Best TWAS P=2.68e-17 · Best GWAS P=2.57e-15 conditioned to 0.278
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LEKR1 | 0.22 | 0.08 | lasso | 17 | 0.16 | 2.2e-18 | -7.8 | 5.2 | 2.3e-07 | -0.82 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | LINC00886 | 0.42 | 0.24 | enet | 28 | 0.38 | 1.7e-32 | -7.0 | -5.5 | 4.4e-08 | 0.35 | 0.72 | 0.28 | FALSE |
| 3 | GTEx | Artery Aorta | LINC00886 | 0.40 | 0.24 | lasso | 9 | 0.22 | 2.7e-12 | -7.0 | -6.8 | 1.3e-11 | 0.54 | 0.77 | 0.23 | FALSE |
| 4 | GTEx | Artery Tibial | TIPARP | 0.13 | 0.02 | enet | 17 | 0.05 | 8.2e-05 | -7.1 | -7.9 | 3.7e-15 | 0.71 | 0.01 | 0.98 | FALSE |
| 5 | GTEx | Artery Tibial | LINC00886 | 0.43 | 0.26 | enet | 59 | 0.42 | 4.2e-35 | -7.0 | -7.8 | 4.4e-15 | 0.59 | 0.62 | 0.38 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Male) | LINC00886 | 0.17 | 0.03 | enet | 4 | 0.04 | 4.4e-02 | -7.0 | -5.9 | 2.8e-09 | 0.60 | 0.06 | 0.16 | FALSE |
| 7 | GTEx | Colon Transverse | LINC00886 | 0.41 | 0.24 | lasso | 14 | 0.24 | 1.7e-11 | -7.0 | -5.4 | 8.0e-08 | 0.53 | 0.82 | 0.18 | FALSE |
| 8 | GTEx | Esophagus Muscularis | METTL15P1 | 0.10 | 0.03 | lasso | 2 | 0.02 | 1.8e-02 | -6.9 | -6.9 | 4.0e-12 | 0.68 | 0.23 | 0.60 | FALSE |
| 9 | GTEx | Heart Atrial Appendage | LINC00886 | 0.33 | 0.04 | lasso | 11 | 0.03 | 2.0e-02 | -3.0 | -5.2 | 2.3e-07 | 0.47 | 0.40 | 0.23 | FALSE |
| 10 | GTEx | Heart Left Ventricle | LINC00886 | 0.25 | 0.08 | lasso | 10 | 0.07 | 1.5e-04 | -6.6 | -5.5 | 4.9e-08 | 0.49 | 0.45 | 0.10 | FALSE |
| 11 | GTEx | Lung | LINC00886 | 0.19 | 0.07 | enet | 21 | 0.13 | 2.5e-10 | -7.0 | -5.4 | 7.7e-08 | 0.41 | 0.80 | 0.20 | FALSE |
| 12 | GTEx | Nerve Tibial | LINC00886 | 0.30 | 0.14 | lasso | 16 | 0.16 | 8.4e-12 | -7.0 | -6.1 | 8.0e-10 | 0.52 | 0.72 | 0.28 | FALSE |
| 13 | GTEx | Pancreas | LINC00886 | 0.32 | 0.23 | enet | 25 | 0.26 | 3.1e-11 | -7.0 | -6.5 | 1.1e-10 | 0.56 | 0.81 | 0.19 | FALSE |
| 14 | GTEx | Testis | LINC00886 | 0.39 | 0.24 | lasso | 9 | 0.21 | 1.5e-09 | -7.0 | -5.7 | 1.4e-08 | 0.47 | 0.74 | 0.26 | FALSE |
| 15 | METSIM | Adipose | LEKR1 | 0.09 | 0.09 | lasso | 3 | 0.09 | 1.7e-13 | -7.8 | 7.7 | 1.6e-14 | -0.99 | 0.00 | 1.00 | FALSE |
| 16 | METSIM | Adipose | TIPARP | 0.07 | 0.08 | lasso | 4 | 0.08 | 6.3e-12 | -5.7 | -5.6 | 1.8e-08 | 0.03 | 1.00 | 0.00 | TRUE |
| 17 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | LEKR1 | 0.10 | 0.14 | lasso | 6 | 0.12 | 1.8e-10 | -7.8 | 7.9 | 2.7e-15 | -1.00 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LEKR1 | 0.13 | 0.16 | lasso | 5 | 0.15 | 3.6e-30 | -7.9 | 7.7 | 1.2e-14 | -1.00 | 0.00 | 1.00 | FALSE |
| 19 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LEKR1 | 0.18 | 0.12 | enet | 8 | 0.10 | 9.2e-06 | -7.9 | 8.2 | 1.9e-16 | -0.99 | 0.00 | 1.00 | FALSE |
