Hub : Genes

SUFU

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0660	0.0290	0.00130	0.036	NA	0.043	NA	0.043	1.1e-03	NA	3.5e-04	NA	3.5e-04
2	GTEx	Esophagus Mucosa	0.0820	0.0350	0.00012	0.020	NA	0.013	NA	0.000	1.6e-02	NA	4.2e-02	NA	3.1e-01
3	GTEx	Esophagus Muscularis	0.0740	0.0320	0.00029	0.037	NA	0.031	NA	-0.003	2.7e-03	NA	5.1e-03	NA	5.9e-01
4	GTEx	Skin Sun Exposed Lower leg	0.0630	0.0270	0.00049	0.055	NA	0.061	NA	0.055	2.4e-05	NA	8.4e-06	NA	2.3e-05
5	TCGA	Brain Lower Grade Glioma	0.0289	0.0185	0.00033	0.029	0.014	0.021	NA	0.030	2.6e-04	0.0088	1.6e-03	NA	2.0e-04
6	TCGA	Ovarian Serous Cystadenocarcinoma	0.0280	0.0190	0.00920	0.019	0.020	0.009	NA	0.018	1.7e-02	0.0150	7.0e-02	NA	2.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.8	2.8	12.1	-3.5	1.6	-0.2	-0.6	-1.2	-0.3
Bipolar Disorder or Schizophrenia	4.0	9.7	39.7	-6.3	2.6	1.9	-2.4	-1.1	1.0
Depressed Affect (Nagel 2018)	0.6	1.2	2.3	-0.9	1.1	1.3	-0.7	1.5	0.8
Depression (Nagel 2018)	0.8	1.2	5.2	-2.3	0.6	0.7	-0.5	0.9	0.4
Intelligence (Savage-Jansen 2018)	0.9	2.7	5.8	-0.5	-0.6	-1.3	1.9	-2.4	-2.1
Neuroticism (Nagel 2018)	2.3	5.4	9.0	-3.0	1.7	2.6	-2.3	2.2	2.0
Schizophrenia (2018)	3.8	8.0	28.1	-5.3	1.8	2.7	-2.6	-0.4	1.6
Schizophrenia vs Biploar Disorder	1.9	2.6	4.1	-2.0	1.6	1.6	-1.5	1.2	1.5
Worry (Nagel 2018)	5.8	12.3	18.6	-4.2	2.8	4.3	-3.5	2.5	3.2
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.7	0.6	-0.2	0.5	-0.0	-0.3
Alzheimer’s Disease (in father)	0.3	0.3	1.5	0.0	0.6	-0.3	0.1	1.2	0.2
Alzheimer’s Disease (including proxy)	0.1	0.2	0.7	0.1	0.4	-0.3	0.8	0.1	-0.5
Crohns Disease (2017)	2.3	5.1	8.4	-1.5	-2.8	-2.9	2.0	-1.8	-2.2
Irritable Bowel Disease (IBD)	3.7	8.9	11.6	-2.5	-2.4	-3.2	2.9	-3.4	-3.3
Ulcerative Colitis (UC)	3.8	7.2	12.3	-2.2	-1.3	-2.8	2.8	-3.5	-3.0
Major Depression (MDD)	4.6	5.6	18.6	-4.3	-1.1	-1.8	1.5	-2.1	-1.9
Reaction Time	6.7	12.8	17.9	0.1	4.0	4.2	-4.0	3.3	4.0
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.4	0.1	-1.0	-0.9	1.3	-1.9	-1.5
Breast Cancer	0.8	1.9	2.5	1.4	1.6	1.5	-0.9	1.5	1.1
Ovarian Cancer	0.9	1.1	3.1	1.0	-0.9	-0.3	1.8	-0.1	-1.4
Prostate Cancer	12.0	16.9	21.4	2.1	4.4	4.6	-4.2	4.1	4.6
Age at First Birth	0.6	0.9	2.5	1.6	-0.1	0.1	1.3	-0.4	-0.9
Bipolar Disorder (2011)	2.7	2.7	11.2	-3.4	0.6	-0.7	-0.2	-1.8	-0.6
Body Mass Index (BMI) (2010)	1.8	2.5	12.7	3.6	-0.3	-0.2	0.0	1.3	0.6
Coronary Artery Disease (CAD)	2.4	2.9	13.7	-3.7	1.1	0.5	-1.2	-0.6	0.4
Crohns Disease (2012)	5.4	8.7	13.4	-1.8	-3.7	-3.2	2.7	-3.0	-3.1
Mean Putamen Volume	4.6	5.2	9.5	-0.2	-0.9	-2.1	3.1	-2.8	-3.0
Fasting Glucose	1.5	1.8	3.1	-0.4	-1.8	-1.0	1.7	-1.0	-1.7
HbA1C	0.3	0.4	1.1	-0.5	1.0	0.8	-0.4	0.2	0.4
HDL Cholesterol	0.6	0.9	2.1	-1.0	1.0	1.5	-1.0	-0.2	0.8
LDL Cholesterol	0.4	0.6	1.3	0.4	1.1	1.0	-0.1	1.0	0.4
Lupus	0.5	0.7	1.6	0.4	-0.4	-0.9	1.2	-0.6	-1.0
Neuroticism (2016)	2.0	2.8	4.5	-1.5	1.6	1.7	-1.5	2.1	1.7
Primary Biliary Cirrhosis	0.3	0.5	0.7	-0.7	-0.3	-0.8	0.4	-0.8	-0.9
Rheumatoid Arthritis	1.3	1.8	4.7	-1.0	-1.7	-2.2	0.8	-0.8	-1.0
Schizophrenia (2014)	3.8	8.4	29.0	-5.4	2.4	2.7	-2.5	-0.3	1.4
Triglycerides	0.4	0.7	1.8	-1.3	-0.6	-0.8	0.8	-0.4	-0.8
