[Hub]/) : Traits : Systolic blood pressure, automated reading :

chr17:6,397,773-8,173,767

Best TWAS P=5.6e-11 · Best GWAS P=5.2e-10 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ACADVL 0.09 0.06 bslmm 467 0.07 2.1e-08 -6.0 -5.5 3.0e-08 0.86 0.01 0.99 FALSE
2 CommonMind Brain Pre-frontal Cortex SLC2A4 0.08 0.06 lasso 2 0.08 1.2e-09 -4.4 5.9 4.6e-09 -0.58 0.10 0.90 FALSE
3 GTEx Artery Aorta ACADVL 0.10 0.09 lasso 3 0.10 2.4e-06 -5.8 -5.9 3.3e-09 0.87 0.02 0.98 FALSE
4 GTEx Artery Tibial ACADVL 0.12 0.10 enet 3 0.10 2.7e-08 -6.2 -6.3 3.6e-10 0.97 0.00 1.00 FALSE
5 GTEx Cells Transformed fibroblasts TNFSF12 0.25 0.22 lasso 8 0.20 7.4e-15 5.7 5.6 2.8e-08 -0.04 0.05 0.95 FALSE
6 GTEx Esophagus Mucosa CTDNEP1 0.21 0.17 lasso 6 0.17 2.3e-11 -4.4 5.1 3.0e-07 -0.79 0.10 0.90 FALSE
7 GTEx Muscle Skeletal DLG4 0.12 0.05 lasso 4 0.05 2.3e-05 -5.8 6.0 1.6e-09 -0.95 0.00 1.00 TRUE
8 GTEx Skin Sun Exposed Lower leg DVL2 0.10 0.03 lasso 2 0.02 1.5e-02 -5.8 -5.9 4.8e-09 0.86 0.02 0.98 FALSE
9 GTEx Whole Blood ACADVL 0.07 0.04 lasso 2 0.03 3.4e-04 -6.0 -5.8 5.4e-09 0.94 0.01 0.99 TRUE
10 METSIM Adipose SENP3 0.06 0.03 lasso 3 0.02 4.9e-04 5.4 -6.6 5.6e-11 0.24 0.17 0.67 TRUE
11 NTR Blood TNFSF12 0.06 0.07 bslmm 462 0.07 9.4e-23 5.4 6.0 1.6e-09 0.01 0.09 0.91 FALSE
12 ROSMAP Brain Pre-frontal Cortex SLC2A4 0.08 0.08 enet 9 0.08 5.5e-11 -6.1 6.0 2.3e-09 -0.80 0.01 0.99 TRUE
13 ROSMAP Brain Pre-frontal Cortex CLDN7 0.07 0.06 lasso 4 0.05 3.9e-07 -5.9 -5.8 6.8e-09 0.85 0.03 0.97 FALSE
14 The Cancer Genome Atlas Breast Invasive Carcinoma C17orf81 0.04 0.05 blup 43 0.06 4.0e-12 -4.3 -5.2 1.7e-07 0.73 0.93 0.06 FALSE
15 The Cancer Genome Atlas Breast Invasive Carcinoma DULLARD 0.03 0.07 enet 13 0.07 5.8e-15 -4.4 5.4 5.1e-08 -0.84 0.42 0.58 TRUE
16 The Cancer Genome Atlas Colon Adenocarcinoma TNFSF12-TNFSF13 0.07 0.05 lasso 3 0.02 1.9e-02 5.4 5.5 4.2e-08 0.00 0.01 0.90 FALSE
17 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DULLARD 0.03 0.03 blup 42 0.03 9.3e-05 -5.9 6.0 1.9e-09 -0.87 0.02 0.97 FALSE
18 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TNFSF12 0.04 0.01 enet 9 0.01 4.3e-02 5.4 -6.0 2.7e-09 0.01 0.01 0.82 FALSE
19 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C17orf81 0.11 0.13 blup 43 0.13 8.7e-08 -4.4 -5.2 2.2e-07 0.74 0.32 0.68 FALSE
20 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma DULLARD 0.13 0.11 blup 42 0.13 8.7e-08 -4.4 5.7 9.8e-09 -0.87 0.04 0.96 FALSE
21 The Cancer Genome Atlas Brain Lower Grade Glioma ACADVL 0.03 0.03 blup 37 0.04 5.5e-05 -6.1 -5.8 7.2e-09 0.88 0.01 0.98 FALSE
22 The Cancer Genome Atlas Brain Lower Grade Glioma C17orf81 0.04 0.05 enet 8 0.04 1.2e-05 -6.1 -5.7 1.1e-08 0.66 0.01 0.99 FALSE
23 The Cancer Genome Atlas Brain Lower Grade Glioma SLC2A4 0.09 0.04 lasso 4 0.06 7.2e-08 -5.9 6.0 2.1e-09 -0.78 0.00 1.00 FALSE
24 The Cancer Genome Atlas Lung Adenocarcinoma DULLARD 0.04 0.06 blup 42 0.08 3.3e-09 -4.3 5.2 2.3e-07 -0.81 0.15 0.85 FALSE
25 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C17orf81 0.06 0.12 lasso 8 0.12 6.3e-14 -5.8 -5.6 2.5e-08 0.82 0.06 0.94 FALSE
26 The Cancer Genome Atlas Pancreatic Adenocarcinoma DULLARD 0.10 0.10 enet 8 0.10 7.7e-05 -5.8 5.4 7.5e-08 -0.80 0.05 0.92 FALSE
27 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma DULLARD 0.07 0.02 blup 42 0.06 2.3e-03 4.8 5.9 4.8e-09 -0.87 0.02 0.80 FALSE
28 The Cancer Genome Atlas Prostate Adenocarcinoma DULLARD 0.05 0.08 blup 42 0.07 1.7e-07 -4.4 5.6 2.3e-08 -0.88 0.07 0.93 FALSE
29 The Cancer Genome Atlas Prostate Adenocarcinoma SHBG 0.04 0.01 blup 60 0.03 5.4e-04 4.1 5.2 2.5e-07 -0.05 0.01 0.60 FALSE
30 The Cancer Genome Atlas Prostate Adenocarcinoma TNFSF12-TNFSF13 0.03 0.00 lasso 4 0.01 2.9e-02 5.7 6.0 1.8e-09 -0.01 0.01 0.76 TRUE
31 The Cancer Genome Atlas Thyroid Carcinoma SHBG 0.04 0.00 blup 59 0.02 4.4e-03 5.6 5.4 6.0e-08 -0.05 0.01 0.81 FALSE