[Hub]/) : Traits : Diastolic blood pressure, automated reading : ← →

chr10:63,856,856-66,034,105

Best TWAS P=1.8e-21 · Best GWAS P=7.37e-17 conditioned to 0.202

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	GTEx	Skin Sun Exposed Lower leg	NRBF2	0.06	0.01	lasso	3	0.00	4.0e-01	-7.3	9.5	1.8e-21	-0.68	0.08	0.15	TRUE
6	GTEx	Muscle Skeletal	RP11-436D10.3	0.08	0.04	enet	13	0.06	3.2e-06	-8.3	8.1	3.8e-16	-0.87	0.00	1.00	TRUE
1	GTEx	Adipose Subcutaneous	REEP3	0.10	0.03	lasso	3	0.03	7.2e-04	6.7	-6.4	1.9e-10	-0.01	0.09	0.85	TRUE
30	The Cancer Genome Atlas	Thyroid Carcinoma	ADO	0.12	0.10	lasso	5	0.09	5.2e-09	-8.3	8.3	1.1e-16	-0.97	0.00	1.00	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	ADO	0.06	0.04	lasso	2	0.06	3.1e-08	-8.3	8.2	2.3e-16	-0.89	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ADO	0.06	0.04	blup	55	0.01	1.4e-01	-8.3	7.9	3.9e-15	-0.84	0.00	0.86	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	ADO	0.14	0.05	blup	53	0.05	3.8e-06	-7.3	7.1	1.0e-12	-0.85	0.01	0.99	FALSE
2	GTEx	Brain Cortex	NRBF2	0.30	0.26	enet	24	0.21	1.4e-06	6.6	7.0	1.8e-12	-0.06	0.92	0.01	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NRBF2	0.10	0.06	lasso	7	0.08	3.5e-09	6.6	7.0	1.9e-12	-0.04	0.00	1.00	FALSE
3	GTEx	Brain Frontal Cortex BA9	NRBF2	0.25	0.17	lasso	6	0.16	6.1e-05	-6.2	6.8	7.8e-12	-0.08	0.56	0.03	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NRBF2	0.04	0.04	enet	5	0.03	1.3e-04	-6.2	6.8	8.3e-12	-0.06	0.02	0.94	FALSE
4	GTEx	Esophagus Mucosa	NRBF2	0.14	0.11	lasso	10	0.11	6.4e-08	-6.5	6.8	1.2e-11	-0.13	0.99	0.00	FALSE
10	GTEx	Testis	NRBF2	0.14	0.08	lasso	12	0.09	6.7e-05	-6.5	6.7	1.7e-11	-0.06	0.79	0.01	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	NRBF2	0.34	0.46	lasso	5	0.46	3.1e-66	-6.2	6.7	2.1e-11	-0.07	1.00	0.00	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NRBF2	0.09	0.02	enet	6	0.04	1.4e-05	4.3	6.7	2.7e-11	-0.03	0.01	0.99	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADO	0.03	0.02	blup	53	0.03	1.8e-06	4.7	6.7	2.8e-11	-0.73	0.17	0.82	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBF2	0.08	0.09	lasso	6	0.08	9.7e-09	-6.2	6.6	3.2e-11	-0.07	0.03	0.97	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADO	0.10	0.03	enet	6	0.06	4.6e-07	5.3	6.6	4.1e-11	-0.79	0.00	0.99	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	NRBF2	0.08	0.08	enet	6	0.08	4.3e-09	-6.2	6.4	1.7e-10	-0.07	0.03	0.97	FALSE
5	GTEx	Muscle Skeletal	ADO	0.15	0.16	lasso	8	0.16	1.1e-15	6.1	6.4	2.1e-10	-0.76	0.84	0.16	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	REEP3	0.04	0.04	blup	59	0.05	1.8e-06	5.3	-6.3	3.5e-10	0.05	0.06	0.93	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	NRBF2	0.05	0.06	lasso	2	0.06	5.5e-12	-6.2	6.2	6.0e-10	-0.08	0.03	0.97	FALSE
11	GTEx	Testis	ADO	0.21	0.23	lasso	7	0.22	6.6e-10	6.1	-6.2	6.8e-10	0.74	0.72	0.28	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	NRBF2	0.14	0.10	enet	16	0.09	8.1e-09	-6.2	6.1	1.1e-09	-0.06	0.04	0.96	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	REEP3	0.10	0.11	lasso	8	0.09	7.2e-12	5.8	-6.0	1.6e-09	0.04	0.55	0.45	FALSE
26	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NRBF2	0.18	0.13	enet	11	0.08	2.5e-04	-6.2	6.0	1.8e-09	-0.10	0.04	0.90	FALSE
9	GTEx	Stomach	NRBF2	0.09	0.04	lasso	6	0.03	1.6e-02	3.7	6.0	2.6e-09	-0.04	0.12	0.09	FALSE
7	GTEx	Nerve Tibial	NRBF2	0.08	0.09	enet	11	0.06	5.0e-05	-6.5	5.8	5.7e-09	-0.11	0.97	0.00	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	JMJD1C	0.04	0.01	blup	88	0.01	9.7e-03	-6.2	5.6	1.7e-08	-0.09	0.03	0.76	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	NRBF2	0.09	0.06	enet	8	0.07	2.7e-08	-6.2	5.4	5.5e-08	-0.09	0.03	0.96	FALSE
27	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NRBF2	0.08	0.02	blup	40	0.04	8.6e-03	-6.2	5.3	1.3e-07	-0.05	0.02	0.42	FALSE