TWAS hub - SLC2A4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0800	0.0250	4.9e-05	0.058	0.035	0.058	0.045	0.077	1.4e-07	4.0e-05	1.3e-07	3.0e-06	1.2e-09
2	ROSMAP	Brain Pre-frontal Cortex	0.0770	0.0228	7.0e-06	0.079	0.057	0.084	0.071	0.082	2.4e-10	7.7e-08	5.5e-11	1.7e-09	9.7e-11
3	TCGA	Cervical Squamous Cell Carcinoma	0.3520	0.1200	1.4e-03	0.109	0.063	0.064	NA	0.097	5.2e-06	4.9e-04	4.5e-04	NA	1.7e-05
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.1012	0.0432	5.0e-03	0.049	0.012	0.035	NA	0.044	2.8e-06	1.5e-02	7.0e-05	NA	1.0e-05
5	TCGA	Brain Lower Grade Glioma	0.0925	0.0426	5.1e-06	0.037	0.041	0.064	NA	0.065	3.9e-05	1.7e-05	8.1e-08	NA	7.2e-08
6	TCGA	Lung Squamous Cell Carcinoma	0.0949	0.0420	5.9e-04	0.070	0.015	0.050	NA	0.062	2.5e-08	6.5e-03	2.0e-06	NA	1.4e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Birth weight	25.4	55.1	97.6	8.1	9.6	5.0	5.0	9.9	5.0
Systolic Blood Pressure	9.2	46.2	72.6	8.3	8.4	4.7	4.7	8.5	4.7
Medication: Atenolol	8.3	10.4	11.3	3.0	2.9	3.3	3.3	3.4	3.3
Medication: Blood pressure	8.1	14.4	25.4	4.2	4.5	2.7	2.7	5.0	2.7
Fed-up feelings	8.0	14.6	19.2	-3.7	-4.1	-3.5	-3.5	-4.4	-3.5
Birth weight of first child	7.9	14.3	16.6	2.6	4.1	4.0	4.0	3.9	4.0
Medication: Lisinopril	7.2	9.4	13.7	3.7	2.9	2.6	2.6	3.6	2.6
Systolic blood pressure, automated reading	6.9	20.0	35.9	5.9	6.0	2.2	2.2	6.0	2.2
Medication for cholesterol, blood pressure or diabetes	6.8	11.3	12.7	-2.7	-3.2	-3.6	-3.6	-3.5	-3.6
High blood pressure	5.7	15.8	31.9	5.3	4.7	2.1	2.1	5.7	2.1
Hypertension (Self-reported)	5.6	15.6	30.7	5.2	4.6	2.2	2.2	5.5	2.2
Medication: Bendroflumethiazide	5.2	7.9	15.6	3.5	3.0	1.9	1.9	3.9	1.9
Vascular/heart problems diagnosed by doctor	5.2	14.2	28.6	-4.8	-4.6	-2.0	-2.0	-5.3	-2.0
Chest pain or discomfort	4.9	7.0	12.6	3.5	3.1	1.7	1.7	3.4	1.7
Maternal smoking around birth	4.7	6.9	10.6	-2.8	-2.8	-2.2	-2.2	-3.3	-2.2
High blood pressure (mother)	4.6	6.4	15.6	3.0	3.6	0.7	0.7	3.9	0.7
Peak expiratory flow (PEF)	4.6	10.6	21.3	-2.9	-4.6	-2.1	-2.1	-4.6	-2.1
Number of treatments/medications taken	4.5	8.1	10.8	2.1	2.6	3.0	3.0	3.3	3.0
Cardiovascular Disease	4.2	13.9	24.0	4.9	4.4	2.6	2.6	4.3	2.6
Medication: Blood pressure	4.2	8.0	18.2	3.7	3.8	0.7	0.7	4.3	0.7
Current tobacco smoking	4.0	6.5	13.0	-2.3	-2.7	-2.1	-2.1	-3.6	-2.1
Medication: Allopurinol	3.9	5.2	6.9	2.3	1.3	2.6	2.6	1.8	2.6
Diastolic blood pressure, automated reading	3.9	12.2	28.0	5.3	5.3	-0.2	-0.2	4.1	-0.2
Diabetes (father)	3.8	4.7	9.2	2.4	2.8	1.4	1.4	3.0	1.4
Hearing difficulty/problems: Yes	3.7	5.7	18.0	-2.8	-4.2	0.3	0.3	-2.9	0.3
Illnesses of mother	3.6	4.5	8.9	-2.8	-2.9	-0.8	-0.8	-3.0	-0.8
Mean time to correctly identify matches	3.6	6.9	14.6	2.5	3.8	1.9	1.9	3.1	1.9
Smoking status: Current	3.6	5.7	10.7	-2.2	-2.6	-2.0	-2.0	-3.3	-2.0
Age at First Birth	3.5	5.0	7.1	1.9	1.3	2.6	2.7	2.0	2.6
Long-standing illness, disability or infirmity	3.4	5.2	9.1	0.6	1.3	3.0	3.0	1.4	3.0
Hayfever/allergic rhinitis (self-reported)	3.0	4.0	7.3	1.1	-0.3	2.7	2.7	-0.9	2.7
Tinnitus: Yes, now most or all of the time	3.0	3.5	7.4	-2.3	-2.1	-1.2	-1.2	-2.7	-1.2
