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chr10:103,313,599-106,371,784

Best TWAS P=9.92e-25 · Best GWAS P=1.42e-28 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	INA	0.21	0.31	lasso	2	0.30	6.9e-37	-6.41	-6.4	1.2e-10	0.23	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NT5C2	0.07	0.04	lasso	5	0.04	2.2e-05	-6.20	-6.6	3.9e-11	0.27	0.90	0.07	FALSE
3	CommonMind	Brain Pre-frontal Cortex	OBFC1	0.12	0.04	lasso	3	0.05	8.4e-07	5.50	-5.5	3.0e-08	-0.03	0.22	0.77	FALSE
4	CommonMind	Brain Pre-frontal Cortex	USMG5	0.03	0.01	bslmm	352	0.00	7.5e-02	-5.83	7.2	8.8e-13	-0.51	0.17	0.38	FALSE
5	GTEx	Adipose Subcutaneous	CALHM2	0.09	0.07	lasso	5	0.07	1.7e-06	-3.41	-5.5	5.1e-08	0.27	0.94	0.03	FALSE
6	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	-6.07	-6.2	6.7e-10	0.67	0.22	0.41	FALSE
7	GTEx	Adipose Visceral Omentum	MIR1307	0.47	0.47	lasso	10	0.46	1.6e-26	-5.83	-6.0	2.1e-09	0.33	1.00	0.00	FALSE
8	GTEx	Adrenal Gland	MIR1307	0.43	0.32	enet	20	0.36	1.1e-13	-5.90	-7.6	2.2e-14	0.28	1.00	0.00	FALSE
9	GTEx	Artery Aorta	ARL3	0.19	0.07	lasso	6	0.06	4.8e-04	-3.43	5.2	2.5e-07	-0.71	0.34	0.43	FALSE
10	GTEx	Artery Aorta	MIR1307	0.57	0.60	enet	27	0.62	2.3e-42	-5.98	-5.5	4.0e-08	0.26	1.00	0.00	FALSE
11	GTEx	Artery Coronary	MIR1307	0.34	0.38	lasso	2	0.32	2.0e-11	-5.90	-5.9	3.7e-09	0.33	1.00	0.00	FALSE
12	GTEx	Artery Tibial	NT5C2	0.06	0.04	lasso	9	0.02	1.5e-02	-4.87	5.2	1.7e-07	-0.40	0.34	0.09	FALSE
13	GTEx	Artery Tibial	MIR1307	0.44	0.53	lasso	8	0.54	2.3e-49	-5.83	-6.0	1.7e-09	0.32	1.00	0.00	FALSE
14	GTEx	Brain Caudate basal ganglia	MIR1307	0.44	0.41	lasso	7	0.41	7.6e-13	-5.98	-5.7	1.4e-08	0.32	1.00	0.00	FALSE
15	GTEx	Brain Cerebellar Hemisphere	MIR1307	0.41	0.48	lasso	4	0.46	2.2e-13	-5.98	-6.0	2.2e-09	0.33	1.00	0.00	FALSE
16	GTEx	Brain Cerebellum	MIR1307	0.29	0.38	lasso	4	0.36	1.4e-11	-5.83	-6.0	2.2e-09	0.33	0.99	0.00	FALSE
17	GTEx	Brain Cortex	NT5C2	0.20	0.04	enet	14	0.05	1.7e-02	1.37	-5.3	1.4e-07	0.28	0.13	0.13	TRUE
18	GTEx	Brain Cortex	MIR1307	0.40	0.46	enet	11	0.44	1.7e-13	-5.98	-6.5	8.4e-11	0.32	0.99	0.01	FALSE
19	GTEx	Brain Frontal Cortex BA9	MIR1307	0.53	0.53	lasso	7	0.53	1.7e-16	-5.98	-5.6	2.0e-08	0.33	1.00	0.00	FALSE
20	GTEx	Brain Hippocampus	MIR1307	0.39	0.47	lasso	5	0.46	3.9e-12	-5.90	-5.9	4.4e-09	0.33	0.98	0.00	FALSE
