TWAS hub - TNNI2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0416	0.0142	0.00057	0.020	0.009	0.021	0.019	0.018	2.7e-07	5.5e-04	1.5e-07	6.4e-07	9.4e-07
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0613	0.0277	0.00320	0.020	0.017	0.042	NA	0.047	2.3e-03	5.0e-03	1.5e-05	NA	4.8e-06
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.1090	0.0400	0.00019	0.086	0.071	0.061	NA	0.081	1.9e-06	1.5e-05	6.3e-05	NA	4.1e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Systolic Blood Pressure	10.2	51.2	118.8	4.5	3.9	-10.9
Medication: Blood pressure	8.8	16.7	42.6	1.3	2.4	-6.5
Medication: Bendroflumethiazide	8.7	13.2	34.3	1.6	1.7	-5.9
Systolic blood pressure, automated reading	8.3	24.2	53.0	3.7	2.5	-7.3
Hypertension (Self-reported)	7.9	22.0	60.5	2.0	1.2	-7.8
High blood pressure	7.8	21.7	59.4	2.0	1.3	-7.7
Ulcerative Colitis	7.2	10.5	24.2	-2.7	0.0	-4.9
Cardiovascular Disease	6.9	22.9	65.6	0.8	1.6	-8.1
Medication: Amlodipine	6.8	9.6	19.1	2.6	1.6	-4.4
Ulcerative Colitis (UC)	6.7	12.5	27.8	-2.0	-2.4	-5.3
Vascular/heart problems diagnosed by doctor	6.5	17.7	48.0	-1.9	-1.3	6.9
Illnesses of father: Heart disease	5.3	7.4	10.1	-2.7	-3.2	-2.2
Medication for cholesterol	5.2	7.9	15.9	-0.8	-2.6	4.0
Breast Cancer	4.8	11.5	24.4	4.9	2.9	-1.3
Illnesses of father: None of the above (group 1)	4.8	5.9	6.6	2.6	2.4	2.4
Irritable Bowel Disease (IBD)	4.6	10.9	23.8	-1.9	-2.3	-4.9
Medication: Blood pressure	4.3	7.5	22.0	0.5	-0.6	-4.7
Financial situation satisfaction	4.3	5.3	6.7	-2.6	-1.6	-2.6
Medication: Lisinopril	4.0	5.2	15.2	0.5	0.4	-3.9
Health satisfaction	3.8	4.9	6.7	-2.5	-1.3	-2.6
Diastolic blood pressure, automated reading	3.8	11.8	32.4	1.4	1.0	-5.7
Illnesses of father: High blood pressure	3.3	4.1	11.7	0.1	-0.8	-3.4
HbA1C	3.0	3.3	3.7	1.7	1.8	1.9
Age when periods started (menarche)	3.0	7.1	21.2	0.4	0.3	4.6
Medication for cholesterol, blood pressure or diabetes	3.0	5.0	13.6	0.6	1.0	3.7
High blood pressure (siblings)	3.0	4.3	8.4	1.4	1.6	-2.9
Number of full sisters	3.0	3.7	7.1	-1.4	-2.7	-1.4
Ever used hormone-replacement therapy (HRT)	2.9	3.7	5.1	1.6	1.9	2.3
Prospective memory result	2.9	3.5	7.7	-2.8	-1.1	-1.3
Mean Putamen Volume	2.7	3.1	6.2	2.5	1.7	0.6
Number of full brothers	2.7	3.4	8.6	0.6	1.2	2.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.7	3.2	6.2	-2.5	-1.7	-0.7
Respiratory disease	2.6	5.8	13.5	-1.4	-3.7	1.3
Medication: Atenolol	2.5	3.2	9.1	-0.5	0.6	-3.0
High blood pressure (mother)	2.5	3.6	9.4	-0.7	-0.9	-3.1
Medication: Ramipril	2.5	3.2	5.0	1.9	0.9	-2.2
Medication: Aspirin	2.5	3.2	5.9	-1.4	-1.3	-2.4
Medication: Ventolin 100micrograms inhaler	2.3	2.9	8.1	0.8	-0.1	2.9
Illnesses of mother	2.2	2.8	7.7	0.6	0.5	2.8
Commuting to job workplace: Cycle	2.2	2.7	4.8	1.5	1.0	2.2