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.6	-1.0	-0.1	0.5	0.7	-1.2	-1.3
Ulcerative Colitis	9.3	13.5	21.8	-3.3	-2.9	-3.6	3.3	-4.7	-3.9
Blood Eosinophil Count	1.4	10.7	19.9	-2.1	-3.1	-2.4	3.0	-4.5	-4.0
Blood Platelet Count	3.8	44.0	58.2	-3.0	-6.8	-7.6	6.3	-7.3	-7.5
Blood Red Count	0.9	8.4	44.0	-6.6	0.8	-1.5	0.1	-1.5	-1.0
Blood White Count	5.5	41.1	59.9	-6.1	-7.5	-7.7	4.1	-6.7	-5.6
Heel T-Score	0.8	6.5	11.8	1.8	-0.7	-1.5	3.1	-3.4	-3.4
BMI	2.1	12.3	55.8	7.5	0.4	1.0	0.1	3.7	1.7
Height	14.0	270.5	372.5	-6.2	-15.6	-18.4	17.6	-17.9	-19.3
Waist Hip Ratio (WHR)	3.9	17.7	23.4	-3.2	-4.0	-4.6	4.0	-4.4	-4.8
Systolic Blood Pressure	4.6	23.1	127.7	-11.3	0.7	0.3	-2.8	-0.0	1.6
Smoking Status	11.7	28.1	60.8	0.3	-7.6	-7.8	4.3	-3.1	-4.7
Allergy or Eczema	20.5	53.9	69.6	4.9	7.4	8.1	-7.3	7.5	8.3
Cardiovascular Disease	4.7	15.6	55.5	-7.5	-2.6	-3.2	1.6	-3.5	-2.5
Hypothyroidism (self reported)	0.5	1.2	2.0	0.5	-1.0	-1.4	1.2	-0.9	-1.2
Respiratory disease	2.9	6.5	8.4	2.3	2.8	2.6	-2.0	2.9	2.5
Type 2 Diabetes (T2D) (2018)	4.1	7.6	12.9	1.6	-3.3	-3.6	3.0	-1.6	-2.8
Lung FEV1/FVC ratio	0.6	3.0	6.8	2.6	-0.5	-0.4	-1.7	1.9	2.0
Lung FVC	1.3	6.9	12.7	-1.5	1.3	1.8	-3.6	3.1	3.4
Neuroticism	4.0	9.6	12.2	-3.3	2.8	3.5	-3.2	2.7	3.0
Chronotype (morning person)	0.2	0.5	1.1	0.9	1.0	-0.7	-0.1	0.7	0.7
Hair Pigment	0.0	0.7	2.0	-1.4	0.3	1.4	0.5	-0.0	-0.1
Tanning	0.3	4.0	10.3	1.4	-3.2	-2.2	1.6	-1.1	-1.7
Hand grip strength (left)	8.9	23.4	37.0	-0.1	-5.9	-6.1	5.3	-3.5	-5.3
Number of treatments/medications taken	1.0	1.8	7.5	-2.7	-0.2	-1.6	-0.1	-0.8	-0.2
Average weekly spirits intake	0.2	0.3	1.4	1.2	-0.2	-0.5	0.0	-0.2	-0.3
Sensitivity / hurt feelings	0.6	1.1	3.1	-1.8	-0.2	1.4	-0.7	0.9	0.5
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.8	-1.7	-0.1	-0.2	0.4	-0.3	-0.7
Hearing difficulty/problems: Yes	5.6	8.6	13.2	-2.5	-1.9	-3.0	3.0	-3.6	-3.2
Relative age of first facial hair	1.6	3.3	5.3	-0.9	-2.1	-2.0	1.4	-2.3	-1.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	4.8	-2.2	0.4	0.3	-0.7	-0.6	0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.3	-0.6	1.5	0.6	-0.2	1.0	0.4
Ever had hysterectomy (womb removed)	1.8	2.0	3.8	0.5	2.0	1.4	-1.3	1.4	1.6
Systolic blood pressure, automated reading	4.1	12.0	56.2	-7.5	1.4	0.9	-2.8	0.8	2.2
Eye problems/disorders: Diabetes related eye disease	2.7	2.9	6.1	0.1	-2.5	-2.1	1.6	-1.0	-1.9
Angina	2.4	3.2	7.3	-2.7	-1.2	-2.1	1.2	-1.5	-1.5
Medication for hormone replacement therapy	0.2	0.3	0.5	-0.0	0.7	-0.5	-0.6	-0.6	-0.2
Vitamin and mineral supplements	1.0	1.3	4.3	-0.3	1.1	2.1	-0.9	0.7	1.0
Supplements: Zinc	2.6	2.9	6.2	-0.4	-1.7	-2.5	1.8	-1.3	-1.7
Medication: Co-codamol	0.8	1.0	1.9	-1.4	0.6	0.5	-1.4	0.2	1.1
Medication: Metformin	1.8	2.6	4.4	1.7	-1.8	-2.1	1.6	-0.8	-1.3
Diabetes (father)	0.4	0.5	1.2	0.0	-1.1	-0.9	0.7	0.1	-0.5
Diabetes (mother)	3.8	4.8	7.0	0.3	-2.6	-2.3	2.2	-2.2	-2.6
Severe depression (siblings)	1.6	1.8	3.3	-1.4	1.2	0.9	-1.8	1.0	1.5
Pack years adult smoking proportion	0.8	1.3	4.5	-0.6	-2.1	-1.3	0.5	-0.4	-0.7
Impedance of leg (right)	2.9	13.9	61.3	-7.8	-1.8	-1.5	0.4	-3.5	-2.1