21	GTEx	Brain Hypothalamus	MIR1307	0.42	0.48	lasso	6	0.45	7.4e-12	-5.98	-6.0	2.6e-09	0.33	0.98	0.01	FALSE
22	GTEx	Brain Nucleus accumbens basal ganglia	MIR1307	0.51	0.51	lasso	11	0.51	6.7e-16	-5.90	-5.8	8.9e-09	0.33	1.00	0.00	FALSE
23	GTEx	Brain Putamen basal ganglia	MIR1307	0.57	0.44	lasso	9	0.45	4.2e-12	-5.98	-5.2	2.4e-07	0.31	0.95	0.02	FALSE
24	GTEx	Breast Mammary Tissue	CYP17A1-AS1	0.10	-0.01	enet	28	0.00	2.4e-01	-3.35	-6.8	7.6e-12	0.52	0.08	0.59	FALSE
25	GTEx	Breast Mammary Tissue	MIR1307	0.32	0.41	lasso	6	0.41	2.0e-22	-5.98	-6.2	6.8e-10	0.32	1.00	0.00	FALSE
26	GTEx	Breast Mammary Tissue	RP11-225H22.7	0.12	0.08	lasso	4	0.03	7.4e-03	-5.83	-5.8	8.6e-09	0.33	0.28	0.13	FALSE
27	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	-9.68	-8.8	1.2e-18	0.87	0.03	0.62	FALSE
28	GTEx	Breast Mammary Tissue (Female)	MIR1307	0.36	0.40	lasso	4	0.40	4.7e-13	-6.01	-6.1	8.4e-10	0.30	1.00	0.00	FALSE
29	GTEx	Cells EBV-transformed lymphocytes	MIR1307	0.58	0.59	lasso	11	0.60	3.1e-24	-5.98	-6.3	2.5e-10	0.31	1.00	0.00	FALSE
30	GTEx	Cells Transformed fibroblasts	GBF1	0.07	0.00	enet	2	0.00	1.4e-01	-6.07	-6.1	1.2e-09	0.78	0.05	0.48	FALSE
31	GTEx	Cells Transformed fibroblasts	SUFU	0.07	0.04	lasso	3	0.04	3.5e-04	-9.86	-7.5	6.5e-14	0.83	0.40	0.11	FALSE
32	GTEx	Cells Transformed fibroblasts	OBFC1	0.14	0.07	lasso	4	0.06	4.9e-05	5.50	-5.3	9.0e-08	-0.03	0.16	0.79	FALSE
33	GTEx	Cells Transformed fibroblasts	CALHM2	0.12	0.12	enet	15	0.12	1.9e-09	-3.78	-5.3	1.3e-07	0.30	1.00	0.00	FALSE
34	GTEx	Cells Transformed fibroblasts	ARL3	0.07	0.00	enet	13	0.04	1.2e-03	-3.54	6.5	6.5e-11	-0.58	0.04	0.80	FALSE
35	GTEx	Cells Transformed fibroblasts	MIR1307	0.59	0.61	enet	31	0.63	2.2e-60	-5.98	-5.8	5.9e-09	0.31	1.00	0.00	FALSE
36	GTEx	Colon Sigmoid	MIR1307	0.60	0.56	lasso	10	0.54	2.1e-22	-5.83	-5.9	3.6e-09	0.34	1.00	0.00	FALSE
37	GTEx	Colon Transverse	MIR1307	0.40	0.47	lasso	4	0.48	2.6e-25	-5.90	-6.2	7.1e-10	0.33	1.00	0.00	FALSE
38	GTEx	Esophagus Gastroesophageal Junction	CYP17A1-AS1	0.23	0.08	enet	23	0.13	1.9e-05	-4.93	-5.5	4.0e-08	0.64	0.17	0.30	TRUE
39	GTEx	Esophagus Gastroesophageal Junction	MIR1307	0.33	0.44	lasso	6	0.44	1.1e-17	-5.83	-6.3	3.2e-10	0.32	1.00	0.00	FALSE