Pulse wave reflection index	2.1	2.6	6.1	1.1	2.5	0.7
Ever highly irritable/argumentative for 2 days	2.1	2.5	6.1	1.1	-0.5	-2.5
Eye problems/disorders: None of the above	2.1	2.5	2.7	1.6	1.5	1.6
Handedness (chirality/laterality): Left-handed	2.1	2.6	4.2	-2.0	-1.9	-0.2
Number of self-reported non-cancer illnesses	2.1	3.6	10.0	0.1	-0.9	-3.2
Alzheimer’s Disease (in mother)	2.0	2.3	2.5	-1.6	-1.6	-1.4
Breast cancer (self-reported)	2.0	2.4	4.0	-2.0	-1.8	0.3
Medication: Aspirin	2.0	2.6	5.4	-1.3	-0.9	-2.3
Age at First Birth	1.9	2.8	8.3	-0.0	0.3	-2.9
Fasting Glucose	1.8	2.1	3.4	1.0	1.9	-1.4
Blood Eosinophil Count	1.8	13.6	24.9	-3.6	-5.0	-1.8
Birth weight of first child	1.8	3.3	6.8	1.0	1.4	2.6
Pulse rate, automated reading	1.8	5.9	9.9	-2.8	-3.1	-0.6
Ever had prostate specific antigen (PSA) test	1.8	2.0	4.2	-1.3	-0.5	-2.0
Pack years adult smoking proportion	1.7	2.6	3.9	-1.5	-2.0	-1.3
Time employed in main current job	1.7	2.0	4.6	-1.0	-0.7	-2.1
Pulse rate	1.7	2.9	3.5	-1.9	-1.8	-1.4
Supplements: Calcium	1.7	1.9	2.9	-0.9	1.4	-1.7
Waist Hip Ratio (WHR)	1.6	7.0	15.3	-2.3	-3.9	-0.8
Asthma (self-reported)	1.6	3.3	4.8	-1.0	-2.2	2.0
Alcohol drinker status: Never	1.6	1.9	2.8	1.7	1.3	1.1
Blood White Count	1.5	11.1	19.3	2.2	3.0	4.4
Number of treatments/medications taken	1.5	2.8	8.1	-0.3	-0.4	-2.8
Medication for hormone replacement therapy	1.5	1.7	3.3	1.8	0.9	0.9
Mouth/teeth dental problems: Dentures	1.5	2.6	7.2	0.2	0.8	2.7
Breastfed as a baby	1.5	1.9	5.7	0.0	0.3	-2.4
Commuting to job workplace: Public transport	1.5	1.8	3.2	-1.8	-0.4	1.4
Pack years of smoking	1.5	2.2	3.3	-1.2	-1.8	-1.4
LDL Cholesterol	1.4	2.2	3.2	1.7	-0.6	1.8
Neuroticism (2016)	1.4	2.0	2.3	1.4	1.3	1.5
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	5.1	0.1	0.6	-2.3
Asthma	1.4	2.8	4.2	-1.1	-2.1	1.8
Length of working week for main job	1.4	1.6	2.5	-1.6	-0.8	-1.3
Birth weight	1.4	3.1	7.3	-1.3	-0.4	2.7
Supplements: Zinc	1.3	1.4	2.3	0.2	1.5	-1.3
Multivitamins +/- minerals	1.3	1.6	2.7	0.9	1.2	1.6
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	4.4	-0.1	-0.3	-2.1
Impedance of arm (right)	1.3	5.9	16.4	-0.9	-0.6	4.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	4.2	1.3	2.0	0.0
Number of children fathered	1.3	1.4	1.6	1.2	1.3	1.1
Neck or shoulder pain in last month	1.3	1.8	3.4	-0.9	-1.1	-1.9
Leg pain on walking	1.3	1.6	2.6	-1.0	-1.6	1.0
Osteoporosis (self-reported)	1.3	1.6	3.0	-1.7	-0.3	-1.4
Rheumatoid Arthritis	1.2	1.7	3.1	1.8	1.4	0.3
Diabetes (mother)	1.2	1.5	3.6	-0.1	1.9	-1.0
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	1.9	-0.7	-1.4	-1.2
Impedance of arm (left)	1.2	5.5	14.6	-1.1	-0.8	3.8
Ever taken oral contraceptive pill	1.2	1.3	3.3	0.2	0.7	1.8
High cholesterol (Self-reported)	1.2	2.2	5.1	-1.1	0.6	-2.2
Fractured/broken bones in last 5 years	1.2	1.6	1.9	-1.1	1.3	-1.4
