	2.7	-0.7	0.6	0.1	0.3	0.1	1.6	0.9	0.0	-0.8	-0.3
Vitamin and mineral supplements	0.6	0.9	5.5	-0.5	0.6	0.2	0.2	1.3	2.3	0.3	0.8	0.3	-0.6
Supplements: Zinc	3.6	4.0	8.8	3.0	1.5	2.1	2.3	-1.8	-1.0	-2.8	-1.2	1.8	1.5
Medication: Co-codamol	0.8	1.0	3.8	0.9	-0.7	-0.2	-0.4	-1.6	-2.0	-0.8	0.1	0.8	0.8
Medication: Metformin	2.1	2.9	4.5	-2.1	-1.6	-1.8	-1.9	1.7	1.7	2.0	0.4	-2.0	-0.8
Diabetes (father)	1.0	1.2	3.1	-1.8	-0.5	-0.8	-0.8	1.4	0.5	1.8	1.4	0.1	0.1
Diabetes (mother)	0.2	0.3	0.8	0.5	-0.1	-0.5	-0.6	-0.2	0.9	-0.5	0.8	0.4	0.0
Severe depression (siblings)	0.8	0.9	2.5	0.8	1.6	0.6	0.3	1.5	1.4	-0.4	1.1	0.1	-0.4
Pack years adult smoking proportion	1.6	2.4	5.7	-2.4	-1.8	-2.4	-2.2	0.6	0.6	1.8	-0.1	0.1	0.6
Impedance of leg (right)	0.6	2.8	11.8	-0.4	1.1	0.2	0.4	1.3	2.6	0.5	0.4	-2.5	-3.4
Leg fat-free mass (left)	0.8	4.5	13.0	0.6	-1.6	-1.1	-1.2	-3.6	-2.7	0.4	-2.3	1.6	3.4
Trunk fat percentage	0.8	3.1	9.0	-1.8	-1.5	-2.6	-3.0	-0.3	1.3	2.4	0.2	-1.1	1.2
Hand grip strength (right)	0.0	0.1	0.6	0.3	-0.1	-0.1	-0.0	-0.8	-0.2	0.0	-0.1	-0.2	-0.5
Townsend deprivation index at recruitment	0.6	0.9	2.6	-0.7	0.3	-0.9	-1.4	1.1	1.6	0.5	0.9	0.7	0.3
Current tobacco smoking	1.4	2.2	5.6	-2.2	-1.6	-1.0	-0.9	0.4	-0.4	1.8	0.1	2.4	2.0
Average weekly fortified wine intake	2.5	2.9	5.4	2.3	1.6	2.1	2.1	-1.1	-0.8	-2.2	-0.5	1.2	2.1
Maternal smoking around birth	1.0	1.5	4.0	-1.5	-1.2	-1.8	-2.0	0.6	0.7	1.5	-0.6	0.3	-0.4
Fed-up feelings	1.7	3.1	6.4	2.5	1.7	2.5	2.2	-0.6	-0.1	-2.5	0.0	1.0	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	6.0	0.4	0.6	0.4	0.0	-0.4	-0.1	-0.1	0.9	2.4	2.4
Relative age voice broke	0.9	1.4	3.3	-0.2	1.1	1.3	1.2	1.6	1.1	0.1	1.1	-1.8	-1.2
Taking other prescription medications	0.4	0.6	1.6	0.3	1.0	0.0	-0.2	0.9	1.2	0.1	0.8	-0.1	1.2
Age when periods started (menarche)	1.3	3.1	11.5	-0.9	-0.4	-0.2	-0.2	2.9	1.9	-0.0	0.9	-2.3	-3.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.7	-0.3	-0.2	-0.8	-1.0	-1.3	0.3	0.5	-0.8	0.5	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.8	1.1	1.1	1.5	1.1	-0.8	-1.2	-0.7	-0.2	1.7	-0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.4	0.8	-0.4	1.1	0.8	-1.0	-0.1	-1.2	0.1	-0.2	0.7
Qualifications: CSEs or equivalent	0.6	0.7	2.7	0.8	0.1	0.4	0.7	-1.3	0.6	-0.6	-1.6	-0.1	0.9
Serious illness, injury or assault to yourself	1.3	1.6	4.1	1.0	1.4	0.9	0.4	1.6	1.5	-1.3	2.0	0.7	-0.7
High blood pressure	0.4	1.1	2.7	-1.1	-1.6	-1.2	-1.6	0.6	-0.3	1.1	-0.1	-0.5	-1.0
Hayfever, allergic rhinitis or eczema	2.2	4.7	14.7	3.8	3.3	2.5	2.2	-1.7	0.1	-2.7	0.1	-0.3	-0.1
Multivitamins +/- minerals	0.5	0.7	2.8	0.4	-0.5	-1.0	-0.9	-1.0	-1.7	-0.0	-0.6	-0.4	0.3
Stomach or abdominal pain in last month	0.5	0.6	2.1	-0.8	-0.2	0.1	-0.6	1.4	0.9	0.9	0.6	-0.8	-0.3
Supplements: Glucosamine	1.2	1.6	4.0	1.2	0.3	1.0	1.1	-0.8	-1.8	-1.2	-0.5	-2.0	-1.6
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.4	1.5	1.0	0.8	0.6	-0.7	-0.0	-1.4	0.4	1.4	0.9
Medication: Atenolol	0.1	0.1	0.5	-0.2	-0.2	0.2	-0.1	0.7	-0.1	0.1	0.2	-0.4	-0.3