Leg fat-free mass (left)	3.5	18.8	26.7	4.2	-4.3	-4.8	5.2	-2.8	-4.5
Trunk fat percentage	0.4	1.5	6.6	2.6	-1.2	-0.1	0.9	0.4	-0.2
Hand grip strength (right)	5.5	14.8	26.7	0.0	-5.2	-4.9	3.8	-2.8	-3.9
Townsend deprivation index at recruitment	1.4	1.9	4.5	1.0	-2.1	-2.0	0.9	-0.4	-1.1
Current tobacco smoking	5.6	9.1	23.5	0.3	-4.8	-4.1	2.3	-1.7	-2.5
Average weekly fortified wine intake	0.6	0.7	1.5	1.2	1.2	1.2	-0.2	0.2	0.3
Maternal smoking around birth	5.9	8.5	18.5	0.3	-4.1	-4.3	2.5	-1.8	-2.5
Fed-up feelings	0.7	1.3	2.8	0.7	0.8	1.3	-1.0	1.7	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.7	-0.8	-0.5	0.0	0.8	0.0
Relative age voice broke	1.7	2.5	3.3	-1.8	-1.3	-1.8	1.3	-1.7	-1.5
Taking other prescription medications	0.2	0.3	1.2	-1.1	0.6	-0.0	-0.4	0.1	0.2
Age when periods started (menarche)	1.4	3.4	6.3	1.1	-2.2	-2.5	1.4	-1.8	-1.6
Bilateral oophorectomy (both ovaries removed)	3.5	4.1	7.0	-1.2	2.6	1.4	-2.3	1.8	2.4
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	5.1	-0.2	-0.8	-0.3	0.9	-2.3	-1.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	0.4	0.9	-0.6	-0.5	0.7	0.6
Qualifications: CSEs or equivalent	0.2	0.3	0.7	0.8	-0.4	-0.0	0.5	0.7	-0.3
Serious illness, injury or assault to yourself	0.9	1.1	1.7	-1.2	0.9	1.0	-0.8	1.3	1.0
High blood pressure	4.7	13.1	49.1	-7.0	-2.2	-3.1	1.1	-3.2	-1.9
Hayfever, allergic rhinitis or eczema	17.2	37.2	48.9	4.0	5.9	7.0	-6.1	6.2	7.0
Multivitamins +/- minerals	0.3	0.4	1.1	0.3	-0.4	-1.1	0.6	-0.4	-0.5
Stomach or abdominal pain in last month	0.3	0.4	1.4	1.2	0.3	0.3	0.0	0.8	0.2
Supplements: Glucosamine	1.2	1.6	4.7	-0.3	0.0	-2.2	1.4	-1.1	-1.2
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	4.1	0.7	2.0	2.0	-1.5	0.9	1.3
Medication: Atenolol	5.2	6.5	12.3	-3.5	-2.5	-2.4	1.1	-3.1	-1.9
Medication: Levothyroxine sodium	0.7	1.2	1.9	0.2	1.1	1.1	-1.3	1.1	1.4
Sitting height	13.4	94.8	127.7	-6.7	-8.1	-10.6	10.4	-10.5	-11.3
Chronic bronchitis/emphysema (father)	0.8	0.9	2.8	0.2	0.5	0.8	-1.0	1.7	1.0
High blood pressure (mother)	2.5	3.5	11.5	-3.4	1.0	1.0	-2.1	0.6	1.7
Body mass index (BMI)	1.5	6.6	26.7	5.2	0.2	0.9	-0.4	3.0	1.7
Impedance of leg (left)	2.9	14.2	59.5	-7.7	-1.8	-1.9	0.7	-3.6	-2.3
Leg predicted mass (left)	3.5	18.7	26.5	4.1	-4.3	-4.8	5.2	-2.8	-4.5
Trunk fat mass	1.5	6.6	9.3	2.9	-3.0	-2.5	3.0	-1.2	-2.4
Waist circumference	2.0	7.3	11.3	1.9	-3.2	-3.0	3.4	-1.2	-2.7
Number of incorrect matches in round	3.1	5.2	10.0	-0.9	3.2	3.0	-2.1	1.5	2.0
Past tobacco smoking	16.4	30.1	57.1	1.5	7.0	7.6	-4.8	4.5	5.4
Alcohol usually taken with meals	0.9	1.5	4.2	-0.3	1.2	2.0	-1.2	0.5	1.2
Nervous feelings	3.6	6.7	12.3	-3.5	2.0	3.3	-2.6	1.2	2.1
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	5.8	-2.4	0.9	0.7	-1.7	1.5	1.5
Hearing difficulty/problems with background noise	10.6	16.9	22.8	-3.6	-3.7	-4.3	3.9	-4.8	-4.4
Hair/balding pattern: Pattern 2	0.6	0.8	3.0	1.7	1.1	0.4	0.5	0.3	-0.1
Had menopause	2.4	2.9	4.3	-1.1	2.0	2.1	-1.8	1.3	1.8
Had other major operations	0.1	0.2	0.6	-0.7	0.3	-0.0	0.5	-0.3	-0.1
Forced vital capacity (FVC)	5.6	21.4	35.4	-4.0	-4.7	-6.0	3.6	-4.6	-4.6