Cholesterol lowering medication	1.2	1.8	5.3	-0.2	2.3	-0.3
Long-standing illness, disability or infirmity	1.1	1.6	4.5	-0.2	0.6	-2.1
Average weekly champagne plus white wine intake	1.1	1.6	3.9	2.0	-0.9	0.3
Had other major operations	1.0	1.2	1.9	0.5	1.4	1.1
Mouth/teeth dental problems	1.0	1.6	3.3	-0.5	-1.1	-1.8
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	2.9	-0.5	-1.7	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.5	0.5	-0.0	1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	5.9	-0.5	0.6	2.4
Pain type(s) experienced in last month: Hip pain	1.0	1.2	2.9	-0.8	-1.7	0.1
Body Mass Index (BMI) (2010)	0.9	1.2	3.2	0.6	-0.1	1.8
Hypothyroidism (self reported)	0.9	2.0	5.7	-0.1	-0.6	2.4
Medication: Levothyroxine sodium	0.9	1.6	3.6	-0.6	-0.9	1.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	2.1	-0.7	-0.8	-1.4
Financial difficulties in last 2 years	0.9	1.3	1.5	-1.2	-0.9	-1.2
Illnesses of siblings	0.9	1.2	3.1	-0.1	0.7	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.0	-1.4	0.8	-0.6
Emphysema/chronic bronchitis	0.9	1.1	1.9	-0.7	-0.9	-1.4
Medication for pain relief, constipation, heartburn	0.9	1.6	2.5	1.0	1.1	1.6
Overall health rating	0.9	1.9	5.0	-0.7	0.6	-2.2
Chest pain or discomfort	0.9	1.3	1.9	1.0	-1.0	-1.4
Had major operations	0.9	1.0	2.6	-1.6	-0.7	-0.0
Smoking status: Current	0.9	1.4	4.2	-0.1	0.2	2.0
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.1	1.4	0.6	1.1
Impedance of whole body	0.9	4.8	11.5	-1.2	-1.2	3.4
Bipolar Disorder or Schizophrenia	0.8	1.9	3.7	1.0	1.9	-1.0
Schizophrenia (2018)	0.8	1.7	3.6	0.1	1.9	-1.3
Medication: Co-codamol	0.8	1.0	2.5	-0.6	-1.6	0.2
Medication: Simvastatin	0.8	1.2	2.1	-1.1	0.4	-1.5
Father’s age at death	0.8	1.0	1.9	0.7	0.8	1.4
Comparative body size at age 10	0.8	2.3	3.2	1.3	1.5	-1.8
Leg fat percentage (left)	0.8	2.8	5.0	-1.7	-2.2	-0.7
Depression (Nagel 2018)	0.7	1.1	2.1	0.9	-0.7	-1.5
Alzheimer’s Disease (in father)	0.7	0.7	1.7	-0.4	1.3	0.6
Alzheimer’s Disease (including proxy)	0.7	1.0	2.4	-1.6	-0.7	-0.0
Crohns Disease (2017)	0.7	1.5	4.3	-0.5	-0.2	-2.1
Lung FEV1/FVC ratio	0.7	3.5	6.7	2.6	0.3	1.9
Impedance of leg (right)	0.7	3.4	4.9	-1.0	-2.2	2.0
Current tobacco smoking	0.7	1.1	3.2	-0.3	0.1	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.5	0.2	-1.2	-1.2
Supplements: Glucosamine	0.7	0.9	2.4	-1.6	-0.5	0.1
Waist circumference	0.7	2.6	3.7	-1.9	-1.9	-0.7
Number of incorrect matches in round	0.7	1.1	3.2	1.8	0.3	0.1
Hair/balding pattern: Pattern 2	0.7	0.9	1.7	-1.0	0.1	-1.3
Worrier / anxious feelings	0.7	1.4	2.9	1.0	1.7	-0.5
Happiness	0.7	0.8	1.2	1.1	0.4	-1.1
Tense / ‘highly strung’	0.7	1.1	1.8	1.3	0.7	1.1
Headache pain in last month	0.7	1.1	1.9	1.4	1.1	-0.5
Shortness of breath walking on level ground	0.7	0.9	1.6	-1.0	-1.3	0.1