Medication: Levothyroxine sodium	0.4	0.7	2.5	-1.6	-0.5	-1.2	-0.9	0.4	0.6	1.3	0.6	0.2	-0.1
Sitting height	0.5	3.3	8.7	2.0	1.3	1.5	1.8	-2.7	-0.2	-0.5	-3.0	0.8	2.2
Chronic bronchitis/emphysema (father)	0.9	1.0	3.3	-0.9	-0.1	-0.1	-0.4	0.7	0.6	1.3	1.8	-1.5	-1.2
High blood pressure (mother)	1.4	1.9	5.0	1.4	2.2	0.7	0.5	0.5	1.9	-0.7	2.1	-1.0	-1.3
Body mass index (BMI)	0.9	3.9	10.0	-1.8	-2.6	-2.5	-3.2	-0.8	-1.0	1.9	0.0	0.8	2.6
Impedance of leg (left)	0.6	3.1	10.8	-0.6	1.2	-0.3	-0.1	1.4	3.0	0.7	0.6	-2.5	-3.3
Leg predicted mass (left)	0.8	4.3	12.6	0.6	-1.5	-1.0	-1.1	-3.5	-2.6	0.4	-2.2	1.5	3.3
Trunk fat mass	0.7	2.8	7.9	-1.2	-1.5	-2.4	-2.8	-1.3	0.3	2.0	-0.6	-0.6	1.9
Waist circumference	1.5	5.4	11.1	-1.4	-3.3	-2.8	-3.2	-2.7	-1.9	1.7	-2.1	0.6	2.2
Number of incorrect matches in round	0.5	0.8	2.7	1.1	-0.5	1.0	1.1	0.2	-0.4	-1.6	0.2	-0.6	-0.9
Past tobacco smoking	0.7	1.3	3.2	-0.5	1.1	0.6	1.3	1.8	1.1	0.5	1.5	-0.7	-1.5
Alcohol usually taken with meals	1.5	2.4	7.8	1.6	-0.2	0.7	0.8	-2.8	-2.7	-1.8	0.3	0.8	0.8
Nervous feelings	0.2	0.5	1.6	0.3	-1.3	-0.0	-0.1	-1.1	-0.5	-0.7	-0.7	-0.3	-0.5
Frequency of tenseness / restlessness in last 2 weeks	2.8	4.3	9.0	3.0	1.8	2.1	1.3	-1.5	-1.2	-2.9	0.1	2.4	2.7
Hearing difficulty/problems with background noise	1.3	2.1	4.5	2.1	0.5	2.0	1.4	-1.6	-0.3	-1.8	-0.8	0.8	1.8
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	0.2	0.5	-0.4	-0.5	-0.1	0.3	0.1	0.4	-0.4	0.3
Had menopause	0.4	0.4	1.3	0.8	0.6	0.9	0.9	-0.3	-0.1	-1.1	-0.6	0.2	-0.0
Had other major operations	0.8	1.0	3.7	0.4	0.7	0.9	1.1	-0.4	1.0	-0.4	-1.4	-0.0	1.9
Forced vital capacity (FVC)	2.6	9.8	28.4	3.6	0.6	2.1	2.2	-5.3	-3.1	-2.9	-2.9	2.7	3.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.0	1.6	1.7	1.5	1.0	-0.1	-0.4	-1.2	0.4	1.0	-1.0
Ever unenthusiastic/disinterested for a whole week	4.2	5.2	16.0	3.7	1.3	2.0	1.6	-0.7	1.5	-4.0	0.3	1.8	2.9
Qualifications: None of the above	0.7	1.5	4.4	-1.6	-1.6	-0.5	-0.8	0.5	0.1	1.1	-0.2	-1.7	-2.1
Financial difficulties in last 2 years	1.1	1.5	6.5	-0.6	-1.2	-0.1	-0.7	-0.9	-0.9	0.7	-1.5	1.5	2.5
Mouth/teeth dental problems	0.3	0.5	1.3	-0.3	-0.4	-1.1	-1.0	0.2	1.0	0.4	-0.1	-0.2	-1.0
Heart attack	0.7	0.9	2.4	-1.4	-1.2	-0.6	-1.1	1.5	0.2	0.6	0.6	-0.7	-0.5
Allergy	0.7	1.7	4.5	-1.9	-1.2	-1.5	-0.9	2.1	1.1	1.0	0.1	-0.3	-1.3
Pain all over the body in last month	0.2	0.2	1.6	0.1	0.2	0.1	-0.2	0.3	-0.3	0.0	-0.4	1.2	0.3
Diabetes (self-reported)	2.0	3.1	6.4	-2.1	-1.2	-2.5	-2.5	1.3	2.2	1.9	0.1	-1.2	-0.9
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	5.6	2.4	1.4	1.5	1.5	-1.6	-0.6	-2.1	-1.5	0.7	0.8
Medication: Ramipril	1.1	1.4	4.5	-0.8	-2.1	-1.1	-1.4	0.5	-0.6	0.7	0.0	-1.0	-1.8
Medication: Simvastatin	1.6	2.4	5.9	-2.0	-1.2	-1.7	-1.3	2.4	1.9	0.9	0.6	-1.1	-1.4
Fluid intelligence score	0.8	1.6	2.5	1.1	1.6	1.3	1.4	-1.2	-1.1	-1.0	1.4	0.3	1.5
Illnesses of siblings	0.8	1.1	3.5	0.8	1.6	1.9	1.6	0.5	-0.7	-0.7	-0.0	0.6	-0.5
Neuroticism score	1.2	2.5	5.9	2.3	0.4	1.7	1.2	-1.6	-0.6	-2.4	-1.3	1.3	1.7
