[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr3:48,381,826-50,546,340

Best TWAS P=1.41e-10 · Best GWAS P=3.8e-08 conditioned to 0.782

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	GTEx	Colon Transverse	RNF123	0.16	0.05	enet	36	0.05	2.3e-03	-5.1	-6.4	1.4e-10	-0.46	0.10	0.66	TRUE
11	GTEx	Brain Cerebellar Hemisphere	GPX1	0.18	0.11	enet	27	0.14	2.6e-04	5.5	-5.2	2.1e-07	-0.45	0.05	0.87	TRUE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	AMIGO3	0.01	0.00	enet	13	0.01	5.7e-03	-5.1	-6.3	3.6e-10	-0.78	0.01	0.52	FALSE
29	GTEx	Lung	GPX1	0.04	0.02	enet	13	0.04	5.7e-04	5.4	-6.2	5.0e-10	-0.84	0.06	0.73	FALSE
28	GTEx	Lung	RNF123	0.13	0.05	enet	18	0.07	5.8e-06	-4.7	-6.2	5.4e-10	-0.77	0.25	0.72	FALSE
52	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GMPPB	0.13	0.08	blup	40	0.09	2.7e-04	-5.1	-6.2	7.5e-10	-0.63	0.02	0.78	FALSE
13	GTEx	Brain Cerebellum	GPX1	0.31	0.09	enet	19	0.23	2.0e-07	5.4	-6.1	9.8e-10	-0.80	0.05	0.94	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	RNF123	0.14	0.13	enet	30	0.10	2.3e-04	-5.1	-6.1	1.1e-09	-0.57	0.13	0.82	FALSE
9	GTEx	Artery Tibial	RNF123	0.08	0.08	enet	12	0.09	2.5e-07	-4.7	-6.0	2.1e-09	-0.67	0.59	0.40	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	GMPPB	0.03	0.03	enet	12	0.03	3.0e-07	-5.1	-6.0	2.5e-09	-0.57	0.02	0.97	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	UBA7	0.07	0.03	lasso	6	0.06	2.9e-04	-5.3	5.9	3.2e-09	0.51	0.13	0.82	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	AMIGO3	0.08	0.07	blup	40	0.06	1.3e-06	-5.1	-5.9	3.7e-09	-0.52	0.02	0.98	FALSE
20	GTEx	Colon Sigmoid	RNF123	0.22	0.10	enet	23	0.20	1.1e-07	-5.1	-5.9	3.8e-09	-0.62	0.18	0.81	FALSE
24	GTEx	Esophagus Muscularis	NICN1	0.11	0.03	enet	22	0.07	2.7e-05	5.2	5.9	4.3e-09	0.85	0.05	0.94	FALSE
33	GTEx	Nerve Tibial	NICN1-AS1	0.15	0.11	lasso	5	0.13	1.1e-09	-4.0	5.8	5.7e-09	0.74	0.30	0.70	FALSE
44	The Cancer Genome Atlas	Glioblastoma Multiforme	AMIGO3	0.18	0.02	enet	24	0.07	2.9e-03	-5.1	-5.8	7.6e-09	-0.69	0.02	0.47	FALSE
38	GTEx	Stomach	RNF123	0.23	0.12	lasso	15	0.16	4.6e-08	-5.2	-5.8	8.8e-09	-0.56	0.17	0.83	FALSE
6	GTEx	Adipose Visceral Omentum	RHOA	0.05	0.00	lasso	8	0.00	4.1e-01	-4.0	-5.7	1.2e-08	-0.49	0.10	0.35	FALSE
25	GTEx	Esophagus Muscularis	GPX1	0.13	0.05	lasso	14	0.06	1.1e-04	5.3	-5.7	1.2e-08	-0.82	0.06	0.93	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	GMPPB	0.08	0.09	lasso	8	0.09	4.3e-09	-5.2	-5.7	1.3e-08	-0.45	0.02	0.97	FALSE
14	GTEx	Brain Frontal Cortex BA9	GPX1	0.16	0.06	lasso	6	0.15	7.9e-05	-4.5	-5.7	1.6e-08	-0.65	0.07	0.76	FALSE
30	GTEx	Muscle Skeletal	FAM212A	0.05	0.08	lasso	3	0.07	4.9e-07	5.5	-5.7	1.6e-08	-0.98	0.04	0.96	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	AMIGO3	0.02	0.00	blup	40	0.00	3.0e-01	-4.7	-5.6	2.0e-08	-0.67	0.04	0.34	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	IP6K1	0.03	0.04	blup	55	0.04	9.2e-05	-5.3	-5.6	2.1e-08	-0.44	0.03	0.95	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	USP4	0.08	0.05	lasso	2	0.09	8.7e-04	-4.1	-5.6	2.2e-08	-0.70	0.10	0.64	FALSE
32	GTEx	Nerve Tibial	GPX1	0.05	0.01	enet	14	0.04	9.0e-04	-5.2	-5.6	2.3e-08	-0.40	0.11	0.49	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	GMPPB	0.15	0.12	enet	17	0.13	1.2e-14	-5.1	-5.6	2.3e-08	-0.50	0.03	0.97	FALSE
51	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GMPPB	0.04	0.02	blup	40	0.02	1.4e-02	-4.7	-5.6	2.7e-08	-0.61	0.03	0.36	FALSE