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	8.0	-0.2	-1.0	-1.0	1.8	-2.8	-2.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.7	-1.3	-0.4	-1.0	0.1	-0.2	-0.3
Qualifications: None of the above	0.3	0.7	1.9	-0.3	-1.4	-1.2	0.4	0.9	-0.1
Financial difficulties in last 2 years	0.7	0.9	1.9	-0.9	-1.3	-1.4	0.6	-0.2	-0.8
Mouth/teeth dental problems	0.5	0.8	2.9	-0.5	1.0	1.7	-0.6	-0.5	0.4
Heart attack	1.3	1.7	7.8	-2.8	-0.3	-0.8	-0.6	-1.0	0.2
Allergy	14.9	34.2	42.7	-4.2	-5.6	-6.5	5.8	-6.2	-6.5
Pain all over the body in last month	1.6	1.7	2.7	0.0	1.3	1.6	-1.7	1.2	1.4
Diabetes (self-reported)	3.3	5.1	7.7	1.3	-2.6	-2.6	2.8	-1.3	-2.5
Hayfever/allergic rhinitis (self-reported)	6.9	9.1	13.2	2.0	2.8	3.6	-3.1	3.1	3.3
Medication: Ramipril	1.4	1.8	9.7	-3.1	0.2	0.1	-0.8	-0.5	0.6
Medication: Simvastatin	0.3	0.4	0.7	-0.1	-0.7	-0.8	0.8	-0.7	-0.6
Fluid intelligence score	0.5	1.0	2.2	1.2	-0.6	-0.4	0.7	-1.5	-1.1
Illnesses of siblings	1.6	2.2	5.1	1.9	1.3	2.2	-1.0	0.8	1.2
Neuroticism score	3.0	6.2	8.3	-2.2	2.1	2.8	-2.9	2.3	2.6
Weight	3.4	16.8	24.3	2.7	-4.5	-4.8	4.9	-2.8	-4.3
Impedance of arm (right)	0.7	3.3	13.7	-3.7	0.7	1.1	-0.8	-2.0	-0.2
Arm fat percentage (right)	0.9	3.5	14.6	3.8	-0.3	1.1	-0.1	1.9	1.1
Trunk fat-free mass	6.9	39.5	61.5	1.1	-6.3	-7.8	7.3	-5.5	-7.1
Hip circumference	1.4	6.1	11.3	3.4	-2.5	-2.4	2.9	-0.8	-2.0
Time employed in main current job	0.1	0.1	0.2	0.2	0.4	0.2	0.3	0.4	-0.0
Alcohol intake versus 10 years previously	0.9	1.4	6.4	-0.1	-1.3	-2.5	0.3	-0.2	-0.4
Father’s age at death	0.7	1.0	2.6	-0.8	-0.3	-0.5	1.1	-1.6	-1.1
Worrier / anxious feelings	8.8	16.6	24.9	-2.7	4.7	5.0	-4.2	3.3	4.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	5.8	0.1	-2.4	-1.6	1.2	-0.9	-1.4
Falls in the last year	1.4	1.9	4.2	-2.0	-0.2	-2.0	0.7	-1.1	-1.2
Hair/balding pattern: Pattern 3	2.1	3.2	6.0	-2.5	-1.3	-2.3	1.0	-1.7	-1.6
Number of live births	0.4	0.5	2.2	-1.5	0.6	0.6	0.2	-0.5	-0.3
Forced expiratory volume in 1-second (FEV1)	3.4	11.3	20.9	-2.8	-3.8	-4.6	2.4	-3.1	-3.1
Pulse rate	2.9	4.9	11.1	-0.0	2.4	3.3	-2.1	1.7	2.3
Happiness	0.7	0.8	1.9	0.3	1.4	1.0	-0.3	1.2	0.7
Noisy workplace	0.2	0.2	0.5	0.3	-0.3	-0.2	-0.5	0.7	0.5
Qualifications: A levels/AS levels or equivalent	2.3	5.1	11.0	-1.3	-1.3	-0.8	2.5	-3.3	-3.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.4	-1.2	0.1	-0.8	-0.1	-0.1	-0.2
Mouth/teeth dental problems: Dentures	1.1	1.9	3.4	0.5	-1.7	-1.8	1.7	-0.8	-1.3
Asthma	2.7	5.2	8.1	2.1	2.4	2.4	-1.6	2.8	2.2
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.0	5.8	1.0	2.4	1.5	-1.6	1.9	1.7
Medication: Cholesterol lowering	0.2	0.3	0.7	-0.6	-0.7	-0.8	0.2	-0.0	-0.0
Depression (self-reported)	0.1	0.1	0.4	-0.3	0.2	0.2	-0.0	0.6	0.1
Medication: Lansoprazole	0.8	0.9	2.3	0.2	1.2	0.7	-0.8	1.5	0.9
Prospective memory result	0.1	0.2	0.5	0.4	-0.3	0.2	0.7	0.3	-0.4
Lung cancer (father)	2.3	2.7	5.0	1.0	-0.5	-1.6	2.2	-1.8	-2.1
Illnesses of mother	0.9	1.1	5.4	2.3	0.4	0.1	0.3	0.9	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.3	7.2	13.4	-2.5	-2.9	-3.7	1.7	-2.5	-2.3
Pulse wave Arterial Stiffness index	2.5	3.0	6.8	-0.6	2.6	1.9	-1.4	1.5	1.7