Medication: Gliclazide	0.7	0.8	1.9	0.2	0.7	1.4
Hearing aid user	0.7	0.8	1.4	-0.9	-1.2	0.3
Heart disease (siblings)	0.7	0.8	1.4	-0.7	-0.8	1.2
Primary Biliary Cirrhosis	0.6	0.9	2.1	0.7	1.5	-0.2
Triglycerides	0.6	1.0	2.4	-0.3	-0.7	1.6
Blood Red Count	0.6	5.6	14.1	1.5	0.7	3.8
Ever had hysterectomy (womb removed)	0.6	0.7	0.8	0.9	0.7	-0.8
Taking other prescription medications	0.6	0.9	1.8	1.4	0.3	0.9
Impedance of leg (left)	0.6	3.0	4.6	-1.2	-2.1	1.7
Alcohol usually taken with meals	0.6	1.0	2.3	-0.4	0.6	-1.5
Alcohol intake versus 10 years previously	0.6	1.0	1.2	-0.9	-1.1	-0.9
Medication: Cholesterol lowering	0.6	0.9	1.9	-0.6	-0.7	-1.4
Medication: Lansoprazole	0.6	0.6	1.2	-0.5	-0.7	-1.1
Blood clot in the leg (DVT)	0.6	0.7	1.3	1.1	0.3	0.9
Leg fat percentage (right)	0.6	2.3	4.8	-1.4	-2.2	-0.3
Qualifications: College or University degree	0.6	1.9	4.6	0.5	1.0	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.0	0.0	1.0	0.9
Commuting to job workplace: Walk	0.6	0.7	1.6	1.3	0.5	0.5
Osteoarthritis (self-reported)	0.6	0.7	1.1	-1.0	-1.0	-0.2
Ever depressed for a whole week	0.6	0.7	1.8	0.5	-0.0	-1.4
Neuroticism (Nagel 2018)	0.5	1.2	1.8	-0.4	-1.2	-1.3
Schizophrenia vs Biploar Disorder	0.5	0.6	1.9	-1.4	0.0	0.0
Prostate Cancer	0.5	0.7	1.2	0.1	0.9	1.1
Crohns Disease (2012)	0.5	0.8	2.3	-1.5	0.0	0.0
HDL Cholesterol	0.5	0.8	2.1	0.2	-0.3	-1.4
Allergy or Eczema	0.5	1.4	3.9	0.0	-0.5	2.0
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.6	1.0	1.3	0.2
Average weekly spirits intake	0.5	0.7	1.1	0.0	1.0	1.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.5	0.8	0.4	-1.2
Diabetes (father)	0.5	0.6	1.4	-0.3	0.6	-1.2
Trunk fat percentage	0.5	2.0	2.7	-1.6	-1.2	1.4
Townsend deprivation index at recruitment	0.5	0.7	1.5	-1.2	-0.8	-0.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.1	0.8	1.0	-0.1
Serious illness, injury or assault to yourself	0.5	0.6	1.3	-1.2	-0.2	-0.6
Nervous feelings	0.5	0.9	1.6	1.3	0.2	1.0
Had menopause	0.5	0.7	1.0	1.0	0.6	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.7	0.9	0.3	1.6
Number of live births	0.5	0.7	0.9	0.7	0.9	0.8
Lung cancer (father)	0.5	0.5	1.3	0.2	0.5	-1.1
Exposure to tobacco smoke at home	0.5	0.6	1.4	-0.3	-0.5	1.2
Gout (self-reported)	0.5	0.6	1.1	-0.6	-0.6	-1.1
Body fat percentage	0.5	1.8	2.6	-1.6	-1.5	0.7
Pulse wave peak to peak time	0.5	0.5	1.5	-0.4	-1.2	0.1
Family relationship satisfaction	0.5	0.6	1.0	-1.0	0.1	-0.9
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	0.3	-1.3	-0.4
Knee pain experienced in last month	0.5	0.8	1.7	-1.3	-0.6	-0.5
Medication: Paracetamol	0.5	0.8	1.4	-0.9	-1.2	0.0
Number of operations (self-reported)	0.5	0.8	1.4	-0.9	-0.4	1.2
Age started oral contraceptive pill	0.5	0.6	1.4	0.4	0.5	-1.2
Basal cell carcinoma (self-reported)	0.5	0.5	0.8	0.8	0.5	-0.9