Weight	0.8	3.9	8.9	-0.5	-2.1	-2.0	-2.4	-2.8	-1.4	1.3	-1.9	0.8	3.0
Impedance of arm (right)	0.9	4.3	13.1	0.3	2.0	1.0	1.6	1.5	3.6	-0.3	0.6	-2.7	-3.6
Arm fat percentage (right)	0.9	3.5	9.7	-2.2	-2.4	-2.7	-3.1	-0.4	0.3	2.2	0.2	-0.3	1.4
Trunk fat-free mass	0.9	5.3	16.2	1.3	-1.3	-0.5	-0.6	-4.0	-2.7	-0.5	-3.3	1.7	3.3
Hip circumference	0.6	2.8	8.1	-0.5	-1.9	-2.0	-2.2	-2.0	-0.6	1.2	-0.8	0.6	2.8
Time employed in main current job	0.6	0.7	2.3	1.0	0.3	1.0	0.7	-1.5	-0.7	-0.1	-1.0	0.0	0.7
Alcohol intake versus 10 years previously	0.6	1.0	3.3	-0.7	-0.3	-1.1	-1.8	1.3	0.7	0.5	1.3	-0.3	-0.4
Father’s age at death	0.6	0.8	1.8	1.2	0.3	0.6	1.3	-0.8	-0.6	-1.2	0.1	-1.2	0.6
Worrier / anxious feelings	0.4	0.8	2.6	1.2	0.4	1.0	1.1	-0.4	-0.5	-1.6	-1.1	0.1	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.2	-0.0	0.1	-0.8	-1.3	-0.9	0.7	0.4	0.9	0.6	1.8
Falls in the last year	0.5	0.7	2.1	0.1	0.4	-0.7	-1.2	1.0	0.6	-0.1	1.4	1.0	0.8
Hair/balding pattern: Pattern 3	0.4	0.6	3.0	-0.0	-0.4	0.3	0.1	0.1	-0.8	-0.2	-0.9	1.7	1.3
Number of live births	1.2	1.8	4.4	-1.7	-0.6	-1.3	-1.5	2.1	0.8	1.2	1.5	-1.2	-0.5
Forced expiratory volume in 1-second (FEV1)	2.7	8.9	30.0	3.4	0.1	1.6	1.7	-5.5	-3.3	-2.8	-2.4	2.7	3.2
Pulse rate	0.8	1.4	3.2	1.6	1.0	1.2	0.9	-0.4	-1.0	-1.8	-0.9	1.5	0.8
Happiness	1.6	1.9	5.1	2.2	0.9	1.6	1.4	-0.3	1.1	-2.3	0.8	0.6	1.1
Noisy workplace	0.8	1.0	2.4	1.6	1.3	0.1	-0.0	-0.9	0.3	-1.4	0.7	0.8	1.3
Qualifications: A levels/AS levels or equivalent	1.6	3.6	10.4	3.2	2.5	1.8	2.0	-0.7	-0.5	-2.9	0.2	1.6	0.8
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	6.2	2.3	1.3	1.4	1.4	-2.5	-0.8	-1.5	-1.2	0.1	1.5
Mouth/teeth dental problems: Dentures	0.2	0.4	2.3	-0.4	0.4	0.5	0.5	0.4	0.4	0.5	0.5	0.3	1.5
Asthma	1.1	2.1	5.0	-1.2	-1.5	-0.2	-0.7	-1.7	-2.0	1.3	-0.5	1.7	2.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.8	0.4	-0.4	1.7	1.2	-0.1	-1.2	-0.1	0.5	-0.4	0.5
Medication: Cholesterol lowering	1.9	2.9	8.4	-2.1	-1.1	-1.5	-1.2	2.9	2.6	1.3	0.8	-1.7	-0.5
Depression (self-reported)	1.3	1.6	3.4	0.1	0.3	-1.4	-1.5	1.5	1.8	0.1	1.6	-1.5	-1.3
Medication: Lansoprazole	0.7	0.8	3.9	0.0	1.1	-0.0	-0.0	0.9	2.0	0.1	1.2	-0.4	0.3
Prospective memory result	1.3	1.5	7.6	-1.2	-2.8	-1.0	-0.9	0.1	-0.5	0.6	-1.9	-0.4	-0.7
Lung cancer (father)	1.4	1.6	6.4	-0.7	1.1	0.7	0.3	1.6	-0.0	0.9	2.5	-1.1	-1.8
Illnesses of mother	1.3	1.6	5.4	-1.1	-1.5	-0.6	-0.2	-1.0	-1.6	0.6	-2.3	1.3	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	8.9	24.4	3.4	0.5	2.2	2.5	-4.9	-2.8	-2.9	-1.3	3.0	3.7
Pulse wave Arterial Stiffness index	1.6	1.8	4.9	-0.2	-0.5	-1.5	-2.0	1.3	0.9	0.2	2.2	-1.6	-1.4
Impedance of arm (left)	0.7	3.4	11.2	0.3	1.9	0.6	1.4	1.2	3.4	-0.2	0.4	-2.5	-3.0
Arm fat mass (right)	0.9	3.5	8.0	-1.5	-2.4	-2.4	-2.8	-1.6	-0.7	1.8	-1.0	0.5	2.4
Trunk predicted mass	0.9	5.2	16.0	1.3	-1.3	-0.6	-0.7	-4.0	-2.6	-0.4	-3.3	1.6	3.3
Standing height	0.6	5.5	21.0	2.6	0.9	0.7	1.3	-4.5	-0.8	-1.0	-4.6	0.3	1.5
Length of working week for main job	2.4	2.6	12.3	-0.7	-1.0	0.2	0.6	-2.3	-1.7	1.0	-3.5	1.3	1.3
