Best TWAS P=4.43e-11 · Best GWAS P=1.26e-17 conditioned to 4.62e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NOC3L | 0.10 | 0.11 | lasso | 5 | 0.12 | 4.7e-14 | -4.1 | -5.3 | 1.1e-07 | 0.43 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | CYP2C8 | 0.21 | 0.00 | lasso | 8 | 0.00 | 2.2e-01 | -3.3 | -5.2 | 1.8e-07 | 0.19 | 0.07 | 0.65 | FALSE |
| 3 | GTEx | Muscle Skeletal | NOC3L | 0.09 | 0.05 | enet | 7 | 0.05 | 7.5e-06 | -4.1 | -6.6 | 4.4e-11 | 0.69 | 0.09 | 0.90 | TRUE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HELLS | 0.04 | 0.01 | blup | 47 | 0.03 | 1.3e-06 | -4.2 | -5.3 | 1.5e-07 | 0.15 | 0.04 | 0.96 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NOC3L | 0.05 | 0.01 | enet | 5 | 0.03 | 6.3e-04 | 6.9 | -5.4 | 6.5e-08 | 0.18 | 0.19 | 0.36 | FALSE |
| 6 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NOC3L | 0.08 | 0.06 | lasso | 2 | 0.04 | 5.8e-03 | -5.3 | -5.3 | 1.1e-07 | 0.46 | 0.04 | 0.24 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TBC1D12 | 0.04 | 0.04 | blup | 63 | 0.03 | 3.9e-04 | -4.2 | -5.3 | 9.8e-08 | 0.12 | 0.24 | 0.50 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | HELLS | 0.05 | 0.02 | blup | 47 | 0.03 | 9.6e-04 | -3.6 | -5.4 | 8.0e-08 | 0.14 | 0.08 | 0.81 | TRUE |