Best TWAS P=3.88e-12 · Best GWAS P=1.93e-21 conditioned to 9.74e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | KLHL7 | 0.18 | 0.10 | lasso | 6 | 0.07 | 7.3e-05 | 4.3 | 5.3 | 1.4e-07 | -0.23 | 0.28 | 0.12 | TRUE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | CCDC126 | 0.52 | 0.39 | enet | 26 | 0.40 | 3.0e-14 | -6.4 | -6.0 | 2.2e-09 | 0.40 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Esophagus Mucosa | CCDC126 | 0.12 | 0.03 | lasso | 7 | 0.01 | 4.3e-02 | -6.9 | 6.7 | 2.3e-11 | -0.79 | 0.01 | 0.96 | FALSE |
| 4 | YFS | Blood | CCDC126 | 0.05 | 0.04 | enet | 10 | 0.05 | 1.6e-15 | -6.5 | -6.0 | 2.5e-09 | 0.51 | 1.00 | 0.00 | TRUE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | TRA2A | 0.18 | 0.02 | blup | 40 | 0.05 | 1.2e-02 | -8.2 | -6.9 | 3.9e-12 | 0.74 | 0.01 | 0.48 | TRUE |
| 6 | The Cancer Genome Atlas | Soft Tissue Sarcoma | RPS2P32 | 0.08 | 0.02 | blup | 27 | 0.02 | 3.1e-02 | -4.3 | 5.6 | 1.7e-08 | -0.72 | 0.02 | 0.48 | FALSE |