Had menopause	2.9	3.7	7.7	-2.8	-2.7	-0.4	-0.4	-2.5	-0.4
Shortness of breath walking on level ground	2.9	3.5	5.6	-1.4	-0.7	-2.4	-2.4	-1.3	-2.4
Basal cell carcinoma (self-reported)	2.8	3.4	5.4	0.2	0.3	2.3	2.3	2.0	2.3
Gout (self-reported)	2.7	3.7	6.2	1.5	0.9	2.5	2.5	1.0	2.5
Ovarian Cancer	2.6	3.5	5.1	-1.3	-1.2	-2.3	-2.2	-1.5	-2.3
Forced vital capacity (FVC)	2.5	9.5	18.8	-2.9	-4.3	-2.4	-2.4	-3.5	-2.4
Osteoporosis (self-reported)	2.5	3.2	5.8	0.2	-0.2	2.4	2.4	1.2	2.4
Bipolar Disorder or Schizophrenia	2.4	5.8	12.5	3.1	3.5	0.8	0.0	3.4	0.8
Reaction Time	2.4	4.6	15.4	2.5	3.9	0.3	0.3	2.4	0.3
Fasting Glucose	2.4	2.9	7.1	2.4	2.7	0.5	0.5	1.9	0.5
Schizophrenia (2014)	2.4	5.3	12.0	2.7	2.9	1.4	0.0	3.5	1.4
Medication: Ramipril	2.4	3.1	5.0	2.2	2.1	1.5	1.5	1.5	1.5
Arm fat percentage (right)	2.4	9.6	21.0	4.2	4.6	-0.6	-0.6	4.2	-0.6
Forced vital capacity (FVC), Best measure	2.4	8.7	16.1	-2.6	-4.0	-2.5	-2.5	-3.3	-2.5
Leg fat percentage (right)	2.4	8.7	18.0	4.2	4.2	-1.3	-1.3	3.4	-1.3
Medication: Gliclazide	2.4	2.8	4.8	-0.7	-0.9	-2.2	-2.2	-0.8	-2.2
Depressed Affect (Nagel 2018)	2.3	4.8	6.1	-1.6	-2.0	-2.3	-2.3	-2.5	-2.3
Leg pain on walking	2.3	2.9	5.5	-0.6	0.3	-2.3	-2.3	-0.8	-2.3
Medication for cholesterol	2.3	3.5	5.0	-2.0	-2.0	-1.6	-1.6	-2.2	-1.6
Neuroticism (Nagel 2018)	2.2	5.1	7.9	-1.2	-1.4	-2.8	-2.8	-2.0	-2.8
Average weekly fortified wine intake	2.2	2.5	4.6	0.8	1.6	1.6	1.6	2.1	1.6
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	7.0	-0.2	0.1	-2.6	-2.6	-0.7	-2.6
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.7	5.2	0.3	1.0	-2.3	-2.3	0.1	-2.3
Illnesses of father: Heart disease	2.2	3.0	5.9	0.1	-0.7	2.4	2.4	-0.3	2.4
Arm fat percentage (left)	2.2	8.8	19.0	3.9	4.4	-0.4	-0.4	4.2	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	3.2	-1.0	-1.8	-1.6	-1.6	-1.6	-1.6
Rheumatoid Arthritis	2.1	3.0	4.7	-1.6	-1.7	-1.6	-1.6	-2.2	-1.6
Smoking Status	2.1	4.9	7.7	-1.3	-2.7	-2.0	-2.0	-2.8	-2.0
Lung FVC	2.1	10.6	19.4	-3.3	-4.4	-3.0	-3.0	-2.7	-3.0
Supplements: Glucosamine	2.1	2.8	3.6	0.7	1.4	1.9	1.9	1.9	1.9
Commuting to job workplace: Car/motor vehicle	2.1	2.4	3.4	0.9	1.8	-1.8	-1.8	-0.3	-1.8
Commuting to job workplace: Walk	2.1	2.3	9.5	-1.2	-3.1	0.5	0.5	-1.4	0.5
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	3.8	-0.7	-0.6	-1.9	-1.9	-0.8	-1.9
Waist circumference	2.0	7.2	19.0	3.6	4.4	-0.0	0.0	3.3	-0.0
Hip circumference	2.0	8.6	17.0	3.8	4.1	-1.8	-1.8	3.2	-1.8
Number of self-reported non-cancer illnesses	2.0	3.5	5.6	1.6	0.9	2.4	2.4	0.9	2.4
Leg fat percentage (left)	2.0	7.2	18.1	4.3	3.6	-1.0	-1.0	3.0	-1.0
Schizophrenia (2018)	1.9	4.0	8.1	2.6	2.6	1.2	0.0	2.9	1.2
Neuroticism	1.9	4.6	6.8	0.0	-1.4	-2.6	-2.6	-2.3	-2.6
Prospective memory result	1.9	2.4	4.6	0.2	0.3	-2.1	-2.1	-0.4	-2.1
Blood clot in the leg (DVT)	1.9	2.5	4.0	-1.5	-0.7	-2.0	-2.0	-0.5	-2.0
Neck or shoulder pain in last month	1.9	2.7	4.0	-2.0	-1.6	-1.4	-1.4	-1.9	-1.4
Wears glasses or contact lenses	1.9	2.1	3.4	-1.3	-1.0	-1.8	-1.8	-0.4	-1.8
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	4.5	-1.2	-0.2	-2.1	-2.1	-0.2	-2.1