Impedance of arm (left)	0.8	3.7	14.1	-3.8	1.1	1.5	-1.5	-1.6	0.4
Arm fat mass (right)	0.8	3.3	12.8	3.6	-1.6	-0.9	1.8	0.3	-0.8
Trunk predicted mass	6.7	38.1	59.6	1.2	-6.1	-7.7	7.2	-5.4	-7.0
Standing height	13.1	130.0	176.9	-4.6	-10.5	-12.8	12.0	-12.8	-13.3
Length of working week for main job	6.1	6.8	10.0	-1.2	-3.1	-2.3	2.4	-3.2	-2.9
Exposure to tobacco smoke at home	0.6	0.7	2.2	1.5	-1.1	-0.2	-0.5	-0.3	0.4
Breastfed as a baby	0.8	1.0	3.9	-2.0	0.3	1.0	-0.8	-0.1	0.6
Tense / ‘highly strung’	1.6	2.6	11.7	-3.4	-0.4	-0.2	-1.3	0.6	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	8.0	-2.8	-0.4	-0.5	0.9	-0.7	-1.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	0.5	-0.0	0.4	0.7	-0.2	-0.6
Birth weight of first child	2.4	4.4	6.1	1.6	-2.5	-2.2	2.5	-1.7	-2.0
Peak expiratory flow (PEF)	5.0	11.7	22.3	-0.5	-4.3	-4.7	3.2	-2.7	-3.4
Pulse wave reflection index	2.8	3.4	7.9	1.6	-1.4	-2.8	2.1	-0.6	-1.8
Ever highly irritable/argumentative for 2 days	1.6	2.0	6.0	-2.5	-1.1	-0.9	0.6	-1.5	-1.1
Loud music exposure frequency	0.9	1.0	1.7	-0.1	-1.3	-1.0	1.0	-0.9	-1.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.5	-0.6	0.0	-0.7	0.6	-1.2	-1.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.4	-0.0	-0.6	0.2	0.4	-0.1
Blood clot in the leg (DVT)	2.1	2.7	3.8	0.7	1.8	2.0	-1.6	1.9	1.6
Medication: Paracetamol	0.6	1.0	1.7	-1.3	1.1	0.4	-1.3	0.8	1.0
Headache pain in last month	1.3	2.2	4.5	1.2	2.1	1.3	-1.0	1.6	1.5
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	6.4	2.5	0.9	1.5	-0.5	1.2	0.6
Glaucoma (self-reported)	0.3	0.3	1.1	-1.0	-0.8	0.2	-0.3	0.3	0.3
Gout (self-reported)	0.6	0.8	2.2	-1.5	-0.8	-0.6	0.9	-0.4	-0.8
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	-0.3	0.3	-0.2	-0.1	-0.2	-0.1
Medication: Amlodipine	1.1	1.6	2.7	-1.6	0.5	1.1	-1.6	0.7	1.4
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.5	1.3	0.9	1.6	-0.2	1.4	0.5
Birth weight	2.6	5.5	7.9	2.4	-1.2	-2.8	2.8	-1.9	-2.6
Chronic bronchitis/emphysema (mother)	2.0	2.3	4.6	-0.3	-1.4	-2.1	1.5	-1.4	-1.7
High blood pressure (siblings)	2.0	2.9	8.3	-2.9	-0.9	-2.1	1.0	-1.2	-1.3
Forced vital capacity (FVC), Best measure	3.5	13.0	20.7	-3.4	-3.5	-4.5	2.7	-3.7	-3.6
Body fat percentage	0.4	1.4	5.9	2.4	-1.2	0.1	0.6	0.8	0.1
Leg fat percentage (right)	0.3	1.3	3.7	1.9	-1.5	-0.2	0.6	1.1	0.2
Arm fat-free mass (right)	5.7	29.2	46.9	1.5	-5.7	-6.8	6.4	-4.2	-6.0
Exposure to tobacco smoke outside home	4.8	6.4	14.0	1.0	-3.7	-3.6	1.9	-1.5	-2.2
Comparative body size at age 10	0.5	1.4	5.8	2.4	-1.6	-0.2	0.1	0.2	0.2
Number of full brothers	0.5	0.6	1.3	-0.7	-1.1	-1.0	-0.5	0.7	0.4
Worry too long after embarrassment	2.2	3.6	5.1	-1.3	1.7	2.1	-2.3	1.9	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.9	-2.0	1.5	1.2	-1.0	1.3	0.9
Wheeze or whistling in the chest in last year	0.4	0.6	3.2	1.8	0.2	-0.2	0.6	0.5	-0.1
Number of children fathered	0.6	0.7	1.8	-0.2	-0.4	-1.4	0.7	-1.2	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	3.6	-1.8	-1.8	-1.5	1.3	-1.9	-1.8
Age at first live birth	0.3	0.5	2.1	1.4	-0.2	0.3	0.8	-0.4	-0.4
Pulse wave peak to peak time	5.1	6.0	10.9	0.4	-3.3	-2.7	2.3	-2.5	-2.6
