[Hub]/) : Traits : Systolic blood pressure, automated reading :

chr11:1,213,806-2,705,175

Best TWAS P=2.5e-22 · Best GWAS P=7.88e-23 conditioned to 0.00644

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta MRPL23-AS1 0.22 0.07 enet 10 0.12 2.9e-07 6.6 5.5 3.2e-08 -0.29 0.97 0.00 FALSE
2 GTEx Brain Cerebellum MRPL23-AS1 0.25 0.14 enet 12 0.18 6.8e-06 5.7 5.3 1.1e-07 -0.36 0.28 0.20 FALSE
3 GTEx Brain Frontal Cortex BA9 MRPL23-AS1 0.36 0.23 lasso 3 0.21 3.8e-06 6.6 6.5 1.0e-10 -0.33 0.39 0.20 FALSE
4 GTEx Brain Nucleus accumbens basal ganglia MRPL23-AS1 0.25 0.07 lasso 5 0.03 6.8e-02 5.1 5.3 1.2e-07 -0.28 0.10 0.14 FALSE
5 GTEx Cells Transformed fibroblasts LSP1 0.21 0.04 enet 28 0.06 3.4e-05 9.8 7.1 1.4e-12 -0.45 0.01 0.99 FALSE
6 GTEx Colon Sigmoid MRPL23-AS1 0.39 0.13 lasso 6 0.23 9.8e-09 5.7 5.4 7.4e-08 -0.31 0.92 0.01 FALSE
7 GTEx Colon Transverse MRPL23-AS1 0.13 0.03 enet 19 0.03 1.0e-02 5.7 5.9 4.5e-09 -0.25 0.12 0.07 FALSE
8 GTEx Esophagus Muscularis MRPL23-AS1 0.21 0.07 lasso 4 0.10 1.8e-06 5.7 5.3 1.2e-07 -0.29 0.94 0.01 FALSE
9 GTEx Nerve Tibial MRPL23-AS1 0.18 0.11 lasso 4 0.16 1.2e-11 6.0 5.2 1.5e-07 -0.28 1.00 0.00 FALSE
10 GTEx Skin Not Sun Exposed Suprapubic TNNT3 0.33 0.16 lasso 7 0.17 2.0e-09 8.7 9.2 4.2e-20 -0.45 0.01 0.99 TRUE
11 GTEx Skin Not Sun Exposed Suprapubic MRPL23-AS1 0.33 0.19 enet 30 0.21 9.5e-12 6.0 6.2 4.6e-10 -0.25 1.00 0.00 FALSE
12 GTEx Skin Sun Exposed Lower leg MRPL23-AS1 0.19 0.19 enet 9 0.21 5.3e-17 5.7 5.8 6.9e-09 -0.30 1.00 0.00 FALSE
13 NTR Blood TNNT3 0.04 0.02 blup 461 0.02 4.3e-06 8.2 -5.7 1.2e-08 0.39 0.20 0.79 FALSE
14 YFS Blood TNNT3 0.02 0.02 lasso 3 0.01 1.9e-05 8.7 -7.7 1.0e-14 0.42 0.08 0.91 FALSE
15 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma LSP1 0.12 0.08 lasso 5 0.10 5.0e-11 -9.0 -9.7 2.5e-22 0.87 0.00 1.00 TRUE
16 The Cancer Genome Atlas Brain Lower Grade Glioma LSP1 0.06 0.04 enet 6 0.04 3.1e-05 7.3 6.5 9.9e-11 -0.50 0.42 0.38 FALSE
17 The Cancer Genome Atlas Lung Squamous Cell Carcinoma LOC100133545 0.03 0.01 blup 49 0.01 1.1e-02 6.0 5.8 6.3e-09 -0.30 0.00 0.92 FALSE
18 The Cancer Genome Atlas Lung Squamous Cell Carcinoma LSP1 0.07 0.03 lasso 4 0.03 2.4e-04 7.3 -9.0 1.6e-19 0.63 0.10 0.15 FALSE
19 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma TNNI2 0.11 0.09 lasso 2 0.08 4.1e-06 7.3 -7.3 3.2e-13 0.48 0.40 0.38 TRUE