Alcohol drinker status: Previous	0.5	0.5	1.3	-0.5	-1.1	0.1
Lupus	0.4	0.5	1.0	-0.4	1.0	0.6
Blood Platelet Count	0.4	5.2	15.3	0.1	0.6	3.9
Height	0.4	7.1	12.5	-3.0	0.5	3.5
Lung FVC	0.4	2.1	6.2	0.0	0.2	-2.5
Hearing difficulty/problems: Yes	0.4	0.6	1.3	-0.6	-1.2	0.4
Fed-up feelings	0.4	0.8	2.1	-0.4	-0.2	-1.5
Qualifications: CSEs or equivalent	0.4	0.5	0.9	-0.0	0.8	1.0
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.8	-0.2	-0.1	1.7
Sitting height	0.4	2.9	4.6	-0.1	2.0	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.7	0.2	-0.2	-1.3
Fluid intelligence score	0.4	0.7	1.5	0.6	1.2	0.6
Neuroticism score	0.4	0.8	1.9	1.4	0.5	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	-0.8	-0.3	-0.9
Pulse wave Arterial Stiffness index	0.4	0.5	1.4	0.2	1.2	-0.0
Standing height	0.4	4.4	10.5	-1.6	-0.2	3.2
Peak expiratory flow (PEF)	0.4	0.9	1.8	-0.5	-0.9	1.3
Medication: Paracetamol	0.4	0.6	1.3	-0.7	-1.2	-0.1
Suffer from ‘nerves’	0.4	0.7	1.0	-0.9	-0.4	-1.0
Supplements: Vitamin C	0.4	0.5	1.1	-0.4	1.1	0.2
Mood swings	0.4	0.7	1.5	1.2	0.2	0.7
Ever had bowel cancer screening	0.4	0.4	1.0	-1.0	0.5	0.1
Qualifications: nursing, teaching	0.4	0.6	1.4	-1.2	0.7	0.1
Eye problems/disorders: Cataract	0.4	0.5	1.4	-1.2	0.4	-0.2
Back pain experienced in last month	0.4	0.6	0.7	-0.8	-0.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.7	0.8	1.3	-0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.9	-1.0	-0.8	-0.1
Average weekly beer plus cider intake	0.4	0.6	1.2	0.2	1.1	0.9
Bipolar Disorder (2018)	0.3	0.4	1.2	1.1	0.0	0.0
Depressed Affect (Nagel 2018)	0.3	0.7	1.2	0.3	-0.9	-1.1
Angina	0.3	0.4	0.6	-0.6	-0.8	0.3
Severe depression (siblings)	0.3	0.3	0.6	-0.5	-0.4	0.7
Stomach or abdominal pain in last month	0.3	0.3	1.0	-0.2	-1.0	0.2
Trunk fat mass	0.3	1.5	2.2	-1.5	-1.0	1.1
Hearing difficulty/problems with background noise	0.3	0.4	0.7	-0.1	-0.8	-0.8
Allergy	0.3	0.8	1.8	0.6	0.5	-1.3
Noisy workplace	0.3	0.4	1.2	0.0	0.1	1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	0.8	1.1	-0.2
Depression (self-reported)	0.3	0.4	0.6	0.8	-0.5	-0.6
Hair/balding pattern: Pattern 4	0.3	0.7	0.9	0.6	-1.0	1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	0.0	-0.2	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.6	0.1	-0.7	-0.8
Age at first live birth	0.3	0.5	1.5	0.1	-0.0	-1.2
Angina (self-reported)	0.3	0.4	0.6	-0.8	-0.7	0.1
Migraine (self-reported)	0.3	0.3	0.9	0.3	0.9	-0.0
Medication: Ibuprofen	0.3	0.3	0.6	-0.7	0.1	-0.7
Medication: Allopurinol	0.3	0.5	0.7	0.7	0.8	0.5
Leg fat mass (right)	0.3	1.0	1.8	-1.1	-1.3	-0.1
Smoking status: Previous	0.3	0.5	1.4	0.0	-0.0	-1.2
Arm fat percentage (left)	0.3	1.2	2.3	-1.5	-1.1	0.3
Friendships satisfaction	0.3	0.3	0.9	-0.3	0.0	-0.9
Mineral and other dietary supplements	0.3	0.4	1.0	1.0	0.1	0.6