Arm fat mass (right)	1.8	7.5	14.8	3.6	3.9	-1.6	-1.6	3.0	-1.6
Body fat percentage	1.8	7.1	14.6	3.7	3.8	-0.9	-0.9	3.4	-0.9
Leg fat mass (right)	1.8	6.8	11.9	3.4	3.2	-2.1	-2.1	2.2	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	3.9	0.4	1.7	1.4	1.4	2.0	1.4
Arm fat mass (left)	1.8	7.3	14.9	3.5	3.9	-1.5	-1.5	3.2	-1.5
Miserableness	1.8	3.1	4.3	-1.2	-1.3	-2.1	-2.1	-1.6	-2.1
Medication: Paracetamol	1.8	2.7	3.7	0.1	1.4	1.9	1.9	1.9	1.9
Lung FEV1/FVC ratio	1.7	8.4	10.0	2.7	2.7	3.1	3.2	2.5	3.1
Hand grip strength (left)	1.7	4.5	10.9	-1.3	-3.3	-1.1	-1.1	-3.3	-1.1
Forced expiratory volume in 1-second (FEV1)	1.7	5.8	13.8	-2.1	-3.7	-1.6	-1.6	-3.0	-1.6
Medication: Aspirin	1.7	2.2	5.7	1.8	2.0	0.2	0.2	2.4	0.2
Irritability	1.7	2.9	7.3	-2.7	-2.2	-0.2	-0.1	-2.2	-0.2
Blood Eosinophil Count	1.6	12.6	33.8	5.1	5.8	1.3	1.3	3.2	1.3
Waist Hip Ratio (WHR)	1.6	7.1	12.1	0.9	1.9	3.5	3.5	1.4	3.5
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	3.5	0.7	0.5	1.9	1.9	1.1	1.9
Taking other prescription medications	1.6	2.5	4.0	0.9	1.1	2.0	2.0	1.0	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	12.5	-1.6	-3.5	-1.5	-1.5	-2.8	-1.5
Worry too long after embarrassment	1.6	2.7	4.2	-0.7	-1.3	-2.0	-2.0	-1.3	-2.0
Myopia	1.6	2.3	3.5	-1.9	-1.8	1.5	1.5	-0.5	1.5
Leg fat mass (left)	1.6	6.4	12.4	3.5	3.0	-2.1	-2.1	2.0	-2.1
Breast Cancer	1.5	3.5	4.6	-0.9	-2.1	-2.1	-2.1	-1.6	-2.1
Trunk fat percentage	1.5	6.0	11.9	3.3	3.5	-0.7	-0.7	3.4	-0.7
Body mass index (BMI)	1.5	6.3	11.7	3.3	3.4	-1.8	-1.8	2.4	-1.8
Medication: Amlodipine	1.5	2.1	6.4	0.8	2.2	0.5	0.5	2.5	0.5
Whole body fat mass	1.5	6.4	11.6	3.4	3.4	-1.7	-1.7	2.6	-1.7
Illnesses of father: None of the above (group 1)	1.5	1.9	3.0	-1.7	-1.7	-1.2	-1.2	-1.1	-1.2
Average weekly beer plus cider intake	1.5	2.2	3.9	-1.2	0.4	-2.0	-2.0	0.1	-2.0
Worry (Nagel 2018)	1.4	3.0	4.3	1.4	1.5	-2.1	-2.1	0.9	-2.1
Alzheimer’s Disease (in mother)	1.4	1.6	3.6	1.9	1.7	0.5	0.5	1.5	0.5
Average weekly spirits intake	1.4	1.7	2.6	-0.4	1.2	-1.6	-1.6	1.1	-1.6
Sensitivity / hurt feelings	1.4	2.4	4.3	1.2	0.5	-2.1	-2.1	0.1	-2.1
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	3.3	0.1	-0.4	1.8	1.8	-0.5	1.8
Trunk fat mass	1.4	6.1	11.9	3.5	3.3	-1.3	-1.3	2.9	-1.3
Worrier / anxious feelings	1.4	2.6	5.3	1.4	2.3	-1.3	-1.3	1.9	-1.3
Medication: Ibuprofen	1.4	1.7	3.1	0.4	0.9	-1.8	-1.8	0.2	-1.8
Medication: Aspirin	1.4	1.9	4.5	1.6	1.9	0.3	0.3	2.1	0.3
Ever smoked	1.4	2.5	7.4	-0.6	-2.7	0.2	0.2	-2.7	0.2
Bipolar Disorder (2018)	1.3	2.1	6.1	1.8	2.5	-0.3	0.0	1.8	-0.3
Number of full sisters	1.3	1.6	3.1	-1.8	-0.6	-1.3	-1.3	-0.9	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	2.6	0.1	-0.3	-1.6	-1.6	-1.2	-1.6
Ever had bowel cancer screening	1.3	1.5	2.3	-0.8	0.9	1.5	1.5	0.8	1.5
High cholesterol (Self-reported)	1.3	2.4	3.4	-0.9	-1.2	1.8	1.8	-1.4	1.8
Medication: Atorvastatin	1.3	1.6	2.8	-0.5	0.3	1.7	1.7	1.0	1.7
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.7	-0.4	0.1	1.6	1.7	0.7	1.6
BMI	1.2	6.7	15.9	4.0	3.9	-1.1	-1.1	2.4	-1.1
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.9	-0.9	-0.7	-1.2	-1.2	-1.7	-1.2
