Hub : Genes

DLG4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.1201 0.0408 0.00100 0.053 NA 0.033 NA 0.046 6.1e-06 NA 2.9e-04 NA 2.3e-05
2 ROSMAP Brain Pre-frontal Cortex 0.0711 0.0246 0.00014 0.087 0.023 0.064 0.064 0.077 2.6e-11 4.8e-04 1.2e-08 1.1e-08 3.8e-10
3 TCGA Colon Adenocarcinoma 0.3080 0.0940 0.00054 0.009 0.071 0.061 NA 0.009 8.8e-02 6.3e-05 1.9e-04 NA 9.7e-02
4 TCGA Skin Cutaneous Melanoma 0.1180 0.0720 0.00920 0.099 0.067 0.021 NA 0.083 1.3e-03 7.4e-03 8.7e-02 NA 3.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 2.0 3.2 3.8 2.0 1.6 -1.7 -1.9
Bipolar Disorder or Schizophrenia 4.1 9.9 13.5 3.1 3.4 -2.3 -3.7
Depressed Affect (Nagel 2018) 1.5 3.1 7.6 -1.4 -1.5 0.7 2.8
Depression (Nagel 2018) 0.5 0.8 1.8 1.3 0.7 -1.0 -0.2
Intelligence (Savage-Jansen 2018) 0.7 2.1 3.2 -1.6 -1.8 0.1 1.7
Neuroticism (Nagel 2018) 1.6 3.7 8.7 -1.2 -1.5 1.7 2.9
Schizophrenia (2018) 3.5 7.4 10.5 2.6 3.1 -1.7 -3.2
Schizophrenia vs Biploar Disorder 0.3 0.4 0.7 0.7 0.9 -0.4 -0.4
Worry (Nagel 2018) 0.5 1.0 2.1 1.5 0.9 1.0 0.4
Alzheimer’s Disease (in mother) 4.3 5.1 6.7 1.7 2.4 -2.3 -2.6
Alzheimer’s Disease (in father) 0.8 0.9 2.1 1.5 0.8 -0.2 -0.8
Alzheimer’s Disease (including proxy) 1.2 1.8 3.2 0.8 1.4 -1.8 -1.2
Crohns Disease (2017) 0.4 0.8 1.8 0.3 0.8 -1.3 -0.7
Irritable Bowel Disease (IBD) 0.9 2.1 3.0 1.0 1.6 -1.7 -1.4
Ulcerative Colitis (UC) 0.8 1.5 2.5 1.1 1.6 -0.8 -1.3
Major Depression (MDD) 2.0 2.4 4.0 -1.5 -1.8 0.5 2.0
Reaction Time 7.4 14.2 22.1 4.7 4.1 -2.3 -3.6
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.1 -1.0 -0.9 -0.5 1.1
Breast Cancer 3.1 7.3 8.9 -3.0 -2.8 2.1 2.9
Ovarian Cancer 1.0 1.3 2.1 -1.1 -1.3 -0.4 1.4
Prostate Cancer 0.1 0.1 0.3 0.4 0.5 -0.1 -0.1
Age at First Birth 5.2 7.5 10.5 2.0 2.9 -3.2 -2.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.1 0.2 0.4 -0.2 -0.5 0.7 -0.1
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.1 0.2 0.7 -0.2 0.1 -0.8 0.1
Mean Putamen Volume 2.2 2.5 4.4 1.4 2.1 -0.8 -1.7
Fasting Glucose 3.4 4.0 8.1 1.8 1.9 -1.0 -2.8
HbA1C 0.2 0.2 0.6 -0.5 -0.2 0.2 -0.8
HDL Cholesterol 0.4 0.7 1.2 -1.1 -1.1 0.6 -0.2
LDL Cholesterol 3.3 5.2 7.6 -2.3 -2.8 1.7 2.3
Lupus 0.3 0.5 1.1 1.1 0.8 0.3 -0.4
Neuroticism (2016) 0.1 0.1 0.4 0.1 -0.1 0.3 0.6
Primary Biliary Cirrhosis 0.7 1.1 2.1 1.2 0.5 0.7 -1.5
Rheumatoid Arthritis 4.3 6.0 7.5 -1.9 -2.5 2.7 2.5
Schizophrenia (2014) 3.8 8.5 11.1 3.1 2.8 -2.2 -3.3
Triglycerides 0.1 0.1 0.3 0.3 0.6 -0.2 0.1
Type 2 Diabetes (T2D) (2012) 2.2 2.5 5.0 2.2 2.2 0.0 0.0
Ulcerative Colitis 0.5 0.7 1.4 1.2 0.8 -0.6 -0.6
Blood Eosinophil Count 2.5 19.6 32.0 5.1 3.8 -2.3 -5.7
