[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr16:2,510,603-5,510,848

Best TWAS P=4.32e-11 · Best GWAS P=8.25e-10 conditioned to 0.0775

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Adipose Subcutaneous	CLUAP1	0.42	0.32	enet	35	0.35	1.2e-29	-5.2	-6.6	4.3e-11	0.70	0.20	0.79	TRUE
27	GTEx	Muscle Skeletal	ZNF213	0.17	0.00	enet	22	0.03	1.0e-03	-3.1	-5.5	3.7e-08	0.03	0.31	0.06	TRUE
23	GTEx	Heart Atrial Appendage	NUDT16L1	0.12	0.17	lasso	1	0.17	4.8e-08	5.2	-5.2	2.2e-07	0.02	0.00	1.00	TRUE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NLRC3	0.13	0.12	blup	39	0.13	4.9e-14	-5.2	5.9	3.3e-09	-0.67	0.00	0.99	FALSE
5	GTEx	Artery Aorta	CLUAP1	0.40	0.33	enet	18	0.33	5.4e-19	-5.2	-5.9	4.3e-09	0.74	0.20	0.80	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	CLUAP1	0.30	0.13	enet	18	0.23	8.1e-13	-5.3	-5.8	5.7e-09	0.70	0.13	0.87	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CLUAP1	0.26	0.17	enet	24	0.17	2.9e-20	-5.2	-5.8	7.3e-09	0.66	0.20	0.79	FALSE
21	GTEx	Heart Atrial Appendage	CLUAP1	0.40	0.16	enet	13	0.29	2.3e-13	-5.3	-5.7	1.1e-08	0.79	0.16	0.84	FALSE
26	GTEx	Lung	ZSCAN32	0.08	0.02	lasso	3	0.02	6.3e-03	-4.8	-5.7	1.2e-08	0.58	0.09	0.25	FALSE
49	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NLRC3	0.03	0.01	lasso	3	0.00	3.3e-01	-4.8	5.7	1.2e-08	-0.73	0.01	0.78	FALSE
25	GTEx	Lung	CLUAP1	0.16	0.10	enet	9	0.12	2.1e-09	-5.2	-5.7	1.4e-08	0.81	0.18	0.82	FALSE
22	GTEx	Heart Atrial Appendage	NLRC3	0.27	0.07	lasso	3	0.08	2.2e-04	-5.2	5.6	1.6e-08	-0.80	0.01	0.98	FALSE
11	GTEx	Brain Hippocampus	CLUAP1	0.37	0.10	lasso	5	0.09	4.9e-03	-6.1	-5.6	2.1e-08	0.89	0.00	0.97	FALSE
40	GTEx	Thyroid	CLUAP1	0.37	0.17	lasso	6	0.27	1.1e-20	-5.2	-5.6	2.1e-08	0.76	0.19	0.81	FALSE
15	GTEx	Colon Sigmoid	CLUAP1	0.47	0.32	lasso	9	0.34	1.1e-12	-5.3	-5.6	2.7e-08	0.78	0.17	0.82	FALSE
6	GTEx	Artery Tibial	CLUAP1	0.45	0.29	enet	47	0.31	5.2e-25	-5.2	-5.5	3.3e-08	0.66	0.20	0.79	FALSE
24	GTEx	Heart Left Ventricle	CLUAP1	0.39	0.30	lasso	6	0.34	1.4e-18	-5.2	-5.5	3.3e-08	0.80	0.18	0.82	FALSE
28	GTEx	Muscle Skeletal	CLUAP1	0.21	0.19	lasso	6	0.20	3.8e-19	-5.2	-5.5	4.1e-08	0.79	0.20	0.79	FALSE
38	GTEx	Skin Sun Exposed Lower leg	NLRC3	0.16	0.17	lasso	3	0.18	1.7e-14	-5.3	5.5	4.3e-08	-0.74	0.16	0.84	FALSE
37	GTEx	Skin Sun Exposed Lower leg	CLUAP1	0.34	0.25	lasso	6	0.27	1.1e-22	-4.8	-5.5	4.5e-08	0.79	0.61	0.39	FALSE
18	GTEx	Esophagus Mucosa	CLUAP1	0.30	0.18	lasso	7	0.19	1.3e-12	-5.2	-5.4	5.5e-08	0.75	0.17	0.83	FALSE
47	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	NLRC3	0.10	0.04	lasso	2	0.04	6.2e-03	-5.2	5.4	5.9e-08	-0.75	0.01	0.76	FALSE
42	GTEx	Uterus	CLUAP1	0.30	0.34	lasso	3	0.31	3.9e-07	-5.3	-5.4	6.6e-08	0.73	0.08	0.80	FALSE
9	GTEx	Brain Cerebellum	NLRC3	0.36	0.36	lasso	4	0.36	1.4e-11	-5.2	5.4	6.8e-08	-0.76	0.05	0.95	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	CLUAP1	0.58	0.36	lasso	9	0.38	1.5e-14	-5.2	-5.4	7.0e-08	0.73	0.16	0.84	FALSE