Wears glasses or contact lenses	0.3	0.4	0.6	0.3	0.8	-0.6
Medication: Atorvastatin	0.3	0.4	0.9	0.9	0.5	-0.3
Ever smoked	0.3	0.6	1.2	-0.7	0.2	-1.1
Irritability	0.3	0.4	0.6	-0.8	0.4	-0.7
Leg fat mass (left)	0.3	1.0	1.6	-1.1	-1.3	-0.4
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.0	0.6	-0.6	1.0
Worry (Nagel 2018)	0.2	0.5	1.1	0.2	-0.6	-1.0
Ovarian Cancer	0.2	0.2	0.7	0.0	0.1	0.8
Coronary Artery Disease (CAD)	0.2	0.3	0.9	-0.9	0.0	0.0
Schizophrenia (2014)	0.2	0.4	1.0	0.5	1.0	-0.2
BMI	0.2	1.1	2.4	-0.9	-0.3	-1.6
Smoking Status	0.2	0.5	0.8	-0.1	0.9	0.8
Sensitivity / hurt feelings	0.2	0.4	1.0	1.0	0.2	-0.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.4	-0.3	-0.7
Vitamin and mineral supplements	0.2	0.3	0.9	0.2	-0.9	-0.3
Medication: Metformin	0.2	0.2	0.4	0.1	0.6	-0.6
Maternal smoking around birth	0.2	0.2	0.5	-0.7	0.4	-0.0
Relative age voice broke	0.2	0.3	0.7	0.3	0.4	0.8
Qualifications: None of the above	0.2	0.5	1.1	0.3	-1.0	-0.5
Pain all over the body in last month	0.2	0.3	0.7	-0.8	-0.3	-0.0
Diabetes (self-reported)	0.2	0.4	0.4	0.6	0.7	-0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	-0.1	-0.8	0.2
Arm fat percentage (right)	0.2	0.8	1.6	-1.3	-0.8	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.4	-0.6	-0.7	-0.3
Falls in the last year	0.2	0.2	0.5	0.7	0.3	-0.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	0.1	-0.6	-0.7
Glaucoma (self-reported)	0.2	0.3	0.4	0.6	-0.4	-0.5
Forced vital capacity (FVC), Best measure	0.2	0.6	1.3	-1.1	0.6	0.2
Wheeze or whistling in the chest in last year	0.2	0.4	0.6	-0.8	-0.7	-0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	-0.3	0.3	-0.7
Medication: Seretide 50 evohaler	0.2	0.3	0.4	0.2	0.6	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	0.5	-0.6	-0.0
Whole body fat mass	0.2	0.7	1.2	-1.1	-0.8	0.6
Alcohol intake frequency.	0.2	0.4	0.9	-0.1	-0.5	0.9
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.3	-0.3	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.4	-0.6	-0.1
Loneliness, isolation	0.2	0.3	0.9	-1.0	-0.1	-0.2
Diabetes diagnosed by doctor	0.2	0.3	0.4	0.3	0.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.3	0.5	0.5	0.5
Miserableness	0.2	0.3	0.8	0.9	-0.2	-0.3
Guilty feelings	0.2	0.3	0.8	0.1	-0.9	0.3
Mother’s age at death	0.2	0.2	0.5	0.7	-0.1	-0.3
Risk taking	0.2	0.3	0.4	-0.6	-0.3	0.5
Unable to work because of sickness or disability	0.2	0.3	0.4	-0.5	-0.6	-0.5
Pain experienced in last month	0.2	0.3	0.4	-0.4	-0.5	0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	0.3	0.4	0.8
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	-0.6	0.0	0.0
Neuroticism	0.1	0.1	0.2	0.3	-0.2	-0.4
Chronotype (morning person)	0.1	0.3	0.4	0.6	-0.6	0.5
Tanning	0.1	1.2	2.0	-1.3	-1.4	0.0
Hand grip strength (left)	0.1	0.3	0.7	0.5	0.8	-0.1