Blood Platelet Count 0.5 5.4 8.8 3.0 2.0 -2.7 -1.3
Blood Red Count 0.2 1.9 4.7 0.8 1.4 -2.2 0.3
Blood White Count 0.7 5.4 21.4 -0.5 -0.0 -4.6 0.0
Heel T-Score 2.9 23.2 30.7 -4.2 -5.0 5.5 4.4
BMI 2.3 13.5 19.0 4.4 3.6 -3.0 -3.7
Height 0.1 2.8 5.8 2.4 0.8 -1.4 1.6
Waist Hip Ratio (WHR) 2.0 8.8 13.0 2.2 3.2 -3.6 -2.7
Systolic Blood Pressure 8.7 43.4 70.6 8.4 6.4 -2.6 -7.4
Smoking Status 1.6 3.7 6.6 -2.6 -2.0 -0.2 2.0
Allergy or Eczema 0.1 0.4 1.1 0.1 -0.6 -1.0 -0.1
Cardiovascular Disease 4.4 14.5 24.8 5.0 3.6 -2.3 -3.8
Hypothyroidism (self reported) 0.3 0.6 1.3 -0.7 0.1 1.2 0.7
Respiratory disease 0.5 1.0 2.1 -0.9 -1.5 0.1 1.0
Type 2 Diabetes (T2D) (2018) 3.1 5.7 9.4 2.3 2.4 -3.1 -1.6
Lung FEV1/FVC ratio 1.8 9.1 11.6 3.4 2.8 -2.3 -3.4
Lung FVC 3.5 17.6 32.0 -5.7 -3.7 2.8 4.1
Neuroticism 1.2 2.9 6.3 -1.3 -1.3 1.3 2.5
Chronotype (morning person) 0.2 0.5 1.1 -0.7 -0.7 1.0 -0.2
Hair Pigment 0.0 0.5 0.9 0.6 -0.9 0.8 0.1
Tanning 0.3 4.1 10.3 -3.2 -1.6 -1.4 1.4
Hand grip strength (left) 1.2 3.2 6.5 -2.6 -1.1 -0.1 2.3
Number of treatments/medications taken 4.3 7.7 12.0 3.5 3.2 -1.5 -2.5
Average weekly spirits intake 1.2 1.4 3.3 1.3 0.9 1.8 -0.2
Sensitivity / hurt feelings 0.3 0.5 1.5 0.8 1.2 0.3 0.2
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.6 0.8 0.2 -0.8 -0.7
Hearing difficulty/problems: Yes 8.3 12.7 17.0 -4.1 -3.7 2.1 4.0
Relative age of first facial hair 0.4 0.8 1.4 1.1 1.2 0.5 -0.7
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.3 0.2 0.2 0.2 -0.6
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.3 -0.1 0.1 1.1 1.1
Ever had hysterectomy (womb removed) 0.1 0.1 0.3 -0.6 0.2 -0.4 0.2
Systolic blood pressure, automated reading 6.5 18.9 36.4 6.0 4.5 0.5 -4.3
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.9 0.4 0.2 -0.9 0.1
Angina 0.6 0.8 1.8 1.3 0.9 0.8 -0.3
Medication for hormone replacement therapy 0.8 0.9 1.2 0.9 1.1 -0.7 -1.0
Vitamin and mineral supplements 0.5 0.7 2.4 0.2 0.3 -1.6 -0.6
Supplements: Zinc 2.0 2.2 4.7 -1.1 -1.4 2.2 0.9
Medication: Co-codamol 0.3 0.3 0.6 0.3 -0.7 0.8 -0.3
Medication: Metformin 0.7 1.0 2.8 0.6 1.0 -1.7 -0.4
Diabetes (father) 5.7 7.1 12.3 2.7 2.6 -1.4 -3.5
Diabetes (mother) 0.1 0.1 0.3 0.1 0.4 -0.6 -0.0
Severe depression (siblings) 0.3 0.4 1.5 0.1 0.2 -1.2 0.1
Pack years adult smoking proportion 0.6 1.0 1.3 -0.8 -1.1 0.9 1.0
Impedance of leg (right) 0.2 0.9 2.6 -0.5 -0.6 1.6 0.7
Leg fat-free mass (left) 1.0 5.1 8.0 2.8 1.9 -2.6 -1.4
Trunk fat percentage 2.2 8.7 18.1 4.3 3.1 -0.1 -2.7
Hand grip strength (right) 0.2 0.7 1.4 -1.2 -0.4 -1.0 0.5
Townsend deprivation index at recruitment 1.7 2.4 5.2 -1.9 -2.3 0.8 0.4