Exposure to tobacco smoke at home	0.3	0.3	0.8	0.1	-0.6	0.0	-0.4	0.8	-0.6	-0.6	0.9	-0.3	0.7
Breastfed as a baby	1.7	2.1	5.0	-1.8	-2.2	-1.8	-1.6	-1.0	-1.0	1.6	-0.7	1.1	0.8
Tense / ‘highly strung’	0.4	0.6	2.0	0.8	0.7	-0.1	-0.7	-0.4	-0.1	-0.7	-0.1	1.4	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	11.1	3.3	1.1	1.7	1.1	-1.2	-0.4	-3.3	0.2	0.4	1.7
Hair/balding pattern: Pattern 4	0.1	0.2	1.0	0.4	0.3	-0.2	-0.4	-0.5	-1.0	-0.4	-0.7	0.2	-0.1
Birth weight of first child	0.5	0.9	5.5	-0.4	-0.2	-0.9	-0.0	-0.2	0.7	0.1	-0.6	-2.4	-1.1
Peak expiratory flow (PEF)	1.6	3.7	14.9	1.0	-1.0	0.6	0.5	-3.8	-3.9	-0.8	-1.8	1.1	0.8
Pulse wave reflection index	1.3	1.6	4.3	-0.3	-0.8	-1.0	-1.2	0.0	0.5	0.4	2.0	-2.1	-2.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.1	0.9	0.2	0.9	0.8	-0.4	0.4	-0.4	-1.1	0.7	1.0
Loud music exposure frequency	0.3	0.3	1.3	0.3	-0.3	-0.3	-0.5	-0.5	1.1	-0.4	-0.4	-0.7	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.0	0.6	1.0	0.1	0.5	-0.4	-0.5	-0.0	-1.0	-0.3	-0.0
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	5.8	0.2	0.1	0.9	0.7	-0.2	-2.4	-0.5	1.3	-0.6	-1.2
Blood clot in the leg (DVT)	0.6	0.7	1.6	-0.7	-0.3	-0.1	0.2	1.2	1.2	0.9	0.7	-1.0	1.3
Medication: Paracetamol	0.4	0.7	2.1	0.8	1.0	1.5	1.2	0.0	-0.0	-0.2	0.8	-0.5	-0.8
Headache pain in last month	0.9	1.5	4.1	-1.9	-1.2	-1.0	-1.1	0.7	1.1	2.0	-0.5	0.5	-1.2
Medication for cholesterol, blood pressure or diabetes	2.6	4.3	10.6	2.1	1.2	1.7	1.6	-3.3	-2.5	-1.4	-0.9	2.4	2.4
Glaucoma (self-reported)	0.6	0.7	2.5	1.2	1.6	-0.1	0.1	-1.1	0.3	-0.8	0.8	0.6	0.7
Gout (self-reported)	0.5	0.7	1.6	0.3	1.3	1.2	1.3	0.7	1.1	0.5	0.0	-0.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.5	-1.6	-0.5	-0.9	-0.5	0.1	0.4	1.4	0.3	0.6	0.0
Medication: Amlodipine	0.6	0.8	3.5	-0.8	-0.6	0.1	-0.0	1.6	0.4	1.0	0.0	-0.5	-1.9
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.4	-1.5	-1.4	-1.3	-1.5	0.0	-1.0	1.4	0.2	0.2	0.1
Birth weight	0.6	1.3	3.3	1.5	1.1	0.4	0.9	-1.6	0.8	-1.2	-0.8	-0.6	1.8
Chronic bronchitis/emphysema (mother)	0.9	1.0	4.1	-0.8	0.2	-0.5	-0.8	2.0	1.6	1.1	0.7	-0.4	-0.1
High blood pressure (siblings)	0.5	0.8	2.0	-0.1	-1.3	-1.4	-1.3	-1.0	0.0	-0.0	0.9	-0.4	0.5
Forced vital capacity (FVC), Best measure	2.4	8.8	20.4	3.5	1.0	2.6	2.9	-4.5	-2.5	-2.7	-1.6	2.7	4.0
Body fat percentage	0.9	3.5	10.6	-2.0	-1.9	-2.8	-3.3	-0.2	1.1	2.4	0.5	-0.9	1.2
Leg fat percentage (right)	0.8	3.0	9.1	-1.8	-2.1	-2.5	-3.0	-0.5	0.4	2.0	0.1	-0.8	1.0
Arm fat-free mass (right)	1.0	5.1	13.2	0.6	-1.8	-1.2	-1.6	-3.6	-2.9	0.2	-2.5	1.8	3.5
Exposure to tobacco smoke outside home	0.6	0.7	2.5	-0.8	-1.6	-1.0	-1.3	0.8	0.2	0.5	0.0	-0.7	0.2
Comparative body size at age 10	0.2	0.5	1.4	0.4	0.0	0.5	0.7	-1.0	-0.6	-0.1	-0.8	1.2	0.6
Number of full brothers	0.3	0.3	1.9	0.0	-0.5	-0.5	-0.7	-0.2	0.4	-0.2	0.3	0.4	1.4
Worry too long after embarrassment	1.4	2.4	8.6	-1.5	-2.9	-1.8	-2.0	-1.2	-1.4	1.3	-1.1	-0.1	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.8	-0.2	-1.4	-0.5	-0.8	0.1	-0.4	-0.3	0.4	-0.6	0.7