Neuroticism score	1.2	2.6	4.3	-0.0	-0.8	-2.1	-2.1	-1.4	-2.1
Weight	1.2	6.0	10.2	3.2	2.8	-2.2	-2.2	1.7	-2.2
Alcohol intake versus 10 years previously	1.2	1.8	4.9	-1.4	-2.2	-0.3	-0.3	-1.9	-0.3
Pulse rate	1.2	2.0	4.2	-1.4	-2.0	-0.7	-0.7	-2.0	-0.7
Medication: Cholesterol lowering	1.2	1.8	3.1	0.6	1.0	1.7	1.8	0.6	1.7
Medication: Paracetamol	1.2	2.0	3.7	0.3	1.3	1.5	1.5	1.9	1.5
Mood swings	1.2	2.2	3.0	0.1	-1.2	-1.7	-1.7	-1.6	-1.7
Guilty feelings	1.2	1.7	3.7	-0.2	-1.5	-1.2	-1.2	-1.9	-1.2
Pain experienced in last month	1.2	1.9	3.2	0.9	0.7	1.8	1.8	0.9	1.8
LDL Cholesterol	1.1	1.7	6.3	-2.0	-2.5	0.0	0.0	0.0	0.0
Neuroticism (2016)	1.1	1.5	3.0	0.5	-0.2	-1.7	-1.7	-0.0	-1.7
Diabetes (mother)	1.1	1.4	2.3	-0.1	-0.5	1.5	1.5	1.0	1.5
Qualifications: CSEs or equivalent	1.1	1.5	3.1	-1.2	-1.8	-0.9	-0.9	-1.5	-0.9
Multivitamins +/- minerals	1.1	1.3	2.1	1.3	0.4	1.4	1.4	0.2	1.4
Medication: Ventolin 100micrograms inhaler	1.1	1.5	2.4	0.2	0.7	1.6	1.5	1.1	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	2.2	-1.3	-1.2	-1.1	-1.1	-1.5	-1.1
Supplements: Fish oil (including cod liver oil)	1.1	1.5	2.7	-1.6	-0.5	1.4	1.4	0.2	1.4
Illnesses of father: High blood pressure	1.1	1.3	3.9	2.0	0.6	1.1	1.0	0.8	1.1
Type 2 Diabetes (T2D) (2012)	1.0	1.2	5.9	1.0	2.4	0.0	0.0	0.0	0.0
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.2	1.8	1.3	-1.1	-1.1	0.2	-1.1
Ever had hysterectomy (womb removed)	1.0	1.1	2.2	-0.1	0.1	-1.5	-1.5	-0.0	-1.5
Serious illness, injury or assault to yourself	1.0	1.3	2.1	0.6	0.9	1.2	1.2	1.4	1.2
Chronic bronchitis/emphysema (father)	1.0	1.2	2.3	-0.5	0.0	-1.5	-1.5	0.1	-1.5
Hearing difficulty/problems with background noise	1.0	1.6	4.3	-2.0	-2.1	-0.1	-0.1	-1.1	-0.1
Impedance of arm (right)	1.0	4.6	7.2	0.2	0.5	2.7	2.7	2.4	2.7
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	1.8	-0.6	0.9	1.4	1.4	0.2	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	1.9	-1.4	-1.4	0.9	0.9	-1.1	0.9
Suffer from ‘nerves’	1.0	1.6	4.1	1.6	2.0	-0.2	-0.2	1.7	-0.2
Back pain experienced in last month	1.0	1.5	2.0	-1.0	-1.1	-1.3	-1.3	-1.4	-1.3
Mineral and other dietary supplements	1.0	1.4	2.4	0.6	-0.4	-1.6	-1.5	-0.8	-1.6
Arm fat-free mass (left)	1.0	5.3	9.1	1.6	0.9	-3.0	-3.0	-1.0	-3.0
Lupus	0.9	1.3	1.9	-0.6	1.1	-1.4	-1.4	-0.8	-1.4
Pack years adult smoking proportion	0.9	1.3	1.7	-0.8	-0.9	-1.3	-1.3	-1.2	-1.3
Townsend deprivation index at recruitment	0.9	1.2	1.6	-1.0	-1.0	-1.3	-1.2	-0.6	-1.3
Hayfever, allergic rhinitis or eczema	0.9	2.1	3.3	1.0	-0.1	1.8	1.8	-1.2	1.8
Impedance of arm (left)	0.9	4.3	6.5	-0.4	0.3	2.6	2.5	2.4	2.6
Arm fat-free mass (right)	0.9	4.4	7.6	1.1	0.3	-2.8	-2.8	-1.4	-2.8
Exposure to tobacco smoke outside home	0.9	1.2	2.2	-0.1	0.7	-1.5	-1.5	-0.3	-1.5
Friendships satisfaction	0.9	1.1	2.7	-0.6	-1.6	0.8	0.8	-1.3	0.8
Ever taken oral contraceptive pill	0.9	1.0	3.8	1.9	1.3	-0.3	-0.3	0.3	-0.3
Arm predicted mass (left)	0.9	4.3	7.1	1.8	0.9	-2.7	-2.6	-0.9	-2.7
Mean Putamen Volume	0.8	1.0	2.6	0.7	1.6	0.3	0.3	1.6	0.3