Current tobacco smoking 3.2 5.2 8.2 -2.3 -2.6 0.7 2.9
Average weekly fortified wine intake 0.7 0.8 1.3 1.1 -0.3 0.9 -1.0
Maternal smoking around birth 3.9 5.7 10.7 -2.6 -2.2 0.6 3.3
Fed-up feelings 6.8 12.4 16.7 -3.9 -3.7 2.1 4.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.4 0.3 -0.6 -0.1 -0.3
Relative age voice broke 0.1 0.1 0.1 0.2 -0.3 0.3 -0.3
Taking other prescription medications 1.2 1.8 2.8 1.5 1.7 -0.9 -1.2
Age when periods started (menarche) 0.1 0.3 0.5 0.7 0.6 0.5 -0.5
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 1.7 -1.2 -1.3 0.6 0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.1 5.6 -1.4 -2.4 2.3 1.9
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.9 -0.9 -1.0 -0.1 0.1
Qualifications: CSEs or equivalent 2.0 2.7 3.5 -1.6 -1.4 -1.9 1.6
Serious illness, injury or assault to yourself 0.5 0.7 1.1 0.8 1.1 -0.0 -0.9
High blood pressure 4.7 13.0 22.6 4.8 3.6 -0.8 -4.0
Hayfever, allergic rhinitis or eczema 0.5 1.0 3.1 0.8 0.2 -1.8 -0.4
Multivitamins +/- minerals 0.4 0.5 1.7 0.3 0.0 1.3 -0.2
Stomach or abdominal pain in last month 0.2 0.3 0.5 -0.5 -0.5 0.7 0.4
Supplements: Glucosamine 1.0 1.3 2.5 1.2 0.0 1.6 -1.2
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 1.8 -1.2 -0.5 1.3 0.4
Medication: Atenolol 5.8 7.3 10.8 3.3 3.2 -0.7 -2.8
Medication: Levothyroxine sodium 0.8 1.4 2.3 -1.2 -0.7 1.5 1.1
Sitting height 0.4 2.9 9.2 0.6 0.2 -3.0 1.4
Chronic bronchitis/emphysema (father) 0.4 0.5 1.4 0.6 1.2 -0.3 -0.1
High blood pressure (mother) 6.9 9.7 12.9 3.6 3.3 -1.6 -3.6
Body mass index (BMI) 2.4 10.4 14.8 3.9 3.1 -2.7 -3.1
Impedance of leg (left) 0.4 1.8 4.4 -1.0 -0.8 2.1 1.1
Leg predicted mass (left) 0.9 4.9 8.0 2.8 1.8 -2.6 -1.3
Trunk fat mass 2.3 10.0 20.5 4.5 3.3 -1.2 -2.7
Waist circumference 5.5 20.3 29.3 5.4 4.8 -3.4 -4.2
Number of incorrect matches in round 1.8 3.0 5.6 -1.8 -2.4 0.9 1.6
Past tobacco smoking 0.8 1.5 4.2 2.0 0.9 0.3 -1.0
Alcohol usually taken with meals 0.0 0.0 0.1 -0.0 0.0 -0.1 0.2
Nervous feelings 0.1 0.3 0.5 0.1 0.6 0.5 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.3 1.1 0.3 -0.5 -0.6
Hearing difficulty/problems with background noise 2.1 3.3 5.2 -2.3 -1.6 1.1 2.0
Hair/balding pattern: Pattern 2 0.2 0.2 0.4 0.1 0.5 -0.6 -0.4
Had menopause 4.8 6.0 9.4 -2.4 -2.1 2.1 3.1
Had other major operations 1.5 1.8 3.4 -1.2 -0.9 1.8 1.1
Forced vital capacity (FVC) 2.7 10.5 18.7 -3.7 -2.9 1.2 4.3
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 4.1 -0.7 -1.6 2.0 0.7
Ever unenthusiastic/disinterested for a whole week 0.5 0.7 1.9 0.0 -0.8 0.1 1.4
Qualifications: None of the above 0.8 1.7 2.4 1.3 1.6 -0.4 -1.6