Wheeze or whistling in the chest in last year	0.6	1.1	2.2	-0.0	-1.5	-0.3	-1.0	-1.4	-1.4	-0.3	-0.6	1.0	1.5
Number of children fathered	0.4	0.5	3.5	0.1	0.2	0.4	0.4	-0.2	-0.2	-0.1	0.1	1.9	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.2	1.1	0.7	0.3	-0.1	-0.0	0.5	-0.8	0.8	0.3	-0.3
Age at first live birth	1.5	2.6	11.5	2.3	3.4	0.5	1.0	0.0	1.0	-1.5	2.0	-0.3	-0.9
Pulse wave peak to peak time	2.2	2.5	6.1	0.7	0.9	1.8	2.4	-1.6	-0.9	-0.5	-2.5	1.7	1.7
Health satisfaction	0.7	0.9	3.7	-0.8	-0.5	-0.2	-0.3	0.4	0.7	0.7	1.7	0.6	1.9
Shortness of breath walking on level ground	1.4	1.6	3.7	-1.5	-1.9	-1.4	-1.9	0.6	0.7	1.3	0.3	-0.5	1.3
Qualifications: College or University degree	0.9	2.8	9.1	3.0	2.4	0.6	0.9	-1.5	-0.2	-2.8	-0.2	1.2	0.9
Eye problems/disorders: None of the above	1.9	2.2	10.9	-1.1	0.6	1.1	0.6	3.3	0.9	1.1	1.2	-0.4	-2.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.6	-0.6	-0.3	-0.9	-1.1	1.3	-0.5	0.7	0.8	0.5	0.4
Emphysema/chronic bronchitis	1.5	1.7	4.1	-1.7	-1.4	-1.2	-2.0	-0.0	-0.3	1.5	0.5	0.7	1.9
Medication for pain relief, constipation, heartburn	0.4	0.6	2.9	-0.6	-0.2	-1.2	-0.6	-0.9	-0.1	0.5	-1.7	0.5	0.2
Neck or shoulder pain in last month	1.2	1.7	3.7	1.4	-0.1	1.4	1.2	-1.9	-1.2	-1.3	-1.2	0.8	1.6
Medication: Blood pressure	2.7	4.8	11.4	-1.7	-1.1	-1.8	-1.8	3.2	2.5	1.2	0.7	-2.9	-3.4
Angina (self-reported)	0.5	0.7	1.5	-1.2	-1.0	-0.9	-1.1	-0.1	-0.4	1.0	0.2	-0.9	0.7
Migraine (self-reported)	0.1	0.2	0.6	-0.5	0.3	0.4	0.2	0.4	-0.1	0.8	-0.0	0.5	-0.4
Medication: Ibuprofen	0.3	0.4	1.4	-0.1	-0.8	1.2	0.7	-0.0	-1.2	0.3	-0.3	-0.0	-0.1
Medication: Allopurinol	1.0	1.4	4.3	1.1	1.3	2.0	2.1	0.3	0.5	-0.6	-0.3	-0.4	-1.0
Medication: Omeprazole	0.4	0.4	1.5	-0.3	-0.2	-1.2	-1.2	0.2	0.9	-0.3	0.4	-0.5	-0.0
Medication: Seretide 50 evohaler	0.5	0.6	2.7	0.2	-0.8	0.6	0.2	0.3	0.6	0.1	0.2	-1.6	1.2
Mean time to correctly identify matches	0.8	1.6	4.8	-1.0	-1.3	-2.2	-2.2	0.9	1.2	0.4	-0.0	0.3	1.2
Heart disease (mother)	1.6	1.9	5.2	1.2	0.3	1.3	0.8	-1.7	-0.7	-1.0	-1.4	2.0	2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.5	0.6	-0.4	0.5	0.4	-1.0	-1.6	-1.0	0.5	-0.6	-1.1
Whole body fat mass	0.8	3.4	9.4	-1.6	-2.1	-2.6	-3.1	-1.3	-0.0	2.2	-0.5	-0.3	1.8
Leg fat mass (right)	0.9	3.3	8.1	-1.4	-2.3	-2.4	-2.9	-1.8	-0.8	1.9	-1.1	-0.1	1.9
Arm predicted mass (right)	1.0	5.0	14.4	0.7	-1.7	-1.3	-1.7	-3.8	-2.8	0.1	-2.5	1.6	3.4
Pulse rate, automated reading	0.2	0.6	4.2	-0.1	-0.4	-1.0	-0.9	-0.1	-0.2	-0.3	-2.0	-0.0	0.0
Alcohol intake frequency.	1.0	2.4	6.2	-1.7	-0.5	-1.4	-2.5	2.1	1.1	1.6	2.0	0.0	-0.4
Comparative height size at age 10	0.5	3.0	18.1	1.7	-0.0	-0.3	0.1	-2.8	-0.4	-0.6	-4.3	0.2	0.4
Number of full sisters	2.0	2.4	7.2	-1.2	-2.7	-1.8	-2.0	-1.3	-0.7	0.2	-2.3	0.4	1.0
Suffer from ‘nerves’	0.9	1.4	2.6	-0.1	-0.2	1.6	1.5	1.2	1.3	-0.6	-0.7	-1.5	-1.6
Overall health rating	2.3	4.9	14.2	-2.9	-2.8	-3.2	-3.8	0.5	0.2	2.4	1.2	0.3	0.7
Chest pain or discomfort	1.1	1.6	6.2	2.2	0.8	0.7	0.2	-0.9	-0.2	-2.5	0.6	-0.1	1.7