40	GTEx	Esophagus Mucosa	MIR1307	0.45	0.54	lasso	4	0.53	2.9e-41	-5.98	-6.0	2.2e-09	0.33	1.00	0.00	FALSE
41	GTEx	Esophagus Muscularis	MIR1307	0.52	0.50	enet	9	0.50	2.4e-34	-5.90	-6.1	1.0e-09	0.31	1.00	0.00	FALSE
42	GTEx	Heart Atrial Appendage	MIR1307	0.61	0.62	enet	7	0.63	2.0e-35	-5.90	-5.4	6.3e-08	0.30	1.00	0.00	FALSE
43	GTEx	Heart Left Ventricle	MIR1307	0.46	0.45	enet	23	0.46	1.3e-26	-5.90	-5.9	4.7e-09	0.29	1.00	0.00	FALSE
44	GTEx	Liver	MIR1307	0.21	0.21	lasso	6	0.15	6.0e-05	-5.90	-6.1	9.6e-10	0.33	0.44	0.10	FALSE
45	GTEx	Lung	MIR1307	0.44	0.49	enet	22	0.53	2.6e-47	-5.98	-5.7	1.2e-08	0.32	1.00	0.00	FALSE
46	GTEx	Muscle Skeletal	MIR1307	0.61	0.62	enet	27	0.65	3.7e-83	-5.90	-6.3	2.9e-10	0.33	1.00	0.00	FALSE
47	GTEx	Nerve Tibial	MIR1307	0.50	0.49	lasso	7	0.49	3.9e-39	-5.90	-6.0	1.8e-09	0.33	1.00	0.00	FALSE
48	GTEx	Ovary	MIR1307	0.33	0.43	lasso	4	0.42	1.8e-11	-5.98	-5.9	3.5e-09	0.30	0.90	0.08	FALSE
49	GTEx	Pancreas	MIR1307	0.48	0.38	lasso	6	0.40	5.0e-18	-5.90	-6.7	2.0e-11	0.31	1.00	0.00	FALSE
50	GTEx	Pituitary	MIR1307	0.56	0.58	lasso	5	0.59	4.1e-18	-5.98	-6.0	2.2e-09	0.33	1.00	0.00	FALSE
51	GTEx	Prostate	MIR1307	0.42	0.45	lasso	2	0.41	1.8e-11	-5.83	-5.7	1.0e-08	0.32	0.98	0.00	FALSE
52	GTEx	Skin Not Sun Exposed Suprapubic	MIR1307	0.46	0.52	enet	23	0.52	4.4e-33	-6.01	-7.0	2.8e-12	0.40	1.00	0.00	FALSE
53	GTEx	Skin Sun Exposed Lower leg	MIR1307	0.36	0.51	lasso	8	0.50	9.1e-48	-5.98	-6.1	9.0e-10	0.33	1.00	0.00	FALSE
54	GTEx	Small Intestine Terminal Ileum	MIR1307	0.50	0.47	enet	21	0.45	1.9e-11	-5.90	-5.9	3.4e-09	0.33	0.98	0.00	FALSE
55	GTEx	Spleen	MIR1307	0.53	0.57	enet	18	0.56	5.1e-17	-5.98	-6.7	2.6e-11	0.26	1.00	0.00	FALSE
56	GTEx	Stomach	MIR1307	0.38	0.43	enet	13	0.46	1.7e-24	-5.90	-6.8	7.8e-12	0.27	1.00	0.00	FALSE
57	GTEx	Testis	NT5C2	0.20	0.03	lasso	8	0.08	2.8e-04	-9.86	-9.7	2.5e-22	0.86	0.04	0.91	TRUE
58	GTEx	Testis	CYP17A1-AS1	0.14	0.08	enet	5	0.10	2.3e-05	-9.70	9.8	9.6e-23	-0.97	0.05	0.93	FALSE
59	GTEx	Thyroid	WBP1L	0.26	0.10	enet	9	0.13	2.1e-10	-4.29	7.4	1.1e-13	-0.80	0.70	0.30	FALSE
60	GTEx	Thyroid	MIR1307	0.52	0.57	lasso	5	0.57	1.2e-52	-5.98	-6.2	6.2e-10	0.33	1.00	0.00	FALSE
61	GTEx	Vagina	MIR1307	0.36	0.40	enet	8	0.42	9.5e-11	-5.90	-6.0	2.7e-09	0.32	0.96	0.01	FALSE