Financial difficulties in last 2 years 0.6 0.8 2.2 -0.4 -0.9 0.1 -1.5
Mouth/teeth dental problems 0.7 1.1 3.3 0.8 -0.4 1.8 -0.5
Heart attack 0.2 0.3 0.5 0.6 -0.4 0.4 -0.7
Allergy 0.2 0.5 1.4 -0.3 0.6 1.2 -0.6
Pain all over the body in last month 0.1 0.1 0.4 0.3 -0.0 0.6 -0.1
Diabetes (self-reported) 0.4 0.6 1.7 0.2 0.7 -1.3 0.0
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 6.8 0.3 0.1 -2.6 -1.0
Medication: Ramipril 2.4 3.1 5.5 2.3 1.7 -1.2 -1.6
Medication: Simvastatin 0.2 0.2 0.5 0.6 0.7 -0.4 -0.2
Fluid intelligence score 0.3 0.6 0.8 -0.6 -0.9 0.9 0.8
Illnesses of siblings 0.2 0.2 0.7 -0.3 -0.3 -0.3 0.8
Neuroticism score 0.9 1.9 2.7 -1.2 -0.9 1.7 1.7
Weight 2.2 11.0 18.8 4.3 3.2 -3.0 -2.4
Impedance of arm (right) 0.9 4.0 15.8 -0.1 -0.6 4.0 -0.0
Arm fat percentage (right) 3.6 14.0 22.2 4.7 3.7 -1.7 -4.1
Trunk fat-free mass 1.4 7.9 18.3 2.7 2.1 -4.3 -1.2
Hip circumference 3.6 15.4 29.5 5.4 4.0 -2.1 -3.4
Time employed in main current job 1.5 1.7 3.6 -1.1 -1.9 0.8 1.2
Alcohol intake versus 10 years previously 1.2 1.8 3.7 -1.9 -1.4 -0.7 1.0
Father’s age at death 0.3 0.4 0.8 -0.9 -0.6 0.7 -0.3
Worrier / anxious feelings 1.0 2.0 3.5 1.9 1.9 0.5 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.6 1.2 -0.3 -1.1 0.8 0.6
Falls in the last year 0.1 0.1 0.4 0.6 -0.2 -0.3 -0.0
Hair/balding pattern: Pattern 3 0.4 0.6 1.2 1.1 0.5 -0.5 -0.8
Number of live births 0.4 0.5 1.0 -0.9 -0.4 -1.0 0.2
Forced expiratory volume in 1-second (FEV1) 1.9 6.4 11.4 -2.9 -2.4 0.5 3.4
Pulse rate 1.1 1.9 3.2 -1.4 -1.5 0.4 1.8
Happiness 2.9 3.5 6.2 -1.4 -2.5 1.8 1.6
Noisy workplace 0.2 0.3 0.4 -0.6 -0.6 0.2 0.5
Qualifications: A levels/AS levels or equivalent 2.3 5.0 5.8 -2.0 -2.4 2.4 2.1
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 0.2 0.4 -0.4 0.2
Mouth/teeth dental problems: Dentures 0.1 0.2 0.7 0.0 0.2 0.2 0.9
Asthma 0.4 0.8 1.2 1.0 0.5 -1.1 -0.7
Medication: Ibuprofen (e.g. Nurofen) 1.5 2.0 4.5 1.1 1.2 -2.1 -0.9
Medication: Cholesterol lowering 0.7 1.1 1.9 1.1 0.9 -0.8 -1.4
Depression (self-reported) 0.2 0.3 0.7 0.6 -0.1 -0.9 0.2
Medication: Lansoprazole 0.2 0.2 0.3 0.5 -0.5 0.5 0.4
Prospective memory result 0.1 0.1 0.3 0.4 0.0 0.5 0.0
Lung cancer (father) 0.3 0.3 0.5 0.6 0.7 0.3 -0.7
Illnesses of mother 4.4 5.4 8.3 -2.4 -2.4 1.4 2.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.8 8.6 -2.9 -2.4 0.6 2.9
Pulse wave Arterial Stiffness index 0.1 0.2 0.6 -0.0 -0.2 -0.0 0.8
Impedance of arm (left) 0.9 4.3 16.4 -0.1 -0.7 4.1 0.4
Arm fat mass (right) 3.1 12.9 21.9 4.7 3.6 -2.4 -3.3
Trunk predicted mass 1.3 7.3 17.8 2.6 1.9 -4.2 -1.1