Had major operations	1.4	1.7	4.0	1.7	0.5	1.4	1.8	-0.2	0.6	-2.0	-1.9	-0.9	0.4
Age at last live birth	1.8	2.6	9.6	1.2	3.1	0.0	0.4	1.5	2.5	-0.8	2.2	-0.3	-0.4
Family relationship satisfaction	1.6	2.0	7.4	1.6	0.9	0.8	0.5	-1.6	-0.5	-1.0	0.6	2.1	2.7
Leg pain on walking	0.2	0.3	1.3	-0.0	-0.5	0.2	-0.0	0.3	0.6	0.3	0.1	-0.7	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.0	-0.3	-1.0	-0.4	-0.9	0.0	-0.2	-0.2	-0.3	-0.5	0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	-1.0	-1.0	-0.7	-0.7	-0.1	0.5	1.0	0.1	-0.2	0.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.0	-1.5	-1.4	-1.7	-1.2	-1.2	-1.1	1.5	-1.0	0.8	0.7
Medication: Aspirin	0.4	0.6	2.3	-0.1	0.4	-0.5	-0.7	1.5	1.2	0.1	1.1	-0.0	-0.1
Supplements: Vitamin C	0.9	1.0	3.1	0.9	-0.2	1.1	1.2	-1.0	-1.3	-1.0	-1.8	0.2	0.3
Knee pain experienced in last month	0.3	0.4	1.8	0.0	-0.9	0.6	0.1	-0.4	-0.7	-0.1	0.4	0.2	1.3
Hypertension (Self-reported)	0.6	1.6	4.3	-1.5	-2.1	-1.1	-1.5	0.7	-0.4	1.4	-0.2	-1.0	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.2	1.7	1.5	0.8	0.9	-0.8	-0.0	-1.8	0.5	1.3	0.1
Illnesses of father: Heart disease	0.4	0.6	2.0	1.0	0.2	0.1	-0.3	0.2	0.6	-1.4	-0.4	-1.4	-0.6
Illnesses of siblings: Diabetes	0.9	1.1	3.6	-1.2	-1.9	0.1	-0.1	-0.8	-0.9	0.8	-1.3	1.1	1.2
Smoking status: Previous	0.4	0.6	1.4	0.6	-0.6	-0.5	-1.0	-1.2	-0.3	-0.6	-1.2	-0.9	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.4	-0.4	0.1	-0.1	-0.3	-1.6	-0.4	1.8	-1.1	1.0	0.5
Whole body fat-free mass	0.9	5.1	15.4	1.1	-1.5	-0.9	-1.0	-3.9	-2.8	-0.1	-2.7	1.7	3.5
Leg fat-free mass (right)	0.8	4.5	13.2	0.7	-1.4	-1.1	-1.3	-3.6	-2.6	0.3	-2.0	1.8	3.6
Arm fat percentage (left)	0.9	3.4	9.7	-2.0	-2.3	-2.7	-3.1	-0.4	0.3	2.2	0.4	-0.4	1.6
Average weekly red wine intake	0.9	1.3	4.1	1.6	0.1	1.1	1.3	-1.0	-1.5	-2.0	-0.5	-0.4	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.1	-0.0	-0.3	-0.3	0.2	0.2	0.2	-0.5	0.3	-0.1
Mood swings	1.6	3.0	6.0	2.5	2.4	2.2	1.7	-0.2	0.2	-2.1	1.0	1.7	1.3
Loneliness, isolation	0.8	1.1	3.6	1.9	1.6	0.4	-0.2	-0.2	0.1	-1.7	0.6	1.1	0.5
Long-standing illness, disability or infirmity	1.2	1.8	5.0	-1.1	-0.3	-2.0	-2.2	0.1	1.8	1.3	0.8	-1.4	0.4
Ever had bowel cancer screening	0.7	0.8	4.0	0.2	-0.0	-0.2	-0.3	-1.4	-1.1	0.0	-2.0	0.9	0.2
Diabetes diagnosed by doctor	3.1	5.1	10.7	-2.5	-1.4	-3.1	-3.3	1.9	2.9	2.4	1.0	-1.7	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	6.3	-2.0	-0.1	-0.6	-0.6	2.1	1.4	2.5	1.7	-1.4	-0.6
Friendships satisfaction	3.7	4.6	9.3	3.0	2.0	1.9	1.6	-1.2	0.7	-2.8	0.6	2.8	3.0
Qualifications: nursing, teaching	1.0	1.5	5.2	2.3	1.6	0.5	1.0	-1.2	-0.5	-1.8	-1.0	-0.1	0.2
Commuting to job workplace: Walk	1.0	1.1	3.0	-1.3	-0.7	-1.3	-0.7	1.3	0.6	1.0	-0.3	-0.3	-1.7
Eye problems/disorders: Cataract	0.9	1.0	3.3	1.7	-0.1	-0.3	0.0	-1.4	-0.6	-1.8	0.1	-0.7	1.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	3.0	0.4	-0.8	0.0	-0.0	-1.7	-1.2	-0.8	-0.2	-0.1	0.3
Medication for cholesterol	0.3	0.4	1.4	0.9	0.1	0.1	-0.0	-0.4	-0.5	-0.7	-1.0	-1.2	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.1	0.5	-0.3	0.4	-0.0	-0.4	-0.2	-0.9	0.7	0.7	1.1
