[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr3:155,695,485-157,456,920

Best TWAS P=2.68e-17 · Best GWAS P=2.57e-15 conditioned to 0.278

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
33	The Cancer Genome Atlas	Soft Tissue Sarcoma	LEKR1	0.15	0.04	lasso	6	0.09	6.9e-06	-7.9	8.5	2.7e-17	-0.85	0.01	0.99	TRUE
16	METSIM	Adipose	TIPARP	0.07	0.08	lasso	4	0.08	6.3e-12	-5.7	-5.6	1.8e-08	0.03	1.00	0.00	TRUE
19	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	LEKR1	0.18	0.12	enet	8	0.10	9.2e-06	-7.9	8.2	1.9e-16	-0.99	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	LEKR1	0.24	0.33	lasso	8	0.37	9.5e-38	-7.6	8.2	2.3e-16	-0.95	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Stomach Adenocarcinoma	LEKR1	0.06	0.07	lasso	3	0.07	1.1e-05	-7.6	8.2	3.0e-16	-0.88	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LEKR1	0.09	0.10	lasso	3	0.09	4.4e-10	-7.7	8.0	1.0e-15	-0.99	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	LEKR1	0.20	0.19	lasso	5	0.19	2.6e-19	-7.9	8.0	1.1e-15	-0.99	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LEKR1	0.16	0.13	lasso	5	0.13	8.4e-08	-7.9	8.0	1.4e-15	-0.98	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	LEKR1	0.09	0.12	lasso	1	0.11	1.2e-12	-7.9	7.9	2.6e-15	-1.00	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LEKR1	0.14	0.15	lasso	1	0.15	9.8e-07	-7.9	7.9	2.6e-15	-1.00	0.00	0.99	FALSE
37	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	LEKR1	0.21	0.14	lasso	4	0.10	8.6e-04	-7.9	7.9	2.6e-15	-1.00	0.00	0.94	FALSE
17	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LEKR1	0.10	0.14	lasso	6	0.12	1.8e-10	-7.8	7.9	2.7e-15	-1.00	0.00	1.00	FALSE
4	GTEx	Artery Tibial	TIPARP	0.13	0.02	enet	17	0.05	8.2e-05	-7.1	-7.9	3.7e-15	0.71	0.01	0.98	FALSE
5	GTEx	Artery Tibial	LINC00886	0.43	0.26	enet	59	0.42	4.2e-35	-7.0	-7.8	4.4e-15	0.59	0.62	0.38	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LEKR1	0.22	0.18	enet	21	0.22	2.1e-24	-7.6	7.8	6.9e-15	-0.89	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	LEKR1	0.16	0.12	lasso	2	0.09	5.2e-06	-7.9	7.8	7.0e-15	-1.00	0.00	1.00	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	LEKR1	0.13	0.16	lasso	5	0.15	3.6e-30	-7.9	7.7	1.2e-14	-1.00	0.00	1.00	FALSE
15	METSIM	Adipose	LEKR1	0.09	0.09	lasso	3	0.09	1.7e-13	-7.8	7.7	1.6e-14	-0.99	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LEKR1	0.23	0.27	lasso	2	0.26	1.7e-17	-7.7	7.7	1.9e-14	-0.99	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Rectum Adenocarcinoma	LEKR1	0.40	0.25	lasso	2	0.26	9.1e-07	-7.6	7.6	2.4e-14	-0.84	0.02	0.96	FALSE
8	GTEx	Esophagus Muscularis	METTL15P1	0.10	0.03	lasso	2	0.02	1.8e-02	-6.9	-6.9	4.0e-12	0.68	0.23	0.60	FALSE
21	The Cancer Genome Atlas	Esophageal Carcinoma	LEKR1	0.25	0.08	blup	112	0.18	2.0e-06	-7.7	6.9	4.7e-12	-0.80	0.01	0.96	FALSE
27	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LEKR1	0.12	0.07	blup	114	0.08	2.6e-09	-7.6	6.8	7.6e-12	-0.91	0.00	1.00	FALSE
3	GTEx	Artery Aorta	LINC00886	0.40	0.24	lasso	9	0.22	2.7e-12	-7.0	-6.8	1.3e-11	0.54	0.77	0.23	FALSE
13	GTEx	Pancreas	LINC00886	0.32	0.23	enet	25	0.26	3.1e-11	-7.0	-6.5	1.1e-10	0.56	0.81	0.19	FALSE
12	GTEx	Nerve Tibial	LINC00886	0.30	0.14	lasso	16	0.16	8.4e-12	-7.0	-6.1	8.0e-10	0.52	0.72	0.28	FALSE
30	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LEKR1	0.27	0.07	blup	113	0.07	1.0e-03	-7.8	6.1	1.0e-09	-0.86	0.01	0.97	FALSE
6	GTEx	Breast Mammary Tissue (Male)	LINC00886	0.17	0.03	enet	4	0.04	4.4e-02	-7.0	-5.9	2.8e-09	0.60	0.06	0.16	FALSE
35	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LEKR1	0.12	0.03	blup	114	0.03	2.5e-02	-6.9	5.9	4.3e-09	-0.76	0.02	0.57	FALSE
14	GTEx	Testis	LINC00886	0.39	0.24	lasso	9	0.21	1.5e-09	-7.0	-5.7	1.4e-08	0.47	0.74	0.26	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	LEKR1	0.06	0.01	blup	112	0.04	4.6e-05	-7.6	5.5	2.9e-08	-0.76	0.01	0.97	FALSE
2	GTEx	Adipose Subcutaneous	LINC00886	0.42	0.24	enet	28	0.38	1.7e-32	-7.0	-5.5	4.4e-08	0.35	0.72	0.28	FALSE
10	GTEx	Heart Left Ventricle	LINC00886	0.25	0.08	lasso	10	0.07	1.5e-04	-6.6	-5.5	4.9e-08	0.49	0.45	0.10	FALSE
11	GTEx	Lung	LINC00886	0.19	0.07	enet	21	0.13	2.5e-10	-7.0	-5.4	7.7e-08	0.41	0.80	0.20	FALSE
7	GTEx	Colon Transverse	LINC00886	0.41	0.24	lasso	14	0.24	1.7e-11	-7.0	-5.4	8.0e-08	0.53	0.82	0.18	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LEKR1	0.22	0.08	lasso	17	0.16	2.2e-18	-7.8	5.2	2.3e-07	-0.82	0.00	1.00	FALSE
9	GTEx	Heart Atrial Appendage	LINC00886	0.33	0.04	lasso	11	0.03	2.0e-02	-3.0	-5.2	2.3e-07	0.47	0.40	0.23	FALSE