Angina	0.8	1.0	1.7	1.0	1.2	0.9	0.9	1.3	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	7.6	-2.8	-1.2	-0.6	-0.6	-0.6	-0.6
Sitting height	0.8	5.5	8.1	-0.0	-1.6	-2.9	-2.8	-2.4	-2.9
Number of incorrect matches in round	0.8	1.3	3.4	-1.8	-1.5	0.3	0.3	-1.4	0.3
Past tobacco smoking	0.8	1.4	4.8	0.6	2.2	-0.1	-0.1	1.8	-0.1
Lung cancer (father)	0.8	1.0	2.3	0.3	0.7	1.0	1.0	1.5	1.0
Hair/balding pattern: Pattern 4	0.8	1.9	7.5	-1.4	-2.7	0.2	0.2	-1.4	0.2
Arm predicted mass (right)	0.8	4.3	7.5	0.9	0.3	-2.7	-2.7	-1.6	-2.7
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.7	-1.5	-1.6	-0.0	-0.0	-1.6	-0.0
Basal metabolic rate	0.8	4.5	6.6	2.2	1.6	-2.6	-2.6	0.2	-2.6
Allergy or Eczema	0.7	1.9	3.0	0.7	-0.3	1.7	1.7	-1.3	1.7
Leg fat-free mass (left)	0.7	3.5	5.0	1.8	1.6	-2.2	-2.2	0.5	-2.2
Alcohol usually taken with meals	0.7	1.1	2.2	0.3	-0.2	1.5	1.5	0.2	1.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.3	-1.1	-0.5	-1.0	-1.0	-0.8	-1.0
Illnesses of siblings	0.7	1.0	2.0	-1.4	-0.6	-0.9	-0.9	-1.1	-0.9
Falls in the last year	0.7	0.9	1.4	-1.2	0.3	1.1	1.1	0.6	1.1
Number of live births	0.7	1.0	1.5	-0.5	-0.6	-1.2	-1.2	-0.9	-1.2
Noisy workplace	0.7	0.9	1.7	-0.1	-0.4	-1.3	-1.3	-0.3	-1.3
Trunk predicted mass	0.7	3.7	6.2	1.6	0.9	-2.5	-2.5	-0.7	-2.5
Exposure to tobacco smoke at home	0.7	0.7	0.9	-0.4	1.0	-0.9	-0.9	0.9	-0.9
Breastfed as a baby	0.7	0.8	2.9	0.8	1.2	0.0	0.0	1.7	0.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.4	-0.1	-0.7	-1.2	-1.2	-0.4	-1.2
Loud music exposure frequency	0.7	0.8	1.2	0.2	-1.1	-1.0	-1.0	-0.5	-1.0
Migraine (self-reported)	0.7	0.8	2.4	-0.1	1.5	-0.4	-0.4	1.4	-0.4
Pulse rate, automated reading	0.7	2.3	8.7	-0.6	-2.1	-0.1	-0.1	-3.0	-0.1
Illnesses of siblings: Diabetes	0.7	0.8	1.5	1.2	1.0	0.8	0.8	0.8	0.8
Whole body fat-free mass	0.7	3.8	6.2	1.7	1.1	-2.5	-2.5	-0.4	-2.5
Whole body water mass	0.7	4.1	6.9	1.6	1.0	-2.6	-2.6	-0.6	-2.6
Fractured/broken bones in last 5 years	0.7	1.0	2.5	1.6	1.0	0.8	0.8	0.2	0.8
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.7	-1.3	-0.9	0.9	0.9	-0.6	0.9
Pack years of smoking	0.7	1.0	1.1	-0.9	-0.9	-1.1	-1.1	-1.0	-1.1
Depression (Nagel 2018)	0.6	0.9	2.9	1.7	1.4	-0.3	-0.3	0.5	-0.3
Primary Biliary Cirrhosis	0.6	0.8	1.5	0.2	1.2	-0.8	-0.8	1.2	-0.8
Heel T-Score	0.6	5.1	20.2	-4.5	-2.6	0.1	0.1	-1.8	0.1
Vitamin and mineral supplements	0.6	0.9	1.5	-0.6	0.4	-1.2	-1.2	0.2	-1.2
Medication: Co-codamol	0.6	0.7	1.9	1.4	0.4	-0.9	-0.9	-0.1	-0.9
Leg predicted mass (left)	0.6	3.4	4.8	1.8	1.6	-2.2	-2.2	0.5	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.0	1.7	1.2	-0.6	-0.6	0.5	-0.6
Fluid intelligence score	0.6	1.3	1.9	-1.3	-0.8	1.4	1.4	0.2	1.4
Trunk fat-free mass	0.6	3.7	6.0	1.7	1.0	-2.4	-2.4	-0.6	-2.4
Hair/balding pattern: Pattern 3	0.6	0.9	1.7	0.3	1.0	-0.9	-0.9	1.3	-0.9
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.3	-1.5	-1.5	0.8	0.8	-1.3	0.8
Eye problems/disorders: None of the above	0.6	0.7	1.3	-0.7	-0.8	0.8	0.8	-1.1	0.8
Angina (self-reported)	0.6	0.7	1.2	0.7	1.0	0.8	0.8	1.1	0.8
Overall health rating	0.6	1.3	3.4	1.6	1.9	0.5	0.5	1.1	0.5
Average weekly red wine intake	0.6	0.9	1.7	-0.2	-0.4	1.3	1.3	0.2	1.3