Standing height 0.2 1.7 3.8 2.0 0.9 -1.2 0.9
Length of working week for main job 1.3 1.4 3.5 -1.2 -1.9 0.1 1.0
Exposure to tobacco smoke at home 0.1 0.2 0.3 0.3 -0.1 0.5 -0.6
Breastfed as a baby 1.2 1.5 2.8 1.7 1.6 -0.1 -0.8
Tense / ‘highly strung’ 0.3 0.4 1.3 -0.3 -0.2 1.1 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.4 -0.0 0.3 0.3 0.7
Hair/balding pattern: Pattern 4 2.2 5.4 6.4 -2.5 -2.3 2.2 2.4
Birth weight of first child 6.6 11.9 21.6 4.7 3.5 -0.8 -3.7
Peak expiratory flow (PEF) 4.7 10.8 19.4 -4.4 -3.5 0.1 3.5
Pulse wave reflection index 0.9 1.1 2.5 -1.6 -1.2 0.3 0.7
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.1 -0.8 -1.1 -0.8 0.3
Loud music exposure frequency 1.8 2.0 3.3 -1.8 -1.6 1.2 0.8
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 2.3 -0.7 -1.5 1.1 1.1
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 5.1 -0.2 1.2 -2.3 -0.4
Blood clot in the leg (DVT) 1.1 1.4 2.4 -0.3 -1.2 1.6 1.3
Medication: Paracetamol 1.6 2.6 3.4 1.8 1.8 -1.1 -1.7
Headache pain in last month 1.2 2.0 2.7 1.2 1.6 -1.1 -1.6
Medication for cholesterol, blood pressure or diabetes 4.6 7.6 11.7 -3.4 -2.8 0.9 3.1
Glaucoma (self-reported) 0.3 0.3 1.2 -1.1 0.1 -0.2 0.2
Gout (self-reported) 1.0 1.4 4.9 0.0 0.6 -0.3 -2.2
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.0 -0.6 -0.1 0.6 1.0
Medication: Amlodipine 1.7 2.3 3.5 1.7 1.6 -0.4 -1.9
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.0 0.5 1.0 -0.1 -0.4
Birth weight 41.6 90.2 123.2 11.1 10.4 -5.7 -9.8
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.2 -0.2 -0.5 0.1 -0.1
High blood pressure (siblings) 0.4 0.6 1.1 0.7 0.9 -0.3 -1.1
Forced vital capacity (FVC), Best measure 2.7 10.0 16.1 -3.6 -3.0 1.4 4.0
Body fat percentage 2.6 10.2 18.9 4.3 3.3 -0.8 -3.2
Leg fat percentage (right) 3.6 13.0 19.9 4.5 3.7 -2.0 -3.8
Arm fat-free mass (right) 0.9 4.7 13.1 1.9 1.4 -3.6 -0.2
Exposure to tobacco smoke outside home 0.1 0.1 0.4 -0.0 0.1 -0.3 -0.6
Comparative body size at age 10 0.1 0.3 1.1 0.3 0.4 1.0 -0.0
Number of full brothers 0.4 0.5 1.1 -0.1 0.8 -1.1 -0.4
Worry too long after embarrassment 1.6 2.6 5.3 -2.3 -2.0 0.2 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 2.4 3.1 4.8 -1.2 -1.7 2.2 1.9
Wheeze or whistling in the chest in last year 0.2 0.4 1.1 -0.6 -1.0 -0.1 -0.1
Number of children fathered 0.2 0.2 0.4 -0.5 0.2 -0.0 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.3 1.0 0.6 -1.1 -0.7
Age at first live birth 0.1 0.1 0.2 0.4 -0.0 0.3 0.4
Pulse wave peak to peak time 0.2 0.2 0.6 0.3 0.3 0.1 -0.8
Health satisfaction 0.8 1.0 2.6 -0.6 -1.6 0.6 0.9
