Best TWAS P=2.5e-22 · Best GWAS P=7.88e-23 conditioned to 0.00644
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | MRPL23-AS1 | 0.22 | 0.07 | enet | 10 | 0.12 | 2.9e-07 | 6.6 | 5.5 | 3.2e-08 | -0.29 | 0.97 | 0.00 | FALSE |
| 2 | GTEx | Brain Cerebellum | MRPL23-AS1 | 0.25 | 0.14 | enet | 12 | 0.18 | 6.8e-06 | 5.7 | 5.3 | 1.1e-07 | -0.36 | 0.28 | 0.20 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | MRPL23-AS1 | 0.36 | 0.23 | lasso | 3 | 0.21 | 3.8e-06 | 6.6 | 6.5 | 1.0e-10 | -0.33 | 0.39 | 0.20 | FALSE |
| 4 | GTEx | Brain Nucleus accumbens basal ganglia | MRPL23-AS1 | 0.25 | 0.07 | lasso | 5 | 0.03 | 6.8e-02 | 5.1 | 5.3 | 1.2e-07 | -0.28 | 0.10 | 0.14 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | LSP1 | 0.21 | 0.04 | enet | 28 | 0.06 | 3.4e-05 | 9.8 | 7.1 | 1.4e-12 | -0.45 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Colon Sigmoid | MRPL23-AS1 | 0.39 | 0.13 | lasso | 6 | 0.23 | 9.8e-09 | 5.7 | 5.4 | 7.4e-08 | -0.31 | 0.92 | 0.01 | FALSE |
| 7 | GTEx | Colon Transverse | MRPL23-AS1 | 0.13 | 0.03 | enet | 19 | 0.03 | 1.0e-02 | 5.7 | 5.9 | 4.5e-09 | -0.25 | 0.12 | 0.07 | FALSE |
| 8 | GTEx | Esophagus Muscularis | MRPL23-AS1 | 0.21 | 0.07 | lasso | 4 | 0.10 | 1.8e-06 | 5.7 | 5.3 | 1.2e-07 | -0.29 | 0.94 | 0.01 | FALSE |
| 9 | GTEx | Nerve Tibial | MRPL23-AS1 | 0.18 | 0.11 | lasso | 4 | 0.16 | 1.2e-11 | 6.0 | 5.2 | 1.5e-07 | -0.28 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | TNNT3 | 0.33 | 0.16 | lasso | 7 | 0.17 | 2.0e-09 | 8.7 | 9.2 | 4.2e-20 | -0.45 | 0.01 | 0.99 | TRUE |
| 11 | GTEx | Skin Not Sun Exposed Suprapubic | MRPL23-AS1 | 0.33 | 0.19 | enet | 30 | 0.21 | 9.5e-12 | 6.0 | 6.2 | 4.6e-10 | -0.25 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | MRPL23-AS1 | 0.19 | 0.19 | enet | 9 | 0.21 | 5.3e-17 | 5.7 | 5.8 | 6.9e-09 | -0.30 | 1.00 | 0.00 | FALSE |
| 13 | NTR | Blood | TNNT3 | 0.04 | 0.02 | blup | 461 | 0.02 | 4.3e-06 | 8.2 | -5.7 | 1.2e-08 | 0.39 | 0.20 | 0.79 | FALSE |
| 14 | YFS | Blood | TNNT3 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.9e-05 | 8.7 | -7.7 | 1.0e-14 | 0.42 | 0.08 | 0.91 | FALSE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LSP1 | 0.12 | 0.08 | lasso | 5 | 0.10 | 5.0e-11 | -9.0 | -9.7 | 2.5e-22 | 0.87 | 0.00 | 1.00 | TRUE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LSP1 | 0.06 | 0.04 | enet | 6 | 0.04 | 3.1e-05 | 7.3 | 6.5 | 9.9e-11 | -0.50 | 0.42 | 0.38 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LOC100133545 | 0.03 | 0.01 | blup | 49 | 0.01 | 1.1e-02 | 6.0 | 5.8 | 6.3e-09 | -0.30 | 0.00 | 0.92 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LSP1 | 0.07 | 0.03 | lasso | 4 | 0.03 | 2.4e-04 | 7.3 | -9.0 | 1.6e-19 | 0.63 | 0.10 | 0.15 | FALSE |
| 19 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TNNI2 | 0.11 | 0.09 | lasso | 2 | 0.08 | 4.1e-06 | 7.3 | -7.3 | 3.2e-13 | 0.48 | 0.40 | 0.38 | TRUE |