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.3	1.5	0.5	0.5	0.5	1.1	0.5
Breast cancer (self-reported)	0.6	0.7	1.0	-0.5	-0.5	1.0	1.0	-0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.4	-0.3	-0.6	-1.5	-1.5	-0.4	-1.5
Commuting to job workplace: Public transport	0.6	0.7	1.1	0.2	-0.8	1.0	1.0	-0.0	1.0
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.3	-1.5	-0.8	-0.6	-0.6	-0.8	-0.6
Stomach or abdominal pain in last month	0.5	0.6	3.1	-1.8	-0.4	-0.4	-0.3	-0.5	-0.4
Mouth/teeth dental problems	0.5	0.7	1.8	1.3	1.1	0.6	0.6	0.4	0.6
Diabetes (self-reported)	0.5	0.8	1.6	-0.0	-0.2	-1.2	-1.2	-0.2	-1.2
Pulse wave reflection index	0.5	0.6	1.8	0.1	-0.9	-0.6	-0.6	-1.4	-0.6
Age at first live birth	0.5	0.9	1.4	0.4	-0.2	1.2	1.2	0.9	1.2
Medication: Seretide 50 evohaler	0.5	0.6	1.4	0.6	1.2	-0.7	-0.7	0.4	-0.7
Alcohol intake frequency.	0.5	1.2	3.8	-0.9	-1.2	-0.5	-0.5	-2.0	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.5	1.9	1.4	0.2	0.2	1.0	0.2
Leg fat-free mass (right)	0.5	2.5	3.8	1.5	1.1	-2.0	-2.0	0.0	-2.0
Leg predicted mass (right)	0.5	2.5	3.7	1.6	1.1	-1.9	-1.9	0.0	-1.9
Impedance of whole body	0.5	2.3	4.1	-0.7	-0.8	2.0	2.0	0.8	2.0
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.9	-1.2	-1.7	-0.8	-0.8	-1.0	-0.8
Alzheimer’s Disease (in father)	0.4	0.4	1.7	-0.3	1.3	-0.3	-0.3	0.5	-0.3
Ulcerative Colitis (UC)	0.4	0.7	3.5	0.1	1.0	0.0	0.0	1.9	0.0
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.8	-1.3	-1.3	-0.8	-0.8	-0.5	-0.8
Respiratory disease	0.4	0.9	2.5	-1.6	-0.5	0.1	0.0	-1.6	0.1
Chronotype (morning person)	0.4	0.9	1.7	-0.2	0.1	-1.3	-1.3	-0.6	-1.3
Tanning	0.4	4.3	9.7	-1.6	-3.1	-1.5	-1.5	-2.7	-1.5
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.1	-0.4	0.0	-1.0	-1.0	-0.0	-1.0
Nervous feelings	0.4	0.8	1.9	1.1	1.4	-0.0	-0.0	1.2	-0.0
Had other major operations	0.4	0.5	2.7	-0.4	-1.6	0.2	0.2	-0.5	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	3.1	-1.8	-0.4	0.9	0.9	0.4	0.9
Financial difficulties in last 2 years	0.4	0.5	1.8	1.4	0.9	0.3	0.3	-0.5	0.3
Allergy	0.4	0.9	4.3	-0.1	0.5	-0.5	-0.5	2.1	-0.5
Time employed in main current job	0.4	0.5	1.6	-1.3	-0.7	-0.2	-0.2	-0.9	-0.2
Medication: Lansoprazole	0.4	0.4	1.1	-0.9	1.0	-0.5	-0.5	0.2	-0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.7	-1.0	-1.3	-0.5	-0.5	-0.9	-0.5
High blood pressure (siblings)	0.4	0.5	1.5	1.2	0.6	-0.1	-0.1	1.1	-0.1
Comparative body size at age 10	0.4	1.0	1.7	0.6	0.7	-1.3	-1.3	0.5	-1.3
Number of full brothers	0.4	0.5	1.1	1.1	0.2	-0.7	-0.7	-0.8	-0.7
Number of children fathered	0.4	0.5	0.6	0.7	-0.7	0.6	0.6	0.7	0.6
Medication for pain relief, constipation, heartburn	0.4	0.7	2.4	-0.4	-1.2	-0.2	-0.2	-1.5	-0.2
Medication: Omeprazole	0.4	0.4	0.7	-0.7	-0.3	0.8	0.8	-0.2	0.8
Family relationship satisfaction	0.4	0.5	1.1	0.6	-0.9	0.5	0.5	-1.1	0.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.8	-0.8	0.2	-0.9	-0.9	-0.0	-0.9
Loneliness, isolation	0.4	0.5	1.1	0.9	0.9	0.2	0.2	1.0	0.2
Eye problems/disorders: Cataract	0.4	0.4	0.8	-0.4	0.1	-0.9	-0.9	0.1	-0.9