31	GTEx	Nerve Tibial	NICN1	0.13	0.15	enet	21	0.16	1.4e-11	-4.0	5.5	3.0e-08	0.67	0.84	0.15	FALSE
36	GTEx	Skin Sun Exposed Lower leg	UBA7	0.04	0.01	lasso	8	0.00	2.9e-01	-4.7	5.5	3.4e-08	0.58	0.13	0.37	FALSE
12	GTEx	Brain Cerebellum	RNF123	0.36	0.31	enet	43	0.36	2.4e-11	-4.7	-5.5	3.6e-08	-0.47	0.58	0.41	FALSE
10	GTEx	Brain Caudate basal ganglia	RNF123	0.13	0.04	enet	20	0.02	1.2e-01	-4.7	-5.5	4.1e-08	-0.68	0.16	0.41	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	RNF123	0.04	0.05	lasso	3	0.05	1.4e-06	-4.4	-5.5	4.9e-08	-0.63	0.53	0.46	FALSE
39	GTEx	Thyroid	GPX1	0.10	0.12	enet	23	0.11	9.1e-09	-4.0	-5.4	8.2e-08	-0.59	0.92	0.07	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBA7	0.05	0.04	enet	7	0.05	1.6e-05	-4.7	5.4	8.3e-08	0.64	0.08	0.91	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	GPX1	0.23	0.25	lasso	10	0.30	1.5e-39	-4.0	-5.3	9.5e-08	-0.68	0.95	0.04	FALSE
3	GTEx	Adipose Subcutaneous	NICN1	0.20	0.12	lasso	17	0.13	6.7e-11	-4.0	5.3	9.8e-08	0.64	0.88	0.11	FALSE
4	GTEx	Adipose Subcutaneous	RNF123	0.19	0.18	enet	29	0.18	2.1e-14	-4.7	-5.3	1.0e-07	-0.60	0.60	0.39	FALSE
7	GTEx	Artery Aorta	RNF123	0.23	-0.01	enet	35	0.04	3.3e-03	5.3	-5.3	1.0e-07	-0.58	0.06	0.56	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	AMT	0.07	0.07	lasso	1	0.01	1.5e-01	-5.3	5.3	1.0e-07	0.30	0.09	0.55	FALSE
26	GTEx	Esophagus Muscularis	NICN1-AS1	0.09	0.04	enet	14	0.06	2.3e-04	5.4	5.3	1.0e-07	0.84	0.06	0.90	FALSE
8	GTEx	Artery Coronary	NICN1	0.10	0.01	lasso	13	0.01	1.3e-01	-4.1	5.3	1.1e-07	0.63	0.10	0.31	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GPX1	0.12	0.19	blup	275	0.19	1.3e-22	-4.0	-5.3	1.3e-07	-0.51	0.95	0.04	FALSE
15	GTEx	Breast Mammary Tissue (Female)	NICN1	0.01	0.00	lasso	1	0.01	1.6e-01	-5.3	5.3	1.4e-07	0.29	0.02	0.09	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	UBA7	0.03	0.01	blup	30	0.02	2.0e-03	-4.7	5.2	1.5e-07	0.61	0.02	0.69	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	KLHDC8B	0.08	0.12	enet	13	0.10	3.0e-04	-4.4	-5.2	1.6e-07	-0.43	0.16	0.58	FALSE
27	GTEx	Heart Atrial Appendage	RNF123	0.06	0.04	lasso	2	0.02	4.0e-02	-4.5	-5.2	1.6e-07	-0.84	0.10	0.70	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	APEH	0.02	0.02	blup	49	0.02	2.5e-03	5.5	5.2	1.6e-07	0.95	0.02	0.89	FALSE
34	GTEx	Ovary	NICN1	0.14	0.07	lasso	9	0.06	1.5e-02	-4.1	5.2	1.8e-07	0.56	0.09	0.33	FALSE
2	GTEx	Adipose Subcutaneous	TCTA	0.05	0.01	enet	10	0.01	5.8e-02	-3.9	5.2	2.0e-07	0.49	0.16	0.27	FALSE
37	GTEx	Spleen	QRICH1	0.24	0.21	enet	26	0.19	1.3e-05	-4.3	-5.2	2.0e-07	-0.56	0.26	0.53	FALSE
21	GTEx	Colon Sigmoid	GPX1	0.12	0.07	enet	24	0.09	6.2e-04	-5.1	-5.2	2.2e-07	-0.34	0.14	0.78	FALSE
5	GTEx	Adipose Subcutaneous	NICN1-AS1	0.16	0.14	enet	20	0.14	2.4e-11	-4.0	5.2	2.3e-07	0.55	0.93	0.06	FALSE
45	The Cancer Genome Atlas	Glioblastoma Multiforme	GMPPB	0.15	0.09	enet	12	0.09	1.3e-03	-5.1	-5.2	2.4e-07	-0.31	0.02	0.58	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GMPPB	0.04	0.04	lasso	3	0.04	2.3e-05	-5.2	-5.2	2.5e-07	-0.31	0.02	0.97	FALSE
16	GTEx	Breast Mammary Tissue (Female)	RNF123	0.03	0.00	lasso	1	0.00	2.3e-01	-5.1	-5.1	2.8e-07	-0.31	0.03	0.16	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	GMPPB	0.38	0.53	lasso	9	0.53	1.2e-64	-5.1	-5.1	2.8e-07	-0.31	0.02	0.97	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	GMPPB	0.06	0.06	lasso	1	0.06	6.5e-08	-5.1	-5.1	2.9e-07	-0.30	0.02	0.97	FALSE