Health satisfaction	0.3	0.4	1.1	-0.4	-0.5	0.1	1.0	0.3	-0.7
Shortness of breath walking on level ground	1.3	1.6	2.4	0.8	1.5	1.2	-0.9	1.6	1.3
Qualifications: College or University degree	0.5	1.7	3.1	-1.3	1.6	1.5	-0.4	-1.7	-0.3
Eye problems/disorders: None of the above	1.3	1.5	2.2	1.4	1.5	0.6	-1.0	1.4	1.3
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.8	1.1	-1.3	-1.1	1.7	-0.0	-1.3
Emphysema/chronic bronchitis	0.4	0.4	1.8	1.3	-0.2	0.3	0.5	0.6	-0.3
Medication for pain relief, constipation, heartburn	0.7	1.2	2.3	1.5	-1.3	-0.5	1.4	-0.2	-1.1
Neck or shoulder pain in last month	0.8	1.2	5.0	-2.2	-0.9	-0.0	-0.8	0.6	0.6
Medication: Blood pressure	1.8	3.1	12.4	-3.5	-1.0	-1.3	0.2	-1.7	-0.7
Angina (self-reported)	2.6	3.5	9.4	-3.1	-1.1	-2.0	1.0	-1.7	-1.4
Migraine (self-reported)	2.0	2.5	9.5	3.1	-0.3	-1.2	1.7	-0.5	-1.0
Medication: Ibuprofen	0.7	0.8	2.0	0.6	1.4	1.0	-0.6	0.9	0.7
Medication: Allopurinol	0.9	1.2	3.0	-1.7	-1.0	-0.9	0.7	-0.9	-0.9
Medication: Omeprazole	0.6	0.7	1.7	-0.8	-0.5	-0.7	0.6	-1.3	-0.8
Medication: Seretide 50 evohaler	0.4	0.4	0.9	0.6	-0.9	-0.5	0.7	-0.6	-0.5
Mean time to correctly identify matches	1.9	3.6	6.0	-1.0	2.5	2.1	-2.1	1.3	2.0
Heart disease (mother)	0.8	1.0	2.3	-1.5	1.4	1.0	-0.8	-0.1	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.8	0.0	-1.7	-0.4	-0.3	0.5	0.3
Whole body fat mass	1.2	5.2	8.8	3.0	-2.8	-2.2	2.5	-0.6	-1.8
Leg fat mass (right)	1.5	5.7	10.0	2.8	-3.2	-2.4	2.7	-0.5	-1.9
Arm predicted mass (right)	5.7	29.2	46.6	1.4	-5.7	-6.8	6.3	-4.3	-6.0
Pulse rate, automated reading	0.9	2.9	6.6	-2.6	1.5	2.6	-1.0	0.5	0.9
Alcohol intake frequency.	1.5	3.6	6.0	-1.4	-2.1	-2.5	1.9	-1.3	-2.0
Comparative height size at age 10	9.8	54.1	79.0	-1.5	-6.6	-8.1	8.1	-8.2	-8.9
Number of full sisters	0.2	0.2	1.0	1.0	-0.0	0.0	-0.2	0.2	0.1
Suffer from ‘nerves’	1.8	2.9	10.2	-3.2	1.1	1.9	-1.1	0.4	0.8
Overall health rating	0.3	0.6	2.8	0.2	-0.2	-0.1	-0.3	1.7	0.7
Chest pain or discomfort	0.2	0.3	0.6	-0.6	0.1	-0.6	-0.4	0.8	0.3
Had major operations	0.2	0.2	0.7	0.3	-0.8	-0.8	0.1	0.1	-0.1
Age at last live birth	1.1	1.6	2.6	0.8	-1.5	-0.9	1.6	-1.2	-1.3
Family relationship satisfaction	0.9	1.1	2.7	-1.7	-1.4	-1.3	0.2	-0.1	-0.4
Leg pain on walking	0.9	1.2	2.3	-0.6	0.8	1.0	-1.1	1.5	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	5.8	-0.6	-2.4	-1.4	0.3	-0.8	-0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.7	1.3	-0.3	-0.1	0.4	0.8	0.1
Illness, injury, bereavement, stress in last 2 years	1.9	2.4	9.5	3.1	0.4	1.4	-0.8	0.9	1.2
Medication: Aspirin	3.6	4.8	10.6	-3.2	-1.8	-2.1	1.3	-2.5	-1.6
Supplements: Vitamin C	1.1	1.3	2.8	0.1	-0.7	-1.7	1.5	-0.6	-1.3
Knee pain experienced in last month	0.8	1.2	3.2	0.7	-0.8	-1.8	1.1	-0.7	-1.1
Hypertension (Self-reported)	3.8	10.6	44.0	-6.6	-1.9	-2.6	0.7	-2.7	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.4	-1.1	0.2	-2.1	0.6	-1.4	-0.9
Illnesses of father: Heart disease	2.2	3.1	6.6	-2.6	-0.7	-2.3	0.9	-1.8	-1.5
Illnesses of siblings: Diabetes	1.7	2.1	3.3	1.1	-1.7	-1.1	1.7	-1.1	-1.8
Smoking status: Previous	8.5	12.8	24.9	-1.8	-4.3	-5.0	2.9	-3.0	-3.5