Osteoarthritis (self-reported)	0.4	0.5	0.9	-0.3	-0.5	-0.9	-0.9	0.2	-0.9
Average weekly champagne plus white wine intake	0.4	0.6	2.5	0.6	-0.7	-0.3	-0.3	-1.6	-0.3
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	-0.3	-1.0	-0.7	-0.7	-0.7	-0.7
Number of operations (self-reported)	0.4	0.7	2.2	-0.9	-1.5	-0.5	-0.5	-0.4	-0.5
Ever depressed for a whole week	0.4	0.5	0.7	-0.4	0.1	0.8	0.8	0.9	0.8
Cholesterol lowering medication	0.4	0.6	0.9	-0.5	-0.5	0.9	0.9	-0.5	0.9
Heart disease (siblings)	0.4	0.5	1.1	0.3	0.8	0.6	0.6	1.0	0.6
Major Depression (MDD)	0.3	0.4	2.3	0.0	-1.5	0.0	0.0	0.0	0.0
Blood Platelet Count	0.3	3.4	5.3	0.6	2.3	-2.1	-2.1	1.0	-2.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.6	0.7	1.2	-0.3	-0.3	1.3	-0.3
Relative age of first facial hair	0.3	0.7	1.5	0.3	1.2	-0.9	-0.9	0.6	-0.9
Severe depression (siblings)	0.3	0.4	2.0	-0.5	-0.1	-0.1	-0.1	-1.4	-0.1
Hand grip strength (right)	0.3	0.8	3.3	0.1	-1.3	-0.2	-0.2	-1.8	-0.2
Age when periods started (menarche)	0.3	0.7	1.2	-0.2	0.9	1.1	1.1	0.3	1.1
Medication: Levothyroxine sodium	0.3	0.6	1.6	-1.2	-1.2	-0.2	-0.1	-0.6	-0.2
Qualifications: None of the above	0.3	0.7	1.8	0.6	1.3	-0.4	-0.4	1.3	-0.4
Depression (self-reported)	0.3	0.3	0.5	0.2	0.6	-0.7	-0.7	-0.4	-0.7
Length of working week for main job	0.3	0.3	0.8	-0.6	-0.9	-0.1	-0.1	-0.7	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.3	-1.5	-0.4	-0.1	-0.1	-0.8	-0.1
Wheeze or whistling in the chest in last year	0.3	0.6	1.7	-0.5	-0.3	-0.7	-0.7	-1.3	-0.7
Pulse wave peak to peak time	0.3	0.3	0.7	0.5	0.9	0.3	0.3	0.9	0.3
Health satisfaction	0.3	0.4	1.1	-0.7	-0.9	-0.0	-0.0	-1.0	-0.0
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.5	-0.4	-0.2	-0.7	-0.7	-0.3	-0.7
Comparative height size at age 10	0.3	1.4	2.3	-0.2	-1.1	-1.5	-1.5	-0.6	-1.5
Age at last live birth	0.3	0.4	1.2	-0.8	-1.1	-0.4	-0.4	-0.1	-0.4
Smoking status: Previous	0.3	0.4	1.4	0.3	-1.2	0.5	0.5	-0.3	0.5
Mother’s age at death	0.3	0.3	0.9	-1.0	-0.7	0.4	0.4	-0.4	0.4
Alcohol drinker status: Never	0.3	0.3	0.4	-0.5	0.6	-0.6	-0.6	-0.2	-0.6
Risk taking	0.3	0.4	0.6	-0.8	-0.3	0.6	0.6	-0.8	0.6
Alcohol drinker status: Previous	0.3	0.4	1.0	0.6	-1.0	-0.1	-0.1	-1.0	-0.1
Crohns Disease (2017)	0.2	0.4	0.7	0.2	0.1	0.8	0.8	0.7	0.8
Irritable Bowel Disease (IBD)	0.2	0.4	2.0	0.2	0.6	-0.0	-0.0	1.4	-0.0
Hypothyroidism (self reported)	0.2	0.4	1.5	-0.5	-1.2	-0.2	-0.1	-0.9	-0.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.1	-0.2	-0.5	-0.5	0.6	-0.5
Medication for hormone replacement therapy	0.2	0.3	0.3	0.5	0.5	0.6	0.6	0.5	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.9	1.0	0.6	-0.3	-0.3	-0.2	-0.3
Hair/balding pattern: Pattern 2	0.2	0.3	0.3	0.5	0.3	0.6	0.6	-0.6	0.6
Heart attack	0.2	0.3	0.6	0.3	0.8	0.5	0.5	-0.4	0.5
Medication: Simvastatin	0.2	0.3	0.5	0.7	0.1	0.7	0.7	-0.2	0.7
Father’s age at death	0.2	0.3	0.4	0.5	-0.0	0.6	0.6	0.4	0.6
Happiness	0.2	0.3	0.5	-0.0	-0.7	0.6	0.6	-0.3	0.6
Mouth/teeth dental problems: Dentures	0.2	0.3	1.7	-1.3	-0.4	-0.2	-0.2	-0.0	-0.2
Pulse wave Arterial Stiffness index	0.2	0.3	0.7	-0.5	-0.8	-0.1	-0.1	-0.8	-0.1