Back pain experienced in last month	0.8	1.1	3.2	-0.8	-1.3	-0.2	-0.2	-0.6	-1.1	0.9	-1.3	1.8	1.2
Mineral and other dietary supplements	0.9	1.2	4.4	0.4	1.5	0.8	0.4	0.8	1.0	-0.0	0.9	2.1	1.4
Breast cancer (self-reported)	1.1	1.3	2.7	-0.9	-1.6	-1.6	-1.6	-0.5	-0.1	0.7	-0.5	-0.9	-1.4
Asthma (self-reported)	1.0	2.1	5.5	-0.9	-1.3	-0.1	-0.5	-2.0	-2.2	1.0	-0.5	1.5	2.4
Osteoporosis (self-reported)	1.2	1.5	2.6	-1.5	-0.7	-1.3	-1.6	1.6	1.1	1.4	1.4	-0.7	-0.5
Osteoarthritis (self-reported)	0.3	0.4	1.8	0.2	-0.7	-0.6	-0.6	-0.3	0.2	-0.5	0.6	-1.3	0.3
Medication: Aspirin	0.4	0.6	2.5	-0.1	0.3	-0.5	-0.6	1.6	1.2	-0.0	0.9	-0.1	-0.3
Medication: Gliclazide	2.1	2.4	6.5	-1.6	-1.6	-2.5	-2.2	0.1	1.5	1.5	-1.7	-0.4	0.2
Illnesses of father: None of the above (group 1)	0.4	0.5	2.8	-0.5	-0.4	-0.2	0.1	0.3	-0.1	0.4	-1.0	1.7	0.9
Smoking status: Current	1.1	1.7	6.0	-1.8	-1.5	-0.6	-0.6	0.3	-0.6	1.4	0.1	2.5	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.3	14.1	2.0	-1.2	0.7	0.8	-3.8	-3.2	-2.4	-1.3	3.6	3.6
Whole body water mass	0.9	5.3	15.8	0.9	-1.6	-0.9	-1.1	-4.0	-2.9	-0.0	-2.8	1.7	3.5
Leg predicted mass (right)	0.8	4.5	13.1	0.6	-1.6	-1.3	-1.4	-3.6	-2.5	0.4	-2.0	1.7	3.5
Arm fat mass (left)	0.9	3.8	8.7	-1.5	-2.5	-2.5	-3.0	-1.6	-0.8	1.9	-0.8	0.5	2.6
Number of self-reported non-cancer illnesses	0.1	0.2	0.8	-0.0	-0.3	-0.2	-0.8	0.1	0.0	0.2	0.8	-0.9	0.3
Average weekly champagne plus white wine intake	1.8	2.4	4.3	2.0	1.6	2.1	2.1	-0.3	-1.5	-1.8	1.2	1.2	0.9
Miserableness	0.5	0.9	6.2	0.9	0.0	0.3	0.0	-0.2	0.7	-0.3	-0.2	0.9	2.5
Guilty feelings	0.6	0.9	2.8	1.7	-0.1	0.6	0.1	-0.2	-0.0	-1.3	0.8	-1.5	-1.2
Wears glasses or contact lenses	2.6	3.0	5.5	2.3	1.4	2.1	2.2	-1.2	-0.3	-2.2	0.5	1.6	2.2
Ever taken oral contraceptive pill	0.7	0.8	2.5	0.9	0.7	-0.1	-0.2	-0.7	-1.3	-0.7	1.6	0.5	1.1
Hearing aid user	2.2	2.5	11.1	-0.4	-0.5	-1.2	-1.0	1.1	2.1	-0.1	-0.3	-3.3	-2.2
Mother’s age at death	0.4	0.5	1.2	1.0	0.7	0.3	0.4	-1.1	-0.4	-0.8	0.1	-0.7	-0.5
Financial situation satisfaction	0.6	0.8	4.0	0.4	-0.5	-0.2	-0.5	-0.6	1.1	0.2	-0.6	0.9	2.0
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.8	0.4	0.5	0.2	0.6	-0.4	0.5	-0.3	-0.1	-1.3	-1.0
Commuting to job workplace: Public transport	0.3	0.4	1.2	1.0	0.4	0.5	0.5	-0.3	-0.7	-1.1	-0.4	0.1	0.5
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	0.6	-0.0	-0.9	-0.9	-0.8	0.3	-0.6	0.5	0.3	0.1
Medication: Blood pressure	0.2	0.5	2.3	-0.6	-0.6	0.3	0.1	0.0	-1.0	0.2	0.4	1.5	0.3
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.5	-1.1	-1.0	-0.2	-0.8	-0.1	-0.6	1.2	1.2	0.2	0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.9	0.1	-1.0	0.3	0.5	-0.7	-1.1	-0.6	-0.7	-1.0	-1.4
High cholesterol (Self-reported)	0.7	1.3	6.1	-1.3	-0.5	0.3	0.0	2.5	1.7	0.8	0.4	0.9	0.1
Medication: Bendroflumethiazide	0.9	1.4	5.8	-0.5	-0.3	-0.2	-0.4	2.4	-0.2	0.2	1.6	-0.8	-1.9
Medication: Paracetamol	0.3	0.4	1.3	0.9	0.8	1.2	0.6	-0.1	0.0	-0.3	-0.2	0.1	-0.8