Forced expiratory volume in 1-second (FEV1), predicted	10.3	21.4	32.7	-1.7	-5.0	-5.7	4.0	-5.2	-5.0
Whole body fat-free mass	5.2	29.9	44.2	2.5	-5.5	-6.7	6.6	-4.3	-6.1
Leg fat-free mass (right)	3.6	19.1	27.9	4.1	-4.1	-4.9	5.3	-2.8	-4.5
Arm fat percentage (left)	1.0	3.9	14.7	3.8	-0.0	1.4	-0.6	2.1	1.5
Average weekly red wine intake	0.3	0.5	1.2	-1.1	0.6	0.2	-0.5	-1.1	0.1
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.5	0.4	-1.6	-0.9	1.3	-0.3	-1.2
Mood swings	1.1	2.1	3.3	-0.1	1.5	1.8	-1.4	1.7	1.4
Loneliness, isolation	0.7	1.0	1.7	-0.1	0.9	0.9	-1.1	1.3	1.2
Long-standing illness, disability or infirmity	3.0	4.5	6.3	-2.5	-2.4	-2.5	1.5	-1.8	-1.8
Ever had bowel cancer screening	3.1	3.6	5.0	-1.8	-1.5	-2.2	1.9	-1.9	-2.0
Diabetes diagnosed by doctor	3.2	5.2	7.7	1.5	-2.6	-2.8	2.7	-1.1	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	5.3	0.1	-2.3	-1.2	1.0	-1.0	-1.4
Friendships satisfaction	1.3	1.6	2.8	1.6	1.1	1.2	-0.7	1.7	1.0
Qualifications: nursing, teaching	2.0	3.0	5.6	-0.6	-0.8	-1.2	2.2	-2.4	-2.3
Commuting to job workplace: Walk	2.2	2.4	4.3	-2.1	1.9	0.5	-1.9	0.2	1.5
Eye problems/disorders: Cataract	0.3	0.4	0.9	0.9	-0.9	0.2	0.6	-0.3	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.1	0.7	0.0	-0.2	0.3	1.0	-0.1
Medication for cholesterol	1.8	2.7	9.2	3.0	0.3	1.4	-0.9	1.4	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.8	-1.2	-1.2	-1.7	0.6	-0.5	-0.7
Back pain experienced in last month	2.1	3.1	6.8	-1.7	-2.2	-2.6	1.2	-0.7	-1.4
Mineral and other dietary supplements	2.3	3.0	6.2	-0.3	1.6	2.5	-2.0	1.5	1.8
Breast cancer (self-reported)	0.1	0.1	0.1	-0.3	0.1	-0.3	0.4	-0.3	-0.2
Asthma (self-reported)	2.6	5.1	7.4	1.9	2.4	2.5	-1.6	2.7	2.2
Osteoporosis (self-reported)	0.6	0.7	1.4	-0.8	0.3	0.5	-0.9	1.2	1.0
Osteoarthritis (self-reported)	0.3	0.4	1.3	-0.6	1.2	-0.1	-0.4	0.8	0.5
Medication: Aspirin	4.1	5.3	12.2	-3.5	-2.0	-2.0	1.5	-2.5	-1.8
Medication: Gliclazide	0.5	0.6	1.4	-0.0	-1.0	-1.2	1.0	-0.1	-0.6
Illnesses of father: None of the above (group 1)	1.0	1.2	5.7	2.4	0.4	0.9	0.5	-0.5	-0.1
Smoking status: Current	5.9	9.3	22.6	0.5	-4.8	-4.3	2.3	-1.7	-2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.7	-1.3	-0.1	0.3	-1.1	0.5	1.2
Whole body water mass	5.1	29.3	42.9	2.5	-5.4	-6.5	6.5	-4.2	-6.0
Leg predicted mass (right)	3.6	19.3	28.1	4.1	-4.1	-4.9	5.3	-2.9	-4.6
Arm fat mass (left)	0.8	3.5	13.1	3.6	-1.7	-1.1	1.7	0.3	-0.8
Number of self-reported non-cancer illnesses	0.5	0.9	2.3	-0.9	1.5	0.3	-1.1	0.7	0.9
Average weekly champagne plus white wine intake	1.9	2.6	6.4	2.5	0.8	1.7	-0.8	1.8	1.2
Miserableness	0.5	0.9	1.5	-0.3	-1.0	-1.2	1.0	-0.4	-1.2
Guilty feelings	0.5	0.8	1.4	0.4	1.1	0.5	-0.9	1.2	1.0
Wears glasses or contact lenses	0.6	0.6	1.4	-1.2	-0.0	-0.4	1.0	-0.9	-0.7
Ever taken oral contraceptive pill	1.0	1.1	3.8	1.9	-0.9	-0.7	0.9	-0.4	-0.8
Hearing aid user	0.1	0.1	0.4	-0.3	0.7	-0.1	0.2	-0.2	-0.1
Mother’s age at death	1.1	1.4	2.1	-1.0	-1.2	-0.3	1.4	-1.4	-1.3
Financial situation satisfaction	2.6	3.2	6.3	0.0	-2.5	-2.2	1.8	-1.0	-2.0
Tinnitus: Yes, now most or all of the time	0.9	1.1	1.9	-0.1	-0.9	-1.4	1.0	-1.3	-1.1