Headache pain in last month	0.2	0.4	1.6	-0.1	1.3	0.2	0.3	0.8	0.2
Glaucoma (self-reported)	0.2	0.2	1.3	0.2	-1.1	0.1	0.1	-0.2	0.1
Qualifications: College or University degree	0.2	0.6	1.0	0.1	-0.8	0.8	0.8	-1.0	0.8
Heart disease (mother)	0.2	0.2	0.7	0.8	0.5	0.1	0.1	0.5	0.1
Had major operations	0.2	0.3	0.8	0.5	0.7	0.2	0.2	0.9	0.2
Supplements: Vitamin C	0.2	0.3	1.1	-1.1	0.1	0.3	0.3	0.5	0.3
Knee pain experienced in last month	0.2	0.4	0.7	-0.9	0.2	-0.7	-0.6	-0.5	-0.7
Diabetes diagnosed by doctor	0.2	0.4	0.7	0.0	-0.1	-0.8	-0.8	0.3	-0.8
Asthma (self-reported)	0.2	0.4	0.5	-0.1	0.7	0.7	0.7	-0.6	0.7
Financial situation satisfaction	0.2	0.2	1.0	0.1	-0.6	0.2	0.2	-1.0	0.2
Unable to work because of sickness or disability	0.2	0.3	0.6	-0.8	-0.0	-0.7	-0.6	0.1	-0.7
Supplements: Calcium	0.2	0.2	0.5	-0.7	-0.5	-0.3	-0.3	-0.5	-0.3
Alzheimer’s Disease (including proxy)	0.1	0.2	1.0	0.0	1.0	-0.2	-0.2	0.3	-0.2
Crohns Disease (2012)	0.1	0.2	0.9	-0.9	-0.4	0.0	0.0	0.1	0.0
HbA1C	0.1	0.1	0.3	0.5	0.0	0.2	0.2	0.6	0.2
Ulcerative Colitis	0.1	0.1	0.3	-0.6	0.5	-0.1	-0.1	0.0	-0.1
Blood Red Count	0.1	1.1	1.6	-0.4	-0.0	-1.3	-1.3	-1.2	-1.3
Blood White Count	0.1	1.0	1.6	-0.8	-0.6	-1.2	-1.3	-0.2	-1.2
Height	0.1	2.5	3.5	0.4	-1.1	-1.9	-1.9	-1.8	-1.9
Supplements: Zinc	0.1	0.1	0.2	-0.2	-0.4	0.4	0.4	-0.1	0.4
Medication: Metformin	0.1	0.1	0.1	0.1	0.1	-0.4	-0.4	-0.1	-0.4
Relative age voice broke	0.1	0.1	0.6	0.1	0.8	-0.0	-0.0	0.2	-0.0
Impedance of leg (left)	0.1	0.5	1.3	-0.1	-1.1	0.7	0.7	-0.5	0.7
Pain all over the body in last month	0.1	0.1	0.6	0.3	0.3	-0.1	-0.1	0.8	-0.1
Asthma	0.1	0.2	0.7	0.0	0.8	0.3	0.3	-0.6	0.3
Standing height	0.1	0.8	1.1	0.4	-0.7	-1.0	-1.0	-1.0	-1.0
Tense / ‘highly strung’	0.1	0.1	0.2	0.4	-0.0	-0.3	-0.3	0.2	-0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.2	-0.4	-0.3	-0.3	-0.0	-0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.2	0.3	0.2	0.2	-0.5	0.2
Emphysema/chronic bronchitis	0.1	0.2	0.4	-0.4	0.6	-0.1	-0.1	-0.6	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.4	-0.2	0.2	0.2	-0.2	0.2
Qualifications: nursing, teaching	0.1	0.2	0.4	0.3	0.3	-0.4	-0.4	-0.6	-0.4
Hearing aid user	0.1	0.1	0.4	-0.2	0.0	0.4	0.3	0.7	0.4
Age started oral contraceptive pill	0.1	0.1	0.3	0.1	0.4	0.4	0.3	0.6	0.4
Commuting to job workplace: Cycle	0.1	0.1	0.4	-0.1	-0.6	0.1	0.1	-0.4	0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.6	0.4	0.8	0.3	0.3	-0.3	0.3
Schizophrenia vs Biploar Disorder	0.0	0.0	0.1	0.3	-0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.1	0.2	0.2	0.4	0.0	0.0	0.4	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	-0.3	0.2	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.1	0.3	-0.3	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.1	0.2	-0.5	-0.3	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.1	0.3	-0.4	0.5	-0.0	0.0	0.4	-0.0
Impedance of leg (right)	0.0	0.1	0.2	-0.1	-0.5	0.4	0.4	0.0	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.1	0.2	-0.1	-0.4	0.2	0.2	0.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.1	-0.4	-0.1

Hub : Genes

SLC2A4

Models

Trait associations