62	GTEx	Whole Blood	MIR1307	0.25	0.30	lasso	4	0.29	4.6e-27	-5.98	-6.0	1.4e-09	0.33	1.00	0.00	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	INA	0.12	0.05	lasso	6	0.06	2.3e-08	-6.41	-5.9	3.7e-09	0.18	1.00	0.00	TRUE
64	ROSMAP	Brain Pre-frontal Cortex	CNNM2	0.11	0.08	lasso	3	0.07	2.2e-09	-10.25	-10.3	9.9e-25	0.99	0.02	0.98	TRUE
65	ROSMAP	Brain Pre-frontal Cortex	USMG5	0.04	0.03	lasso	9	0.03	1.6e-04	-5.83	8.9	6.0e-19	-0.64	0.04	0.94	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	CYP17A1-AS1	0.15	0.18	lasso	6	0.19	1.3e-23	-4.58	-6.3	2.2e-10	0.52	1.00	0.00	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	RP11-541N10.3	0.09	0.06	enet	10	0.06	1.6e-08	5.47	-5.9	3.4e-09	-0.04	0.23	0.77	TRUE
68	YFS	Blood	NT5C2	0.13	0.10	bslmm	382	0.11	7.3e-35	-10.85	-9.6	6.2e-22	0.94	0.01	0.99	FALSE
69	YFS	Blood	USMG5	0.50	0.71	lasso	4	0.71	0.0e+00	-5.98	-6.0	1.9e-09	0.33	1.00	0.00	FALSE
70	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	-5.35	7.7	1.1e-14	-0.68	0.39	0.58	TRUE
71	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SFXN2	0.18	0.13	enet	8	0.15	7.0e-13	-5.17	5.2	2.4e-07	-0.55	0.97	0.03	FALSE
72	The Cancer Genome Atlas	Breast Invasive Carcinoma	SFXN2	0.12	0.09	lasso	4	0.10	4.4e-19	-5.37	5.3	1.2e-07	-0.56	0.99	0.01	FALSE
73	The Cancer Genome Atlas	Colon Adenocarcinoma	SFXN2	0.11	0.05	blup	47	0.05	7.2e-04	-5.17	5.3	1.4e-07	-0.63	0.16	0.50	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AS3MT	0.04	0.05	enet	3	0.04	8.6e-06	-5.35	5.4	8.2e-08	-0.44	0.74	0.10	FALSE
75	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SFXN2	0.16	0.11	enet	6	0.12	6.4e-13	-5.29	5.4	7.6e-08	-0.56	0.99	0.01	FALSE
76	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SFXN2	0.20	0.08	blup	48	0.13	9.3e-07	-5.37	5.7	1.3e-08	-0.46	0.03	0.96	FALSE
77	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PCGF6	0.10	0.03	blup	30	0.06	1.1e-03	-6.41	-5.5	4.5e-08	0.14	0.01	0.81	TRUE
78	The Cancer Genome Atlas	Stomach Adenocarcinoma	AS3MT	0.05	0.02	blup	62	0.03	2.1e-03	0.86	-6.1	9.8e-10	0.72	0.03	0.30	FALSE
79	The Cancer Genome Atlas	Stomach Adenocarcinoma	SFXN2	0.15	0.10	enet	9	0.11	2.4e-08	-5.17	5.2	1.9e-07	-0.53	0.24	0.76	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf26	0.06	0.05	lasso	5	0.04	4.1e-05	-4.93	6.8	7.2e-12	-0.57	0.57	0.06	TRUE