Shortness of breath walking on level ground 1.0 1.2 1.9 -0.6 -1.4 0.9 1.4
Qualifications: College or University degree 0.4 1.3 4.0 -0.5 -0.5 2.0 0.9
Eye problems/disorders: None of the above 0.3 0.4 0.6 -0.8 -0.6 -0.8 -0.1
Mouth/teeth dental problems: Loose teeth 1.6 1.9 5.5 -0.2 1.1 -2.4 -1.0
Emphysema/chronic bronchitis 0.1 0.1 0.4 0.1 -0.6 -0.0 0.1
Medication for pain relief, constipation, heartburn 1.2 2.0 3.8 -1.9 -1.7 0.5 1.1
Neck or shoulder pain in last month 2.0 2.9 4.6 -2.0 -2.1 0.3 1.7
Medication: Blood pressure 7.9 13.9 22.2 4.7 3.9 -0.8 -4.2
Angina (self-reported) 0.4 0.6 1.1 1.0 0.5 0.9 -0.2
Migraine (self-reported) 1.4 1.7 3.1 1.5 1.8 -1.0 -0.7
Medication: Ibuprofen 1.5 1.8 4.3 1.0 1.1 -2.1 -0.8
Medication: Allopurinol 1.8 2.4 6.0 0.5 1.4 -1.3 -2.5
Medication: Omeprazole 1.0 1.2 3.2 -0.5 -0.8 1.8 0.8
Medication: Seretide 50 evohaler 0.6 0.7 1.4 0.6 0.7 1.2 -0.7
Mean time to correctly identify matches 8.1 15.5 22.7 4.8 4.5 -2.4 -3.7
Heart disease (mother) 0.9 1.1 3.7 0.0 -0.3 -1.9 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.2 2.6 4.0 -2.0 -1.9 1.4 0.8
Whole body fat mass 2.3 9.7 18.9 4.3 3.1 -1.5 -2.8
Leg fat mass (right) 2.5 9.7 16.4 4.1 3.1 -2.2 -2.9
Arm predicted mass (right) 0.8 3.9 10.4 1.9 1.3 -3.2 -0.1
Pulse rate, automated reading 0.7 2.3 3.5 -1.9 -1.2 -1.5 1.4
Alcohol intake frequency. 0.7 1.6 2.8 -0.9 -1.4 -1.7 0.9
Comparative height size at age 10 0.2 0.9 1.4 0.9 -0.0 -1.1 1.2
Number of full sisters 0.8 1.0 1.1 -0.8 -1.1 -1.1 1.0
Suffer from ‘nerves’ 0.6 0.9 1.3 1.1 0.7 0.8 -1.2
Overall health rating 1.0 2.1 4.5 1.3 1.1 -0.8 -2.1
Chest pain or discomfort 6.5 9.4 17.1 2.9 3.2 -1.5 -4.1
Had major operations 0.1 0.1 0.4 0.4 0.1 -0.1 -0.6
Age at last live birth 0.6 0.8 1.6 -0.7 -0.9 0.5 1.3
Family relationship satisfaction 1.0 1.2 2.6 -0.5 -1.6 0.9 1.1
Leg pain on walking 0.3 0.3 0.8 0.9 0.2 0.6 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.4 -1.2 -0.9 -0.4 0.3
Commuting to job workplace: Car/motor vehicle 0.7 0.7 1.2 1.1 0.6 -0.8 -0.9
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.3 0.5 0.4 -0.5 0.0
Medication: Aspirin 2.0 2.6 4.2 2.0 1.4 -0.6 -2.0
Supplements: Vitamin C 0.2 0.2 0.7 0.1 0.1 0.8 0.3
Knee pain experienced in last month 0.2 0.2 0.4 0.2 -0.5 0.7 0.4
Hypertension (Self-reported) 4.8 13.3 23.0 4.8 3.7 -1.1 -3.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 0.8 -0.9 -0.6 0.5 0.7
Illnesses of father: Heart disease 0.7 1.0 3.7 0.2 -0.0 -1.9 0.4
Illnesses of siblings: Diabetes 0.7 0.9 2.1 -0.1 -0.4 1.2 -1.5
Smoking status: Previous 0.3 0.5 1.5 -1.2 -0.3 -0.5 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.6 5.3 1.8 1.8 -2.3 -1.6