19	GTEx	Esophagus Muscularis	CLUAP1	0.42	0.42	lasso	2	0.44	4.8e-29	-5.2	-5.4	7.1e-08	0.75	0.20	0.80	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	NLRC3	0.29	0.16	lasso	6	0.16	6.2e-09	-5.2	5.4	7.1e-08	-0.73	0.14	0.86	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	NLRC3	0.09	0.07	lasso	5	0.10	2.9e-19	-5.2	5.4	7.7e-08	-0.73	0.00	1.00	FALSE
12	GTEx	Brain Hippocampus	NLRC3	0.49	0.28	lasso	5	0.34	8.0e-09	-5.2	5.4	7.8e-08	-0.65	0.03	0.84	FALSE
32	GTEx	Nerve Tibial	LA16c-306E5.3	0.19	0.12	lasso	2	0.10	2.5e-07	-5.2	5.3	9.8e-08	-0.77	0.05	0.95	FALSE
14	GTEx	Brain Hypothalamus	NLRC3	0.38	0.15	lasso	6	0.17	8.3e-05	-5.2	5.3	1.0e-07	-0.74	0.05	0.67	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	NLRC3	0.09	0.08	enet	3	0.08	3.5e-09	-5.2	5.3	1.1e-07	-0.74	0.00	1.00	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	NLRC3	0.29	0.16	lasso	3	0.18	5.1e-07	-5.2	5.3	1.2e-07	-0.75	0.08	0.90	FALSE
50	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NLRC3	0.14	0.11	enet	7	0.14	2.5e-06	-5.2	5.3	1.4e-07	-0.74	0.00	0.98	FALSE
7	GTEx	Brain Caudate basal ganglia	NLRC3	0.41	0.11	lasso	4	0.24	2.0e-07	-5.2	5.3	1.5e-07	-0.71	0.14	0.70	FALSE
8	GTEx	Brain Cerebellar Hemisphere	NLRC3	0.40	0.39	lasso	2	0.40	2.1e-11	-5.2	5.3	1.5e-07	-0.76	0.02	0.97	FALSE
30	GTEx	Nerve Tibial	CLUAP1	0.53	0.27	lasso	7	0.42	9.9e-32	-5.2	-5.2	1.6e-07	0.75	0.27	0.73	FALSE
33	GTEx	Ovary	CLUAP1	0.29	0.14	lasso	3	0.11	1.4e-03	-5.2	-5.2	1.6e-07	0.74	0.04	0.72	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	NLRC3	0.31	0.21	lasso	3	0.26	8.4e-26	-5.2	5.2	1.6e-07	-0.71	0.00	1.00	FALSE
34	GTEx	Prostate	CLUAP1	0.44	0.36	lasso	3	0.35	1.1e-09	-5.2	-5.2	1.8e-07	0.73	0.14	0.81	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	DNASE1	0.09	0.00	enet	12	0.05	3.4e-06	2.4	-5.2	2.0e-07	0.51	0.00	0.32	FALSE
3	GTEx	Adipose Visceral Omentum	CLUAP1	0.25	0.17	enet	16	0.16	7.7e-09	-5.2	-5.2	2.2e-07	0.69	0.14	0.85	FALSE
29	GTEx	Muscle Skeletal	NLRC3	0.16	0.11	lasso	2	0.11	7.9e-11	-5.2	5.2	2.2e-07	-0.74	0.19	0.81	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NLRC3	0.05	0.01	blup	39	0.02	9.8e-03	-5.0	5.2	2.2e-07	-0.72	0.01	0.84	FALSE
10	GTEx	Brain Cortex	NLRC3	0.30	0.34	lasso	1	0.31	2.3e-09	-5.2	5.2	2.5e-07	-0.73	0.06	0.93	FALSE
13	GTEx	Brain Hypothalamus	CLUAP1	0.47	0.31	lasso	8	0.32	3.3e-08	-5.2	-5.2	2.5e-07	0.73	0.06	0.78	FALSE
31	GTEx	Nerve Tibial	NLRC3	0.29	0.24	lasso	3	0.32	8.7e-23	-5.2	5.2	2.5e-07	-0.72	0.20	0.80	FALSE
41	GTEx	Thyroid	LA16c-306E5.3	0.11	0.15	lasso	1	0.15	1.0e-11	-5.2	5.2	2.5e-07	-0.73	0.20	0.80	FALSE
51	The Cancer Genome Atlas	Soft Tissue Sarcoma	NLRC3	0.13	0.09	lasso	1	0.09	8.2e-06	-5.2	5.2	2.5e-07	-0.73	0.00	1.00	FALSE
39	GTEx	Stomach	ZNF500	0.20	0.11	enet	10	0.08	1.5e-04	4.8	5.1	2.7e-07	0.00	0.02	0.96	FALSE
20	GTEx	Esophagus Muscularis	NLRC3	0.48	0.29	lasso	6	0.36	5.1e-23	-5.2	5.1	2.8e-07	-0.71	0.20	0.80	FALSE
4	GTEx	Adrenal Gland	ZNF500	0.11	0.07	enet	15	0.01	9.6e-02	5.2	5.1	3.1e-07	0.04	0.01	0.90	FALSE