| 20 | The Cancer Genome Atlas | Colon Adenocarcinoma | LEKR1 | 0.16 | 0.12 | lasso | 2 | 0.09 | 5.2e-06 | -7.9 | 7.8 | 7.0e-15 | -1.00 | 0.00 | 1.00 | FALSE |
| 21 | The Cancer Genome Atlas | Esophageal Carcinoma | LEKR1 | 0.25 | 0.08 | blup | 112 | 0.18 | 2.0e-06 | -7.7 | 6.9 | 4.7e-12 | -0.80 | 0.01 | 0.96 | FALSE |
| 22 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LEKR1 | 0.09 | 0.10 | lasso | 3 | 0.09 | 4.4e-10 | -7.7 | 8.0 | 1.0e-15 | -0.99 | 0.01 | 0.99 | FALSE |
| 23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LEKR1 | 0.22 | 0.18 | enet | 21 | 0.22 | 2.1e-24 | -7.6 | 7.8 | 6.9e-15 | -0.89 | 0.01 | 0.99 | FALSE |
| 24 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LEKR1 | 0.16 | 0.13 | lasso | 5 | 0.13 | 8.4e-08 | -7.9 | 8.0 | 1.4e-15 | -0.98 | 0.00 | 1.00 | FALSE |
| 25 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LEKR1 | 0.06 | 0.01 | blup | 112 | 0.04 | 4.6e-05 | -7.6 | 5.5 | 2.9e-08 | -0.76 | 0.01 | 0.97 | FALSE |
| 26 | The Cancer Genome Atlas | Lung Adenocarcinoma | LEKR1 | 0.09 | 0.12 | lasso | 1 | 0.11 | 1.2e-12 | -7.9 | 7.9 | 2.6e-15 | -1.00 | 0.00 | 1.00 | FALSE |
| 27 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LEKR1 | 0.12 | 0.07 | blup | 114 | 0.08 | 2.6e-09 | -7.6 | 6.8 | 7.6e-12 | -0.91 | 0.00 | 1.00 | FALSE |
| 28 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LEKR1 | 0.23 | 0.27 | lasso | 2 | 0.26 | 1.7e-17 | -7.7 | 7.7 | 1.9e-14 | -0.99 | 0.00 | 1.00 | FALSE |
| 29 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LEKR1 | 0.14 | 0.15 | lasso | 1 | 0.15 | 9.8e-07 | -7.9 | 7.9 | 2.6e-15 | -1.00 | 0.00 | 0.99 | FALSE |
| 30 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LEKR1 | 0.27 | 0.07 | blup | 113 | 0.07 | 1.0e-03 | -7.8 | 6.1 | 1.0e-09 | -0.86 | 0.01 | 0.97 | FALSE |
| 31 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LEKR1 | 0.20 | 0.19 | lasso | 5 | 0.19 | 2.6e-19 | -7.9 | 8.0 | 1.1e-15 | -0.99 | 0.00 | 1.00 | FALSE |
| 32 | The Cancer Genome Atlas | Rectum Adenocarcinoma | LEKR1 | 0.40 | 0.25 | lasso | 2 | 0.26 | 9.1e-07 | -7.6 | 7.6 | 2.4e-14 | -0.84 | 0.02 | 0.96 | FALSE |
| 33 | The Cancer Genome Atlas | Soft Tissue Sarcoma | LEKR1 | 0.15 | 0.04 | lasso | 6 | 0.09 | 6.9e-06 | -7.9 | 8.5 | 2.7e-17 | -0.85 | 0.01 | 0.99 | TRUE |
| 34 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LEKR1 | 0.06 | 0.07 | lasso | 3 | 0.07 | 1.1e-05 | -7.6 | 8.2 | 3.0e-16 | -0.88 | 0.02 | 0.98 | FALSE |
| 35 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | LEKR1 | 0.12 | 0.03 | blup | 114 | 0.03 | 2.5e-02 | -6.9 | 5.9 | 4.3e-09 | -0.76 | 0.02 | 0.57 | FALSE |
| 36 | The Cancer Genome Atlas | Thyroid Carcinoma | LEKR1 | 0.24 | 0.33 | lasso | 8 | 0.37 | 9.5e-38 | -7.6 | 8.2 | 2.3e-16 | -0.95 | 0.01 | 0.99 | FALSE |
| 37 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | LEKR1 | 0.21 | 0.14 | lasso | 4 | 0.10 | 8.6e-04 | -7.9 | 7.9 | 2.6e-15 | -1.00 | 0.00 | 0.94 | FALSE |