Medication: Lisinopril	1.3	1.7	2.8	-1.7	-0.9	-1.6	-1.4	1.5	1.0	1.4	1.3	-1.0	-1.2
Medication: Atorvastatin	0.6	0.7	3.3	0.7	1.1	0.5	0.1	0.9	1.8	-0.5	0.4	-0.5	-0.9
Illnesses of father: High blood pressure	0.2	0.3	1.1	0.7	0.2	-0.1	-0.1	-1.0	-0.8	-0.5	0.5	0.0	0.4
Alcohol drinker status: Never	4.9	5.9	11.5	-1.9	1.3	-0.9	-1.0	3.4	3.4	2.2	3.1	-2.4	-2.9
Ever smoked	2.3	4.0	10.2	0.6	-1.3	-0.8	-1.3	-3.2	-2.3	-0.4	-2.3	2.3	3.0
Basal metabolic rate	0.9	5.0	14.4	0.6	-1.8	-1.2	-1.5	-3.8	-2.6	0.4	-2.7	1.6	3.5
Leg fat percentage (left)	1.0	3.7	11.5	-2.1	-2.2	-2.9	-3.4	-0.6	0.6	2.2	0.1	-0.9	1.1
Arm fat-free mass (left)	0.8	4.3	12.5	0.6	-1.5	-1.2	-1.4	-3.5	-2.3	0.2	-2.6	1.6	3.1
Number of operations (self-reported)	0.8	1.2	2.5	0.6	1.1	1.3	1.3	0.0	1.6	-0.6	-1.1	-1.2	1.3
Average weekly beer plus cider intake	1.4	2.0	5.7	-1.2	-1.0	-2.4	-2.4	0.9	0.9	1.2	0.2	-1.1	-1.3
Irritability	0.7	1.3	3.0	1.7	1.4	1.3	0.7	-1.1	-0.7	-1.4	-0.7	1.1	0.3
Risk taking	0.4	0.6	1.3	-1.0	-0.2	1.0	0.6	0.2	-0.6	1.2	1.1	0.1	0.5
Ever had prostate specific antigen (PSA) test	2.2	2.6	4.0	2.0	1.0	1.6	1.3	-1.8	-0.9	-2.0	-1.1	1.9	1.9
Fractured/broken bones in last 5 years	0.7	0.9	2.7	0.8	1.6	0.4	0.6	0.6	0.5	-0.8	1.0	0.6	1.7
Age started oral contraceptive pill	0.3	0.4	2.4	0.5	0.6	-0.2	0.1	-1.6	-0.4	0.1	-0.6	-0.2	0.6
Diastolic blood pressure, automated reading	0.2	0.5	1.8	-0.7	-1.3	-0.6	-0.7	-0.2	-0.9	0.6	-0.6	0.1	0.7
Ever depressed for a whole week	3.3	4.0	12.4	3.2	1.2	2.0	1.2	-1.7	-0.8	-3.5	1.3	1.8	1.4
Unable to work because of sickness or disability	2.1	2.7	7.6	-2.0	-1.6	-1.8	-2.8	1.2	0.0	1.4	2.4	-0.0	0.3
Commuting to job workplace: Cycle	1.5	1.9	4.8	2.2	1.5	1.8	1.8	-0.4	-0.0	-1.7	-0.2	0.3	1.3
Myopia	1.1	1.7	5.2	-2.3	-0.2	-1.6	-1.0	0.9	-0.0	2.1	1.4	-0.5	-0.5
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.7	1.2	1.3	0.8	1.3	-1.0	-0.2	-1.2	-0.3	0.7	1.0
Cholesterol lowering medication	0.7	1.0	1.9	-1.3	-1.0	-1.3	-1.4	0.7	0.9	1.1	-0.3	0.7	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.9	-0.2	-0.1	-1.3	-1.7	0.6	0.7	-0.3	1.1	-1.3	-0.8
Pain experienced in last month	0.6	1.0	4.2	1.6	1.2	-0.2	0.1	-1.1	-0.5	-2.1	0.5	0.0	0.2
Supplements: Calcium	0.8	0.9	3.4	-0.8	-0.0	0.3	-0.1	1.3	0.5	0.7	1.8	1.2	0.9
Basal cell carcinoma (self-reported)	1.2	1.4	5.9	0.1	1.5	1.3	1.1	1.2	-0.1	-0.2	2.4	-1.1	0.5
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.8	-1.3	-1.3	-0.6	-1.0	1.2	-0.1	0.5	0.3	-0.6	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.2	-0.5	-0.3	-0.1	0.2	1.1	1.2	0.7	0.3	-1.5	0.9
Heart disease (siblings)	3.7	4.6	9.8	-2.9	-1.4	-3.1	-3.1	1.3	2.0	3.1	0.0	-0.8	0.7
Alcohol drinker status: Previous	0.6	0.7	3.0	0.0	0.4	-0.4	-0.9	1.7	0.3	0.2	1.6	-0.5	-0.5
Pack years of smoking	1.8	2.7	6.2	-2.5	-1.9	-2.5	-2.4	0.5	0.4	2.0	-0.6	0.2	0.7
Impedance of whole body	0.8	4.1	13.8	-0.2	1.9	0.5	1.1	1.5	3.5	0.4	0.5	-2.6	-3.7
Leg fat mass (left)	1.1	4.1	10.6	-1.7	-2.5	-2.9	-3.2	-1.8	-0.7	2.2	-1.0	-0.1	1.9
Arm predicted mass (left)	0.9	4.6	12.8	0.6	-1.6	-1.0	-1.3	-3.6	-2.4	0.2	-2.6	1.7	3.4