Whole body fat-free mass 1.0 5.9 11.9 2.7 1.9 -3.5 -1.0
Leg fat-free mass (right) 0.6 3.4 5.6 2.4 1.4 -2.3 -0.9
Arm fat percentage (left) 3.2 12.7 21.0 4.6 3.6 -1.5 -3.8
Average weekly red wine intake 0.1 0.1 0.2 -0.4 -0.3 0.4 0.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.1 0.3 0.5 -1.1 -0.7
Mood swings 0.7 1.3 1.9 -1.3 -1.4 0.6 1.2
Loneliness, isolation 0.5 0.6 1.9 1.4 0.7 -0.2 -0.4
Long-standing illness, disability or infirmity 0.9 1.3 2.1 1.5 0.6 -0.9 -1.4
Ever had bowel cancer screening 0.6 0.8 1.3 0.8 0.9 1.1 -0.5
Diabetes diagnosed by doctor 0.9 1.5 4.5 0.6 1.0 -2.1 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 2.1 2.3 4.4 -1.5 -2.1 -0.1 1.6
Friendships satisfaction 3.7 4.6 6.7 -1.8 -2.6 2.1 2.0
Qualifications: nursing, teaching 0.3 0.5 1.2 -0.1 -0.4 1.1 0.7
Commuting to job workplace: Walk 4.4 4.7 7.2 -2.7 -2.4 1.7 1.8
Eye problems/disorders: Cataract 0.1 0.1 0.4 0.1 -0.2 -0.0 0.6
Mouth/teeth dental problems: Mouth ulcers 1.2 1.9 2.7 -1.6 -1.4 -0.9 1.5
Medication for cholesterol 2.9 4.3 7.5 -2.7 -2.4 1.3 1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.2 2.6 4.1 2.0 1.8 0.9 -1.5
Back pain experienced in last month 1.4 2.0 3.5 -1.4 -1.9 -1.1 1.2
Mineral and other dietary supplements 0.4 0.5 1.9 -0.4 0.2 -1.4 0.1
Breast cancer (self-reported) 0.5 0.6 1.9 0.0 -0.4 -1.4 0.6
Asthma (self-reported) 0.3 0.7 1.2 0.9 0.5 -1.1 -0.5
Osteoporosis (self-reported) 0.3 0.4 1.0 -0.2 0.4 1.0 -0.7
Osteoarthritis (self-reported) 0.7 0.9 1.7 0.6 0.6 1.1 1.3
Medication: Aspirin 2.7 3.6 4.8 2.2 2.0 -0.9 -2.2
Medication: Gliclazide 1.2 1.4 4.5 -0.3 0.2 -2.1 0.9
Illnesses of father: None of the above (group 1) 3.1 3.8 5.8 -2.0 -1.5 2.4 1.8
Smoking status: Current 2.8 4.4 7.0 -2.1 -2.4 0.8 2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 1.6 -1.3 -1.2 0.7 0.9
Whole body water mass 1.0 6.0 12.7 2.6 1.9 -3.6 -0.9
Leg predicted mass (right) 0.7 3.7 6.0 2.5 1.5 -2.3 -1.0
Arm fat mass (left) 3.1 12.8 22.6 4.8 3.6 -2.2 -3.2
Number of self-reported non-cancer illnesses 0.4 0.7 1.4 1.2 0.3 -0.8 -0.9
Average weekly champagne plus white wine intake 0.6 0.8 1.8 -0.7 -1.3 -0.1 0.9
Miserableness 0.9 1.5 2.5 -1.6 -1.4 0.4 1.1
Guilty feelings 2.5 3.8 5.4 -2.2 -2.3 0.9 2.0
Wears glasses or contact lenses 0.3 0.3 0.8 -0.2 0.7 0.1 0.9
Ever taken oral contraceptive pill 2.1 2.3 4.1 1.2 0.8 -2.0 -1.8
Hearing aid user 0.1 0.1 0.2 -0.1 0.4 0.3 -0.2
Mother’s age at death 1.5 1.9 5.1 -1.2 -0.8 2.3 0.7
Financial situation satisfaction 0.7 0.9 2.6 -0.7 -1.6 -0.3 0.5
Tinnitus: Yes, now most or all of the time 4.7 5.5 8.0 -2.2 -2.2 2.0 2.8