Commuting to job workplace: Public transport	0.3	0.3	0.7	-0.7	-0.5	0.5	0.1	-0.8	-0.5
Eye problems/disorders: Glaucoma	0.5	0.6	1.8	-1.3	-1.0	-0.1	0.5	-0.6	-0.5
Medication: Blood pressure	3.8	7.2	23.2	-4.8	-1.9	-2.6	1.4	-2.1	-1.8
Pain type(s) experienced in last month: Hip pain	3.6	4.6	8.6	0.5	1.7	1.8	-2.4	2.9	2.6
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.2	-0.3	-1.2	-1.5	0.8	-1.1	-0.8
High cholesterol (Self-reported)	0.4	0.8	1.3	-0.8	-0.8	-1.1	0.7	-1.0	-0.8
Medication: Bendroflumethiazide	4.6	7.0	9.3	-3.1	-2.1	-3.0	2.2	-2.7	-2.6
Medication: Paracetamol	0.5	0.8	2.9	-1.7	0.8	0.1	-0.8	0.1	0.5
Medication: Lisinopril	1.8	2.3	5.8	-2.4	-0.5	-1.4	0.8	-1.9	-1.3
Medication: Atorvastatin	1.0	1.3	6.0	-2.4	-0.6	-1.1	-0.3	-0.2	-0.1
Illnesses of father: High blood pressure	0.6	0.7	3.3	-1.8	0.4	-0.4	-0.7	-0.2	0.4
Alcohol drinker status: Never	0.1	0.1	0.2	-0.0	0.3	0.3	-0.3	0.5	0.4
Ever smoked	10.9	19.1	37.5	-1.1	-6.1	-6.1	3.3	-3.6	-3.9
Basal metabolic rate	4.8	26.6	38.7	2.6	-5.3	-6.2	6.2	-4.0	-5.7
Leg fat percentage (left)	0.4	1.4	4.5	2.1	-1.3	-0.5	0.8	1.1	0.1
Arm fat-free mass (left)	5.4	27.5	41.9	1.8	-5.4	-6.5	6.4	-4.0	-5.8
Number of operations (self-reported)	0.2	0.3	0.6	0.7	0.7	0.1	0.7	-0.0	-0.3
Average weekly beer plus cider intake	0.2	0.2	1.1	1.1	0.3	-0.2	0.1	0.0	-0.2
Irritability	1.2	2.0	5.1	-1.3	-1.9	-2.2	0.9	-0.4	-0.9
Risk taking	1.0	1.4	6.4	-0.4	-0.6	-2.5	0.4	-1.0	-0.5
Ever had prostate specific antigen (PSA) test	1.6	1.8	3.6	0.6	1.2	1.2	-1.6	1.2	1.9
Fractured/broken bones in last 5 years	2.7	3.5	5.6	-0.5	1.7	2.1	-2.4	1.6	2.3
Age started oral contraceptive pill	0.3	0.3	0.7	-0.6	-0.5	-0.0	0.8	-0.5	-0.8
Diastolic blood pressure, automated reading	5.4	16.8	56.7	-7.5	-2.2	-4.5	2.0	-2.9	-2.6
Ever depressed for a whole week	2.4	3.0	5.7	-2.4	-1.2	-1.6	1.3	-1.7	-1.9
Unable to work because of sickness or disability	1.0	1.3	4.3	-2.1	-0.8	-1.6	-0.1	-0.6	-0.3
Commuting to job workplace: Cycle	0.6	0.7	3.0	-1.7	-0.3	-0.8	-0.0	-0.7	-0.4
Myopia	0.3	0.4	1.0	0.4	1.0	0.9	0.4	0.6	-0.1
Vascular/heart problems diagnosed by doctor	4.9	13.3	49.7	7.0	2.4	3.3	-1.1	3.0	1.8
Cholesterol lowering medication	0.3	0.5	2.6	-1.6	0.1	-0.4	-0.3	-0.4	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	-0.4	0.2	-0.4	0.4	-0.7	-0.5
Pain experienced in last month	0.3	0.4	0.6	0.7	-0.8	-0.3	0.7	-0.7	-0.6
Supplements: Calcium	0.1	0.2	0.5	-0.1	-0.7	-0.2	-0.1	0.4	0.4
Basal cell carcinoma (self-reported)	1.9	2.3	4.8	-1.0	-0.4	-1.5	1.4	-2.2	-1.9
Heart attack/myocardial infarction (self-reported)	1.2	1.5	7.3	-2.7	-0.3	-0.7	-0.6	-0.9	0.2
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	4.1	0.5	1.6	2.0	-1.8	1.8	1.7
Heart disease (siblings)	2.7	3.3	11.3	-3.4	-1.5	-1.9	0.3	-1.4	-0.8
Alcohol drinker status: Previous	0.1	0.1	0.5	-0.7	-0.1	0.0	-0.0	-0.4	-0.1
Pack years of smoking	0.9	1.4	4.2	-0.7	-2.1	-1.5	0.7	-0.6	-0.8
Impedance of whole body	1.5	7.5	36.7	-6.1	-0.2	0.2	-0.6	-2.7	-0.8
Leg fat mass (left)	1.4	5.6	9.0	2.8	-3.0	-2.4	2.6	-0.4	-1.8
Arm predicted mass (left)	5.5	27.9	41.8	1.8	-5.5	-6.5	6.4	-4.1	-5.9