Relative age of first facial hair	0.1	0.3	0.5	0.2	0.7	0.5
Leg fat-free mass (left)	0.1	0.4	0.6	-0.6	0.8	0.5
Hand grip strength (right)	0.1	0.2	0.5	0.7	0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	0.6	-0.1	0.7
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.2	0.0	-0.5
Body mass index (BMI)	0.1	0.6	1.7	-0.4	-0.2	-1.3
Leg predicted mass (left)	0.1	0.4	0.7	-0.4	0.8	0.7
Past tobacco smoking	0.1	0.2	0.5	-0.0	-0.2	0.7
Forced vital capacity (FVC)	0.1	0.6	1.1	-1.1	-0.4	-0.6
Heart attack	0.1	0.1	0.2	0.3	-0.3	-0.4
Weight	0.1	0.4	1.1	-1.1	-0.3	0.2
Hip circumference	0.1	0.4	1.2	-1.1	-0.2	0.1
Arm fat mass (right)	0.1	0.3	0.7	-0.8	-0.4	0.3
Loud music exposure frequency	0.1	0.1	0.3	-0.2	0.5	0.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	0.2	0.6	-0.0
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.2	0.2	0.4
Exposure to tobacco smoke outside home	0.1	0.2	0.4	0.1	-0.2	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.2	0.5	-0.4	-0.4
Medication: Omeprazole	0.1	0.1	0.2	-0.4	-0.2	-0.0
Mean time to correctly identify matches	0.1	0.1	0.3	0.6	-0.0	0.1
Comparative height size at age 10	0.1	0.3	0.5	0.5	-0.7	-0.6
Age at last live birth	0.1	0.2	0.5	-0.2	-0.0	-0.7
Illnesses of siblings: Diabetes	0.1	0.2	0.4	-0.0	-0.4	-0.6
Leg fat-free mass (right)	0.1	0.6	1.3	-0.5	1.2	0.4
Average weekly red wine intake	0.1	0.2	0.3	0.4	0.1	-0.6
Leg predicted mass (right)	0.1	0.7	1.5	-0.5	1.2	0.5
Arm fat mass (left)	0.1	0.5	1.0	-1.0	-0.6	0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.1	0.2	0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.4	-0.0	-0.2
Myopia	0.1	0.2	0.4	0.1	0.2	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.3	-0.2	-0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.3	-0.3	-0.4
Arm predicted mass (left)	0.1	0.3	0.9	0.1	0.9	-0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.0	0.1	0.1	0.4	-0.3	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.4	0.7	-0.5	-0.4	0.8
Hair Pigment	0.0	0.9	2.0	0.4	-0.7	-1.4
Average weekly fortified wine intake	0.0	0.1	0.1	0.3	0.1	0.2
Trunk fat-free mass	0.0	0.1	0.2	-0.1	0.5	-0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	-0.1	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.2	0.3	-0.3	0.2	0.6
Trunk predicted mass	0.0	0.1	0.3	-0.0	0.5	-0.0
Arm fat-free mass (right)	0.0	0.2	0.2	-0.5	0.2	-0.4
Worry too long after embarrassment	0.0	0.1	0.1	0.3	-0.2	0.1
Heart disease (mother)	0.0	0.0	0.0	-0.0	-0.2	0.1
Arm predicted mass (right)	0.0	0.2	0.2	-0.4	0.4	-0.5
Whole body fat-free mass	0.0	0.2	0.4	-0.3	0.6	0.1
Whole body water mass	0.0	0.2	0.5	-0.2	0.7	-0.1
Basal metabolic rate	0.0	0.2	0.3	-0.6	0.4	0.1
Arm fat-free mass (left)	0.0	0.2	0.4	-0.1	0.7	-0.4

Hub : Genes

TNNI2

Models

Trait associations