Commuting to job workplace: Public transport 0.3 0.3 0.9 -0.9 0.1 -0.5 -0.2
Eye problems/disorders: Glaucoma 0.3 0.3 0.8 -0.9 -0.1 -0.1 0.7
Medication: Blood pressure 6.0 11.4 17.6 4.2 3.8 -1.5 -3.3
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.7 -0.6 -1.3 0.3 1.1
Supplements: Fish oil (including cod liver oil) 1.3 1.7 4.2 -0.6 -1.0 2.1 1.1
High cholesterol (Self-reported) 0.2 0.3 0.8 -0.3 -0.4 -0.4 0.9
Medication: Bendroflumethiazide 3.9 5.9 9.5 2.9 2.2 -1.0 -3.1
Medication: Paracetamol 1.4 2.2 3.2 1.8 1.5 -1.1 -1.4
Medication: Lisinopril 4.2 5.5 10.8 2.3 2.3 -0.5 -3.3
Medication: Atorvastatin 0.3 0.3 0.7 0.5 0.5 -0.8 -0.3
Illnesses of father: High blood pressure 0.2 0.3 0.5 0.4 -0.7 0.2 -0.6
Alcohol drinker status: Never 0.1 0.1 0.1 0.2 -0.4 -0.2 0.3
Ever smoked 1.3 2.3 5.4 -2.3 -0.8 -0.3 1.7
Basal metabolic rate 1.4 7.7 12.2 3.3 2.4 -3.5 -1.5
Leg fat percentage (left) 3.1 11.3 16.5 4.1 3.6 -1.8 -3.5
Arm fat-free mass (left) 1.2 6.2 13.9 2.6 1.9 -3.7 -0.8
Number of operations (self-reported) 0.8 1.2 2.0 -1.4 -1.0 0.1 1.3
Average weekly beer plus cider intake 0.2 0.2 0.9 0.2 -0.0 -1.0 -0.0
Irritability 4.7 7.9 8.5 -2.7 -2.9 2.7 2.9
Risk taking 0.1 0.2 0.3 -0.3 -0.5 -0.5 0.2
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.8 0.4 0.4 1.4 -0.5
Fractured/broken bones in last 5 years 0.3 0.4 0.9 0.6 0.2 0.4 -1.0
Age started oral contraceptive pill 0.7 0.9 2.4 -0.5 -0.8 1.5 0.5
Diastolic blood pressure, automated reading 5.0 15.4 31.3 5.6 3.8 -0.9 -3.9
Ever depressed for a whole week 0.3 0.4 0.5 0.7 0.2 -0.6 0.7
Unable to work because of sickness or disability 0.1 0.1 0.3 -0.2 -0.6 -0.2 0.2
Commuting to job workplace: Cycle 0.7 0.8 1.2 -1.1 -0.5 1.1 0.8
Myopia 2.4 3.5 4.2 -2.0 -2.0 2.0 1.4
Vascular/heart problems diagnosed by doctor 4.3 11.8 22.3 -4.7 -3.2 0.4 3.8
Cholesterol lowering medication 0.2 0.3 1.1 -0.0 -0.4 0.3 1.0
Medication: Omeprazole (e.g. Zanprol) 1.6 1.9 4.1 -0.8 -1.2 2.0 1.2
Pain experienced in last month 0.4 0.6 1.0 0.9 1.0 0.8 -0.2
Supplements: Calcium 1.5 1.6 2.4 -1.6 -1.1 1.4 0.9
Basal cell carcinoma (self-reported) 0.4 0.5 1.4 0.6 1.2 -0.1 0.3
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.7 0.7 -0.1 0.0 -0.8
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.0 0.1 -0.9 1.4 0.9
Heart disease (siblings) 1.2 1.4 3.3 1.1 1.8 -0.6 -0.9
Alcohol drinker status: Previous 0.6 0.7 2.6 -0.3 0.3 -1.6 0.1
Pack years of smoking 0.7 1.0 1.2 -0.8 -1.1 1.0 1.1
Impedance of whole body 0.9 4.4 14.0 -1.0 -1.2 3.7 1.2
Leg fat mass (left) 2.3 9.0 15.0 3.9 3.0 -2.0 -2.8
Arm predicted mass (left) 1.2 6.3 14.2 2.6 1.8 -3.8 -0.9